Detailed information for compound 700323

Basic information

Technical information
  • TDR Targets ID: 700323
  • Name: 4-ethyl-N-[3-(6-morpholin-4-ylpyridazin-3-yl) phenyl]benzenesulfonamide
  • MW: 424.516 | Formula: C22H24N4O3S
  • H donors: 1 H acceptors: 4 LogP: 2.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)c1ccc(nn1)N1CCOCC1
  • InChi: 1S/C22H24N4O3S/c1-2-17-6-8-20(9-7-17)30(27,28)25-19-5-3-4-18(16-19)21-10-11-22(24-23-21)26-12-14-29-15-13-26/h3-11,16,25H,2,12-15H2,1H3
  • InChiKey: CGQLYMAPGNAOGV-UHFFFAOYSA-N  


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Synonyms

  • 4-ethyl-N-[3-(6-morpholinopyridazin-3-yl)phenyl]benzenesulfonamide
  • 4-ethyl-N-[3-(6-morpholino-3-pyridazinyl)phenyl]benzenesulfonamide
  • G620-0235
  • NCGC00132342-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0107 0.0088
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0343 0.0514
Brugia malayi ecdysteroid receptor 0.0018 0.0107 0.0183
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0077 0.0129
Onchocerca volvulus 0.0472 0.6663 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0082 0.0082
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0077
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0239 0.0451
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.011 0.0271
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0239 0.0316
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0239 0.0316
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.011 0.0271
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.011 0.011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0602 0.103
Echinococcus multilocularis pyruvate kinase 0.0027 0.0239 0.0239
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.011 0.0271
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.0088
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0082 0.0139
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0107 0.0107
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0266 0.0654
Brugia malayi nuclear hormone receptor 0.0018 0.0107 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.071 0.071
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0077
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0089 0.0089
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1367 0.3368
Echinococcus granulosus tar DNA binding protein 0.0127 0.1691 0.1691
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0107 0.0107
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0107 0.0107
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0107 0.0107
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0107 0.0183
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0266 0.0837
Onchocerca volvulus 0.0078 0.0985 0.1339
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0194 0.0239
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1367 0.3368
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0082 0.0396
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0516 0.1002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0107 0.0107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0107 0.0107
Echinococcus granulosus NADH dehydrogenase subunit 1 0.0291 0.406 0.406
Leishmania major ATP-dependent phosphofructokinase 0.023 0.3171 0.6281
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.011 0.0271
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0749 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0082 0.0203
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0082 0.0139
Brugia malayi glutaminase DH11.1 0.0266 0.3692 0.6326
Echinococcus multilocularis pyruvate kinase 0.0034 0.0343 0.0343
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0104 0.0401
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0077 0.0319
Loa Loa (eye worm) hypothetical protein 0.0029 0.0266 0.0362
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0266 0.0837
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0343 0.0844
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0161 0.1181
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.011 0.0271
Trichomonas vaginalis set domain proteins, putative 0.0472 0.6663 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0082 0.0203
Schistosoma mansoni hypothetical protein 0.0016 0.0089 0.0089
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.1691 0.2897
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0077
Trichomonas vaginalis phosphofructokinase, putative 0.023 0.3171 0.476
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0266 0.0654
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0343 0.0514
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0107 0.0107
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0343 0.4148
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.011 0.0271
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.023 0.3171 0.7811
Brugia malayi NADH dehydrogenase subunit 1 0.0078 0.0985 0.1687
Giardia lamblia Pyruvate kinase 0.0034 0.0343 0.3907
Onchocerca volvulus 0.0059 0.071 0.092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.0088
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1691 0.1691
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0107 0.0183
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0239 0.0451
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0181
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0062 0.0749 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0266 0.0362
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0089 0.0089
Treponema pallidum NADH oxidase 0.0016 0.0082 0.026
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0107 0.0107
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1536 0.3784
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0343 0.0359
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1691 0.1691
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0021 0.0035
Echinococcus multilocularis 0.0018 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0602 0.0944
