Detailed information for compound 40503

Basic information

Technical information
  • TDR Targets ID: 40503
  • Name: 3-methyl-8-oxo-7-[(2-phenylacetyl)amino]-5-th ia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • MW: 332.374 | Formula: C16H16N2O4S
  • H donors: 2 H acceptors: 4 LogP: 0.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccccc1)NC1C(=O)N2C1SCC(=C2C(=O)O)C
  • InChi: 1S/C16H16N2O4S/c1-9-8-23-15-12(14(20)18(15)13(9)16(21)22)17-11(19)7-10-5-3-2-4-6-10/h2-6,12,15H,7-8H2,1H3,(H,17,19)(H,21,22)
  • InChiKey: CIPQGGYPCPIDBB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-methyl-8-oxo-7-[(1-oxo-2-phenylethyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 3-methyl-8-oxo-7-(2-phenylethanoylamino)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 8-keto-3-methyl-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • EU-0082884
  • 3-Methyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • MLS000123641
  • SMR000124223
  • STK177339
  • BAS 06290987

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni adapter molecule crk 0.0009 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0041
Toxoplasma gondii exonuclease III APE 0.0016 0.0015 0.0219
Loa Loa (eye worm) hypothetical protein 0.0049 0.0079 0.0209
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0037 0.3563
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0023 0.122
Echinococcus granulosus stromal interaction molecule 1 0.044 0.0826 0.2183
Echinococcus granulosus c-Jun N-terminal kinases 0.0269 0.0499 0.1318
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0137
Brugia malayi jmjC domain containing protein 0.0094 0.0164 0.0434
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0022 0.0026 0.0382
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0016 0.023
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0016 0.1534
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.2485
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0041
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0016 0.0042
Plasmodium vivax heat shock protein, putative 0.0011 0.0006 0.0052
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0016 0.0042
Echinococcus multilocularis dna polymerase eta 0.0016 0.0016 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0006 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Schistosoma mansoni hypothetical protein 0.0014 0.0011 0.003
Brugia malayi MH2 domain containing protein 0.01 0.0175 0.0463
Brugia malayi AMP-binding enzyme family protein 0.002 0.0023 0.0061
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0177 0.0467
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0068
Schistosoma mansoni jumonji domain containing protein 0.0009 0.0003 0.0007
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0035 0.0052 0.0867
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0039 0.0039
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0051 0.0136
Echinococcus multilocularis protoporphyrinogen oxidase 0.037 0.069 0.1825
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.037 0.069 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.004 0.3889
Giardia lamblia PHD finger protein 15 0.0029 0.004 0.2796
Echinococcus granulosus snurportin 1 0.0308 0.0574 0.1516
Mycobacterium ulcerans oxidoreductase 0.037 0.069 0.069
Schistosoma mansoni Protein orai-1 0.199 0.3784 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0051 0.0135
Brugia malayi PHD-finger family protein 0.0029 0.004 0.0105
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0007
Schistosoma mansoni patched 1 0.0035 0.0052 0.0139
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0328 0.0612 0.1617
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0008 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0331 0.0616 0.1628
Loa Loa (eye worm) flap endonuclease-1 0.0022 0.0027 0.007
Brugia malayi photoreceptor-specific nuclear receptor 0.0008 0.0001 0.0003
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0002 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0104 0.1854
Echinococcus granulosus Niemann Pick C1 protein 0.0082 0.0142 0.0375
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0003 0.0295
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0104 0.0275
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0015 0.1459
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Plasmodium vivax acyl-CoA synthetase, putative 0.0015 0.0013 0.0153
Mycobacterium ulcerans hypothetical protein 0.002 0.0023 0.0023
Schistosoma mansoni coup transcription factor 0.0008 0.0001 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0001 0.0003
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0004 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0008 0.0001 0.0003
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0016 0.1534
Echinococcus multilocularis snurportin 1 0.0308 0.0574 0.1516
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0066 0.0915
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0001 0.0003
Onchocerca volvulus 0.0252 0.0466 0.6748
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0041
Plasmodium falciparum phd finger protein, putative 0.0029 0.004 0.0539
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0009 0.0002 0.0005
Schistosoma mansoni hypothetical protein 0.0035 0.0052 0.0137
Schistosoma mansoni hypothetical protein 0.0035 0.0051 0.0135
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0026 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0013
