Detailed information for compound 1260762

Basic information

Technical information
  • TDR Targets ID: 1260762
  • Name: N-cyclohexyl-2-(1-methyltetrazol-5-yl)sulfany lacetamide
  • MW: 255.34 | Formula: C10H17N5OS
  • H donors: 1 H acceptors: 4 LogP: 1.57 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCCCC1)CSc1nnnn1C
  • InChi: 1S/C10H17N5OS/c1-15-10(12-13-14-15)17-7-9(16)11-8-5-3-2-4-6-8/h8H,2-7H2,1H3,(H,11,16)
  • InChiKey: JYNNXRDUMVRCEY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-cyclohexyl-2-(1-methyltetrazol-5-yl)sulfanyl-acetamide
  • N-cyclohexyl-2-[(1-methyl-5-tetrazolyl)thio]acetamide
  • N-cyclohexyl-2-[(1-methyltetrazol-5-yl)thio]acetamide
  • N-cyclohexyl-2-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanyl]ethanamide
  • SMR000061632
  • AG-690/40721868
  • ZINC00291966
  • Oprea1_233337
  • MLS000082208
  • ST5438636
  • Oprea1_402217

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Sus scrofa Calpain 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis calpain family protein 1, d Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma japonicum ko:K08585 calpain, invertebrate, putative Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus family C2 unassigned peptidase C02 family Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Calpain-A, putative Get druggable targets OG5_127139 All targets in OG5_127139
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Calpain-1 catalytic subunit, putative Get druggable targets OG5_127139 All targets in OG5_127139
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax hypothetical protein, conserved Calpain 2   324 aa 277 aa 19.9 %
Echinococcus granulosus calpain A Calpain 2   324 aa 297 aa 27.6 %
Echinococcus multilocularis calpain Calpain 2   324 aa 320 aa 31.9 %
Schistosoma japonicum Calpain-9, putative Calpain 2   324 aa 275 aa 27.6 %
Echinococcus multilocularis hypothetical protein Calpain 2   324 aa 297 aa 27.9 %
Schistosoma mansoni calpain (C02 family) Calpain 2   324 aa 318 aa 24.2 %
Echinococcus granulosus calpain Calpain 2   324 aa 322 aa 31.7 %
Schistosoma mansoni calpain C (C02 family) Calpain 2   324 aa 319 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni bromodomain containing protein 0.0084 0.1071 0.1184
Brugia malayi PWWP domain containing protein 0.004 0.034 0.0305
Loa Loa (eye worm) hypothetical protein 0.0076 0.0925 0.1876
Schistosoma mansoni hypothetical protein 0.0023 0.0048 0.0053
Schistosoma mansoni alpha-glucosidase 0.0169 0.2479 0.2742
Schistosoma mansoni hepatoma derived growth factor 0.004 0.034 0.0376
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0397 0.03
Schistosoma mansoni enhancer of polycomb 0.0094 0.1233 0.1364
Schistosoma mansoni calpain-7 (C02 family) 0.0023 0.0057 0.0063
Echinococcus granulosus PHD finger protein rhinoceros 0.0154 0.2226 0.2182
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0397 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0579 0.1174
Onchocerca volvulus 0.0114 0.1559 0.646
Loa Loa (eye worm) calpain 5 0.0023 0.0057 0.0116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0253 0.0211
Trypanosoma cruzi transcription elongation factor s-II, putative 0.004 0.034 0.8334
Schistosoma mansoni hypothetical protein 0.004 0.034 0.0376
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1942
Schistosoma mansoni hepatoma derived growth factor 0.004 0.034 0.0376
Schistosoma mansoni hypothetical protein 0.005 0.0508 0.0562
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0823 0.167
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.1504 0.156
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0925 0.0935
Echinococcus granulosus PWWP domain containing protein 2A 0.004 0.034 0.0285
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0326 0.027
Loa Loa (eye worm) hypothetical protein 0.0055 0.0579 0.1174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0253 0.0513
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.0508 0.0562
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0823 0.091
Trichomonas vaginalis conserved hypothetical protein 0.0317 0.4929 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.005 0.0508 0.0889
Toxoplasma gondii PHD-finger domain-containing protein 0.005 0.0508 0.0889
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0155 0.2238 0.2351
Schistosoma mansoni hypothetical protein 0.004 0.034 0.0376
Echinococcus granulosus enhancer of polycomb 0.0094 0.1233 0.1183
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0397 1
Brugia malayi hypothetical protein 0.004 0.034 0.0305
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0823 0.077
Echinococcus granulosus zinc finger protein 0.0036 0.0278 0.0222
Plasmodium vivax hypothetical protein, conserved 0.0154 0.2226 1
