Detailed information for compound 205055

Basic information

Technical information
  • TDR Targets ID: 205055
  • Name: (6R,7R)-3-methyl-8-oxo-7-[(2-phenylacetyl)ami no]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-car boxylic acid
  • MW: 332.374 | Formula: C16H16N2O4S
  • H donors: 2 H acceptors: 4 LogP: 0.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccccc1)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)C
  • InChi: 1S/C16H16N2O4S/c1-9-8-23-15-12(14(20)18(15)13(9)16(21)22)17-11(19)7-10-5-3-2-4-6-10/h2-6,12,15H,7-8H2,1H3,(H,17,19)(H,21,22)/t12-,15-/m1/s1
  • InChiKey: CIPQGGYPCPIDBB-IUODEOHRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6R,7R)-3-methyl-8-oxo-7-[(1-oxo-2-phenylethyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-3-methyl-8-oxo-7-(2-phenylethanoylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-8-keto-3-methyl-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • phenylacetyl 7-aminodesacetoxycephalosporanic acid
  • 34708-38-8
  • 27255-72-7
  • (6R-trans)-3-Methyl-8-oxo-7-(phenylacetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-methyl-8-oxo-7-((phenylacetyl)amino)-, (6R-trans)-
  • EINECS 248-379-3
  • BB_NC-1401

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0137
Brugia malayi jmjC domain containing protein 0.0094 0.0164 0.0434
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0001 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0016 0.023
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0022 0.0026 0.0382
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0016 0.0042
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0041
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0016 0.1534
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.2485
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0041
Schistosoma mansoni adapter molecule crk 0.0009 0.0002 0.0005
Toxoplasma gondii exonuclease III APE 0.0016 0.0015 0.0219
Loa Loa (eye worm) hypothetical protein 0.0049 0.0079 0.0209
Echinococcus granulosus stromal interaction molecule 1 0.044 0.0826 0.2183
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0023 0.122
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0037 0.3563
Echinococcus granulosus c-Jun N-terminal kinases 0.0269 0.0499 0.1318
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0051 0.0136
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0039 0.0039
Giardia lamblia PHD finger protein 15 0.0029 0.004 0.2796
Echinococcus multilocularis protoporphyrinogen oxidase 0.037 0.069 0.1825
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.037 0.069 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.004 0.3889
Echinococcus granulosus snurportin 1 0.0308 0.0574 0.1516
Brugia malayi PHD-finger family protein 0.0029 0.004 0.0105
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0007
Mycobacterium ulcerans oxidoreductase 0.037 0.069 0.069
Schistosoma mansoni Protein orai-1 0.199 0.3784 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0135
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0016 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0006 0.0015
Echinococcus multilocularis dna polymerase eta 0.0016 0.0016 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Plasmodium vivax heat shock protein, putative 0.0011 0.0006 0.0052
Brugia malayi MH2 domain containing protein 0.01 0.0175 0.0463
Brugia malayi AMP-binding enzyme family protein 0.002 0.0023 0.0061
Schistosoma mansoni hypothetical protein 0.0014 0.0011 0.003
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0068
Schistosoma mansoni jumonji domain containing protein 0.0009 0.0003 0.0007
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0177 0.0467
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0035 0.0052 0.0867
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Mycobacterium ulcerans hypothetical protein 0.002 0.0023 0.0023
Plasmodium vivax acyl-CoA synthetase, putative 0.0015 0.0013 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Schistosoma mansoni coup transcription factor 0.0008 0.0001 0.0003
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0004 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0001 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0001 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0016 0.1534
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0066 0.0915
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0001 0.0003
Echinococcus multilocularis snurportin 1 0.0308 0.0574 0.1516
Loa Loa (eye worm) flap endonuclease-1 0.0022 0.0027 0.007
Schistosoma mansoni patched 1 0.0035 0.0052 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0331 0.0616 0.1628
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0328 0.0612 0.1617
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0104 0.1854
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0002 0.0005
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0001 0.0003
Echinococcus granulosus Niemann Pick C1 protein 0.0082 0.0142 0.0375
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0015 0.1459
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0003 0.0295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0104 0.0275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0013
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0177 0.0467
Trypanosoma brucei unspecified product 0.0011 0.0006 0.0615