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0177 0.0467
Echinococcus multilocularis sterol regulatory element binding protein 0.0035 0.0052 0.0139
Trypanosoma brucei unspecified product 0.0011 0.0006 0.0615
Plasmodium falciparum heat shock protein 90, putative 0.0011 0.0006 0.0052
Echinococcus granulosus heat shock protein 90 0.0027 0.0037 0.0098
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0037 0.2253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0008 0.0001 0.0003
Schistosoma mansoni Protein orai-1 0.199 0.3784 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0008 0.0001 0.0003
Echinococcus multilocularis lysine specific demethylase 6a 0.0009 0.0003 0.0007
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0009 0.0003 0.0041
Plasmodium falciparum tyrosine kinase-like protein 0.0036 0.0054 0.0747
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0006 0.0615
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0016 0.0042
Trichomonas vaginalis heat shock protein, putative 0.0017 0.0017 0.0201
Schistosoma mansoni lip-related protein (liprin) alpha 0.0035 0.0052 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0054 0.0143
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0164 0.0434
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0001 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0008 0.0001 0.0003
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0026 0.0381
Brugia malayi ecdysteroid receptor 0.0008 0.0001 0.0003
Brugia malayi Flap endonuclease-1 0.0022 0.0027 0.007
Onchocerca volvulus 0.0036 0.0054 0.0765
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0054 0.0143
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Loa Loa (eye worm) SRC-1 0.001 0.0004 0.0011
Giardia lamblia Grp94/Hsp90 0.0022 0.0026 0.1273
Giardia lamblia Heat shock protein HSP 90-alpha 0.0022 0.0026 0.1273
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0041
Echinococcus multilocularis lysine specific histone demethylase 1A 0.037 0.069 0.1825
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0016 0.023
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0026 0.0373
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0016 0.0042
Plasmodium vivax SET domain protein, putative 0.0036 0.0054 0.0744
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0011 0.0006 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Echinococcus multilocularis tankyrase 0.0035 0.0052 0.0137
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0015 0.0016
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0016 0.023
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0026 0.0068
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0009 0.0002 0.0005
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0104 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Loa Loa (eye worm) hypothetical protein 0.0259 0.0479 0.1266
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.0132
Loa Loa (eye worm) transcription factor SMAD2 0.01 0.0175 0.0463
Brugia malayi Neurabin protein 1 0.0035 0.0052 0.0137
Echinococcus granulosus Protein patched homolog 1 0.0035 0.0052 0.0139
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.0132
Leishmania major hypothetical protein, conserved 0.0009 0.0003 0.0041
Schistosoma mansoni heat shock protein 0.0027 0.0037 0.0098
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0008 0.0001 0.0003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0023 0.0023
Echinococcus multilocularis liprin alpha 2 0.0035 0.0052 0.0137
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0143
Echinococcus granulosus lysine specific histone demethylase 1A 0.037 0.069 0.1825
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0448
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0015 0.0167
Schistosoma mansoni phd/f-box containing protein 0.0009 0.0003 0.0007
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0016 0.0042
Echinococcus multilocularis heat shock protein 0.0027 0.0037 0.0098
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0051 0.0136
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0009 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0009 0.0003 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0029 0.004 0.0539
Echinococcus multilocularis expressed conserved protein 0.0077 0.0132 0.035
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0037 0.2463
Plasmodium vivax heat shock protein 90, putative 0.0011 0.0006 0.0052
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0003 0.0041
Onchocerca volvulus 0.01 0.0177 0.2547
Schistosoma mansoni Lysine-specific histone demethylase 1 0.037 0.069 0.1825
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0001 0.0003
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.004 0.0584
Trichomonas vaginalis endoplasmin, putative 0.0017 0.0017 0.0201
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0039 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0104 0.0275
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0867
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0066 0.1132
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0004 0.0011
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.037 0.069 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0022 0.0026 0.4703
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0104 0.0274
