TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 290.268 | Formula: C15H14O6
H donors: 1 H acceptors: 2 LogP: 1.94 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC/C(=C/COc1c2OCOc2cc2c1ccc(=O)o2)/C
InChi: 1S/C15H14O6/c1-9(7-16)4-5-18-14-10-2-3-13(17)21-11(10)6-12-15(14)20-8-19-12/h2-4,6,16H,5,7-8H2,1H3/b9-4+
InChiKey: TXSDPJCNNHYCOH-RUDMXATFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cysteine protease	0.0026	0.0499	0.1404
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0499	0.5
Trichomonas vaginalis	esterase, putative	0.0039	0.1056	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0499	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0379
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0133	0.5092	1
Brugia malayi	beta-lactamase	0.0039	0.1056	0.2694
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.1056	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.003	0.0656	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.3555	0.6942
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.1056	0.2374
Schistosoma mansoni	terminal deoxycytidyl transferase	0.003	0.0656	0.1174
Trypanosoma cruzi	DNA polymerase kappa, putative	0.003	0.0656	0.0505
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0499	0.1066
Echinococcus granulosus	cathepsin l1	0.0017	0.0135	0.0138
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0499	0.3956
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0499	0.6998
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0029	0.0624	0.1112
Echinococcus granulosus	cathepsin l1	0.0026	0.0499	0.0863
Schistosoma mansoni	hypothetical protein	0.0017	0.0101	0.0072
Onchocerca volvulus		0.0026	0.0499	0.3956
Onchocerca volvulus		0.0026	0.0499	0.3956
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0788	0.2217
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0135	0.0138
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.003	0.0656	0.1844
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.1561	0.2975
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0499	0.1066
Mycobacterium tuberculosis	Conserved protein	0.0039	0.1056	0.0429
Onchocerca volvulus		0.0039	0.1056	1
Trypanosoma brucei	DNA polymerase eta, putative	0.003	0.0656	0.1172
Brugia malayi	Bromodomain containing protein	0.0031	0.0705	0.1667
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0499	0.0863
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.1056	0.0429
Trypanosoma brucei	DNA polymerase IV, putative	0.003	0.0656	0.1172
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.3555	0.6942
Echinococcus granulosus	fetal alzheimer antigen falz	0.0018	0.0167	0.0202
Giardia lamblia	DINP protein human, muc B family	0.003	0.0656	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.1056	0.0429
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0133	0.5092	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0077	0.2699	0.7098
Brugia malayi	PHD-finger family protein	0.002	0.0248	0.033
Trypanosoma brucei	unspecified product	0.003	0.0656	0.1172
Onchocerca volvulus		0.0026	0.0499	0.3956
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0499	0.3956
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.3555	0.6942
Loa Loa (eye worm)	hypothetical protein	0.003	0.0656	0.1844
Onchocerca volvulus		0.0026	0.0499	0.3956
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.3555	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1056	0.2971
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.1561	0.2975
Brugia malayi	ImpB/MucB/SamB family protein	0.003	0.0656	0.1523
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0499	0.3956
Loa Loa (eye worm)	fibroinase	0.0026	0.0499	0.1404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0499	0.3956
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.1056	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.3598	1
Mycobacterium ulcerans	hypothetical protein	0.0039	0.1056	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1056	0.2971
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0048	0.1436	0.2727
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.1056	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.1056	0.2971
Mycobacterium tuberculosis	Conserved protein	0.0039	0.1056	0.0429
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.1056	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.1056	0.1971
Echinococcus multilocularis	tar DNA binding protein	0.0051	0.1561	0.2975
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0018	0.0167	0.0202
Brugia malayi	Bromodomain containing protein	0.006	0.1959	0.5333
Leishmania major	hypothetical protein, conserved	0.0039	0.1056	0.1213
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.1056	0.1797
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.1056	0.0429
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Mycobacterium ulcerans	beta-lactamase	0.0039	0.1056	0.0903
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.003	0.0656	0.1174
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0499	0.0863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Echinococcus granulosus	dna polymerase eta	0.003	0.0656	0.1174
Brugia malayi	beta-lactamase family protein	0.0039	0.1056	0.2694
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.1056	0.0429
Trypanosoma cruzi	DNA polymerase kappa, putative	0.003	0.0656	0.0505
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.3555	0.6942
Toxoplasma gondii	aldehyde dehydrogenase	0.0133	0.5092	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0379
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0499	0.0863
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0499	0.1066
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.003	0.0656	0.1174
Brugia malayi	RNA recognition motif domain containing protein	0.0051	0.1561	0.4169
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1056	0.2971
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0499	0.1066
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.003	0.0656	0.1174
Leishmania major	DNA polymerase kappa, putative	0.003	0.0656	0.0341
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0499	0.3956
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0499	0.0863
Trypanosoma cruzi	DNA polymerase kappa, putative	0.003	0.0656	0.0505
Onchocerca volvulus		0.0039	0.1056	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.1056	0.1971
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0499	0.3956
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.1056	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.1056	0.0903
Brugia malayi	TAR-binding protein	0.0051	0.1561	0.4169
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0499	0.1066
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0499	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.3598	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0499	0.1066
