TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 331.365 | Formula: C14H25N3O6
H donors: 4 H acceptors: 5 LogP: -2.8 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C(NC(=O)C(NC(=O)C(CC(=O)O)N)C)(CC)CC
InChi: 1S/C14H25N3O6/c1-5-14(6-2,13(22)23-4)17-11(20)8(3)16-12(21)9(15)7-10(18)19/h8-9H,5-7,15H2,1-4H3,(H,16,21)(H,17,20)(H,18,19)
InChiKey: XYPPUCBUADTJCA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0537	0.4934	1
Toxoplasma gondii	bromodomain-containing protein	0.0033	0.0036	0.0114
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0036	0.0114
Schistosoma mansoni	hypothetical protein	0.0261	0.2251	0.2487
Brugia malayi	TAZ zinc finger family protein	0.0033	0.0036	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1134	0.2281
Onchocerca volvulus		0.0033	0.0036	0.0108
Toxoplasma gondii	hypothetical protein	0.0033	0.0036	0.0114
Onchocerca volvulus	Peroxidasin homolog	0.0083	0.0519	0.2145
Loa Loa (eye worm)	hypothetical protein	0.0041	0.011	0.0201
Echinococcus granulosus	E3 ubiquitin protein ligase TRIM33	0.0241	0.206	0.206
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0052
Loa Loa (eye worm)	acetyltransferase	0.0033	0.0036	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1134	0.2281
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.0519	0.1031
Schistosoma mansoni	lipoxygenase	0.0169	0.1363	0.1502
Onchocerca volvulus		0.0041	0.011	0.0418
Onchocerca volvulus	Peroxidasin homolog	0.0083	0.0519	0.2145
Echinococcus multilocularis	peroxidasin	0.0083	0.0519	0.0508
Brugia malayi	hypothetical protein	0.0083	0.0519	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Loa Loa (eye worm)	jmjC domain-containing protein	0.0175	0.1422	0.2867
Brugia malayi	hypothetical protein	0.0068	0.0378	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Onchocerca volvulus	Brd8 homolog	0.0033	0.0036	0.0108
Onchocerca volvulus		0.0041	0.011	0.0418
Echinococcus granulosus	polybromo 1	0.0033	0.0036	0.0036
Plasmodium vivax	multidomain scavenger receptor, putative	0.0041	0.011	0.0442
Schistosoma mansoni	hepatoma derived growth factor	0.0068	0.0378	0.0407
Toxoplasma gondii	PHD-finger domain-containing protein	0.0261	0.2251	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0052
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0033	0.0036	0.0028
Echinococcus multilocularis	PWWP domain containing protein 2A	0.0068	0.0378	0.0367
Onchocerca volvulus		0.0083	0.0519	0.2145
Schistosoma mansoni	hypothetical protein	0.0033	0.0036	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0033	0.0036	0.0028
Echinococcus multilocularis	RUN	0.0041	0.011	0.0099
Echinococcus multilocularis	bromodomain containing 2	0.0033	0.0036	0.0026
Loa Loa (eye worm)	bromodomain containing protein	0.0033	0.0036	0.0052
Loa Loa (eye worm)	CBP-B	0.0033	0.0036	0.0052
Schistosoma mansoni	peroxidasin	0.0083	0.0519	0.0564
Brugia malayi	Doublecortin family protein	0.0041	0.011	0.0106
Toxoplasma gondii	bromodomain-containing protein	0.0033	0.0036	0.0114
Echinococcus granulosus	hepatoma derived growth factor protein	0.0068	0.0378	0.0378
Onchocerca volvulus	Chorion peroxidase homolog	0.0083	0.0519	0.2145
Brugia malayi	hypothetical protein	0.0041	0.011	0.0106
Echinococcus granulosus	lipoxygenase domain containing protein	0.0041	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0242	0.2072	0.2072
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Onchocerca volvulus		0.0146	0.1134	0.4745
Brugia malayi	Bromodomain containing protein	0.0033	0.0036	0.0027
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.0519	0.1031
Echinococcus granulosus	protein kinase C binding protein 1	0.0033	0.0036	0.0036
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0519	0.0544
Entamoeba histolytica	ankyrin repeat protein, putative	0.0033	0.0036	0.0000003618
Echinococcus granulosus	Bromodomain containing protein	0.0033	0.0036	0.0036
Echinococcus multilocularis	CREB binding protein	0.0033	0.0036	0.0026
Toxoplasma gondii	bromodomain-containing protein	0.0033	0.0036	0.0114
Echinococcus granulosus	PH interacting protein	0.0033	0.0036	0.0036
Brugia malayi	Bromodomain containing protein	0.0033	0.0036	0.0027
Loa Loa (eye worm)	PWWP domain-containing protein	0.0068	0.0378	0.0745
Echinococcus granulosus	PWWP domain containing protein 2A	0.0068	0.0378	0.0378
Plasmodium vivax	SET domain containing protein	0.0034	0.0047	0.0163