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0051 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Leishmania major GTP-binding protein, putative 0.0021 0.0026 0.0373
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0009 0.0003 0.0274
Echinococcus granulosus c src tyrosine kinase 0.001 0.0004 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0006 0.0015
Echinococcus granulosus liprin alpha 2 0.0035 0.0052 0.0137
Echinococcus granulosus dna polymerase kappa 0.0016 0.0016 0.0042
Brugia malayi TAR-binding protein 0.0062 0.0104 0.0275
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0043 0.0588
Loa Loa (eye worm) hypothetical protein 0.0082 0.0142 0.0375
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0104 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0041
Brugia malayi jmjC domain containing protein 0.0009 0.0003 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0008 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.003 0.0042 0.2662
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0035 0.0052 0.0137
Echinococcus multilocularis protein patched 0.0035 0.0052 0.0139
Brugia malayi jmjC domain containing protein 0.0009 0.0003 0.0007
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0002 0.0005
Plasmodium falciparum flap endonuclease 1 0.0022 0.0027 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0008 0.0001 0.0003
Schistosoma mansoni heat shock protein 0.0027 0.0037 0.0098
Echinococcus granulosus phd:f box containing protein 0.0009 0.0003 0.0007
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0022 0.0026 0.007
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0026 0.0381
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0023 0.0025
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0008 0.0001 0.0003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0083 0.0144 0.0381
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0164 0.0434
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0035 0.0052 0.0137
Toxoplasma gondii heat shock protein 90, putative 0.0027 0.0037 0.0535
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.002 0.0023 0.0023
Echinococcus granulosus ecdysone induced protein 78C 0.0008 0.0001 0.0003
Loa Loa (eye worm) RNA binding protein 0.0062 0.0104 0.0275
Echinococcus granulosus FTZ F1 alpha 0.0008 0.0001 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0373
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0061
Trypanosoma brucei unspecified product 0.0011 0.0006 0.0615
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.004 0.0578
Brugia malayi beta-NAC-like protein 0.0042 0.0066 0.0174
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0004 0.0011
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0066 0.0915
Echinococcus multilocularis phd:f box containing protein 0.0009 0.0003 0.0007
Echinococcus granulosus lysine specific histone demethylase 1A 0.037 0.069 0.1825
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0023 0.0023
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0066 0.4381
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0008 0.0001 0.0003
Schistosoma mansoni transcription factor btf3 0.0042 0.0066 0.0174
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0008 0.0001 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0016 0.0041
Schistosoma mansoni hypothetical protein 0.0035 0.0052 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Entamoeba histolytica Ran family GTPase 0.0021 0.0026 0.1429
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0043 0.0588
Plasmodium falciparum protein kinase, putative 0.0036 0.0054 0.0747
Schistosoma mansoni endoplasmin 0.0027 0.0037 0.0098
Toxoplasma gondii Hsp90 domain-containing protein 0.0011 0.0006 0.0092
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0004 0.0011
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0037 0.3563
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0004 0.0011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0035 0.0052 0.0139
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0023 0.0332
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Brugia malayi Liprin-alpha 2 0.0035 0.0052 0.0137
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0039 0.0039
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0004 0.0011
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0009 0.0003 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0016 0.0702
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0004 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0008 0.0001 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.003 0.0448
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0039 0.0527
Brugia malayi AMP-binding enzyme family protein 0.002 0.0023 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0043 0.0627
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0051 0.0136
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0016 0.0016
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.002 0.0023 0.0025
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0066 0.0953
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0139
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Onchocerca volvulus 0.0035 0.0052 0.0734
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0026 0.0373
Leishmania major DNA polymerase kappa, putative 0.0016 0.0016 0.023
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0023 0.0023
Plasmodium vivax heat shock protein 86, putative 0.0027 0.0037 0.0496
