pI: 7.51 |
Length (AA): 389 |
MW (Da): 45703 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
6 | 283 | 1y8q (A) | 30 | 337 | 15.00 | 0 | 1 | 0.35 | -1.47 |
6 | 401 | 1y8q (B) | 11 | 548 | 23.00 | 0 | 1 | 0.19 | -0.82 |
657 | 1218 | 1xzp (A) | 34 | 450 | 30.00 | 0 | 1 | 0.43 | 0.67 |
657 | 716 | 1xzp (B) | 34 | 92 | 37.00 | 0.000013 | 0.89 | 0.56 | -0.73 |
1 | 389 | 1y8q (B) | 7 | 533 | 23.00 | 0 | 1 | 0.933 | 0 |
2 | 388 | 3dbh (B) | 40 | 438 | 26.00 | 0 | 1 | 1.10586 | 0.22 |
6 | 217 | 1jw9 (B) | 25 | 242 | 19.00 | 0.00000000043 | 1 | 0.871087 | -0.61 |
8 | 135 | 4p22 (A) | 68 | 190 | 22.00 | 0.0021 | 1 | 0.648249 | -0.52 |
15 | 121 | 1jwa (B) | 34 | 139 | 31.00 | 0.0000021 | 0.97 | 0.656264 | -0.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Ring. | Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | early trophozoite, late trophozoite, Male Gametocyte. | PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 32 hs, early schizont, Oocyst, Female Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Sporozoite. | Otto TD Zanghi G |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_128095)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G19180 | NEDD8-activating enzyme E1 catalytic subunit |
Babesia bovis | BBOV_I001030 | ThiF family domain containing protein |
Brugia malayi | Bm1_35445 | Ectopic membrane ruffles in embryo protein 1 |
Candida albicans | CaO19.11685 | Ubiquitin activating enzyme |
Candida albicans | CaO19.4209 | Ubiquitin activating enzyme |
Caenorhabditis elegans | CELE_F11H8.1 | Protein RFL-1 |
Cryptosporidium hominis | Chro.80201 | ubiquitin-activating enzyme |
Cryptosporidium parvum | cgd8_1730 | Uba3p like ubiquitin activating enzyme E1 |
Dictyostelium discoideum | DDB_G0283891 | NEDD8-activating enzyme E1 catalytic subunit |
Drosophila melanogaster | Dmel_CG13343 | Ubiquitin activating enzyme 3 |
Echinococcus granulosus | EgrG_000970100 | NEDD8 activating enzyme E1 catalytic subunit |
Entamoeba histolytica | EHI_098550 | ubiquitin-activating enzyme, putative |
Echinococcus multilocularis | EmuJ_000970100 | NEDD8 activating enzyme E1 catalytic subunit |
Homo sapiens | ENSG00000144744 | ubiquitin-like modifier activating enzyme 3 |
Leishmania braziliensis | LbrM.01.0690 | ubiquitin activating enzyme, putative |
Leishmania donovani | LdBPK_010730.1 | ubiquitin activating enzyme, putative |
Leishmania infantum | LinJ.01.0730 | ubiquitin activating enzyme, putative |
Leishmania major | LmjF.01.0710 | ubiquitin activating enzyme, putative |
Leishmania mexicana | LmxM.01.0710 | ubiquitin activating enzyme, putative |
Loa Loa (eye worm) | LOAG_01766 | ectopic membrane ruffles in embryo protein 1 |
Mus musculus | ENSMUSG00000030061 | ubiquitin-like modifier activating enzyme 3 |
Neospora caninum | NCLIV_040320 | ubiquitin-activating enzyme, putative |
Oryza sativa | 4325169 | Os01g0271500 |
Plasmodium berghei | PBANKA_0713800 | NEDD8-activating enzyme E1 catalytic subunit, putative |
Plasmodium falciparum | PF3D7_0817000 | NEDD8-activating enzyme E1 catalytic subunit, putative |
Plasmodium knowlesi | PKNH_0503400 | NEDD8-activating enzyme E1 catalytic subunit, putative |
Plasmodium vivax | PVX_089560 | ubiquitin-activating enzyme E1C, putative |
Saccharomyces cerevisiae | YPR066W | NEDD8-activating protein UBA3 |
Schistosoma japonicum | Sjp_0033200 | ko:K10686 ubiquitin-activating enzyme E1 C, putative |
Schistosoma japonicum | Sjp_0090040 | NEDD8-activating enzyme E1 catalytic subunit, putative |
Schistosoma japonicum | Sjp_0124080 | ko:K06917 tRNA 2-selenouridine synthase, putative |
Schistosoma japonicum | Sjp_0131750 | NEDD8-activating enzyme E1 catalytic subunit, putative |
Schistosoma mansoni | Smp_151760 | ubiquitin-activating enzyme E1C |
Schmidtea mediterranea | mk4.001703.08 | NEDD8-activating enzyme E1 catalytic subunit |
Trypanosoma brucei gambiense | Tbg972.9.2440 | ubiquitin-activating enzyme e1, putative |
Trypanosoma brucei | Tb927.9.4620 | NEDD8 activating enzyme subunit, putative |
Trypanosoma congolense | TcIL3000_9_1520 | ubiquitin-activating enzyme E1, putative |
Trypanosoma cruzi | TcCLB.510155.120 | ubiquitin activating enzyme, putative |
Trypanosoma cruzi | TcCLB.511585.130 | ubiquitin activating enzyme, putative |
Toxoplasma gondii | TGME49_264880 | NEDD8-activating enzyme E1 catalytic subunit |
Theileria parva | TP01_0601 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_161040 | molybdopterin biosynthesis moeb protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.3210 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.3210 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.3210 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb09.160.3210 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F11H8.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_264880 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ubiquitin-like modifier activating enzyme 3 | Compounds | References |