Detailed information for compound 990653

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 587.644 | Formula: C22H41NO15Si
  • H donors: 10 H acceptors: 11 LogP: -3.53 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCC(=O)N[C@@H]1[C@@H](O)C[C@](O[C@H]1[C@@H]([C@@H](CO)O)O)(OC[C@H]1O[C@@H](OCC[Si](C)(C)C)[C@@H]([C@H]([C@H]1O)O)O)C(=O)O
  • InChi: 1S/C22H41NO15Si/c1-39(2,3)5-4-35-20-18(32)17(31)16(30)12(37-20)9-36-22(21(33)34)6-10(26)14(23-13(28)8-25)19(38-22)15(29)11(27)7-24/h10-12,14-20,24-27,29-32H,4-9H2,1-3H3,(H,23,28)(H,33,34)/t10-,11+,12+,14+,15+,16-,17-,18+,19+,20+,22+/m0/s1
  • InChiKey: MXMLYOVDSKETSY-FSZSPIRPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0208 0.0406
Echinococcus multilocularis Smad4 0.0009 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0406
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0261
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0076
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0039 0.0076
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0208 0.0484
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0076
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0036 0.0817
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0208 0.0406
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0147 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0249 0.0485
Echinococcus multilocularis smad 0.0009 0.0015 0.0015
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0147 0.3357
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0135
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0208 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0036 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0076
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0039 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0361 0.0703
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0039 0.0076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0243 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0039 0.0076
Loa Loa (eye worm) hypothetical protein 0.0106 0.1138 0.2216
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0134 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.038 0.4301 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0039 0.0076
Schistosoma mansoni ap endonuclease 0.002 0.0147 0.0287
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0093 0.0181
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0039 0.0039
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.1398 0.2724
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0039 0.0076
Onchocerca volvulus 0.0052 0.0513 0.1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0261
Loa Loa (eye worm) hypothetical protein 0.0056 0.0557 0.1085
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0039 0.0076
Schistosoma mansoni topbp1 0.0011 0.0036 0.007
Brugia malayi hypothetical protein 0.0255 0.2855 0.556
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0036 0.0083
Loa Loa (eye worm) hypothetical protein 0.038 0.4301 0.8376
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0147 1
Entamoeba histolytica hypothetical protein 0.0039 0.0361 0.3171
Brugia malayi hypothetical protein 0.0011 0.0036 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0261
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0261
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0036 0.2435
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0208 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0036 0.0083
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0439 0.0855
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.007
Onchocerca volvulus 0.0029 0.0249 0.0485
Loa Loa (eye worm) hypothetical protein 0.0247 0.2771 0.5396
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0208 0.183
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0147
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0039 0.0076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0134 0.6421
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0039 0.0076
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0147 0.0343
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0208 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.1138 0.2216
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0076
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0439 0.0439
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0147 0.0287
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.1138 1
Schistosoma mansoni survival motor neuron protein 0.0052 0.0513 0.1
Brugia malayi Smad1 0.0009 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.007
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0701 0.1366
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0039 0.0076
Toxoplasma gondii exonuclease III APE 0.002 0.0147 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0036 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0817
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0039 0.0076
Loa Loa (eye worm) hypothetical protein 0.0255 0.2855 0.556
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0701 0.0701
Mycobacterium ulcerans hypothetical protein 0.0026 0.0208 1
Echinococcus granulosus lamin dm0 0.0029 0.0249 0.0485
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0452 0.5135 1
Schistosoma mansoni topbp1 0.0011 0.0036 0.007
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.1664 0.324
Brugia malayi CHE-14 protein 0.0046 0.0439 0.0855
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0134 0.6421
Schistosoma mansoni smad1 5 8 and 0.0009 0.0015 0.0028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0015 0.0015
Echinococcus granulosus biogenic amine 5HT receptor 0.0247 0.2771 0.5396
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0039 0.0076
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0701 0.1366
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0039 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0039 0.0076
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0208 0.183
Echinococcus multilocularis serotonin receptor 0.0247 0.2771 0.2771
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0015 0.0028
Schistosoma mansoni smad1 5 8 and 0.0009 0.0015 0.0028
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0701 0.1366
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0406