Entamoeba histolytica hypothetical protein 0.003 0.0042 0.2662
Entamoeba histolytica acyl-coA synthetase, putative 0.002 0.0023 0.122
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0139 0.0251 0.0662
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0008 0.0001 0.0003
Echinococcus multilocularis geminin 0.0331 0.0616 0.1628
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.037 0.069 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.0027 0.0386
Brugia malayi RNA binding protein 0.0062 0.0104 0.0275
Echinococcus granulosus lysine specific demethylase 6a 0.0009 0.0003 0.0007
Brugia malayi Bromodomain containing protein 0.0029 0.004 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0104 0.1854
Echinococcus granulosus SAM domain containing protein 0.0035 0.0052 0.0137
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0104 0.1501
Brugia malayi hypothetical protein 0.037 0.069 0.1825
Schistosoma mansoni tyrosine kinase 0.001 0.0004 0.0011
Brugia malayi RNA, U transporter 1 0.0082 0.0142 0.0375
Schistosoma mansoni ran 0.0021 0.0026 0.0068
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0022 0.0027 0.0386
Echinococcus multilocularis ecdysone induced protein 78C 0.0008 0.0001 0.0003
Brugia malayi CHE-14 protein 0.0035 0.0052 0.0139
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0039 0.0566
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.004 0.0105
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0039 0.0527
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0016 0.1534
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.012 0.0214 0.0565
Echinococcus granulosus tyrosine protein kinase Lyn 0.0011 0.0006 0.0016
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.0132
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.037 0.069 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0104 0.1854
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0016 0.0017
Plasmodium vivax protoporphyrinogen oxidase, putative 0.037 0.069 1
Schistosoma mansoni hypothetical protein 0.0331 0.0616 0.1628
Schistosoma mansoni importin beta-1 0.0029 0.004 0.0107
Echinococcus granulosus transcription factor btf3 0.0042 0.0066 0.0174
Echinococcus granulosus endoplasmin 0.0022 0.0026 0.007
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0015 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0008 0.0001 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0009 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0029 0.004 0.0105
Echinococcus granulosus Sterile alpha motif SAM 0.0035 0.0052 0.0137
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0269 0.0499 0.1318
Toxoplasma gondii heat shock protein HSP90 0.0027 0.0037 0.0535
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0008 0.0001 0.0003
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0008 0.0001 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0043 0.0627
Brugia malayi Sex muscle abnormal protein 5 0.0009 0.0002 0.0005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0082 0.0216
Mycobacterium ulcerans acyl-CoA synthetase 0.002 0.0023 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0008 0.0001 0.0003
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.0002 0.0005
Brugia malayi Muscleblind-like protein 0.0125 0.0223 0.0589
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0043 0.0588
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0016 0.0041
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0066 0.0953
Brugia malayi Importin beta-1 subunit 0.0029 0.004 0.0107
Schistosoma mansoni hypothetical protein 0.0034 0.005 0.0132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0008 0.0001 0.0003
Chlamydia trachomatis protoporphyrinogen oxidase 0.037 0.069 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0016 0.0181
Brugia malayi Stress-activated protein kinase jnk-1 0.0269 0.0499 0.1318
Plasmodium falciparum endoplasmin, putative 0.0017 0.0017 0.0205
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0104 0.1501
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.003 0.0042 0.0112
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0004 0.0011
Echinococcus multilocularis 0.037 0.069 0.1825
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0127 0.0337
Echinococcus granulosus tankyrase 0.0035 0.0052 0.0137
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.0002 0.0005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0016 0.0041
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0004 0.0011
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0104 0.0274
Echinococcus multilocularis NCK adaptor protein 0.0009 0.0002 0.0005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0015 0.004
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0035 0.0052 0.0137
Schistosoma mansoni transcription factor LCR-F1 0.003 0.0042 0.0112
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0037 0.0582
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0066 0.6345
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0054 0.0782
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trichomonas vaginalis heat shock protein, putative 0.0022 0.0026 0.0381
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0003 0.0007
Plasmodium falciparum heat shock protein 90 0.0027 0.0037 0.0496
Onchocerca volvulus 0.037 0.069 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0008 0.0001 0.0003
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.0002 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0006 0.0615