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0343 0.0844
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0343 0.0657
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0749 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1691 0.1691
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.0291 0.406 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0525 0.0525
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0107 0.0183
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0266 0.0454
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0024 0.0194 0.0239
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0715 0.0715
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.011 0.0271
Brugia malayi phosphofructokinase 0.023 0.3171 0.5433
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0749 1
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0082 0.0124
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0082 0.0203
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.011 0.0271
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0749 0.1124
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1691 0.1691
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1367 0.3368
Chlamydia trachomatis pyruvate kinase 0.0034 0.0343 0.3907
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0107 0.0183
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0062 0.0749 1
Schistosoma mansoni hypothetical protein 0.0035 0.0365 0.0365
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.011 0.0271
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.011 0.0271
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0749 0.1124
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.1691 0.2828
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0077 0.0077
Toxoplasma gondii thioredoxin reductase 0.0046 0.0516 0.6662
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.011 0.0271
Onchocerca volvulus 0.0078 0.0985 0.1339
Trichomonas vaginalis glutaminase, putative 0.0266 0.3692 0.5541
Plasmodium falciparum thioredoxin reductase 0.0046 0.0516 0.654
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.011 0.0194
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0107 0.0107
Entamoeba histolytica phosphofructokinase, putative 0.023 0.3171 1
Brugia malayi RNA binding protein 0.0127 0.1691 0.2897
Giardia lamblia Pyruvate kinase 0.0017 0.0104 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0107 0.0183
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.011 0.0271
Echinococcus granulosus pyruvate kinase 0.0017 0.0104 0.0104
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0107 0.0107
Onchocerca volvulus 0.006 0.0715 0.0926
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0107 0.0107
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0082 0.0139
Mycobacterium ulcerans formate hydrogenlyase HycD 0.0078 0.0985 0.2426
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0104 0.074
Echinococcus granulosus 6 phosphofructokinase 0.023 0.3171 0.3171
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0602 0.0944
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0266 0.0654
Trichomonas vaginalis phosphofructokinase, putative 0.023 0.3171 0.476
Leishmania major pyruvate kinase 0.0034 0.0343 0.0657
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0077 0.0129
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0088 0.0149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0181
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0343 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0107 0.0183
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0107 0.0107
Mycobacterium ulcerans glutaminase 0.0266 0.3692 0.9093
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.5836 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.071 0.071
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0359 0.5042 0.8639
Plasmodium vivax 6-phosphofructokinase, putative 0.0062 0.0749 1
Entamoeba histolytica phosphofructokinase, putative 0.023 0.3171 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.011 0.0271
Schistosoma mansoni pyruvate kinase 0.0034 0.0343 0.0343
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0012 0.0018
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.011 0.0271
Schistosoma mansoni lamin 0.003 0.0292 0.0292
Schistosoma mansoni glutaminase 0.0266 0.3692 0.3692
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.011 0.0271
Brugia malayi hypothetical protein 0.0078 0.0985 0.1687
Echinococcus granulosus lamin dm0 0.003 0.0292 0.0292
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0077 0.0129
Loa Loa (eye worm) hypothetical protein 0.0184 0.2505 0.4236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0107 0.0183
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.011 0.0194
Echinococcus granulosus pyruvate kinase 0.0034 0.0343 0.0343
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.011 0.0271
Brugia malayi intermediate filament protein 0.003 0.0292 0.0499
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0525 0.0811
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0359 0.5042 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0292 0.0408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0107 0.0088
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0292 0.0499
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0082 0.0429
Onchocerca volvulus 0.003 0.0292 0.0282
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1536 0.3784
Leishmania major pyruvate kinase 0.0034 0.0343 0.0657
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0082 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0107 0.0183
Schistosoma mansoni hypothetical protein 0.0018 0.011 0.011
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0107 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.011 0.0271
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0082 0.0139