Echinococcus multilocularis sterol regulatory element binding protein 0.0035 0.0052 0.0139
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0026 0.0068
Schistosoma mansoni Protein orai-1 0.199 0.3784 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0001 0.0003
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0037 0.2253
Echinococcus granulosus heat shock protein 90 0.0027 0.0037 0.0098
Plasmodium falciparum heat shock protein 90, putative 0.0011 0.0006 0.0052
Plasmodium falciparum tyrosine kinase-like protein 0.0036 0.0054 0.0747
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0001 0.0003
Echinococcus multilocularis lysine specific demethylase 6a 0.0009 0.0003 0.0007
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0009 0.0003 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0013
Onchocerca volvulus 0.0252 0.0466 0.6748
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0041
Plasmodium falciparum phd finger protein, putative 0.0029 0.004 0.0539
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0002 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0035 0.0052 0.0137
Schistosoma mansoni hypothetical protein 0.0035 0.0051 0.0135
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0054 0.0143
Onchocerca volvulus 0.0036 0.0054 0.0765
Loa Loa (eye worm) SRC-1 0.001 0.0004 0.0011
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0041
Echinococcus multilocularis lysine specific histone demethylase 1A 0.037 0.069 0.1825
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0016 0.023
Giardia lamblia Heat shock protein HSP 90-alpha 0.0022 0.0026 0.1273
Giardia lamblia Grp94/Hsp90 0.0022 0.0026 0.1273
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0026 0.0373
Trichomonas vaginalis heat shock protein, putative 0.0017 0.0017 0.0201
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0016 0.0042
Schistosoma mansoni lip-related protein (liprin) alpha 0.0035 0.0052 0.0137
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0164 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0054 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0006 0.0615
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0001 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0001 0.0003
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0026 0.0381
Brugia malayi Flap endonuclease-1 0.0022 0.0027 0.007
Brugia malayi ecdysteroid receptor 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0259 0.0479 0.1266
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0104 0.0275
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.0132
Leishmania major hypothetical protein, conserved 0.0009 0.0003 0.0041
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0001 0.0003
Brugia malayi Neurabin protein 1 0.0035 0.0052 0.0137
Schistosoma mansoni heat shock protein 0.0027 0.0037 0.0098
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.0132
Echinococcus granulosus Protein patched homolog 1 0.0035 0.0052 0.0139
Loa Loa (eye worm) transcription factor SMAD2 0.01 0.0175 0.0463
Echinococcus granulosus lysine specific histone demethylase 1A 0.037 0.069 0.1825
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0143
Echinococcus multilocularis liprin alpha 2 0.0035 0.0052 0.0137
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0023 0.0023
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0016 0.0042
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0011 0.0006 0.0017
Plasmodium vivax SET domain protein, putative 0.0036 0.0054 0.0744
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0026 0.0068
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0002 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0015 0.0016
Echinococcus multilocularis tankyrase 0.0035 0.0052 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0016 0.023
Schistosoma mansoni Lysine-specific histone demethylase 1 0.037 0.069 0.1825
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0037 0.2463
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0003 0.0041
Onchocerca volvulus 0.01 0.0177 0.2547
Plasmodium vivax heat shock protein 90, putative 0.0011 0.0006 0.0052
Trichomonas vaginalis endoplasmin, putative 0.0017 0.0017 0.0201
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0001 0.0003
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.004 0.0584
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0104 0.0275
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0039 1
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0041
Schistosoma mansoni phd/f-box containing protein 0.0009 0.0003 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0015 0.0167
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0016 0.0042
Echinococcus multilocularis heat shock protein 0.0027 0.0037 0.0098
Brugia malayi jmjC domain containing protein 0.0009 0.0003 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0051 0.0136
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0009 0.0003 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0029 0.004 0.0539
Echinococcus multilocularis expressed conserved protein 0.0077 0.0132 0.035
Loa Loa (eye worm) hypothetical protein 0.0082 0.0142 0.0375
Echinococcus granulosus dna polymerase kappa 0.0016 0.0016 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0043 0.0588
Brugia malayi TAR-binding protein 0.0062 0.0104 0.0275
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0035 0.0052 0.0137