Trypanosoma brucei Heat shock protein 83, putative 0.0027 0.0037 0.3563
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.1201
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0013
Echinococcus multilocularis stromal interaction molecule 1 0.044 0.0826 0.2183
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0003 0.0007
Brugia malayi nuclear hormone receptor 0.0008 0.0001 0.0003
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0104 0.0274
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0037 0.0535
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Onchocerca volvulus 0.002 0.0023 0.0314
Echinococcus multilocularis heat shock protein 90 0.0022 0.0026 0.007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0008 0.0001 0.0003
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0037 0.0535
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0039 0.0379
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0051 0.0135
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0004 0.0011
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0023 0.0332
Schistosoma mansoni ap endonuclease 0.0016 0.0015 0.004
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0011 0.0006 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.004 0.0578
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0066 0.0953
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0007
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0104 0.0274
Loa Loa (eye worm) hypothetical protein 0.01 0.0177 0.0467
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0104 0.1501
Loa Loa (eye worm) MH2 domain-containing protein 0.01 0.0175 0.0463
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trypanosoma brucei heat shock protein 84, putative 0.0011 0.0006 0.0616
Plasmodium vivax hypothetical protein, conserved 0.037 0.069 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.037 0.069 1
Schistosoma mansoni flap endonuclease-1 0.002 0.0023 0.006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0137
Schistosoma mansoni protein phosphatase 2C 0.0009 0.0003 0.0007
Echinococcus multilocularis GPCR, family 2 0.0016 0.0016 0.0041
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0008 0.0001 0.0003
Echinococcus multilocularis endoplasmin 0.0022 0.0026 0.007
Echinococcus granulosus JmjC domain containing protein 4 0.0009 0.0003 0.0007
Echinococcus granulosus flap endonuclease 1 0.0022 0.0027 0.007
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0026 0.0382
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.0499 0.1318
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0002 0.0005
Giardia lamblia DINP protein human, muc B family 0.0016 0.0016 0.0088
Schistosoma mansoni nck2/grb4 0.0009 0.0002 0.0005
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0011 0.0006 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0006 0.0615
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Schistosoma mansoni heat shock protein 0.0011 0.0006 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0015 0.0219
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.004 0.3889
Brugia malayi Tnks protein 0.0035 0.0052 0.0137
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0016 0.0042
Echinococcus multilocularis liprin beta 1 0.0035 0.0052 0.0137
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0004 0.0011
Mycobacterium ulcerans heat shock protein 90 0.0022 0.0026 0.0026
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0004 0.0011
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0022 0.0027 0.0386
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0022 0.0026 0.0382
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0008 0.0001 0.0003
Echinococcus multilocularis importin subunit beta 1 0.0029 0.004 0.0107
Onchocerca volvulus Alhambra homolog 0.0029 0.004 0.056
Brugia malayi heat shock protein 90 0.0027 0.0037 0.0098
Trypanosoma cruzi Heat shock protein 83, putative 0.0027 0.0037 0.0535
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0008 0.0001 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0043 0.4175
Loa Loa (eye worm) hypothetical protein 0.0069 0.0118 0.0311
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Entamoeba histolytica hypothetical protein 0.003 0.0042 0.2662
Schistosoma mansoni amine oxidase 0.037 0.069 0.1825
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0015 0.0179
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0015 0.0167
Brugia malayi Niemann-Pick C1 protein precursor 0.0082 0.0142 0.0375
Toxoplasma gondii heat shock protein 75, putative 0.0011 0.0006 0.0092
Echinococcus granulosus tar DNA binding protein 0.0062 0.0104 0.0275
Trichomonas vaginalis importin beta-1, putative 0.0023 0.003 0.0448
Brugia malayi Endoplasmin precursor 0.0027 0.0037 0.0098
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0009 0.0003 0.0007
Plasmodium vivax importin-beta 2, putative 0.0029 0.004 0.0545
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.004 0.0105
Loa Loa (eye worm) hypothetical protein 0.003 0.0043 0.0114
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.4878 0.9295 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.037 0.069 0.0743
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.1734
Echinococcus multilocularis JmjC domain containing protein 4 0.0009 0.0003 0.0007
Leishmania major DNA polymerase eta, putative 0.0016 0.0016 0.023
