Detailed information for compound 1838926

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 522.659 | Formula: C29H40N5O4+
  • H donors: 2 H acceptors: 5 LogP: 2.88 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C[N+]12CCC(CC1)[C@H](C2)OC(=O)C1(CCCCCC1)C1=CC=CC1)NCCNC(=O)c1nccnc1
  • InChi: 1S/C29H39N5O4/c35-26(32-15-16-33-27(36)24-19-30-13-14-31-24)21-34-17-9-22(10-18-34)25(20-34)38-28(37)29(23-7-3-4-8-23)11-5-1-2-6-12-29/h3-4,7,13-14,19,22,25H,1-2,5-6,8-12,15-18,20-21H2,(H-,32,33,35,36)/p+1/t22?,25-,34?/m0/s1
  • InChiKey: QNSUTEZULRGESR-HSQDXKERSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholinergic receptor, muscarinic 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0082 0.0325 0.0313
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0209 0.0905 0.0905
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0061 0.0198
Entamoeba histolytica acyl-CoA synthetase, putative 0.0014 0.0012 0.0012
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.0142 0.0596 0.1931
Echinococcus multilocularis neuropeptide s receptor 0.0082 0.0325 0.0313
Mycobacterium ulcerans epimerase 0.002 0.004 0.0056
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0012 0.0017
Onchocerca volvulus Putative pyridoxal kinase 0.003 0.0084 0.068
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0076 0.0294 0.0953
Brugia malayi Pax transcription factor protein 2 0.0236 0.1027 0.1016
Trypanosoma cruzi nucleoside transporter-like, putative 0.0043 0.0145 0.0469
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.0325 0.0313
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0101 0.0089
Schistosoma mansoni adenosine kinase 0.0261 0.1143 0.1133
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0014 0.0002
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0443 0.0432
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0007
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.0108 0.0444 0.1438
Loa Loa (eye worm) hypothetical protein 0.005 0.0178 0.0167
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0019 0.0007
Echinococcus granulosus NEDD8 activating enzyme E1 regulatory subunit 0.0113 0.0466 0.0455
Echinococcus multilocularis dro:myosuppressin receptor 0.0082 0.0325 0.0313
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0443 0.0614
Onchocerca volvulus 0.0082 0.0325 0.2928
Echinococcus granulosus neuropeptide FF receptor 2 0.0082 0.0325 0.0313
Trypanosoma cruzi ribokinase, putative 0.003 0.0084 0.0273
Trichomonas vaginalis ubiquitin-activating enzyme E1c, putative 0.0176 0.0755 0.1048
Toxoplasma gondii ThiF family protein 0.0086 0.0343 0.0332
Echinococcus multilocularis sex peptide receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0019 0.0007
Toxoplasma gondii kinase, pfkB family protein 0.0261 0.1143 0.1133
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.041 0.1822 0.5889
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0019 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0082 0.0113
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0122 0.0508 0.1615
Trypanosoma brucei adenosine kinase, putative 0.0261 0.1143 0.3705
Brugia malayi RE15519p 0.0082 0.0325 0.0313
Brugia malayi 6-phosphofructokinase 0.0108 0.0443 0.0432
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0176 0.0755 0.1048
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0082 0.0325 0.2928
Brugia malayi Death domain containing protein 0.0014 0.0014 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis adenosine kinase 0.0261 0.1143 0.1133
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0582 0.2612 0.2603
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis serotonin receptor 0.0082 0.0325 0.0313
Trypanosoma cruzi adenosine kinase, putative 0.0261 0.1143 0.3705
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.041 0.1822 0.5905
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0268 0.1176 0.1631
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis G protein coupled receptor 139 0.0082 0.0325 0.0313
Mycobacterium tuberculosis Possible molybdopterin biosynthesis protein MoeW 0.0076 0.0294 0.0578
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0113 0.0466 0.0646
Giardia lamblia Ubiquitin-conjugating enzyme E1 0.0076 0.0294 0.1219
Echinococcus granulosus ubiquitin modifier activating enzyme ATG7 0.0076 0.0294 0.0283
Schistosoma mansoni neuropeptide receptor 0.0082 0.0325 0.0313
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.011 0.0453 0.0629
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Brugia malayi G protein-coupled receptor 0.0082 0.0325 0.0313
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0082 0.0113
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0082 0.0325 0.0313
Leishmania major ubiquitin activating enzyme, putative 0.0076 0.0294 0.0953
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0113 0.0466 0.0646
Trypanosoma brucei purine nucleoside transporter 0.0043 0.0145 0.0469
Loa Loa (eye worm) hypothetical protein 0.0122 0.0508 0.0497
Schistosoma mansoni hypothetical protein 0.0335 0.1479 0.1469
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0283 0.1242 0.1231
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0256 0.0828
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0019 0.0007
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0061 0.0198
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0012 0.0017
Giardia lamblia Molybdopterin biosynthesis MoeB protein 0.0076 0.0294 0.1219
Toxoplasma gondii hypothetical protein 0.0122 0.0508 0.0497
Leishmania major tagatose-6-phosphate kinase-like protein 0.003 0.0084 0.0273
Loa Loa (eye worm) hypothetical protein 0.0582 0.2612 0.2603
Echinococcus multilocularis adenylyltransferase and sulfurtransferase 0.0076 0.0294 0.0283
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Trypanosoma cruzi nucleobase transporter, putative 0.0043 0.0145 0.0469
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.0325 0.0313
Brugia malayi Ribokinase 0.003 0.0084 0.0073
Echinococcus granulosus somatostatin receptor 0.0082 0.0325 0.0313
Brugia malayi Melatonin receptor type 1A 0.0082 0.0325 0.0313
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0019 0.0061