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0041
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0001 0.0003
Brugia malayi jmjC domain containing protein 0.0009 0.0003 0.0007
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0104 1
Entamoeba histolytica hypothetical protein 0.003 0.0042 0.2662
Brugia malayi jmjC domain containing protein 0.0009 0.0003 0.0007
Echinococcus multilocularis protein patched 0.0035 0.0052 0.0139
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.037 0.069 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0066 0.1132
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0867
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0004 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0104 0.0274
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0022 0.0026 0.4703
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0051 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0013
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0009 0.0003 0.0274
Leishmania major GTP-binding protein, putative 0.0021 0.0026 0.0373
Echinococcus granulosus liprin alpha 2 0.0035 0.0052 0.0137
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0006 0.0015
Echinococcus granulosus c src tyrosine kinase 0.001 0.0004 0.0011
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0035 0.0052 0.0137
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0164 0.0434
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0001 0.0003
Loa Loa (eye worm) RNA binding protein 0.0062 0.0104 0.0275
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0001 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0373
Toxoplasma gondii heat shock protein 90, putative 0.0027 0.0037 0.0535
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.002 0.0023 0.0023
Echinococcus multilocularis phd:f box containing protein 0.0009 0.0003 0.0007
Trypanosoma brucei unspecified product 0.0011 0.0006 0.0615
Brugia malayi beta-NAC-like protein 0.0042 0.0066 0.0174
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0061
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.004 0.0578
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0004 0.0011
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0066 0.0915
Echinococcus granulosus lysine specific histone demethylase 1A 0.037 0.069 0.1825
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Plasmodium falciparum flap endonuclease 1 0.0022 0.0027 0.0346
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0002 0.0005
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0022 0.0026 0.007
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0026 0.0381
Schistosoma mansoni heat shock protein 0.0027 0.0037 0.0098
Echinococcus granulosus phd:f box containing protein 0.0009 0.0003 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0001 0.0003
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0001 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0005
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0083 0.0144 0.0381
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0023 0.0332
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0035 0.0052 0.0139
Brugia malayi Liprin-alpha 2 0.0035 0.0052 0.0137
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0004 0.0011
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0039 0.0039
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0009 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0023 0.0023
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0001 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0041
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0066 0.4381
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0001 0.0003
Schistosoma mansoni transcription factor btf3 0.0042 0.0066 0.0174
Schistosoma mansoni hypothetical protein 0.0035 0.0052 0.0137
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0037 0.3563
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0004 0.0011
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0004 0.0011
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0043 0.0588
Entamoeba histolytica Ran family GTPase 0.0021 0.0026 0.1429
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Plasmodium falciparum protein kinase, putative 0.0036 0.0054 0.0747
Schistosoma mansoni endoplasmin 0.0027 0.0037 0.0098
Toxoplasma gondii Hsp90 domain-containing protein 0.0011 0.0006 0.0092
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0043 0.0627
Brugia malayi AMP-binding enzyme family protein 0.002 0.0023 0.0061
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0066 0.0953
Onchocerca volvulus 0.0035 0.0052 0.0734
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.002 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0139
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0051 0.0136
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0016 0.0016
Plasmodium vivax heat shock protein 86, putative 0.0027 0.0037 0.0496
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.003 0.0042 0.2662
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Entamoeba histolytica acyl-coA synthetase, putative 0.002 0.0023 0.122
Leishmania major DNA polymerase kappa, putative 0.0016 0.0016 0.023
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0373
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0016 0.0702
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0448