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0499	0.3956
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0048	0.1436	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0853	0.2401
Schistosoma mansoni	aldehyde dehydrogenase	0.0133	0.5092	1
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0499	0.3956
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1056	0.2971
Onchocerca volvulus		0.0039	0.1056	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Onchocerca volvulus		0.0026	0.0499	0.3956
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.3555	0.6942
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0499	0.6998
Trichomonas vaginalis	DNA polymerase eta, putative	0.003	0.0656	0.5653
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.1056	0.1971
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0018	0.0167	0.0202
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0499	0.6998
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0133	0.5092	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.3555	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0098	0.3598	1
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.1561	0.2975
Loa Loa (eye worm)	TAR-binding protein	0.0051	0.1561	0.439
Echinococcus multilocularis	cysteine protease	0.0026	0.0499	0.0863
Mycobacterium leprae	Probable lipase LipE	0.0039	0.1056	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Brugia malayi	beta-lactamase family protein	0.0039	0.1056	0.2694
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0499	0.3956
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Echinococcus multilocularis	cysteine protease	0.0026	0.0499	0.0863
Brugia malayi	RNA binding protein	0.0051	0.1561	0.4169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0499	0.3956
Trypanosoma brucei	DNA polymerase IV, putative	0.003	0.0656	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0135	0.0379
Echinococcus multilocularis	dna polymerase kappa	0.003	0.0656	0.1174
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0499	0.3956
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0029	0.0624	0.1112
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.1056	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0133	0.5092	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.3555	0.6942
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.1056	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.1056	0.0429
Trypanosoma cruzi	DNA polymerase eta, putative	0.003	0.0656	0.0505
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.1561	0.2975
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.3555	0.6942
Onchocerca volvulus		0.0026	0.0499	0.3956
Leishmania major	cathepsin L-like protease	0.0098	0.3598	0.6747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0499	0.0863
Echinococcus granulosus	dna polymerase kappa	0.003	0.0656	0.1174
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Echinococcus granulosus	tar DNA binding protein	0.0051	0.1561	0.2975
Leishmania major	DNA polymerase eta, putative	0.003	0.0656	0.0341
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.1056	0.0429
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.1056	0.1971
Loa Loa (eye worm)	ctsf protein	0.0026	0.0499	0.1404
Schistosoma mansoni	aldehyde dehydrogenase	0.0133	0.5092	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0499	0.0863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0499	0.5
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.003	0.0656	0.0341
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Loa Loa (eye worm)	RNA binding protein	0.0051	0.1561	0.439
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0133	0.5092	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.1056	0.0429
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.009	0.3233	0.8824
Onchocerca volvulus	Cathepsin F homolog	0.0026	0.0499	0.3956
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Brugia malayi	ImpB/MucB/SamB family protein	0.003	0.0656	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1056	0.2971
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0133	0.5092	0.4747
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0499	0.1404
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.1056	0.0903
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0499	0.1404
Leishmania major	cathepsin L-like protease	0.0098	0.3598	0.6747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0499	0.3956
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0499	0.0863
Loa Loa (eye worm)	PHD-finger family protein	0.0017	0.0101	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0499	0.1404
Trypanosoma cruzi	DNA polymerase kappa, putative	0.003	0.0656	0.0505
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.1056	0.1797
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Mycobacterium tuberculosis	Conserved protein	0.0039	0.1056	0.0429
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0707	0.199
Loa Loa (eye worm)	beta-lactamase	0.0039	0.1056	0.2971
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0499	0.0863
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.1056	0.2694
Leishmania major	cathepsin L-like protease	0.0098	0.3598	0.6747
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0051	0.1561	0.439
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1813	0.5099
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1056	0.2971
Schistosoma mansoni	bromodomain containing protein	0.0051	0.1558	0.2971
Toxoplasma gondii	ABC1 family protein	0.0039	0.1056	0.1213
Onchocerca volvulus		0.0026	0.0499	0.3956
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0656	0.1172
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.003	0.0656	0.5653
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Onchocerca volvulus	Cathepsin L homolog	0.0026	0.0499	0.3956
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0133	0.5092	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0499	0.3956
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Trypanosoma brucei	DNA polymerase IV, putative	0.003	0.0656	0.1172
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.3598	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.3598	1
Mycobacterium ulcerans	lipase LipD	0.0039	0.1056	0.0903
Echinococcus multilocularis	dna polymerase eta	0.003	0.0656	0.1174
Schistosoma mansoni	tar DNA-binding protein	0.0051	0.1561	0.2975
Schistosoma mansoni	DNA polymerase eta	0.003	0.0656	0.1174

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 48.08 uM	Inhibition of Thermus aquaticus taq DNA polymerase by PCR analysis	ChEMBL.	24418776

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3116093

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1831602