Loa Loa (eye worm) hypothetical protein 0.0076 0.0294 0.0283
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0076 0.0294 0.0953
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0045 0.0034
Schistosoma mansoni amine GPCR 0.0082 0.0325 0.0313
Schistosoma mansoni adenosine kinase 0.0261 0.1143 0.1133
Leishmania major ubiquitin activating enzyme, putative 0.0686 0.3086 1
Echinococcus granulosus orexin receptor type 2 0.0082 0.0325 0.0313
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0082 0.0325 0.0313
Entamoeba histolytica nucleoside transporter, putative 0.0043 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Giardia lamblia Molybdopterin biosynthesis MoeB protein 0.0076 0.0294 0.1219
Brugia malayi putative neuropeptide receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Leishmania major nucleobase transporter 0.0043 0.0145 0.0469
Echinococcus granulosus Ankyrin 0.0014 0.0014 0.0003
Schistosoma mansoni biogenic amine receptor 0.0082 0.0325 0.0313
Brugia malayi follicle stimulating hormone receptor 0.0311 0.1371 0.1361
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0076 0.0294 0.0283
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0082 0.0325 0.0313
Brugia malayi hypothetical protein 0.0248 0.1081 0.107
Brugia malayi G protein-coupled receptor F59B2.13 0.0082 0.0325 0.0313
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0268 0.1176 0.1166
Brugia malayi ube1-prov protein 0.0209 0.0905 0.0895
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.041 0.1822 0.5905
Loa Loa (eye worm) TYRA-2 protein 0.0082 0.0325 0.0313
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0082 0.0082
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.0145 0.0469
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0443 0.0443
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.041 0.1822 0.5905
Leishmania major adenosine kinase-like protein 0.003 0.0084 0.0273
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.041 0.1822 0.1822
Schistosoma mansoni histamine h1 receptor 0.0082 0.0325 0.0313
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0019 0.0032
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0076 0.0294 0.0283
Mycobacterium leprae Probable adenosine kinase adk 0.003 0.0084 0.1246
Schistosoma mansoni myosin xvIII 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0316 0.1392 0.1382
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0205 0.0884 0.0873
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0014 0.0002
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0082 0.0325 0.0313
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.0145 0.0469
Trypanosoma cruzi adenosine kinase, putative 0.003 0.0084 0.0273
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0025 0.0013
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0141 0.0594 0.0825
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0686 0.3086 1
Trypanosoma brucei nucleoside transporter 1, putative 0.0043 0.0145 0.0469
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0807 0.3639 0.3631
Echinococcus granulosus neuropeptide s receptor 0.0082 0.0325 0.0313
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.0325 0.0313
Brugia malayi MoeZ/MoeB domain containing protein 0.0076 0.0294 0.0283
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0076 0.0294 0.0408
Plasmodium vivax ubiquitin-activating enzyme, putative 0.0086 0.0343 0.1079
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.0325 0.0313
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0122 0.0508 0.0497
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.0145 0.0201
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0297 0.0928
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0248 0.1081 0.107
Echinococcus granulosus tachykinin peptides receptor 99D 0.0082 0.0325 0.0313
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Toxoplasma gondii ThiF family protein 0.0113 0.0466 0.0455
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.0325 0.0313
Trypanosoma brucei nucleoside transporter 1, putative 0.0043 0.0145 0.0469
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.041 0.1822 0.3597
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0019 0.0007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0014 0.0012 0.0017
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0017
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.041 0.1822 0.1813
Schistosoma mansoni neuropeptide receptor 0.0082 0.0325 0.0313
Leishmania major tagatose-6-phosphate kinase-like protein 0.003 0.0084 0.0273
Schistosoma mansoni netrin receptor unc5 0.0014 0.0014 0.0002
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0045 0.0063
Toxoplasma gondii ThiF family protein 0.0076 0.0294 0.0283
Trypanosoma brucei purine nucleoside transporter 0.0043 0.0145 0.0469
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0268 0.1175 0.3807
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0007
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.041 0.1822 0.2528
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0089
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Entamoeba histolytica hypothetical protein 0.0035 0.0109 0.0109
Leishmania major adenosine kinase-like protein 0.003 0.0084 0.0273
Leishmania major ubiquitin-activating enzyme e1, putative 0.0119 0.0493 0.1598
Brugia malayi CG1749-PA 0.0076 0.0294 0.0283
Mycobacterium tuberculosis Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) 0.0076 0.0294 0.0578
Brugia malayi GnHR receptor homolog 0.0082 0.0325 0.0313
Trypanosoma brucei ribokinase, putative 0.003 0.0084 0.0273
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0019 0.0007
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0012 0.0038
Trypanosoma brucei Ubiquitin-like modifier-activating enzyme ATG7, putative 0.0076 0.0294 0.0953
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0017
Echinococcus granulosus adenylyltransferase and sulfurtransferase 0.0076 0.0294 0.0283
Echinococcus granulosus dro:myosuppressin receptor 0.0082 0.0325 0.0313
Leishmania major NAD/FAD dependent dehydrogenase, putative 0.0076 0.0294 0.0953
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0061 0.0161