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0004 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0001 0.0003
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0039 0.0527
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0001 0.0003
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0022 0.0027 0.0386
Schistosoma mansoni ran 0.0021 0.0026 0.0068
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0016 0.1534
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0039 0.0527
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.012 0.0214 0.0565
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.004 0.0105
Brugia malayi CHE-14 protein 0.0035 0.0052 0.0139
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0039 0.0566
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.0132
Echinococcus granulosus tyrosine protein kinase Lyn 0.0011 0.0006 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.037 0.069 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0251 0.0662
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0001 0.0003
Echinococcus granulosus lysine specific demethylase 6a 0.0009 0.0003 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Brugia malayi Bromodomain containing protein 0.0029 0.004 0.0105
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.037 0.069 1
Echinococcus multilocularis geminin 0.0331 0.0616 0.1628
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.0027 0.0386
Brugia malayi RNA binding protein 0.0062 0.0104 0.0275
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0104 0.1854
Schistosoma mansoni tyrosine kinase 0.001 0.0004 0.0011
Brugia malayi hypothetical protein 0.037 0.069 0.1825
Brugia malayi RNA, U transporter 1 0.0082 0.0142 0.0375
Echinococcus granulosus SAM domain containing protein 0.0035 0.0052 0.0137
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0104 0.1501
Echinococcus granulosus Sterile alpha motif SAM 0.0035 0.0052 0.0137
Toxoplasma gondii heat shock protein HSP90 0.0027 0.0037 0.0535
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0001 0.0003
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0269 0.0499 0.1318
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0029 0.004 0.0105
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0043 0.0627
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0001 0.0003
Brugia malayi Sex muscle abnormal protein 5 0.0009 0.0002 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0082 0.0216
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0023 0.0023
Plasmodium vivax protoporphyrinogen oxidase, putative 0.037 0.069 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0016 0.0017
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0104 0.1854
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Schistosoma mansoni importin beta-1 0.0029 0.004 0.0107
Echinococcus granulosus transcription factor btf3 0.0042 0.0066 0.0174
Schistosoma mansoni hypothetical protein 0.0331 0.0616 0.1628
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0015 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0001 0.0003
Echinococcus granulosus endoplasmin 0.0022 0.0026 0.007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0001 0.0003
Brugia malayi Importin beta-1 subunit 0.0029 0.004 0.0107
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.0132
Chlamydia trachomatis protoporphyrinogen oxidase 0.037 0.069 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0016 0.0181
Brugia malayi Stress-activated protein kinase jnk-1 0.0269 0.0499 0.1318
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0104 0.1501
Plasmodium falciparum endoplasmin, putative 0.0017 0.0017 0.0205
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0002 0.0005
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0001 0.0003
Brugia malayi Muscleblind-like protein 0.0125 0.0223 0.0589
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0043 0.0588
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0066 0.0953
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.0041
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0066 0.6345
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0054 0.0782
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0042 0.0112
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0037 0.0582
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0003 0.0007
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0026 0.0381
Onchocerca volvulus 0.037 0.069 1
Plasmodium falciparum heat shock protein 90 0.0027 0.0037 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0001 0.0003
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0002 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0006 0.0615
Trypanosoma brucei Heat shock protein 83, putative 0.0027 0.0037 0.3563
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0042 0.0112
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Echinococcus multilocularis 0.037 0.069 0.1825
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0004 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.0041
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0004 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0127 0.0337
Echinococcus granulosus tankyrase 0.0035 0.0052 0.0137
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0002 0.0005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0015 0.004