Loa Loa (eye worm)	blistered cuticle protein 3	0.0083	0.0519	0.1031
Schistosoma mansoni	rab6-interacting	0.0041	0.011	0.011
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0519	0.0544
Plasmodium falciparum	bromodomain protein 1	0.0033	0.0036	0.000000055788
Schistosoma mansoni	lipoxygenase	0.0242	0.2072	0.2289
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0011	0.0011
Schistosoma mansoni	bromodomain containing protein	0.0039	0.0096	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0052
Echinococcus granulosus	peroxidasin	0.0083	0.0519	0.0519
Echinococcus granulosus	microtubule associated protein 2	0.0701	0.6534	0.6534
Echinococcus granulosus	enhancer of polycomb	0.0159	0.1264	0.1264
Brugia malayi	jmjC domain containing protein	0.0175	0.1422	0.1513
Echinococcus granulosus	CREB binding protein	0.0033	0.0036	0.0036
Onchocerca volvulus		0.0241	0.2056	0.864
Echinococcus granulosus	lipoxygenase domain containing protein	0.0041	0.011	0.011
Echinococcus multilocularis	enhancer of polycomb	0.0159	0.1264	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0261	0.2251	0.4549
Brugia malayi	Pre-SET motif family protein	0.0211	0.1772	0.1888
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0957	0.9018	1
Plasmodium vivax	hypothetical protein, conserved	0.0085	0.0544	0.2382
Echinococcus multilocularis	microtubule associated protein 2	0.0701	0.6534	0.653
Brugia malayi	Bromodomain containing protein	0.099	0.9338	1
Trichomonas vaginalis	conserved hypothetical protein	0.0537	0.4934	1
Echinococcus granulosus	bromodomain containing 2	0.0033	0.0036	0.0036
Schistosoma mansoni	CREB-binding protein 2	0.0033	0.0036	0.0028
Echinococcus multilocularis	expressed protein	0.0379	0.3404	0.3396
Onchocerca volvulus	Dual oxidase homolog	0.0083	0.0519	0.2145
Schistosoma mansoni	hypothetical protein	0.0033	0.0036	0.0028
Echinococcus granulosus	transcription initiation factor TFIID subunit 1	0.0033	0.0036	0.0036
Brugia malayi	PWWP domain containing protein	0.0068	0.0378	0.0393
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0096	0.0085
Onchocerca volvulus	Alhambra homolog	0.0261	0.2251	0.9462
Brugia malayi	Bromodomain containing protein	0.0033	0.0036	0.0027
Schistosoma mansoni	helicase	0.0033	0.0036	0.0028
Onchocerca volvulus		0.0083	0.0519	0.2145
Echinococcus granulosus	Bromodomain containing protein	0.0033	0.0036	0.0036
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0211	0.1772	0.3577
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0033	0.0036	0.0114
Echinococcus multilocularis	E3 ubiquitin protein ligase TRIM33	0.0241	0.206	0.2051
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0052
Echinococcus multilocularis	polybromo 1	0.0033	0.0036	0.0026
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0519	0.0544
Toxoplasma gondii	PHD-finger domain-containing protein	0.0085	0.0544	0.2382
Loa Loa (eye worm)	PHD-finger family protein	0.0261	0.2251	0.4549
Brugia malayi	polybromodomain protein	0.0033	0.0036	0.0027
Schistosoma mansoni	rab6-interacting	0.0041	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0096	0.0172
Echinococcus multilocularis	enhancer of polycomb	0.0159	0.1264	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0604	0.1204
Giardia lamblia	PHD finger protein 15	0.0261	0.2251	1
Brugia malayi	Bromodomain containing protein	0.0033	0.0036	0.0027
Schistosoma mansoni	enhancer of polycomb	0.0159	0.1264	0.1392
Plasmodium falciparum	LCCL domain-containing protein	0.0041	0.011	0.0332
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0085	0.0544	0.2294
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0175	0.1422	0.1422
Schistosoma mansoni	microtubule-associated protein tau	0.0701	0.6534	0.7242
Loa Loa (eye worm)	BRM protein	0.0033	0.0036	0.0052
Brugia malayi	hypothetical protein	0.0041	0.011	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0052
Onchocerca volvulus		0.0068	0.0378	0.155
Brugia malayi	PHD-finger family protein	0.0091	0.0604	0.0636
Schistosoma mansoni	hypothetical protein	0.0085	0.0544	0.0592
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0085	0.0544	1
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0519	0.0544
Brugia malayi	Peroxidasin	0.0083	0.0519	0.0544
Echinococcus granulosus	CREB binding protein	0.0033	0.0036	0.0036
Loa Loa (eye worm)	doublecortin family protein	0.0041	0.011	0.0201