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.041 0.1822 0.5905
Loa Loa (eye worm) hypothetical protein 0.0049 0.0171 0.016
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0248 0.1081 0.1499
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0176 0.0755 0.1048
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis orexin receptor type 2 0.0082 0.0325 0.0313
Echinococcus multilocularis g-protein coupled receptor 0.0082 0.0325 0.0313
Schistosoma mansoni equilibrative nucleoside transporter 0.0043 0.0145 0.0133
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0019 0.0007
Onchocerca volvulus 0.0082 0.0325 0.2928
Toxoplasma gondii endonuclease IV APN 0.0076 0.0297 0.0286
Loa Loa (eye worm) ube1-prov protein 0.0209 0.0905 0.0895
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.041 0.1822 0.5905
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0325 0.0313
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.041 0.1822 0.5889
Schistosoma mansoni amine GPCR 0.0082 0.0325 0.0313
Mycobacterium tuberculosis Possible molybdopterin biosynthesis protein MoeY 0.0076 0.0294 0.0578
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.041 0.1822 0.5905
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0017
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0019 0.0007
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0082 0.0325 0.0313
Entamoeba histolytica kinase, PfkB family 0.003 0.0084 0.0084
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.003 0.0084 0.0073
Leishmania major 4-coumarate:coa ligase-like protein 0.0014 0.0012 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Echinococcus granulosus 7tm_1 domain containing protein 0.0082 0.0325 0.0313
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0443 0.0432
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.041 0.1822 0.5905
Onchocerca volvulus 0.0082 0.0325 0.2928
Brugia malayi neuropeptide F receptor 0.0082 0.0325 0.0313
Entamoeba histolytica HesA/MoeB/ThiF family protein, putative 0.0076 0.0294 0.0294
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0325 0.0313
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0082 0.0113
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0325 0.0313
Echinococcus granulosus peptide allatostatin:somatostatin 0.0082 0.0325 0.0313
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.041 0.1822 0.1813
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.003 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.1114 0.5045 1
Brugia malayi hypothetical protein 0.0035 0.0109 0.0098
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0268 0.1176 0.1631
Trypanosoma cruzi E1-like ubiquitin-activating enzyme, putative 0.0076 0.0294 0.0953
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Loa Loa (eye worm) RecQ helicase 0.0021 0.0045 0.0034
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0082 0.0325 0.0313
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0082 0.0325 0.0313
Leishmania major ribokinase, putative 0.003 0.0084 0.0273
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0268 0.1175 0.3807
Schistosoma mansoni hypothetical protein 0.0082 0.0325 0.0313
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0012 0.0038
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.0145 0.0469
Schistosoma mansoni protein kinase 0.0043 0.0145 0.0133
Leishmania major ubiquitin-activating enzyme, putative 0.0076 0.0294 0.0953
Trypanosoma cruzi ubiquitin-activating enzyme E1, putative 0.0142 0.0596 0.1931
Entamoeba histolytica acyl-CoA synthetase, putative 0.0014 0.0012 0.0012
Entamoeba histolytica nucleoside transporter, putative 0.0248 0.1081 0.1081
Echinococcus multilocularis ubiquitin modifier activating enzyme 1 0.0209 0.0905 0.0895
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0248 0.1081 0.107
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.041 0.1822 0.2528
Schistosoma mansoni adenoreceptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) melatonin receptor type 1A 0.0082 0.0325 0.0313
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.041 0.1822 0.1813
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0171 0.016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.0325 0.0313
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0109 0.0098
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.0076 0.0294 0.0953
Trichomonas vaginalis sumo-1-activating enzyme E1a, putative 0.0076 0.0294 0.0408
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.0145 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0325 0.0313
Schistosoma mansoni neuropeptide f receptor 76f 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0082 0.0325 0.0313
Brugia malayi G-protein coupled receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0019 0.0007
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0014 0.0002
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.003 0.0084 0.0073
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.0325 0.0313
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0076 0.0294 0.0953
Toxoplasma gondii kinase, pfkB family protein 0.003 0.0084 0.0073
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0256 0.0244
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0256 0.0256
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0019 0.0007
Trypanosoma brucei molybdopterin synthase sulphurylase protein, putative 0.0076 0.0294 0.0953
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0019 0.0061
Onchocerca volvulus 0.005 0.0178 0.1561
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.0076 0.0294 0.1219
Leishmania major ubiquitin activating E1 enzyme, putative 0.0076 0.0294 0.0953
Echinococcus granulosus g protein coupled receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0086 0.0343 0.0476
Trypanosoma brucei adenosine transporter 2 0.0043 0.0145 0.0469
Plasmodium falciparum NEDD8-activating enzyme E1 catalytic subunit, putative 0.0686 0.3086 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0082 0.0325 0.2928
Leishmania major 4-coumarate:coa ligase-like protein 0.0014 0.0012 0.0038
Onchocerca volvulus 0.0082 0.0325 0.2928
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0256 0.0244
