Detailed information for compound 1186941

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 361.321 | Formula: C18H16FNO6
  • H donors: 3 H acceptors: 5 LogP: 2.65 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@H](NC(=O)C(=O)O)Cc1ccc(cc1)OCc1ccccc1F
  • InChi: 1S/C18H16FNO6/c19-14-4-2-1-3-12(14)10-26-13-7-5-11(6-8-13)9-15(17(22)23)20-16(21)18(24)25/h1-8,15H,9-10H2,(H,20,21)(H,22,23)(H,24,25)/t15-/m1/s1
  • InChiKey: AQCSGRMDEPBHTH-OAHLLOKOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.2681 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0635 0.1759
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0058 0.0161
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0058 0.0161
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.347 0.4525
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0635 0.0635
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0058 0.0076
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.011 0.2986 0.8277
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0058 0.0161
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0635 0.0828
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.4821 0.6286
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.7669 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0058 0.0058
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0748 0.1449
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0058 0.0076
Plasmodium falciparum phd finger protein, putative 0.0035 0.0534 0.179
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0058 0.0161
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.3607 1
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0534 0.0697
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.2681 0.3496
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0076
Giardia lamblia PHD finger protein 15 0.0035 0.0534 0.1994
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0984 0.2729
Brugia malayi MH2 domain containing protein 0.0125 0.347 0.4525
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0026 0.0237 0.0237
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0026 0.0237 0.0237
Plasmodium vivax aspartyl proteinase, putative 0.011 0.2986 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0534 0.0697
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0076
Trypanosoma brucei polo-like protein kinase 0.0101 0.2681 1
Plasmodium falciparum plasmepsin II 0.011 0.2986 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0635 0.0828
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0026 0.0237 0.0237
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0026 0.0237 0.0237
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0026 0.0237 0.0237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0058 0.0076
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.2681 0.5507
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0058 0.0161
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0984 0.2729
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0635 0.0828
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0776 0.2152
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0058 0.0076
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0058 0.0161
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0058 0.0076
Plasmodium vivax aspartyl proteinase, putative 0.0026 0.0237 0.0793
Echinococcus granulosus chromobox protein 1 0.0074 0.1816 0.5035
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.3148 0.8728
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.2681 0.3496
Giardia lamblia Kinase, PLK 0.0101 0.2681 1
Trichomonas vaginalis chromobox protein, putative 0.0074 0.1816 0.2368
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0076
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.2681 0.7432
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0534 0.179
Brugia malayi nuclear hormone receptor 0.0021 0.0058 0.0076
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0534 0.1482
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0058 0.0058
Echinococcus granulosus chromobox protein 1 0.0074 0.1816 0.5035
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0058 0.0161
Onchocerca volvulus 0.0026 0.0237 0.0375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0058 0.0076
Echinococcus multilocularis peregrin 0.0035 0.0534 0.1482
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.7669 1
Plasmodium falciparum plasmepsin III 0.0026 0.0237 0.0793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0058 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.5113 0.6667
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0058 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0058 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0635 0.0828
Toxoplasma gondii aspartyl protease 0.0026 0.0237 0.0656
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0534 0.1482
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0635 0.2367
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.011 0.2986 0.8277
Brugia malayi hypothetical protein 0.0026 0.0237 0.0309
Brugia malayi jmjC domain containing protein 0.0043 0.0776 0.1012
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.7669 1
Plasmodium vivax plasmepsin IV, putative 0.011 0.2986 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0058 0.0076
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0635 0.2367
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.011 0.2986 0.2986
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.3607 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0058 0.0076
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0534 0.1482
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0058 0.0076
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0635 0.2367
Plasmodium vivax plasmepsin V, putative 0.0026 0.0237 0.0793
Toxoplasma gondii aspartyl protease ASP3 0.0026 0.0237 0.0656
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.2681 0.2681
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0026 0.0237 0.0237
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.347 0.4525
Brugia malayi Eukaryotic aspartyl protease family protein 0.0026 0.0237 0.0309
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1758 0.2292
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0851 0.1666
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0748 0.0975
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.3607 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0058 0.0076
Schistosoma mansoni chromobox protein 0.0074 0.1816 0.1816
Plasmodium falciparum plasmepsin IV 0.011 0.2986 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0026 0.0237 0.0309
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0058 0.0076
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.2681 0.7432
Schistosoma mansoni coup transcription factor 0.0021 0.0058 0.0058
Echinococcus multilocularis chromobox protein 1 0.0074 0.1816 0.5035
Brugia malayi jmjC domain containing protein 0.0115 0.3148 0.4105
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0058 0.0161
Brugia malayi chromobox protein homolog 3 0.0042 0.0748 0.0975
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.2681 0.7432
Schistosoma mansoni memapsin-2 (A01 family) 0.0026 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0076
Plasmodium falciparum plasmepsin VI 0.011 0.2986 1
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.3607 0.3607
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0058 0.0161
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0851 0.111
Brugia malayi steroid hormone receptor 0.0021 0.0058 0.0076
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0058 0.0058
Plasmodium falciparum plasmepsin X 0.0026 0.0237 0.0793