Loa Loa (eye worm) intermediate filament protein 0.003 0.0292 0.0408
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.0078 0.0985 0.1607
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0343 0.0496
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0525 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0107 0.0183
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0082 0.0139
Loa Loa (eye worm) hypothetical protein 0.0359 0.5042 0.8626
Loa Loa (eye worm) hypothetical protein 0.0309 0.4308 0.7357
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0266 0.0654
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0107 0.0107
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0082 0.0139
Plasmodium vivax glutathione reductase, putative 0.0046 0.0516 0.665
Schistosoma mansoni 6-phosphofructokinase 0.023 0.3171 0.3171
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0343 0.4168
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0152 0.0228
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.0088
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0216 0.2968 0.5038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0525 0.0525
Schistosoma mansoni 6-phosphofructokinase 0.023 0.3171 0.3171
Echinococcus multilocularis pyruvate kinase 0.0034 0.0343 0.0343
Brugia malayi Cytochrome P450 family protein 0.0018 0.011 0.0188
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0082 0.0139
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.011 0.0271
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0391 0.0578
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0082 0.0396
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0343 0.0586
Echinococcus granulosus vesicular acetylcholine transporter 0.0216 0.2968 0.2968
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0104 0.0708
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0089 0.0057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0602 0.103
Echinococcus granulosus GPCR family 2 0.0016 0.0089 0.0089
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0679 0.0679
Schistosoma mansoni lamin 0.003 0.0292 0.0292
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.011 0.0271
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0516 0.665
Brugia malayi 6-phosphofructokinase 0.023 0.3171 0.5433
Loa Loa (eye worm) hypothetical protein 0.0016 0.0089 0.0057
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.071 0.071
Echinococcus multilocularis lamin 0.003 0.0292 0.0292
Mycobacterium tuberculosis Probable reductase 0.0105 0.1367 0.3368
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.011 0.0827
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0082 0.014
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0064 0.0064
Loa Loa (eye worm) 6-phosphofructokinase 0.023 0.3171 0.5389
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0062 0.0749 0.2332
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0144 0.0355
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.011 0.0271
Plasmodium falciparum thioredoxin reductase 0.0016 0.0082 0.0079
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.011 0.0271
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0107 0.0107
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.011 0.0271
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0107 0.0107
Brugia malayi Thioredoxin reductase 0.0046 0.0516 0.0884
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.011 0.0271
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1536 0.4845
Schistosoma mansoni cytochrome P450 0.0018 0.011 0.011
Loa Loa (eye worm) TAR-binding protein 0.0127 0.1691 0.2828
Loa Loa (eye worm) hypothetical protein 0.003 0.0284 0.0394
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0343 0.0586
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0062 0.0749 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0516 0.0796
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0266 0.0654
Brugia malayi glutathione reductase 0.0046 0.0516 0.0884
Brugia malayi TAR-binding protein 0.0127 0.1691 0.2897
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0144 0.0355
Echinococcus granulosus tumor protein p63 0.0408 0.5744 0.5744
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0525 0.0525
Echinococcus multilocularis lamin dm0 0.003 0.0292 0.0292
Leishmania major C-8 sterol isomerase-like protein 0.0359 0.5042 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0266 0.0654
Brugia malayi Pre-SET motif family protein 0.0059 0.071 0.1216
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0107 0.0107
Toxoplasma gondii phosphofructokinase PFKII 0.0062 0.0749 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.023 0.3171 0.6281
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0516 0.0796
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0077 0.019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0107 0.0183
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.011 0.0271
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0194 0.0576
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0181
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0082 0.0203
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0082 0.0139
Brugia malayi Cytochrome P450 family protein 0.0037 0.0391 0.0668
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1367 0.3368
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0749 0.1124
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.0291 0.406 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0082 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0266 0.0454
Trichomonas vaginalis phosphofructokinase, putative 0.023 0.3171 0.476
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.011 0.0271
Trichomonas vaginalis phosphofructokinase, putative 0.023 0.3171 0.476
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0343 0.1081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0107 0.0088
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0216 0.2968 0.4364