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0007
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.003 0.0084 0.0084
Brugia malayi hypothetical protein 0.003 0.0084 0.0073
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.041 0.1822 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0012 0.0038
Plasmodium falciparum ubiquitin-activating enzyme E1, putative 0.0076 0.0294 0.0918
Schistosoma mansoni neuropeptide receptor 0.0082 0.0325 0.0313
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0082 0.007
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0141 0.0594 0.0583
Leishmania major nucleobase transporter 0.0043 0.0145 0.0469
Echinococcus granulosus g-protein coupled receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0082 0.0325 0.0313
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0019 0.0007
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.0325 0.0313
Chlamydia trachomatis endonuclease IV 0.0076 0.0297 0.1237
Brugia malayi phosphofructokinase 0.0108 0.0443 0.0432
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus granulosus ubiquitin modifier activating enzyme 6 0.0209 0.0905 0.0895
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0012 0.0016
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0082 0.0325 0.0313
Trypanosoma cruzi nucleobase transporter, putative 0.0043 0.0145 0.0469
Toxoplasma gondii ThiF family protein 0.0076 0.0294 0.0283
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.041 0.1822 0.5905
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0082 0.0325 0.0313
Plasmodium vivax ubiquitin activating enzyme, putative 0.0122 0.0508 0.1615
Brugia malayi putative neuropeptide receptor NPR1 0.0082 0.0325 0.0313
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0007
Onchocerca volvulus 0.0082 0.0325 0.2928
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0012 0.0017
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0082 0.0325 0.0313
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0012 0.0017
Schistosoma mansoni neuropeptide receptor 0.0082 0.0325 0.0313
Trypanosoma cruzi nucleoside transporter 1, putative 0.0043 0.0145 0.0469
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.1587 0.7208 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0014 0.0012 0.0038
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0076 0.0294 0.0953
Trypanosoma cruzi adenosine kinase, putative 0.0261 0.1143 0.3705
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0443 0.0432
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0073
Schistosoma mansoni amine GPCR 0.0082 0.0325 0.0313
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.041 0.1822 0.1813
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0178 0.0167
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0109 0.0098
Schistosoma mansoni clathrin coat associated protein ap-50 0.0154 0.0652 0.0642
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0061 0.005
Leishmania major nucleoside transporter 1, putative 0.0043 0.0145 0.0469
Echinococcus granulosus alpha 1A adrenergic receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0082 0.0325 0.0313
Echinococcus granulosus serotonin receptor 0.0082 0.0325 0.0313
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.041 0.1822 0.1822
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0443 0.1435
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0076 0.0297 0.0928
Entamoeba histolytica acyl-coA synthetase, putative 0.0014 0.0012 0.0012
Onchocerca volvulus 0.0232 0.1007 0.9314
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.041 0.1822 0.1813
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0127 0.0529 0.1713
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.0325 0.0313
Onchocerca volvulus 0.0082 0.0325 0.2928
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Leishmania major putative PfkB family sugar kinase 0.003 0.0084 0.0273
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0248 0.1081 0.1499
Trypanosoma brucei NEDD8 activating enzyme subunit, putative 0.0686 0.3086 1
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.041 0.1822 1
Trypanosoma brucei adenosine kinase, putative 0.0261 0.1143 0.3705
Echinococcus granulosus adenosine kinase 0.0261 0.1143 0.1133
Trypanosoma brucei adenosine transporter 2 0.0043 0.0145 0.0469
Brugia malayi 6-phosphofructokinase 0.0108 0.0443 0.0432
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.041 0.1822 1
Echinococcus multilocularis Ankyrin 0.0014 0.0014 0.0003
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0268 0.1175 0.3807
Echinococcus multilocularis fmrfamide receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0483 0.0472
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0268 0.1176 0.1166
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0012 0.0012
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0061 0.0161
Onchocerca volvulus 0.0082 0.0325 0.2928
Loa Loa (eye worm) hypothetical protein 0.0113 0.0466 0.0455
Echinococcus granulosus neuropeptide receptor A26 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Mycobacterium ulcerans molybdopterin biosynthesis-like protein MoeZ 0.0076 0.0294 0.0561
Plasmodium falciparum ubiquitin-activating enzyme E1 0.0209 0.0905 0.2906
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0443 0.0443
Leishmania major ubiquitin-activating enzyme-like protein 0.0076 0.0294 0.0953
Onchocerca volvulus 0.0082 0.0325 0.2928
Schistosoma mansoni opsin-like receptor 0.0082 0.0325 0.0313
Brugia malayi ThiF family protein 0.0113 0.0466 0.0455
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0017
Echinococcus granulosus hypothetical protein 0.0082 0.0325 0.0313
Loa Loa (eye worm) ThiF family protein 0.0086 0.0343 0.0332
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Brugia malayi Serotonin receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0443 0.0432
Trypanosoma cruzi E1-like ubiquitin-activating enzyme, putative 0.0076 0.0294 0.0953
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.0325 0.0313
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Schistosoma mansoni amine GPCR 0.0082 0.0325 0.0313
Trypanosoma cruzi nucleobase transporter, putative 0.0043 0.0145 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0325 0.0313