Trypanosoma cruzi C-8 sterol isomerase, putative 0.038 0.4301 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0208 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0015 0.0028
Echinococcus multilocularis expressed conserved protein 0.01 0.1064 0.1064
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0513 0.1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.038 0.4301 0.8376
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0439 0.0855
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0039 0.0076
Echinococcus multilocularis protein dispatched 1 0.0052 0.0513 0.0513
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0075 0.0075
Echinococcus granulosus smad 0.0009 0.0015 0.0028
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0015 0.0015
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0036 0.0817
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0015 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0039 0.0076
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.1157 0.2253
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0817
Brugia malayi hypothetical protein 0.0011 0.0036 0.007
Leishmania major C-8 sterol isomerase-like protein 0.038 0.4301 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0039 0.0076
Brugia malayi vesicular acetylcholine transporter unc-17 0.0452 0.5135 1
Brugia malayi topoisomerase 0.0011 0.0036 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0039 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0039 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0039 0.0076
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0147 0.1295
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0036 0.2435
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0039 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0817
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0039 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0039 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0039 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0039 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0249 0.0485
Schistosoma mansoni DNA ligase IV 0.0011 0.0036 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0039 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.007
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0208 0.0484
Entamoeba histolytica hypothetical protein 0.0039 0.0361 0.3171
Echinococcus multilocularis vesicular acetylcholine transporter 0.0452 0.5135 0.5135
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0036 0.0083
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0036 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0039 0.0076
Echinococcus multilocularis nibrin 0.0011 0.0036 0.0036
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0039 0.0039
Echinococcus multilocularis lamin 0.0029 0.0249 0.0249
Entamoeba histolytica hypothetical protein 0.0039 0.0361 0.3171
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0015 0.0028
Schistosoma mansoni ap endonuclease 0.002 0.0147 0.0287
Loa Loa (eye worm) hypothetical protein 0.0019 0.0134 0.0261
Brugia malayi nuclear receptor NHR-88 0.0011 0.0039 0.0076
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0208 0.0484
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.2855 0.556
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.1138 0.1138
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0036 0.007
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0039 0.0076
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0039 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0039 0.0076
Entamoeba histolytica hypothetical protein 0.0011 0.0036 0.0315
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0208 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0039 0.0076
Echinococcus multilocularis protein patched 0.0046 0.0439 0.0439
Schistosoma mansoni coup transcription factor 0.0011 0.0039 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0817
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0036 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0208 0.0406
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0701 0.1366
Echinococcus granulosus intermediate filament protein 0.0029 0.0249 0.0485
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0039 0.0076
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0147 0.0343
Schistosoma mansoni biogenic amine (5HT) receptor 0.0247 0.2771 0.5396
Onchocerca volvulus 0.0011 0.0036 0.007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0208 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0039 0.0076
Schistosoma mansoni hypothetical protein 0.0044 0.042 0.0818
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0147 1
Entamoeba histolytica hypothetical protein 0.0039 0.0361 0.3171
Brugia malayi hypothetical protein 0.0039 0.0361 0.0703
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.007
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0039 0.0076
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0208 1
Echinococcus multilocularis musashi 0.0029 0.0249 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0039 0.0076
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0208 1
Schistosoma mansoni hypothetical protein 0.0044 0.042 0.0818
Loa Loa (eye worm) hypothetical protein 0.0029 0.0249 0.0485
Brugia malayi MH2 domain containing protein 0.0009 0.0015 0.0028
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0701 0.1366
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0134 0.9078
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0817
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0208 1
Brugia malayi intermediate filament protein 0.0029 0.0249 0.0485
Brugia malayi MH2 domain containing protein 0.0129 0.1398 0.2724
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0122 0.5844
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0439 0.0855
Onchocerca volvulus 0.0026 0.0208 0.0406
Loa Loa (eye worm) Smad1 0.0009 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0135
Schistosoma mansoni lamin 0.0029 0.0249 0.0485
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0147 0.0343
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0036 0.2435
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0147 0.3357
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0039 0.0076