Entamoeba histolytica acyl-CoA synthetase, putative 0.002 0.0023 0.122
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0009 0.0003 0.0041
Brugia malayi Pre-SET motif family protein 0.0251 0.0465 0.1229
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0001 0.0003
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0068
Leishmania major UDP-galactopyranose mutase 0.037 0.069 1
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0035 0.0052 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0143
Loa Loa (eye worm) endoplasmin 0.0027 0.0037 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0878
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0039 0.377
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0008 0.0001 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0023 0.0332
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0016 0.023
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0676 0.1276 0.3372
Echinococcus multilocularis Niemann Pick C1 protein 0.0117 0.0209 0.0553
Loa Loa (eye worm) jmjC domain-containing protein 0.0009 0.0003 0.0007
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0177 0.0467
Schistosoma mansoni tyrosine kinase 0.001 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0125 0.0223 0.0589
Echinococcus granulosus jumonji domain containing protein 0.004 0.0061 0.0162
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0004 0.0011
Brugia malayi nuclear receptor NHR-88 0.0008 0.0001 0.0003
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0104 0.0274
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0105
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0036 0.0054 0.0782
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0015 0.0179
Echinococcus granulosus sterol regulatory element binding protein 0.0035 0.0052 0.0139
Echinococcus granulosus liprin beta 1 0.0035 0.0052 0.0137
Mycobacterium tuberculosis Possible oxidoreductase 0.037 0.069 0.0743
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0039 0.0566
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0104 0.1501
Treponema pallidum heat shock protein 90 0.0022 0.0026 0.4703
Echinococcus granulosus expressed conserved protein 0.0077 0.0132 0.035
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.037 0.069 1
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0037 0.2253
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0051 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0066 0.1132
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0016 0.023
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0037 0.0535
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0143
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0015 0.0013 0.0014
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0104 0.1501
Plasmodium falciparum protoporphyrinogen oxidase 0.037 0.069 1
Loa Loa (eye worm) hypothetical protein 0.0252 0.0466 0.1232
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0039 0.0566
Entamoeba histolytica hypothetical protein 0.0042 0.0066 0.4381
Schistosoma mansoni hypothetical protein 0.003 0.0042 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0137
Loa Loa (eye worm) hypothetical protein 0.0008 0.0001 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0531 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0104 0.1501
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0008 0.0001 0.0003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0016 0.0017
Schistosoma mansoni tyrosine kinase 0.001 0.0004 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0051 0.0136
Echinococcus multilocularis SAM domain containing protein 0.0035 0.0052 0.0137
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.004 0.0105
Onchocerca volvulus 0.0035 0.0052 0.0734
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0015 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0867
Loa Loa (eye worm) hypothetical protein 0.199 0.3784 1
Leishmania major heat shock protein, putative 0.0011 0.0006 0.0092
Schistosoma mansoni thyroid hormone receptor 0.0008 0.0001 0.0003
Brugia malayi hypothetical protein 0.003 0.0042 0.0112
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Brugia malayi jmjC domain containing protein 0.0009 0.0003 0.0007
Plasmodium vivax hypothetical protein, conserved 0.037 0.069 1
Brugia malayi Variant SH3 domain containing protein 0.0009 0.0002 0.0005
Echinococcus granulosus GPCR family 2 0.0016 0.0016 0.0041
Loa Loa (eye worm) heat shock protein 75 0.0011 0.0006 0.0017
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.5247 1 1
Plasmodium vivax flap endonuclease 1, putative 0.0022 0.0027 0.0346
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0054 0.0143
Echinococcus multilocularis thyroid hormone receptor alpha 0.0008 0.0001 0.0003
Trichomonas vaginalis ran, putative 0.0021 0.0026 0.0369
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Schistosoma mansoni hypothetical protein 0.0202 0.037 0.0978
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.037 0.069 0.1825
Echinococcus multilocularis heat shock protein 90 0.0027 0.0037 0.0098
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0003 0.0044
Brugia malayi Hsp90 protein 0.0011 0.0006 0.0017
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0104 0.0274
Echinococcus granulosus importin subunit beta 1 0.0029 0.004 0.0107
Leishmania major hypothetical protein, conserved 0.003 0.0043 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0016 0.1534