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0017 0.0091 0.006
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1691 0.1691
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0343 0.0359
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0077 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0266 0.0454
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0077 0.0353
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0082 0.0139
Schistosoma mansoni microtubule-associated protein tau 0.0703 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0107 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0082 0.0139
Brugia malayi NADH dehydrogenase subunit 1, identical 0.0078 0.0985 0.1687
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.023 0.3171 0.6281
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0749 0.1124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0144 0.0355
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0089 0.0152
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0266 0.0654
Echinococcus granulosus geminin 0.0368 0.5163 0.5163
Leishmania major cytochrome p450-like protein 0.0018 0.011 0.0194
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.071 0.9449
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0343 0.0496
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0082 0.0139
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0343 0.0657
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0266 0.0504
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0749 0.1124
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0525 0.0898
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0107 0.0088
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0062 0.0749 0.1124
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0077 0.0131
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.011 0.0194
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.011 0.0271
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0082 0.0079
Plasmodium vivax SET domain protein, putative 0.0059 0.071 0.9447
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.011 0.0271
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0161 0.0397
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0077 0.0129
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0239 0.0451
Loa Loa (eye worm) hypothetical protein 0.0035 0.0365 0.0534
Toxoplasma gondii 6-phosphofructokinase 0.0062 0.0749 1
Schistosoma mansoni coup transcription factor 0.0018 0.0107 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0525 0.0525
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0016 0.0089 0.0089
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0077 0.0036
Echinococcus granulosus pyruvate kinase 0.0017 0.0104 0.0104
Schistosoma mansoni NADH dehydrogenase subunit 1 0.0078 0.0985 0.0985
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.071 0.071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0089 0.0089
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.011 0.0271
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.0088
Loa Loa (eye worm) hypothetical protein 0.006 0.0715 0.1139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0144 0.0355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0107 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.011 0.0271
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0082 0.0139
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0077 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0107 0.0183
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0516 0.1272
Mycobacterium ulcerans 6-phosphofructokinase 0.023 0.3171 0.7811
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.011 0.0271
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.011 0.0194
Brugia malayi isocitrate dehydrogenase 0.0016 0.0077 0.0131
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0064 0.0064
Plasmodium falciparum glutathione reductase 0.0016 0.0082 0.0079
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1367 0.3368
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.0088
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0343 0.0496
Leishmania major cytochrome p450-like protein 0.0027 0.0239 0.0451
Schistosoma mansoni hypothetical protein 0.0016 0.0089 0.0089
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0082 0.0124
Echinococcus multilocularis tar DNA binding protein 0.0127 0.1691 0.1691
Brugia malayi Cytochrome P450 family protein 0.0027 0.0239 0.0408
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0152 0.0228
Loa Loa (eye worm) hypothetical protein 0.0029 0.0266 0.0362
Trypanosoma brucei trypanothione reductase 0.0046 0.0516 0.1002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0082 0.0139
Entamoeba histolytica phosphofructokinase, putative 0.023 0.3171 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0082 0.0139
Schistosoma mansoni vesicular acetylcholine transporter 0.0216 0.2968 0.2968
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0292 0.0408
Loa Loa (eye worm) glutaminase 0.0266 0.3692 0.629
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.011 0.0271
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0115 0.0573
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0107 0.0107
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0516 0.0516
Brugia malayi steroid hormone receptor 0.0018 0.0107 0.0183
Onchocerca volvulus 0.003 0.0292 0.0282
Loa Loa (eye worm) hypothetical protein 0.0015 0.0064 0.0014
Loa Loa (eye worm) hypothetical protein 0.0059 0.071 0.1132
Schistosoma mansoni hypothetical protein 0.0368 0.5163 0.5163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0107 0.0088
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.011 0.0271
Loa Loa (eye worm) cytochrome P450 0.0018 0.011 0.0093
Echinococcus multilocularis pyruvate kinase 0.0017 0.0104 0.0104
Schistosoma mansoni pyruvate kinase 0.0034 0.0343 0.0343
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0266 0.0802
