Detailed view for Bm1_12470

Basic information

TDR Targets ID: 237373
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 8.1799 | Length (AA): 433 | MW (Da): 48025 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 3

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07856   Mediator of CRAC channel activity

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Calcium signaling pathway (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
226 402 4hkr (A) 146 328 50.00 0 0.72 0.775976 0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130743)

Species Accession Gene Product
Brugia malayi Bm1_12470   hypothetical protein
Caenorhabditis elegans CELE_C09F5.2   Protein ORAI-1, isoform A
Drosophila melanogaster Dmel_CG11430   CG11430 gene product from transcript CG11430-RB
Echinococcus granulosus EgrG_001014000   calcium release activated calcium channel
Echinococcus multilocularis EmuJ_001014000   calcium release activated calcium channel
Homo sapiens 84876   ORAI calcium release-activated calcium modulator 1
Homo sapiens ENSG00000160991   ORAI calcium release-activated calcium modulator 2
Loa Loa (eye worm) LOAG_11516   hypothetical protein
Mus musculus ensembl-mmu:ENSMUSG00000039747   ORAI calcium release-activated calcium modulator 2
Mus musculus ENSMUSG00000049686   ORAI calcium release-activated calcium modulator 1
Schistosoma japonicum Sjp_0308840   IPR012446,Protein of unknown function DUF1650,domain-containing
Schistosoma mansoni Smp_076650.3   Protein orai-1
Schistosoma mansoni Smp_076650.1   Protein orai-1
Schmidtea mediterranea mk4.015565.00  
Schmidtea mediterranea mk4.015565.01  
Schmidtea mediterranea mk4.015565.02  

Essentiality

Bm1_12470 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C09F5.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ORAI calcium release-activated calcium modulator 1 Compounds References
Homo sapiens ORAI calcium release-activated calcium modulator 2 Compounds References
Rattus norvegicus Calcium release-activated calcium channel protein 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0429 0.2584 0.2584
0.0436 0.2603 0.2603
0.1323 0.3273 1
0.0432 0.2593 0.2591
0.1323 0.7222 1
0.1866 0.9594 0.9594
0.1323 0.4107 1
0.0437 0.7525 1
0.0436 0.2605 0.2605
0.199 0.3784 1
0.7668 0.3248 0.3248
0.0432 0.2592 0.2591
0.6607 0.8761 1
0.0508 0.5954 1
0.0438 0.2592 0.2591
0.0867 0.3185 0.3185
0.0436 0.2603 0.2603
0.0436 0.2603 0.2603
0.0927 0.2721 0.7058
0.0436 0.2603 0.2603
0.0436 0.2603 0.2603
0.0426 0.2592 0.2591
0.1323 0.8374 1
0.1323 0.8236 0.8236
0.0435 0.457 1
0.1323 0.801 1
0.0507 0.2594 0.2592
0.2021 0.6657 1
0.0433 0.2586 0.2585
0.0436 0.2603 0.2603
0.1323 0.8236 0.8236
0.0432 0.2587 0.2585
0.0303 0.5742 0.5734
0.199 0.3784 1
0.1866 0.9594 0.9594
0.0432 0.2587 0.2585
0.1323 0.6665 1
0.7668 0.3248 0.3248
0.0426 0.2592 0.2591
0.0424 0.2592 0.2591
0.0927 0.2721 0.7058
0.199 0.3784 1
0.7668 0.3248 0.3248
0.1323 0.6383 0.6383
0.0428 0.2591 0.2591
0.199 0.3784 1
0.043 0.2591 0.2591
0.1123 0.9812 0.9812
0.0371 0.4639 1
0.2198 0.9919 1
0.1323 0.8374 1
0.2198 0.9919 1
0.1323 0.9513 1
0.0303 0.5742 0.5734
0.1323 0.6665 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Bm1_12470 (Brugia malayi), hypothetical protein
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