Mycobacterium ulcerans monoamine oxidase 0.037 0.069 0.069
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Entamoeba histolytica Flap nuclease, putative 0.0022 0.0027 0.1495
Schistosoma mansoni hypothetical protein 0.0035 0.0052 0.0137
Trypanosoma cruzi heat shock protein 85, putative 0.0022 0.0026 0.0382
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0082 0.0216
Schistosoma mansoni endoplasmin 0.0027 0.0037 0.0098
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0042
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0066 0.0174
Plasmodium falciparum acyl-CoA synthetase 0.0015 0.0013 0.0153
Echinococcus granulosus geminin 0.0331 0.0616 0.1628
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0098 0.0259
Onchocerca volvulus 0.0286 0.0531 0.7689
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0016 0.0181
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Echinococcus multilocularis transcription factor btf3 0.0042 0.0066 0.0174
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0016 0.0042
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0022 0.0027 0.257
Echinococcus multilocularis protein dispatched 1 0.004 0.0062 0.0164
Loa Loa (eye worm) hypothetical protein 0.0015 0.0013 0.0035
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0026 0.0333
Loa Loa (eye worm) steroid hormone receptor 0.0008 0.0001 0.0003
Leishmania major importin beta-1 subunit, putative 0.0023 0.003 0.0433
Brugia malayi hypothetical protein 0.002 0.0023 0.006
Giardia lamblia Flap structure-specific endonuclease 0.0022 0.0027 0.1301
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0004 0.0011
Echinococcus granulosus heat shock protein 90 0.0022 0.0026 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0867
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0008 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0008 0.0001 0.0003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0015 0.0219
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0016 0.0041
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.003 0.0042 0.0112
Echinococcus multilocularis muscleblind protein 1 0.0125 0.0223 0.0589
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0023 0.0332
Brugia malayi hypothetical protein 0.199 0.3784 1
Plasmodium falciparum heat shock protein 90, putative 0.0011 0.0006 0.0052
Schistosoma mansoni DNA polymerase eta 0.0016 0.0016 0.0042
Brugia malayi steroid hormone receptor 0.0008 0.0001 0.0003
Brugia malayi hypothetical protein 0.044 0.0826 0.2183
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0003 0.0295
Brugia malayi MAP kinase sur-1 0.0062 0.0104 0.0274
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0041
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0039 0.0042
Plasmodium vivax tyrosine kinase-like protein, putative 0.0036 0.0054 0.0747
Trypanosoma cruzi heat shock protein, putative 0.0011 0.0006 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0054 0.0143
Leishmania major basic transcription factor 3a, putative 0.0042 0.0066 0.0953
Brugia malayi jmjC domain containing protein 0.0035 0.0051 0.0136
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0035 0.0052 0.0137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0008
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0104 0.1501
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0009 0.0003 0.0041
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0008 0.0001 0.0003
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0104 0.0275
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0008 0.0001 0.0003
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0011 0.003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0082 0.0142 1
Echinococcus multilocularis jumonji domain containing 1A 0.0009 0.0003 0.0007
Brugia malayi hypothetical protein 0.003 0.0043 0.0114
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0061 0.0162
Echinococcus granulosus muscleblind protein 0.0125 0.0223 0.0589
Schistosoma mansoni hypothetical protein 0.0239 0.0441 0.1165
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Plasmodium vivax endoplasmin, putative 0.0027 0.0037 0.0496
Loa Loa (eye worm) hypothetical protein 0.044 0.0826 0.2183
Echinococcus granulosus peregrin 0.0029 0.004 0.0105
Echinococcus multilocularis muscleblind protein 0.0125 0.0223 0.0589
Mycobacterium ulcerans dehydrogenase 0.037 0.069 0.069
Entamoeba histolytica hypothetical protein 0.0028 0.0039 0.2412
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0465 0.1229
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.003 0.0433
Schistosoma mansoni tankyrase 0.0035 0.0052 0.0137
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Schistosoma mansoni amine oxidase 0.037 0.069 0.1825
Loa Loa (eye worm) hypothetical protein 0.0125 0.0223 0.0589
Brugia malayi Pre-SET motif family protein 0.0036 0.0054 0.0143
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0008 0.0001 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0082 0.0216
Echinococcus granulosus Niemann Pick C1 protein 0.0117 0.0209 0.0553
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0039 0.0566
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0104 0.0275
Entamoeba histolytica hypothetical protein 0.003 0.0042 0.2662
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0004 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0043 0.0627
Echinococcus multilocularis flap endonuclease 1 0.0022 0.0027 0.007