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0076 0.0297 0.4889
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0325 0.0313
Loa Loa (eye worm) ubiquitin-activating enzyme 5 0.0076 0.0294 0.0283
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0043 0.0145 0.0133
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0082 0.007
Echinococcus multilocularis somatostatin receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0014
Brugia malayi AKH receptor 0.0082 0.0325 0.0313
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.0325 0.0313
Brugia malayi E1-like protein-activating enzyme Gsa7p/Apg7p containing protein 0.0076 0.0294 0.0283
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0082 0.0325 0.0313
Leishmania major adenosine kinase, putative 0.0261 0.1143 0.3705
Echinococcus granulosus G protein coupled receptor 139 0.0082 0.0325 0.0313
Echinococcus multilocularis G-protein coupled receptor, putative 0.0082 0.0325 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0325 0.0313
Leishmania major nucleoside transporter 1, putative 0.0043 0.0145 0.0469
Mycobacterium ulcerans hypothetical protein 0.0076 0.0294 0.0561
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis tumor protein p63 0.0344 0.1522 0.1512
Brugia malayi Adenosine kinase-like 0.0261 0.1143 0.1133
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0082 0.0113
Leishmania major hypothetical protein, conserved 0.0025 0.0061 0.0198
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0014 0.0018
Trichomonas vaginalis ribokinase, putative 0.003 0.0084 0.0117
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Mycobacterium leprae POSSIBLE MOLYBDOPTERIN BIOSYNTHESIS PROTEIN MOEY 0.0076 0.0294 0.4837
Echinococcus granulosus tumor protein p63 0.0344 0.1522 0.1512
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.041 0.1822 0.1813
Brugia malayi ORL1-like opioid receptor 0.0082 0.0325 0.0313
Leishmania major ubiquitin-activating enzyme e1, putative 0.0142 0.0596 0.1931
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0014 0.0007
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0142 0.0596 0.1931
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.041 0.1822 0.1813
Trypanosoma brucei adenosine transporter, putative 0.0043 0.0145 0.0469
Brugia malayi Nucleoside transporter family protein 0.0248 0.1081 0.107
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.0325 0.0313
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0181 0.0776 0.0765
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0248 0.1081 0.107
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0086 0.0343 0.0476
Giardia lamblia Ubiquitin-conjugating enzyme E1 0.0142 0.0596 0.2954
Schistosoma mansoni ribokinase 0.003 0.0084 0.0073
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0061 0.0161
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0082 0.0325 0.0313
Onchocerca volvulus 0.0082 0.0325 0.2928
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0019 0.0007
Schistosoma mansoni amine GPCR 0.0082 0.0325 0.0313
Entamoeba histolytica hypothetical protein 0.0035 0.0109 0.0109
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0325 0.0313
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0483 0.0472
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0256 0.0828
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis NEDD8 activating enzyme E1 regulatory subunit 0.0113 0.0466 0.0455
Toxoplasma gondii nucleoside transporter protein 0.0043 0.0145 0.0133
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0012 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0061 0.0198
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.041 0.1822 0.5905
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0002
Schistosoma mansoni alpha-1 adrenergic receptor 0.0082 0.0325 0.0313
Trypanosoma cruzi adenosine kinase, putative 0.003 0.0084 0.0273
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0007
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0082 0.0325 0.0313
Brugia malayi Dopamine receptor protein 2 0.0082 0.0325 0.0313
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Mycobacterium ulcerans fructokinase, PfkB 0.003 0.0084 0.0145
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0082 0.0228
Brugia malayi hypothetical protein 0.0016 0.0021 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis ribokinase 0.003 0.0084 0.0073
Loa Loa (eye worm) hypothetical protein 0.0248 0.1081 0.107
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0082 0.0325 0.0313
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.0325 0.0313
Trypanosoma cruzi nucleoside transporter-like, putative 0.0043 0.0145 0.0469
Entamoeba histolytica fructokinase, putative 0.003 0.0084 0.0084
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.041 0.1822 0.5905
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.002 0.004 0.0028
Loa Loa (eye worm) hypothetical protein 0.0076 0.0297 0.0286
Trypanosoma brucei NEDD8-activating enzyme E1 regulatory subunit, putative 0.0113 0.0466 0.1509
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0019 0.0007
Leishmania major hypothetical protein, conserved 0.0113 0.0466 0.1509
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0019 0.0061
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0443 0.0614
Echinococcus multilocularis neuropeptide receptor 0.0082 0.0325 0.0313
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.0145 0.0469
Trypanosoma brucei adenosine transporter 2, putative 0.0043 0.0145 0.0469
Onchocerca volvulus 0.0082 0.0325 0.2928
Entamoeba histolytica ubiquitin-activating enzyme E1 1, putative 0.0176 0.0755 0.0755
Brugia malayi Dopamine receptor protein 1 0.0082 0.0325 0.0313
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0443 0.2075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0043 0.0145 0.0469
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0019 0.0007
Trichomonas vaginalis ubiquitin-activating enzyme E1 X, putative 0.0115 0.0473 0.0656
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0443 0.0873
Onchocerca volvulus 0.0082 0.0325 0.2928
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.003 0.0084 0.0073
