Detailed view for Rv3152

Basic information

TDR Targets ID: 6611
Mycobacterium tuberculosis, Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)
Source Database / ID:  Tuberculist 

pI: 9.807 | Length (AA): 410 | MW (Da): 44658 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 9

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00146   NADH dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 367 4he8 (H) 4 353 41.00 0 1 1.01354 1
3 363 4hea (H) 4 352 45.00 0 1 1.31579 0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_128714)

Species Accession Gene Product
Arabidopsis thaliana ArthMp044   NADH dehydrogenase subunit 1
Arabidopsis thaliana ArthCp079   NADH dehydrogenase subunit 1
Arabidopsis thaliana AT2G07785   NADH dehydrogenase I subunit 1
Candida albicans CaalfMp03   NADH dehydrogenase subunit 1
Dictyostelium discoideum DidioMp14   NADH dehydrogenase subunit 1
Escherichia coli b2282   NADH:ubiquinone oxidoreductase, membrane subunit H
Echinococcus granulosus EgrG_900000600   NADH dehydrogenase subunit 1
Homo sapiens 4535   NADH dehydrogenase, subunit 1 (complex I)
Mus musculus 17716   NADH dehydrogenase subunit 1
Mycobacterium tuberculosis Rv3152   Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)
Mycobacterium ulcerans MUL_2466   NADH dehydrogenase subunit H
Oryza sativa 3131395   NADH dehydrogenase subunit 1
Oryza sativa 6450162   NADH dehydrogenase subunit 1
Schistosoma japonicum Sjp_0124320   IPR000883,Cytochrome c oxidase, subunit I;IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1,domain-containing
Schistosoma japonicum Sjp_0126390   IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma japonicum Sjp_0128660   IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000298,Cytochrome c oxidase, subunit III;IPR000568,ATPase, F0 compl
Schistosoma japonicum Sjp_0120620   expressed protein
Schistosoma japonicum Sjp_0122570   IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma japonicum Sjp_0126330   IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1,domain-containing
Schistosoma japonicum Sjp_0128700   IPR001694,Respiratory-chain NADH dehydrogenase, subunit 1;IPR000568,ATPase, F0 complex, subunit A,domain-containing
Schistosoma mansoni Smp_182970   hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0375   NADH dehydrogenase subunit H