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0035 0.0052 0.0137
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0104 0.0274
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0002 0.0005
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0011 0.0006 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0007
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.004 0.0578
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0066 0.0953
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0013
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.1201
Onchocerca volvulus 0.002 0.0023 0.0314
Brugia malayi nuclear hormone receptor 0.0008 0.0001 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0003 0.0007
Echinococcus multilocularis stromal interaction molecule 1 0.044 0.0826 0.2183
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0037 0.0535
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0104 0.0274
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0004 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0051 0.0135
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0001 0.0003
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0039 0.0379
Echinococcus multilocularis heat shock protein 90 0.0022 0.0026 0.007
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0037 0.0535
Schistosoma mansoni ap endonuclease 0.0016 0.0015 0.004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0023 0.0332
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0001 0.0003
Echinococcus multilocularis endoplasmin 0.0022 0.0026 0.007
Echinococcus granulosus flap endonuclease 1 0.0022 0.0027 0.007
Echinococcus granulosus JmjC domain containing protein 4 0.0009 0.0003 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0499 0.1318
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0026 0.0382
Schistosoma mansoni nck2/grb4 0.0009 0.0002 0.0005
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0002 0.0005
Giardia lamblia DINP protein human, muc B family 0.0016 0.0016 0.0088
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0104 0.0274
Loa Loa (eye worm) MH2 domain-containing protein 0.01 0.0175 0.0463
Loa Loa (eye worm) hypothetical protein 0.01 0.0177 0.0467
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0104 0.1501
Trypanosoma cruzi UDP-galactopyranose mutase 0.037 0.069 1
Schistosoma mansoni flap endonuclease-1 0.002 0.0023 0.006
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Plasmodium vivax hypothetical protein, conserved 0.037 0.069 1
Trypanosoma brucei heat shock protein 84, putative 0.0011 0.0006 0.0616
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0137
Schistosoma mansoni protein phosphatase 2C 0.0009 0.0003 0.0007
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.0041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0016 0.0042
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0004 0.0011
Mycobacterium ulcerans heat shock protein 90 0.0022 0.0026 0.0026
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0022 0.0027 0.0386
Echinococcus multilocularis importin subunit beta 1 0.0029 0.004 0.0107
Onchocerca volvulus Alhambra homolog 0.0029 0.004 0.056
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0022 0.0026 0.0382
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0001 0.0003
Trypanosoma cruzi Heat shock protein 83, putative 0.0027 0.0037 0.0535
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0001 0.0003
Brugia malayi heat shock protein 90 0.0027 0.0037 0.0098
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0011 0.0006 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0006 0.0615
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0015 0.0219
Schistosoma mansoni heat shock protein 0.0011 0.0006 0.0017
Brugia malayi Tnks protein 0.0035 0.0052 0.0137
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0016 0.0042
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.004 0.3889
Echinococcus multilocularis liprin beta 1 0.0035 0.0052 0.0137
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0004 0.0011
Toxoplasma gondii heat shock protein 75, putative 0.0011 0.0006 0.0092
Brugia malayi Niemann-Pick C1 protein precursor 0.0082 0.0142 0.0375
Echinococcus granulosus tar DNA binding protein 0.0062 0.0104 0.0275
Brugia malayi Endoplasmin precursor 0.0027 0.0037 0.0098
Trichomonas vaginalis importin beta-1, putative 0.0023 0.003 0.0448
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Plasmodium vivax importin-beta 2, putative 0.0029 0.004 0.0545
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0009 0.0003 0.0007
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0043 0.4175
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Loa Loa (eye worm) hypothetical protein 0.0069 0.0118 0.0311
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Schistosoma mansoni amine oxidase 0.037 0.069 0.1825
Entamoeba histolytica hypothetical protein 0.003 0.0042 0.2662
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0015 0.0179
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0015 0.0167
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0878
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0143
Loa Loa (eye worm) endoplasmin 0.0027 0.0037 0.0098
Leishmania major UDP-galactopyranose mutase 0.037 0.069 1
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0035 0.0052 0.0137
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0023 0.0332