Schistosoma mansoni enhancer of polycomb 0.0094 0.1233 0.1364
Echinococcus multilocularis enhancer of polycomb 0.0094 0.1233 0.1183
Schistosoma mansoni hypothetical protein 0.0076 0.0925 0.1023
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0823 0.091
Trypanosoma brucei glucosidase, putative 0.0044 0.0397 0.7535
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0048 0.0097
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.004 0.034 0.8334
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2933 0.31
Echinococcus multilocularis calpain family protein 1, d 0.0055 0.0579 0.0525
Loa Loa (eye worm) hypothetical protein 0.011 0.1504 0.3051
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0083 0.0026
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0397 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.037 0.075
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0253 0.0197
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.005 0.0508 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2933 0.2892
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.004 0.034 0.8334
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0397 0.0805
Schistosoma mansoni hypothetical protein 0.004 0.034 0.0376
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.1504 0.156
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.004 0.034 0.0285
Schistosoma mansoni zinc finger protein 0.0036 0.0278 0.0307
Echinococcus granulosus hepatoma derived growth factor protein 0.004 0.034 0.0285
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0253 0.0197
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0823 0.091
Toxoplasma gondii PHD-finger domain-containing protein 0.0154 0.2226 1
Echinococcus granulosus enhancer of polycomb 0.0094 0.1233 0.1183
Loa Loa (eye worm) RNA binding protein 0.0069 0.0823 0.167
Loa Loa (eye worm) hypothetical protein 0.004 0.034 0.069
Schistosoma mansoni alpha glucosidase 0.0044 0.0397 0.0439
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0823 0.091
Echinococcus granulosus calpain A 0.0082 0.1028 0.0977
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0326 0.027
Schistosoma mansoni calpain C (C02 family) 0.0023 0.0057 0.0063
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0397 1
Loa Loa (eye worm) PHD-finger family protein 0.0154 0.2226 0.4517
Echinococcus multilocularis hepatoma derived growth factor protein 0.004 0.034 0.0285
Brugia malayi PHD-finger family protein 0.0052 0.0543 0.0523
Toxoplasma gondii PHD-finger domain-containing protein 0.0154 0.2226 1
Brugia malayi F/Y-rich N-terminus family protein 0.0052 0.0543 0.0523
Schistosoma mansoni alpha-glucosidase 0.0169 0.2479 0.2742
Onchocerca volvulus 0.0055 0.0579 0.1265
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2933 0.595
Loa Loa (eye worm) hypothetical protein 0.006 0.0662 0.1342
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0823 0.0826
Schistosoma mansoni Mername-AA248 (C02 family) 0.0023 0.0057 0.0063
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0082 0.1028 0.0977
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.008 0.1006 0.0954
Loa Loa (eye worm) bromodomain containing protein 0.0034 0.0243 0.0493
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0319 0.4956 0.4927
Brugia malayi Bromodomain containing protein 0.0583 0.9333 1
Schistosoma mansoni tyrosine kinase 0.0313 0.4863 0.5378
Schistosoma mansoni hypothetical protein 0.0035 0.0253 0.0279
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0397 0.0366
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2933 0.2892
Brugia malayi AF-10 protein 0.005 0.0508 0.0486
Schistosoma mansoni SET domain protein 0.0042 0.0375 0.0415
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.034 0.8334
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0253 0.0197
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0155 0.2238 0.2194
Loa Loa (eye worm) hypothetical protein 0.0062 0.0696 0.1413
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.1392 0.1343
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0319 0.4956 0.4927
Onchocerca volvulus Alhambra homolog 0.0154 0.2226 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.008 0.1006 0.0954
Plasmodium vivax hypothetical protein, conserved 0.005 0.0508 0.2079
Brugia malayi RNA binding protein 0.0069 0.0823 0.0826
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0083 0.0091
Plasmodium falciparum phd finger protein, putative 0.0154 0.2226 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0082 0.1028 0.1137
Schistosoma mansoni hypothetical protein 0.0035 0.0253 0.0279
Brugia malayi jmjC domain containing protein 0.0104 0.1392 0.1439
Giardia lamblia PHD finger protein 15 0.0154 0.2226 0.5