Essentiality

Rv3152 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu3204 this record Mycobacterium tuberculosis non-essential nmpdr
b2282 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Bos taurus NADH-ubiquinone oxidoreductase chain 1 Compounds References
Homo sapiens NADH dehydrogenase, subunit 1 (complex I) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0149 0.2922 0.3074
0.0151 0.2696 1
0.0454 0.3832 0.4095
0.0298 0.3062 0.4254
0.0294 0.3585 0.6263
0.093 0.2762 0.2762
0.0291 1 1
0.0172 0.4831 1
0.061 1 1
0.0149 0.2753 0.604
0.0441 0.3401 0.9525
0.1381 1 1
0.0299 0.3259 1
0.1242 0.7879 1
0.0146 0.4379 1
0.0551 0.5552 1
0.0155 0.3985 1
0.0782 0.3276 1
0.1082 1 1
0.0463 0.5481 1
0.0434 0.6654 1
0.015 0.7791 1
0.1322 0.2552 1
0.0933 0.2858 1
0.0179 1 0.5
0.0143 0.4125 0.5
0.0771 0.4819 1
0.059 0.6854 1
0.0447 0.5592 1
0.138 1 1
0.0299 0.2973 0.6026
0.0326 0.3201 1
0.0463 0.5481 1
0.0641 0.3029 0.8778
0.0621 0.581 1
0.0166 0.4018 1
0.0309 0.3032 1
0.0343 1 1
0.1114 0.4759 1
0.0474 0.9445 1
0.0326 0.3201 1
0.0681 0.3313 0.2952
0.0596 0.2513 1
0.0145 0.2933 0.5668
0.0448 1 1
0.093 0.2762 0.2762
0.0447 0.5592 1
0.0174 0.7916 1
0.0296 0.4339 1
0.0549 0.4627 0.4574
0.0148 0.3208 0.9448
0.0295 0.2932 0.5922
0.0179 0.5 0.5
0.0145 0.3606 1
0.0592 0.3089 1
0.0297 0.4414 0.4336
0.0293 0.4248 1
0.0163 0.585 1
0.0145 0.7939 1
0.0151 0.304 1
0.0159 0.391 0.6031
0.0945 0.6662 0.9598
0.0149 0.3543 1
0.0179 0.7066 1
0.0963 0.4447 0.9772
0.0309 0.389 0.5566
0.0465 0.8278 0.9884
0.0151 0.2811 1
0.0154 0.3811 1
0.0171 1 1
0.0306 0.3784 0.5559
0.0435 0.251 1
0.0179 0.2859 0.2565
0.0322 0.8255 1
0.1351 1 1
0.0795 0.6184 1
0.0463 0.5681 0.9764
0.0926 0.2654 0.2651
0.0158 0.3722 1
0.0291 0.406 1
0.0638 0.4475 0.917
0.0964 0.6607 0.984
0.0591 0.2543 1
0.0303 1 1
0.0448 0.9259 1
0.1069 0.3235 1
0.0146 0.2958 1
0.1403 1 1
0.0347 0.6295 0.5
0.0785 0.5693 1
0.0771 0.4819 1
0.0928 0.5817 1
0.0298 0.7251 1
0.0435 0.5344 0.9639
0.0784 0.4643 0.6601
0.0152 0.3191 1
0.0289 1 1
0.0452 0.2779 0.4828
0.0328 0.6726 1
0.0179 1 1
0.0461 0.4969 0.494
0.0304 0.7088 1
0.0147 0.2548 1
0.0145 1 1
0.0785 0.4716 0.798
0.0159 0.391 0.6031
0.0303 0.7741 0.7734
0.0304 0.6062 1
0.0291 0.3343 0.6352
0.0151 0.2811 0.5302
0.0145 0.2811 0.2978
0.0605 0.5128 0.5503
0.0179 1 1
0.0795 0.5487 0.6443
0.0159 0.391 0.6031
0.0296 0.6153 1
0.0155 0.2977 0.5515
0.1322 0.2552 1
0.0459 0.2828 0.4911
0.0751 1 1
0.0152 0.2983 1
0.029 0.2961 0.5749
0.0455 0.3927 0.6552
0.0144 1 1
0.0458 0.8928 1
0.0145 0.3539 0.3539
0.0458 0.8928 1
0.0498 1 1
0.0151 0.313 1
0.1395 0.2718 0.881
0.0448 0.5251 1
0.0605 0.6345 0.6333
0.0145 0.4265 1
0.03 1 1
0.0152 0.2983 1
0.0591 0.2543 1
0.0752 0.449 1
0.0628 0.4529 1
0.0151 0.7355 1
0.0315 0.3699 1
0.0145 0.2642 0.2558
0.0757 0.7534 1
0.0154 0.3202 1
0.0768 1 1
0.0448 0.9267 1
0.0179 0.2859 0.2565
0.0343 1 1
0.0449 0.5405 1
0.0549 0.4627 0.4574
0.0159 0.391 0.6031
0.0305 0.3727 1
0.0447 1 1
0.0144 0.4261 1
0.1069 0.3235 1
0.1433 1 1
0.0435 0.5344 0.9639
0.0775 0.2709 0.3421
0.0461 0.9621 1
0.1072 1 1
0.0443 0.5246 1
0.0759 0.3262 1
0.1585 0.9679 1
0.015 0.2567 0.2515
0.0163 0.585 1
0.0303 0.3657 1
0.0145 0.4265 1
0.0509 0.5552 1
0.0575 0.4172 1
0.0333 0.2654 0.5
0.0287 0.5549 1
0.0152 0.2983 1
0.0149 0.3702 0.5936
0.0785 0.5693 1
0.0595 0.4252 1
0.0455 0.9619 1
0.0154 0.3249 1
0.0146 0.2619 1
0.0147 0.3309 0.5325
0.0146 1 1
0.0292 0.8212 1
0.093 0.2762 0.2762
0.093 0.2762 0.2762
0.1086 1 1
0.0792 0.3632 1
0.0624 0.4565 0.5243
0.0295 0.2968 0.6022
0.0785 0.5693 1
0.0452 0.2779 0.4828
0.0152 0.6076 0.5603
0.0146 0.5838 0.562
0.0468 0.5828 0.9903
0.0447 0.7893 1
0.0305 0.3231 1
0.0145 0.4596 1
0.0422 0.3625 1
0.0287 0.5549 1
0.0318 0.3215 0.3456
0.0564 0.3096 0.7864
0.0148 0.3212 1
0.0146 0.5838 0.562
0.0292 0.3524 0.5633
0.0453 0.369 0.6417
0.0412 0.3283 0.872
0.1137 0.6353 1
0.015 0.5972 1
0.0465 0.8283 0.9884
0.0308 0.2695 1
0.0151 0.2876 1
0.0119 0.4161 1
0.0159 0.391 0.6031
0.0147 0.2548 1
0.0145 0.5453 1
0.0317 0.3897 0.975
0.0649 0.7788 1
0.0297 0.4055 1
0.0454 0.8147 0.972
0.0179 0.5 0.5
0.0146 0.3544 0.6064
0.0147 0.3513 1
0.0816 0.5918 0.8575
0.1089 0.8875 0.9548
0.0145 0.2642 0.2558
0.0308 0.2695 1
0.0614 0.4958 0.515
0.0144 1 1
0.0179 1 1
0.0179 1 1
0.0471 0.4727 0.6588
0.0179 0.2525 1
0.0146 1 1
0.03 0.3618 1
0.0159 0.391 0.6031
0.0788 1 1
0.0308 0.3893 1
0.1381 1 1
0.1131 1 1
0.0575 0.4172 1
0.0145 0.2788 0.2788
0.0798 0.3682 0.8486
0.0871 0.2774 0.2774
0.0297 0.3745 1
0.0339 1 1
0.0623 0.3612 1
0.0144 0.3342 1
0.0163 0.3828 1
0.0752 0.449 1
0.0148 0.3529 0.9851
0.0291 0.2992 0.6693
0.0147 0.5801 0.5801
0.0305 0.3717 1
0.0498 0.5925 1
0.0412 0.2668 1
0.0293 0.6162 0.872
0.0775 0.2709 0.3421
0.0308 0.2695 1
0.0443 0.5295 1
0.0456 0.3297 1
0.0823 0.364 1
0.1254 0.2552 1
0.0147 0.3398 1
0.0171 1 1
0.031 0.3853 0.6679
0.0295 0.9423 1
0.0648 0.4612 0.6764
0.0636 0.4528 0.8833
0.0444 0.5154 1
0.0594 1 1
0.0144 0.3832 1
0.0312 0.6161 0.9777
0.0149 0.2876 1
0.1322 0.2552 1
0.1114 0.4759 1
0.0946 0.9573 1
0.0607 0.7016 1
0.0564 0.3094 1
0.1069 0.3235 1
0.1585 0.9679 1
0.0962 0.5908 0.7845
0.0624 0.4547 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3152 (Mycobacterium tuberculosis), Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)
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