Brugia malayi amine oxidase, flavin-containing family protein 0.037 0.069 0.1825
Brugia malayi AF-10 protein 0.0009 0.0003 0.0008
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0004 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0023 0.0332
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0015 0.004
Schistosoma mansoni RAR-like nuclear receptor 0.0008 0.0001 0.0003
Trypanosoma cruzi heat shock protein 90, putative 0.0016 0.0016 0.0228
Schistosoma mansoni sarm1 0.0035 0.0052 0.0137
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0008 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0052 0.0867
Brugia malayi PHD-finger family protein 0.0009 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.005 0.0082 0.0216
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0177 0.0467
Schistosoma mansoni ran 0.0021 0.0026 0.0068
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0052 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0066 0.1132
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0022 0.0027 0.0386
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0001 0.0003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0011 0.003
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0015 0.004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0016 0.023
Brugia malayi hypothetical protein 0.0035 0.0052 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0008 0.0001 0.0003
Mycobacterium ulcerans protoporphyrinogen oxidase 0.037 0.069 0.069
Trypanosoma cruzi UDP-galactopyranose mutase 0.037 0.069 1
Brugia malayi hypothetical protein 0.0252 0.0466 0.1232
Schistosoma mansoni retinoic acid receptor RXR 0.0008 0.0001 0.0003
Echinococcus multilocularis peregrin 0.0029 0.004 0.0105
Echinococcus granulosus NCK adaptor protein 0.0009 0.0002 0.0005
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.004 0.0105
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0026 0.0333
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0015 0.0645
Loa Loa (eye worm) hypothetical protein 0.0043 0.0068 0.0179
Schistosoma mansoni hypothetical protein 0.0009 0.0003 0.0008
Schistosoma mansoni phosphatidylserine receptor 0.0009 0.0003 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0015 0.0013 0.0013
Echinococcus granulosus heat shock protein 0.0027 0.0037 0.0098
Schistosoma mansoni ap endonuclease 0.0016 0.0015 0.004
Schistosoma mansoni hypothetical protein 0.0308 0.0574 0.1516
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0022 0.0026 0.0028
Echinococcus multilocularis Niemann Pick C1 protein 0.0082 0.0142 0.0375
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0039 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0104 1
Plasmodium falciparum importin beta, putative 0.0029 0.004 0.0545
Toxoplasma gondii histone lysine-specific demethylase 0.037 0.069 1
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0016 0.1534
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0269 0.0499 0.1318
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0054 0.0143
Brugia malayi SWIRM domain containing protein 0.037 0.069 0.1825
Echinococcus multilocularis FTZ F1 alpha 0.0008 0.0001 0.0003
Brugia malayi SRC-1 0.001 0.0004 0.0011
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0003 0.0044
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0037 0.0535
Leishmania major heat shock protein 83-1 0.0027 0.0037 0.0535
Echinococcus granulosus dna polymerase eta 0.0016 0.0016 0.0042
Brugia malayi AMP-binding enzyme family protein 0.002 0.0023 0.0061
Schistosoma mansoni tyrosine kinase 0.001 0.0004 0.0011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0008 0.0001 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0104 0.1854
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0004 0.0011
Echinococcus granulosus calcium release activated calcium channel 0.199 0.3784 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0016 0.0041
Echinococcus multilocularis calcium release activated calcium channel 0.199 0.3784 1
Brugia malayi coiled-coil like protein 1 0.0035 0.0052 0.0137
Trypanosoma brucei unspecified product 0.0016 0.0016 0.1534
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0015 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0008 0.0001 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.037 0.069 0.1825
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0061
Trypanosoma brucei heat shock protein, putative 0.0027 0.0037 0.3563
Trypanosoma brucei protein kinase, putative 0.0062 0.0104 1
Loa Loa (eye worm) heat shock protein 90 0.0027 0.0037 0.0098
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.0574 0.1516
Echinococcus granulosus jumonji domain containing 1A 0.0009 0.0003 0.0007
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.002 0.0023 0.0023
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0009 0.0003 0.0007

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.027 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
MIC (functional) = 6.2 ug ml-1 Inhibition of gram positive bacteria growth. ChEMBL. 2724308
MIC (functional) = 123 ug ml-1 Inhibition of gram negative bacteria growth. ChEMBL. 2724308
MIC (functional) = 200 ug ml-1 Inhibition of gram positive (resistant) bacteria growth. ChEMBL. 2724308
MIC (functional) > 200 ug ml-1 Inhibition of gram negative (resistant) growth. ChEMBL. 2724308
Potency (functional) 0.2818 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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