Schistosoma mansoni phd finger protein 0.0058 0.0632 0.0699
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0155 0.2238 0.2194
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0565 0.9042 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0155 0.2238 0.4541
Brugia malayi Bromodomain containing protein 0.0057 0.0617 0.0604
Schistosoma mansoni hypothetical protein 0.0035 0.0253 0.0279
Loa Loa (eye worm) PWWP domain-containing protein 0.004 0.034 0.069
Echinococcus multilocularis enhancer of polycomb 0.0094 0.1233 0.1183
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0823 0.091
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2933 0.2892
Brugia malayi PHD-finger family protein 0.0154 0.2226 0.2339
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.004 0.034 0.0285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0155 0.2238 0.2194
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0253 0.0211
Schistosoma mansoni hypothetical protein 0.0154 0.2226 0.2462
Echinococcus granulosus GPCR family 2 0.0035 0.0253 0.0197
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0253 0.0197
Schistosoma mansoni enhancer of polycomb 0.0094 0.1233 0.1364
Loa Loa (eye worm) calpain family protein 1 0.0055 0.0579 0.1174
Leishmania major hypothetical protein, conserved 0.004 0.034 0.8334
Loa Loa (eye worm) calpain 0.0023 0.0057 0.0116
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0397 0.0342
Loa Loa (eye worm) hypothetical protein 0.0317 0.4929 1
Echinococcus multilocularis PWWP domain containing protein 2A 0.004 0.034 0.0285
Echinococcus granulosus PWWP domain containing protein 2A 0.004 0.034 0.0285
Schistosoma mansoni calpain-7 (C02 family) 0.0023 0.0057 0.0063
Brugia malayi hypothetical protein 0.004 0.034 0.0305
Schistosoma mansoni hypothetical protein 0.0035 0.0253 0.0279
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0078 0.0962 0.1064
Trypanosoma brucei transcription elongation factor s-II, putative 0.004 0.034 0.628
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0082 0.1028 0.0977
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0082 0.1028 0.1137
Brugia malayi calpain family protein 1 0.0078 0.0962 0.0976
Brugia malayi calpain family protein 1 0.0078 0.0962 0.0976
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.2238 0.2476
Echinococcus multilocularis zinc finger protein 0.0036 0.0278 0.0222
Brugia malayi Bromodomain containing protein 0.0097 0.1283 0.1322
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0083 0.0026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.2238 0.2476
Schistosoma mansoni enhancer of polycomb 0.0094 0.1233 0.1364
Loa Loa (eye worm) hypothetical protein 0.0078 0.0962 0.1952
Echinococcus multilocularis peregrin 0.0623 1 1
Echinococcus multilocularis GPCR, family 2 0.0035 0.0253 0.0197
Echinococcus multilocularis calpain A 0.0082 0.1028 0.0977
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0155 0.2238 0.2476
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.1392 0.1343
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0155 0.2238 0.2194
Entamoeba histolytica hypothetical protein 0.004 0.034 0.8334
Loa Loa (eye worm) hypothetical protein 0.0078 0.0962 0.1952
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.1504 0.3051
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0397 1
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0823 0.167
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0397 0.0342
Schistosoma mansoni calpain (C02 family) 0.0023 0.0057 0.0063
Loa Loa (eye worm) hypothetical protein 0.0154 0.2226 0.4517
Loa Loa (eye worm) jmjC domain-containing protein 0.0104 0.1392 0.2824
Echinococcus granulosus tar DNA binding protein 0.0069 0.0823 0.077
Loa Loa (eye worm) hypothetical protein 0.0052 0.0543 0.1101
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0253 0.0513
Echinococcus multilocularis PWWP domain containing protein 2A 0.004 0.034 0.0285
Loa Loa (eye worm) calpain family protein 1 0.0078 0.0962 0.1952
Brugia malayi TAR-binding protein 0.0069 0.0823 0.0826
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.034 0.8334
Brugia malayi PHD-finger family protein 0.0042 0.0374 0.0342
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.005 0.0508 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0154 0.2226 0.2182

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) < 0.4 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Calpain Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1236 (Primary screen preceding this confirmatory assay.)] ChEMBL. No reference
Potency (functional) 0.0828 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.7783 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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