Brugia malayi	acetyltransferase, GNAT family protein	0.0033	0.0036	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Brugia malayi	BRM protein	0.0033	0.0036	0.0027
Echinococcus granulosus	RUN	0.0041	0.011	0.011
Plasmodium vivax	bromodomain protein, putative	0.0033	0.0036	0.0114
Schistosoma mansoni	enhancer of polycomb	0.0159	0.1264	0.1392
Toxoplasma gondii	bromodomain-containing protein	0.0033	0.0036	0.0114
Echinococcus multilocularis	Bromodomain containing protein	0.0033	0.0036	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0041	0.011	0.0201
Schistosoma mansoni	bromodomain containing protein	0.0039	0.0096	0.0094
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0041	0.011	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0052
Echinococcus granulosus	PWWP domain containing protein 2A	0.0068	0.0378	0.0378
Schistosoma mansoni	peroxidasin	0.0083	0.0519	0.0564
Schistosoma mansoni	bromodomain-containing protein 3 brd3	0.0033	0.0036	0.0028
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.0519	0.1031
Brugia malayi	bromodomain containing protein	0.0033	0.0036	0.0027
Schistosoma mansoni	phd finger protein	0.0101	0.0698	0.0763
Onchocerca volvulus	Peroxidase homolog	0.0083	0.0519	0.2145
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0034	0.0047	0.0163
Schistosoma mansoni	bromodomain containing	0.0033	0.0036	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1212	0.2439
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0378	0.0745
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0033	0.0036	0.0114
Trichomonas vaginalis	set domain proteins, putative	0.0241	0.2056	0.4124
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0096	0.0172
Schistosoma mansoni	SET domain protein	0.0075	0.0448	0.0485
Schistosoma mansoni	transcription intermediary factor 1-related	0.0241	0.206	0.2275
Schistosoma mansoni	hypothetical protein	0.0068	0.0378	0.0407
Brugia malayi	Animal haem peroxidase family protein	0.0083	0.0519	0.0544
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0242	0.2072	0.2064
Toxoplasma gondii	PHD-finger domain-containing protein	0.0261	0.2251	1
Onchocerca volvulus		0.0083	0.0519	0.2145
Brugia malayi	Bromodomain containing protein	0.0274	0.2378	0.2538
Toxoplasma gondii	bromodomain-containing protein	0.0033	0.0036	0.0114
Echinococcus multilocularis	PH interacting protein	0.0033	0.0036	0.0026
Echinococcus granulosus	ATPase family AAA domain containing protein 2B	0.0033	0.0036	0.0036
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0085	0.0544	1
Echinococcus multilocularis		0.0033	0.0036	0.0026
Echinococcus multilocularis	histone lysine N methyltransferase, H3 lysine 36	0.0069	0.0389	0.0378
Schistosoma mansoni	bromodomain containing protein	0.0033	0.0036	0.0028
Brugia malayi	F/Y-rich N-terminus family protein	0.0092	0.0615	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0052
Onchocerca volvulus		0.0033	0.0036	0.0108
Plasmodium vivax	bromodomain protein, putative	0.0033	0.0036	0.0114
Echinococcus multilocularis	bromodomain containing protein 8	0.0033	0.0036	0.0026
Toxoplasma gondii	hypothetical protein	0.0068	0.0378	0.1638
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0041	0.011	0.0099
Loa Loa (eye worm)	bromodomain containing protein	0.0033	0.0036	0.0052
Onchocerca volvulus		0.0274	0.2378	1
Onchocerca volvulus		0.0068	0.0378	0.155
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0175	0.1422	0.1413
Echinococcus granulosus	histone lysine N methyltransferase H3 lysine 36	0.0069	0.0389	0.0389
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.0378	1
Brugia malayi	PHD-finger family protein	0.0039	0.0096	0.0091
Echinococcus multilocularis	Polycystic kidney disease protein	0.0041	0.011	0.0099
Echinococcus multilocularis	PWWP domain containing protein 2A	0.0068	0.0378	0.0367
Echinococcus multilocularis	protein kinase C binding protein 1	0.0033	0.0036	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0274	0.2378	0.4808
Schistosoma mansoni	hepatoma derived growth factor	0.0068	0.0378	0.0407
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0033	0.0036	0.0026
Schistosoma mansoni	enhancer of polycomb	0.0159	0.1264	0.1392
Echinococcus multilocularis	zinc finger protein	0.0039	0.0096	0.0085
Onchocerca volvulus	Bromodomain adjacent to zinc finger domain protein 1A homolog	0.0033	0.0036	0.0108
Echinococcus granulosus	PHD finger protein rhinoceros	0.0261	0.2251	0.2251