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0039 0.0076
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0039 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0039 0.0076
Schistosoma mansoni vesicular acetylcholine transporter 0.0452 0.5135 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0039 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0122 0.5844
Onchocerca volvulus 0.0029 0.0249 0.0485
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0039 0.0076
Echinococcus multilocularis lamin dm0 0.0029 0.0249 0.0249
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0036 0.007
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0015 0.0028
Echinococcus granulosus Smad4 0.0009 0.0015 0.0028
Schistosoma mansoni hypothetical protein 0.0039 0.0361 0.0703
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0076
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.1664 0.1664
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0039 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0208 1
Loa Loa (eye worm) hypothetical protein 0.0247 0.2771 0.5396
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0701 0.1366
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0039 0.0039
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0036 0.1722
Brugia malayi steroid hormone receptor 0.0011 0.0039 0.0076
Brugia malayi RNA binding protein 0.0068 0.0701 0.1366
Schistosoma mansoni hypothetical protein 0.0044 0.042 0.0818
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0076
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0036 0.0817
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0452 0.5135 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0039 0.0039
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0039 0.0076
Echinococcus granulosus nibrin 0.0011 0.0036 0.007
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0147 0.7073
Brugia malayi MH1 domain containing protein 0.0009 0.0015 0.0028
Brugia malayi follicle stimulating hormone receptor 0.0254 0.2849 0.5548
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0039 0.0076
Echinococcus multilocularis serotonin receptor 0.0247 0.2771 0.2771
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0039 0.0076
Schistosoma mansoni intermediate filament proteins 0.0029 0.0249 0.0485
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0147 0.0147
Loa Loa (eye worm) RNA binding protein 0.0068 0.0701 0.1366
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0036 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0439 1
Brugia malayi MH2 domain containing protein 0.0009 0.0015 0.0028
Brugia malayi TAR-binding protein 0.0068 0.0701 0.1366
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0076
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0039 0.0039
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0134 0.9078
Schistosoma mansoni lamin 0.0029 0.0249 0.0485
Brugia malayi ecdysteroid receptor 0.0011 0.0039 0.0076
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0147 1
Schistosoma mansoni hypothetical protein 0.0052 0.0513 0.1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0122 0.5844
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0036 0.2435
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0147 0.7073
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0147 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0075 0.0147
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0039 0.0039
Schistosoma mansoni patched 1 0.0046 0.0439 0.0855
Schistosoma mansoni smad 0.0009 0.0015 0.0028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0361 0.0361
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0093 0.0181
Brugia malayi MH1 domain containing protein 0.0009 0.0015 0.0028
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0015 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0701 0.1366
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0208 0.183
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0036 0.0817
Echinococcus granulosus tar DNA binding protein 0.0068 0.0701 0.1366
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0036 0.0315
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0147 0.0287
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0249 0.0485
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.1138 0.2216
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0208 1
Echinococcus granulosus expressed conserved protein 0.01 0.1064 0.2072
Schistosoma mansoni hypothetical protein 0.0044 0.042 0.0818
Schistosoma mansoni Smad4 0.0009 0.0015 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0122 0.5844
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.1398 0.2724
Echinococcus granulosus vesicular acetylcholine transporter 0.0452 0.5135 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0076
Brugia malayi DKFZp564C0469 protein 0.0011 0.0036 0.007
Onchocerca volvulus 0.0011 0.0039 0.0076
Loa Loa (eye worm) hypothetical protein 0.0046 0.0439 0.0855
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0039 0.0076
Echinococcus granulosus lamin 0.0029 0.0249 0.0485
Loa Loa (eye worm) hypothetical protein 0.0194 0.2156 0.4198
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0039 0.0076
Brugia malayi nuclear hormone receptor 0.0011 0.0039 0.0076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0147 0.0343
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0701 0.1366
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0406
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.2855 0.2855
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0039 0.0039
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0361 0.0703
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0039 0.0076
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0036 0.1722
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0147 0.0287
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0036 0.0036
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.2849 0.5548
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0039 0.0039
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0039 0.0076

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 550 uM Binding affinity to biotinylated human CD22-human IgG1 chimeric protein expressed in mouse J558LST6 cells by flow cytometry ChEMBL. 18841881

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.