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0039 0.377
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0001 0.0003
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.004 0.0105
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0114
Mycobacterium tuberculosis Conserved hypothetical protein 0.037 0.069 0.0743
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.1734
Echinococcus multilocularis JmjC domain containing protein 4 0.0009 0.0003 0.0007
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.4878 0.9295 1
Brugia malayi Pre-SET motif family protein 0.0251 0.0465 0.1229
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0009 0.0003 0.0041
Leishmania major DNA polymerase eta, putative 0.0016 0.0016 0.023
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0023 0.122
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0104 0.0274
Brugia malayi nuclear receptor NHR-88 0.0008 0.0001 0.0003
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0004 0.0011
Echinococcus granulosus sterol regulatory element binding protein 0.0035 0.0052 0.0139
Echinococcus granulosus liprin beta 1 0.0035 0.0052 0.0137
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0039 0.0566
Mycobacterium tuberculosis Possible oxidoreductase 0.037 0.069 0.0743
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0105
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0015 0.0179
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0036 0.0054 0.0782
Echinococcus granulosus expressed conserved protein 0.0077 0.0132 0.035
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.037 0.069 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0104 0.1501
Treponema pallidum heat shock protein 90 0.0022 0.0026 0.4703
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0037 0.2253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0016 0.023
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0003 0.0007
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0177 0.0467
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0676 0.1276 0.3372
Echinococcus multilocularis Niemann Pick C1 protein 0.0117 0.0209 0.0553
Loa Loa (eye worm) hypothetical protein 0.0125 0.0223 0.0589
Schistosoma mansoni tyrosine kinase 0.001 0.0004 0.0011
Echinococcus granulosus jumonji domain containing protein 0.004 0.0061 0.0162
Plasmodium falciparum protoporphyrinogen oxidase 0.037 0.069 1
Loa Loa (eye worm) hypothetical protein 0.0252 0.0466 0.1232
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0039 0.0566
Entamoeba histolytica hypothetical protein 0.0042 0.0066 0.4381
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0531 1
Schistosoma mansoni hypothetical protein 0.003 0.0042 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0137
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0066 0.1132
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0051 0.0136
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0037 0.0535
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0016 0.023
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0104 0.1501
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0015 0.0013 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0143
Loa Loa (eye worm) hypothetical protein 0.199 0.3784 1
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0867
Brugia malayi hypothetical protein 0.003 0.0042 0.0112
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0001 0.0003
Leishmania major heat shock protein, putative 0.0011 0.0006 0.0092
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0002 0.0005
Brugia malayi jmjC domain containing protein 0.0009 0.0003 0.0007
Plasmodium vivax hypothetical protein, conserved 0.037 0.069 1
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0041
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0016 0.0017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0001 0.0003
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0104 0.1501
Schistosoma mansoni tyrosine kinase 0.001 0.0004 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0051 0.0136
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.004 0.0105
Echinococcus multilocularis SAM domain containing protein 0.0035 0.0052 0.0137
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0015 0.0219
Onchocerca volvulus 0.0035 0.0052 0.0734
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0104 0.0274
Echinococcus granulosus importin subunit beta 1 0.0029 0.004 0.0107
Leishmania major hypothetical protein, conserved 0.003 0.0043 0.0627
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Mycobacterium ulcerans monoamine oxidase 0.037 0.069 0.069
Trypanosoma cruzi heat shock protein 85, putative 0.0022 0.0026 0.0382
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0082 0.0216
Entamoeba histolytica Flap nuclease, putative 0.0022 0.0027 0.1495
Schistosoma mansoni hypothetical protein 0.0035 0.0052 0.0137
Schistosoma mansoni endoplasmin 0.0027 0.0037 0.0098
Plasmodium vivax flap endonuclease 1, putative 0.0022 0.0027 0.0346
Loa Loa (eye worm) heat shock protein 75 0.0011 0.0006 0.0017
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.5247 1 1
Schistosoma mansoni hypothetical protein 0.0202 0.037 0.0978
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0054 0.0143
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0001 0.0003
Trichomonas vaginalis ran, putative 0.0021 0.0026 0.0369