Schistosoma mansoni hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis allatostatin A receptor 0.0082 0.0325 0.0313
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.041 0.1822 0.1813
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Mycobacterium ulcerans hypothetical protein 0.002 0.004 0.0056
Trypanosoma brucei adenosine transporter, putative 0.0043 0.0145 0.0469
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0256 0.0828
Echinococcus multilocularis fmrfamide receptor 0.0082 0.0325 0.0313
Echinococcus granulosus allatostatin A receptor 0.0082 0.0325 0.0313
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0082 0.0228
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.041 0.1822 0.5905
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.0145 0.0201
Plasmodium falciparum autophagy-related protein 7, putative 0.0076 0.0294 0.0918
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0043 0.0145 0.0469
Echinococcus multilocularis ubiquitin modifier activating enzyme 6 0.0209 0.0905 0.0895
Echinococcus granulosus g protein coupled receptor 0.0082 0.0325 0.0313
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.0145 0.0201
Trypanosoma cruzi Ubiquitin-like modifier-activating enzyme ATG7, putative 0.0076 0.0294 0.0953
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0127 0.0529 0.0518
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.0145 0.0201
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0047 0.0162 0.0151
Brugia malayi larval opioid receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0082 0.0325 0.0313
Giardia lamblia Ribokinase 0.003 0.0084 0.0015
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0014 0.0002
Brugia malayi MH2 domain containing protein 0.0117 0.0483 0.0472
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0019 0.0007
Schistosoma mansoni ubiquitin-activating enzyme E1-related 0.0076 0.0294 0.0283
Brugia malayi sulfakinin receptor protein 0.0082 0.0325 0.0313
Schistosoma mansoni biogenic amine receptor 0.0082 0.0325 0.0313
Trypanosoma brucei unspecified product 0.0043 0.0145 0.0469
Plasmodium vivax ubiquitin-activating enzyme E1C, putative 0.0686 0.3086 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis neuropeptide receptor A26 0.0082 0.0325 0.0313
Loa Loa (eye worm) STAT protein 0.0131 0.0547 0.0536
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0012 0.0038
Brugia malayi hypothetical protein 0.0043 0.0145 0.0133
Echinococcus multilocularis neuropeptide receptor 0.0082 0.0325 0.0313
Echinococcus granulosus 7TM GPCR rhodopsin 0.0082 0.0325 0.0313
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0045 0.0063
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0325 0.0313
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0325 0.0313
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0076 0.0294 0.0283
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.0325 0.0313
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0268 0.1175 0.6281
Echinococcus granulosus ribokinase 0.003 0.0084 0.0073
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Mycobacterium tuberculosis Adenosine kinase 0.003 0.0084 0.0162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0082 0.0325 0.0313
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.004 0.0056
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0122 0.0508 0.0497
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.0145 0.0469
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0325 0.0313
Brugia malayi Serotonin receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis serotonin receptor 0.0082 0.0325 0.0313
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.041 0.1822 0.2528
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0076 0.0294 0.0294
Brugia malayi ThiF family protein 0.0122 0.0508 0.0497
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0082 0.0325 0.0313
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0013 0.0001
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0119 0.0493 0.1598
Echinococcus granulosus geminin 0.0335 0.1479 0.1469
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0084 0.0117
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0082 0.0325 0.0313
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.0325 0.0313
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0033 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0325 0.0313
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.041 0.1822 0.5905
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0014 0.0002
Brugia malayi Protein kinase domain containing protein 0.0014 0.0014 0.0002
Schistosoma mansoni hypothetical protein 0.0082 0.0325 0.0313
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0268 0.1175 0.3807
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0127 0.0529 0.1713
Brugia malayi G-protein coupled receptor 0.0082 0.0325 0.0313
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.0145 0.0469
Mycobacterium ulcerans carbohydrate kinase CbhK 0.003 0.0084 0.0145
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.004 0.0074
Loa Loa (eye worm) hypothetical protein 0.0261 0.1143 0.1133
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0014 0.0003
Schistosoma mansoni app binding protein 0.0113 0.0466 0.0455
Trypanosoma brucei ubiquitin activating enzyme, putative 0.0076 0.0294 0.0953
Schistosoma mansoni hypothetical protein 0.0082 0.0325 0.0313
Entamoeba histolytica molybdenum cofactor synthesis protein3, putative 0.0076 0.0294 0.0294
Brugia malayi STAT protein, DNA binding domain containing protein 0.0131 0.0547 0.0536
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0045 0.0034
Trypanosoma cruzi nucleoside transporter 1, putative 0.0043 0.0145 0.0469
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0082 0.0113
Brugia malayi ThiF family protein 0.0076 0.0294 0.0283
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0082 0.0113
Trypanosoma cruzi NEDD8-activating enzyme E1 regulatory subunit, putative 0.0113 0.0466 0.1509
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.004 0.0028
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0283 0.1242 0.1231