Plasmodium falciparum plasmepsin I 0.011 0.2986 1
Plasmodium vivax aspartyl protease, putative 0.0026 0.0237 0.0793
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.4821 0.6286
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0076
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0635 0.2367
Plasmodium falciparum plasmepsin V 0.0026 0.0237 0.0793
Brugia malayi ecdysteroid receptor 0.0021 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.0309
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0635 0.2367
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.7669 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.4821 0.6286
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0534 0.1482
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0748 0.0975
Brugia malayi PHD-finger family protein 0.0035 0.0534 0.0697
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.011 0.2986 0.3893
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0776 0.1012
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.4821 0.6286
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0058 0.0161
Onchocerca volvulus Alhambra homolog 0.0035 0.0534 0.1
Brugia malayi hypothetical protein 0.0026 0.0237 0.0309
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0635 0.0828
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.4821 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0748 0.0975
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.2681 1
Loa Loa (eye worm) aspartyl protease 6 0.0026 0.0237 0.0309
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0058 0.0161
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0026 0.0237 0.0656
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.4821 0.6286
Schistosoma mansoni jumonji domain containing protein 0.0092 0.2375 0.2375
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0058 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.2681 0.3496
Brugia malayi Bromodomain containing protein 0.0035 0.0534 0.0697
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0776 0.0776
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0058 0.0058
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0635 0.1759
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.0309
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0026 0.0237 0.0237
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0058 0.0058
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0058 0.0058
Onchocerca volvulus 0.0033 0.0454 0.0831
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0851 0.111
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.3607 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0635 0.1759
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.3148 0.8728
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.1816 0.2368
Loa Loa (eye worm) hypothetical protein 0.0033 0.0454 0.0592
Loa Loa (eye worm) hypothetical protein 0.006 0.1355 0.1767
Trichomonas vaginalis chromobox protein, putative 0.0074 0.1816 0.2368
Toxoplasma gondii aspartyl protease ASP1 0.011 0.2986 0.8277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0058 0.0076
Plasmodium falciparum plasmepsin VIII, putative 0.0026 0.0237 0.0793
Trichomonas vaginalis CAMK family protein kinase 0.005 0.1017 0.1326
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0058 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.003 0.035 0.0457
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.2681 0.3496
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0776 0.0776
Brugia malayi nuclear receptor NHR-88 0.0021 0.0058 0.0076
Brugia malayi aspartic protease BmAsp-2, identical 0.0026 0.0237 0.0309
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0635 0.1759
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.3607 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.2681 0.3496
Echinococcus granulosus peregrin 0.0035 0.0534 0.1482
Brugia malayi aspartic protease BmAsp-1, identical 0.0026 0.0237 0.0309
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0026 0.0237 0.0237
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.3607 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.4821 0.6286
Schistosoma mansoni kinase 0.0051 0.106 0.106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0058 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0076
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0058 0.0076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.3607 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.2681 0.3496
Echinococcus multilocularis chromobox protein 1 0.0074 0.1816 0.5035
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.7669 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0058 0.0076
Onchocerca volvulus 0.0026 0.0237 0.0375
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.7669 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0058 0.0161
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0058 0.0161
Trichomonas vaginalis CAMK family protein kinase 0.005 0.1017 0.1326
Brugia malayi Heterochromatin protein 1 0.0074 0.1816 0.2368
Plasmodium vivax aspartyl protease, putative 0.0026 0.0237 0.0793
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0058 0.0161
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.2681 0.3496
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.3607 0.3607
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.5113 0.6667
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.7669 1
Schistosoma mansoni chromobox protein 0.0074 0.1816 0.1816
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.2681 0.3496
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.011 0.2986 0.8277
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0058 0.0161
Brugia malayi Pepsin A precursor 0.0026 0.0237 0.0309
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0776 0.2152
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0058 0.0076
Schistosoma mansoni hypothetical protein 0.0035 0.0534 0.0534
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0058 0.0076
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.011 0.2986 0.3893
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0635 0.1759
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.2681 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0058 0.0161
Loa Loa (eye worm) aspartic protease BmAsp-2 0.011 0.2986 0.3893
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0058 0.0076
Plasmodium vivax aspartyl protease, putative 0.0026 0.0237 0.0793
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.4821 0.6286
Plasmodium falciparum plasmepsin VII 0.0026 0.0237 0.0793
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.7669 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0058 0.0161
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0058 0.0058
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.3607 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0534 0.0534
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0635 0.1759
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0635 0.0635
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0058 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0058 0.0076
Plasmodium falciparum plasmepsin IX 0.0026 0.0237 0.0793
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0058 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.003 0.035 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0058 0.0076
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0635 0.1759
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.2681 0.3496

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10 uM Inhibition of JMJD2A by MALDI-TOF assay ChEMBL. 20088513

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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