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0096	0.0096
Echinococcus granulosus	zinc finger protein	0.0039	0.0096	0.0096
Brugia malayi	polybromodomain protein	0.0033	0.0036	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1134	0.2281
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0033	0.0036	0.0114
Brugia malayi	Bromodomain containing protein	0.0033	0.0036	0.0027
Echinococcus multilocularis	Bromodomain containing protein	0.0033	0.0036	0.0026
Brugia malayi	PHD-finger family protein	0.0261	0.2251	0.2401
Brugia malayi	hypothetical protein	0.0068	0.0378	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0157	0.1244	0.2504
Schistosoma mansoni	hypothetical protein	0.0033	0.0036	0.0028
Echinococcus granulosus	expressed protein	0.0379	0.3404	0.3404
Plasmodium vivax	bromodomain protein, putative	0.0033	0.0036	0.0114
Leishmania major	hypothetical protein, conserved	0.0068	0.0378	1
Plasmodium vivax	hypothetical protein, conserved	0.0261	0.2251	1
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0085	0.0544	0.2382
Onchocerca volvulus	Peroxidase homolog	0.0083	0.0519	0.2145
Echinococcus multilocularis	ATPase family AAA domain containing protein 2B	0.0033	0.0036	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Brugia malayi	Bromodomain containing protein	0.0039	0.0096	0.0091
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0086	0.0555	0.0604
Echinococcus granulosus	global transcription activator snf2l2	0.0033	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Schistosoma mansoni	polybromo-1	0.0033	0.0036	0.0028
Schistosoma mansoni	zinc finger protein	0.0039	0.0096	0.0094
Echinococcus granulosus	Polycystic kidney disease protein	0.0041	0.011	0.011
Entamoeba histolytica	hypothetical protein	0.0068	0.0378	1
Trypanosoma cruzi	MIZ/SP-RING zinc finger, putative	0.0068	0.0378	1
Brugia malayi	Bromodomain containing protein	0.0033	0.0036	0.0027
Schistosoma mansoni	loxhd1	0.0041	0.011	0.011
Trypanosoma cruzi	transcription elongation factor-like protein, putative	0.0068	0.0378	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0036	0.0052
Brugia malayi	Blistered cuticle protein 3	0.0083	0.0519	0.0544
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0033	0.0036	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Schistosoma mansoni	hypothetical protein	0.0068	0.0378	0.0407
Toxoplasma gondii	SWI2/SNF2 Brahma-like putative	0.0033	0.0036	0.0114
Schistosoma mansoni	hypothetical protein	0.0033	0.0036	0.0028
Trypanosoma cruzi	transcription elongation factor s-II, putative	0.0068	0.0378	1
Schistosoma mansoni	transcription initiation factor tfiid	0.0033	0.0036	0.0028
Trypanosoma brucei	transcription elongation factor s-II, putative	0.0068	0.0378	0.6721
Loa Loa (eye worm)	animal heme peroxidase	0.0083	0.0519	0.1031
Echinococcus multilocularis	hepatoma derived growth factor protein	0.0068	0.0378	0.0367
Schistosoma mansoni	enhancer of polycomb	0.0159	0.1264	0.1392
Brugia malayi	ATPase, AAA family protein	0.0033	0.0036	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Echinococcus granulosus	bromodomain containing protein 8	0.0033	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0519	0.1031
Echinococcus granulosus	enhancer of polycomb	0.0159	0.1264	0.1264
Plasmodium falciparum	phd finger protein, putative	0.0261	0.2251	1
Echinococcus multilocularis	peregrin	0.1058	1	1
Schistosoma mansoni	polycystin 1-related	0.0041	0.011	0.011
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0033	0.0036	0.0036
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0261	0.2251	0.2242
Brugia malayi	Bromodomain containing protein	0.0033	0.0036	0.0027
Schistosoma mansoni	hypothetical protein	0.0068	0.0378	0.0407
Trypanosoma cruzi	hypothetical protein, conserved	0.0068	0.0378	1
Echinococcus multilocularis	global transcription activator snf2l2	0.0033	0.0036	0.0026
Schistosoma mansoni	hypothetical protein	0.0041	0.011	0.011
Brugia malayi	AF-10 protein	0.0085	0.0544	0.0572
Toxoplasma gondii	histone acetyltransferase TAF1/250	0.0033	0.0036	0.0114

Activities

Activity type	Activity value	Assay description	Source	Reference
Sweetness potency (binding)	0	Compound is evaluated for sweet potency; +=Sweet	ChEMBL.	4045926

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 154871

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 54225