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0014 0.0002
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0443 0.0432
Schistosoma mansoni hypothetical protein 0.0335 0.1479 0.1469
Echinococcus multilocularis geminin 0.0335 0.1479 0.1469
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0082 0.0113
Echinococcus granulosus ubiquitin modifier activating enzyme 1 0.0209 0.0905 0.0895
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0126 0.0115
Mycobacterium leprae conserved hypothetical protein 0.002 0.004 0.0484
Loa Loa (eye worm) hypothetical protein 0.0248 0.1081 0.107
Echinococcus granulosus GPCR family 2 0.0015 0.0019 0.0007
Trichomonas vaginalis ubiquitin-activating enzyme E1b, putative 0.0076 0.0294 0.0408
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0325 0.0313
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0127 0.0529 0.1713
Entamoeba histolytica hypothetical protein 0.0035 0.0109 0.0109
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0076 0.0297 0.0584
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0256 0.0244
Echinococcus granulosus fmrfamide receptor 0.0082 0.0325 0.0313
Giardia lamblia Hypothetical protein 0.0248 0.1081 0.5739
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0012 0.0017
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.0325 0.0313
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0686 0.3086 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0082 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0256 0.0244
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0443 0.0614
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.004 0.0265
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0109 0.0098
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0126 0.0115
Entamoeba histolytica autophagy protein apg7, putative 0.0076 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.0268 0.1176 0.1166
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Schistosoma mansoni hypothetical protein 0.0076 0.0294 0.0283
Schistosoma mansoni hypothetical protein 0.0035 0.0109 0.0098
Brugia malayi hypothetical protein 0.0025 0.0061 0.005
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0082 0.0228
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0086 0.0343 0.1079
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0443 0.0432
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Echinococcus granulosus equilibrative nucleoside transporter 0.0248 0.1081 0.107
Echinococcus granulosus bloom syndrome protein 0.0021 0.0045 0.0034
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0076 0.0294 0.0953
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0082 0.0325 0.0313
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0012 0.0016
Trypanosoma cruzi Ubiquitin-like modifier-activating enzyme ATG7, putative 0.0076 0.0294 0.0953
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Mycobacterium ulcerans endonuclease IV 0.0076 0.0297 0.0567
Trypanosoma cruzi ubiquitin activating enzyme, putative 0.0076 0.0294 0.0953
Echinococcus multilocularis ubiquitin modifier activating enzyme 5 0.0076 0.0294 0.0283
Toxoplasma gondii nucleoside transporter protein 0.0043 0.0145 0.0133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0012 0.0017
Brugia malayi hypothetical protein 0.0121 0.0502 0.0491
Trichomonas vaginalis ubiquitin-activating enzyme E1c, putative 0.0076 0.0294 0.0408
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0019 0.0024
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0686 0.3086 0.4281
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0268 0.1176 0.1166
Onchocerca volvulus 0.0082 0.0325 0.2928
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.041 0.1822 0.2528
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.041 0.1822 0.1822
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0311 0.1371 0.1361
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0019 0.0061
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.0325 0.0313
Entamoeba histolytica hypothetical protein 0.0035 0.0109 0.0109
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.041 0.1822 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.1114 0.5045 1
Plasmodium vivax ubiquitin-activating enzyme E1, putative 0.0076 0.0294 0.0918
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0256 0.0244
Trypanosoma brucei ubiquitin activating enzyme, putative 0.0076 0.0294 0.0953
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0076 0.0294 0.0408
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0171 0.016
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0248 0.1081 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0082 0.0325 0.0313
Plasmodium vivax autophagy-related protein 7, putative 0.0076 0.0294 0.0918
Schistosoma mansoni opsin-like receptor 0.0082 0.0325 0.0313
Toxoplasma gondii nucleoside transporter protein 0.0043 0.0145 0.0133
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0248 0.1081 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus granulosus sex peptide receptor 0.0082 0.0325 0.0313
Echinococcus granulosus death domain containing protein 0.0014 0.0014 0.0002
Onchocerca volvulus 0.0082 0.0325 0.2928
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.041 0.1822 0.1813
Schistosoma mansoni hypothetical protein 0.0015 0.0019 0.0007
Echinococcus multilocularis neuropeptide FF receptor 2 0.0082 0.0325 0.0313
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0283 0.0272
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0248 0.1081 0.1499
Trypanosoma brucei ribokinase, putative 0.003 0.0084 0.0273
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0082 0.0325 0.0313
Trichomonas vaginalis ribokinase, putative 0.003 0.0084 0.0117
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0127 0.0529 0.1713
Echinococcus granulosus ubiquitin modifier activating enzyme 5 0.0076 0.0294 0.0283
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.0145 0.0469
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0076 0.0294 0.0918
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Toxoplasma gondii ThiF family protein 0.0076 0.0294 0.0283
Entamoeba histolytica ribokinase, putative 0.003 0.0084 0.0084