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.037 0.069 0.1825
Echinococcus multilocularis heat shock protein 90 0.0027 0.0037 0.0098
Brugia malayi Hsp90 protein 0.0011 0.0006 0.0017
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0003 0.0044
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0016 0.0181
Echinococcus multilocularis transcription factor btf3 0.0042 0.0066 0.0174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0016 0.0042
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0022 0.0027 0.257
Echinococcus multilocularis protein dispatched 1 0.004 0.0062 0.0164
Leishmania major importin beta-1 subunit, putative 0.0023 0.003 0.0433
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0333
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0042
Plasmodium falciparum acyl-CoA synthetase 0.0015 0.0013 0.0153
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0066 0.0174
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0098 0.0259
Echinococcus granulosus geminin 0.0331 0.0616 0.1628
Onchocerca volvulus 0.0286 0.0531 0.7689
Plasmodium falciparum heat shock protein 90, putative 0.0011 0.0006 0.0052
Brugia malayi steroid hormone receptor 0.0008 0.0001 0.0003
Schistosoma mansoni DNA polymerase eta 0.0016 0.0016 0.0042
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0003 0.0295
Brugia malayi MAP kinase sur-1 0.0062 0.0104 0.0274
Brugia malayi hypothetical protein 0.044 0.0826 0.2183
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0041
Giardia lamblia Flap structure-specific endonuclease 0.0022 0.0027 0.1301
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0004 0.0011
Brugia malayi hypothetical protein 0.002 0.0023 0.006
Echinococcus granulosus heat shock protein 90 0.0022 0.0026 0.007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0867
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0015 0.0219
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0001 0.0003
Echinococcus multilocularis muscleblind protein 1 0.0125 0.0223 0.0589
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0023 0.0332
Brugia malayi hypothetical protein 0.199 0.3784 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0042 0.0112
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0104 0.0275
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0001 0.0003
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0104 0.1501
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0001 0.0003
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0003 0.0041
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0011 0.003
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0082 0.0142 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Brugia malayi hypothetical protein 0.003 0.0043 0.0114
Echinococcus multilocularis jumonji domain containing 1A 0.0009 0.0003 0.0007
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0061 0.0162
Echinococcus granulosus muscleblind protein 0.0125 0.0223 0.0589
Trypanosoma cruzi heat shock protein, putative 0.0011 0.0006 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0143
Leishmania major basic transcription factor 3a, putative 0.0042 0.0066 0.0953
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0039 0.0042
Plasmodium vivax tyrosine kinase-like protein, putative 0.0036 0.0054 0.0747
Brugia malayi jmjC domain containing protein 0.0035 0.0051 0.0136
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0035 0.0052 0.0137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.003 0.0433
Schistosoma mansoni tankyrase 0.0035 0.0052 0.0137
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Loa Loa (eye worm) hypothetical protein 0.0125 0.0223 0.0589
Schistosoma mansoni amine oxidase 0.037 0.069 0.1825
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0001 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0082 0.0216
Echinococcus granulosus Niemann Pick C1 protein 0.0117 0.0209 0.0553
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0061
Brugia malayi Pre-SET motif family protein 0.0036 0.0054 0.0143
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Entamoeba histolytica hypothetical protein 0.003 0.0042 0.2662
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0039 0.0566
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Schistosoma mansoni hypothetical protein 0.0239 0.0441 0.1165
Plasmodium vivax endoplasmin, putative 0.0027 0.0037 0.0496
Loa Loa (eye worm) hypothetical protein 0.044 0.0826 0.2183
Echinococcus granulosus peregrin 0.0029 0.004 0.0105
Echinococcus multilocularis muscleblind protein 0.0125 0.0223 0.0589
Mycobacterium ulcerans dehydrogenase 0.037 0.069 0.069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0465 0.1229
Entamoeba histolytica hypothetical protein 0.0028 0.0039 0.2412
Trypanosoma cruzi heat shock protein 90, putative 0.0016 0.0016 0.0228
Schistosoma mansoni sarm1 0.0035 0.0052 0.0137
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Brugia malayi PHD-finger family protein 0.0009 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.0082 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0867
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0001 0.0003
Schistosoma mansoni ran 0.0021 0.0026 0.0068
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0016 0.0016
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0177 0.0467
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0137
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0022 0.0027 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0066 0.1132
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0043 0.0627
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0004 0.0011
Brugia malayi amine oxidase, flavin-containing family protein 0.037 0.069 0.1825
Echinococcus multilocularis flap endonuclease 1 0.0022 0.0027 0.007
Brugia malayi AF-10 protein 0.0009 0.0003 0.0008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0015 0.004
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0001 0.0003
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0023 0.0332
Brugia malayi hypothetical protein 0.0252 0.0466 0.1232
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0001 0.0003
Trypanosoma cruzi UDP-galactopyranose mutase 0.037 0.069 1
Echinococcus granulosus NCK adaptor protein 0.0009 0.0002 0.0005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.004 0.0105
Echinococcus multilocularis peregrin 0.0029 0.004 0.0105
Schistosoma mansoni phosphatidylserine receptor 0.0009 0.0003 0.0007
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0043 0.0068 0.0179
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0015 0.0013 0.0013
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0015 0.0645
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0026 0.0333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0001 0.0003
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0015 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0016 0.023
Brugia malayi hypothetical protein 0.0035 0.0052 0.0137
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0011 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0001 0.0003
Mycobacterium ulcerans protoporphyrinogen oxidase 0.037 0.069 0.069
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0003 0.0044
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0037 0.0535
Echinococcus granulosus dna polymerase eta 0.0016 0.0016 0.0042
Brugia malayi AMP-binding enzyme family protein 0.002 0.0023 0.0061
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Schistosoma mansoni tyrosine kinase 0.001 0.0004 0.0011
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0022 0.0026 0.0028
Schistosoma mansoni ap endonuclease 0.0016 0.0015 0.004
Echinococcus granulosus heat shock protein 0.0027 0.0037 0.0098
Schistosoma mansoni hypothetical protein 0.0308 0.0574 0.1516
Echinococcus multilocularis Niemann Pick C1 protein 0.0082 0.0142 0.0375
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0039 1
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0016 0.1534
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0269 0.0499 0.1318
Toxoplasma gondii histone lysine-specific demethylase 0.037 0.069 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0104 1
Plasmodium falciparum importin beta, putative 0.0029 0.004 0.0545
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0001 0.0003
Brugia malayi SRC-1 0.001 0.0004 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0054 0.0143
Brugia malayi SWIRM domain containing protein 0.037 0.069 0.1825
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0001 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0015 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0061
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0574 0.1516
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Trypanosoma brucei protein kinase, putative 0.0062 0.0104 1
Loa Loa (eye worm) heat shock protein 90 0.0027 0.0037 0.0098
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.002 0.0023 0.0023
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0009 0.0003 0.0007
Echinococcus granulosus jumonji domain containing 1A 0.0009 0.0003 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0001 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0104 0.1854
Echinococcus granulosus calcium release activated calcium channel 0.199 0.3784 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0004 0.0011
Echinococcus multilocularis calcium release activated calcium channel 0.199 0.3784 1
Brugia malayi coiled-coil like protein 1 0.0035 0.0052 0.0137
Trypanosoma brucei unspecified product 0.0016 0.0016 0.1534
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0041

Activities

Activity type Activity value Assay description Source Reference
k cat/Km (binding) = 3690 M-1 s-1 Second order rate constant for metallo-beta-lactamase hydrolysis at pH 7.02 ChEMBL. 15026061
MIC (functional) = 0.64 ug ml-1 In Vitro minimal inhibitory concentration against Staphylococcus aureus (FDA 209P) ChEMBL. 9822538
MIC (functional) = 2.98 ug ml-1 In Vitro minimal inhibitory concentration against Klebsiella pneumoniae (NCTC 418) ChEMBL. 9822538
MIC (functional) = 13.13 ug ml-1 In Vitro minimal inhibitory concentration against Escherichia coli (ATCC 39188) ChEMBL. 9822538
MIC (functional) = 13.13 ug ml-1 In Vitro minimal inhibitory concentration against Escherichia coli (ATCC 39188) ChEMBL. 9822538
MIC (functional) = 24.5 ug ml-1 In Vitro minimal inhibitory concentration against Salmonella typhi (O-901) ChEMBL. 9822538
MIC (functional) = 100 ug ml-1 In Vitro minimal inhibitory concentration against Pseudomonas aeruginosa (1101-75) ChEMBL. 9822538
T1/2 (ADMET) = 45 min Hydrolysis half life of the compound using immobilized penicillin-G acylase ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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