Plasmodium falciparum ubiquitin-activating enzyme 0.0086 0.0343 0.1079
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0082 0.0325 0.0313
Onchocerca volvulus 0.003 0.0084 0.068
Schistosoma mansoni hypothetical protein 0.0014 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Onchocerca volvulus 0.0236 0.1027 0.9495
Brugia malayi Uncoordinated protein 44 0.0014 0.0014 0.0002
Loa Loa (eye worm) pax transcription factor protein 2 0.0236 0.1027 0.1016
Plasmodium falciparum ubiquitin-activating enzyme 0.0076 0.0294 0.0918
Onchocerca volvulus 0.0082 0.0325 0.2928
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0141 0.0595 0.1175
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.0325 0.0313
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0127 0.0529 0.1713
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0019 0.0007
Onchocerca volvulus Ribokinase homolog 0.003 0.0084 0.068
Toxoplasma gondii autophagy-related protein 7 atg7, putative 0.0076 0.0294 0.0283
Echinococcus granulosus neuropeptide receptor 0.0082 0.0325 0.0313
Trypanosoma brucei unspecified product 0.0043 0.0145 0.0469
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0086 0.0343 0.0343
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.041 0.1822 0.2528
Entamoeba histolytica ThiF family protein 0.0113 0.0466 0.0466
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0082 0.0325 0.0313
Trypanosoma cruzi nucleoside transporter 1, putative 0.0043 0.0145 0.0469
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0443 0.1435
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0325 0.0313
Schistosoma mansoni clathrin coat associated protein ap-50 0.0154 0.0652 0.0642
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0076 0.0297 0.0286
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0141 0.0595 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0019 0.0007
Schistosoma mansoni hypothetical protein 0.0033 0.0101 0.0089
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0325 0.0313
Onchocerca volvulus 0.0082 0.0325 0.2928
Entamoeba histolytica nucleoside transporter, putative 0.0043 0.0145 0.0145
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0171 0.016
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0443 0.0614
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0443 0.0432
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0043 0.0145 0.0469
Mycobacterium tuberculosis Ribokinase RbsK 0.003 0.0084 0.0162
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.041 0.1822 0.1813
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0076 0.0294 0.0283
Brugia malayi neuropeptide F receptor 0.0082 0.0325 0.0313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0325 0.0313
Brugia malayi hypothetical protein 0.0082 0.0325 0.0313
Brugia malayi Tachykinin-like peptides receptor 99D 0.0082 0.0325 0.0313
Trichomonas vaginalis ubiquitin-activating enzyme E1, putative 0.0086 0.0343 0.0476
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0325 0.0313
Trypanosoma brucei E1-like ubiquitin-activating enzyme, putative 0.0076 0.0294 0.0953
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0443 0.1435
Loa Loa (eye worm) hypothetical protein 0.0248 0.1081 0.107
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0283 0.0272
Trichomonas vaginalis ribokinase, putative 0.003 0.0084 0.0117
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0012 0.0038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0003
Schistosoma mansoni biogenic amine receptor 0.0082 0.0325 0.0313
Loa Loa (eye worm) hypothetical protein 0.0025 0.0061 0.005
Schistosoma mansoni growth hormone secretagogue receptor 0.0082 0.0325 0.0313
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.003 0.0084 0.0162
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0268 0.1176 0.1166
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0122 0.0508 0.0497
Loa Loa (eye worm) hypothetical protein 0.0076 0.0294 0.0283
Onchocerca volvulus 0.0082 0.0325 0.2928
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0043 0.0145 0.0201
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0325 0.0313
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0325 0.0313
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0082 0.007
Onchocerca volvulus 0.0082 0.0325 0.2928
Echinococcus granulosus g protein coupled receptor 0.0082 0.0325 0.0313
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0248 0.1081 0.1499
Echinococcus multilocularis GPCR, family 2 0.0015 0.0019 0.0007
Mycobacterium leprae PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) 0.0076 0.0294 0.4837
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0443 0.7388
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.041 0.1822 0.1813
Loa Loa (eye worm) hypothetical protein 0.0082 0.0325 0.0313
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0443 0.0857
Schistosoma mansoni opsin-like receptor 0.0082 0.0325 0.0313
Echinococcus multilocularis ubiquitin modifier activating enzyme ATG7 0.0076 0.0294 0.0283
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0256 0.0828
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0443 0.0443
Brugia malayi isocitrate dehydrogenase 0.0015 0.0019 0.0007
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0012 0.0017
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0014 0.0002
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0043 0.0145 0.0469
Brugia malayi Dopamine receptor 0.0082 0.0325 0.0313
Echinococcus granulosus neuropeptide receptor 0.0082 0.0325 0.0313
Trichomonas vaginalis autophagy protein, putative 0.0076 0.0294 0.0408
Trypanosoma cruzi molybdopterin synthase sulphurylase-like protein, putative 0.0076 0.0294 0.0953
Plasmodium vivax ubiquitin-activating enzyme, putative 0.0076 0.0294 0.0918

Activities

Activity type Activity value Assay description Source Reference
CL (ADMET) = 74 microL/min/mg Intrinsic clearance in human liver microsomes ChEMBL. 24144851
IC50 (binding) = 8.5 Displacement of [3H]NMS from recombinant human M3 receptor expressed in CHO-K1 cells after 16 hrs by SPA method ChEMBL. 24144851

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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