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0088 0.0054
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0107 0.0107
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0082 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0107 0.0107
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0152 0.0259
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.071 0.071
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0107 0.0107
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0161 0.1251
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0266 0.0654
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0343 0.0657
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0089 0.0152
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0107 0.0183
Echinococcus multilocularis GPCR, family 2 0.0016 0.0089 0.0089
Echinococcus multilocularis pyruvate kinase 0.0017 0.0104 0.0104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0107 0.0107
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0107 0.0107
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1536 0.3784
Echinococcus multilocularis microtubule associated protein 2 0.0703 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0266 0.0504
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.071 0.071
Echinococcus granulosus pyruvate kinase 0.0034 0.0343 0.0343
Mycobacterium tuberculosis Possible formate hydrogenlyase HycD (FHL) 0.0078 0.0985 0.2426
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0152 0.0152
Mycobacterium ulcerans hypothetical protein 0.0029 0.0266 0.0654
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0181
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0161 0.0397
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0082 0.0139
Trypanosoma brucei C-8 sterol isomerase, putative 0.0359 0.5042 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0082 0.0079
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.071 0.071
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0107 0.0183
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0107 0.0107
Leishmania major trypanothione reductase 0.0046 0.0516 0.1002
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.011 0.0347
Loa Loa (eye worm) hypothetical protein 0.0034 0.0343 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0525 0.0525
Brugia malayi hypothetical protein 0.0118 0.1562 0.2676
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1367 0.4311
Plasmodium falciparum pyruvate kinase 0.0034 0.0343 0.3955
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0107 0.0107
Echinococcus granulosus bloom syndrome protein 0.0021 0.0152 0.0152
Echinococcus granulosus intermediate filament protein 0.003 0.0292 0.0292
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0343 0.0657
Onchocerca volvulus 0.0029 0.0266 0.0241
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.011 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0107 0.0183
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0107 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0082 0.0139
Echinococcus granulosus lamin 0.003 0.0292 0.0292
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0266 0.0654
Schistosoma mansoni hypothetical protein 0.0016 0.0089 0.0089
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0266 0.0802
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0239 0.0316
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.023 0.3171 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.011 0.0271
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0266 0.0504
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.011 0.0271
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.0291 0.406 1
Plasmodium falciparum glutathione reductase 0.0046 0.0516 0.654
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.011 0.0271
Loa Loa (eye worm) RNA binding protein 0.0127 0.1691 0.2828
Loa Loa (eye worm) glutaminase 2 0.0266 0.3692 0.629
Echinococcus multilocularis tumor protein p63 0.0408 0.5744 0.5744
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0062 0.0749 0.2361
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0082 0.0203
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0082 0.0203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0107 0.0107
Trichomonas vaginalis phosphofructokinase, putative 0.0062 0.0749 0.1124
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.011 0.0271
Loa Loa (eye worm) 6-phosphofructokinase 0.023 0.3171 0.5389
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.011 0.0271
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0077 0.0353
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0077 0.0129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0107 0.0088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.0088
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0021 0.0035
Schistosoma mansoni hypothetical protein 0.0291 0.406 0.406
Loa Loa (eye worm) phosphofructokinase 0.023 0.3171 0.5389
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.011 0.0194
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0077 0.0077
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0062 0.0749 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0239 0.0588
Loa Loa (eye worm) RecQ helicase 0.0021 0.0152 0.0165
Schistosoma mansoni pyruvate kinase 0.0017 0.0104 0.0104
Echinococcus multilocularis pyruvate kinase 0.0017 0.0104 0.0104
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0107 0.0107
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0107 0.0107
Echinococcus multilocularis vesicular acetylcholine transporter 0.0216 0.2968 0.2968
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0365 0.0624
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0107 0.0107
Leishmania major cytochrome p450-like protein 0.0018 0.011 0.0194
Brugia malayi Cytochrome P450 family protein 0.0027 0.0239 0.0408
Schistosoma mansoni hypothetical protein 0.0368 0.5163 0.5163
Brugia malayi cytochrome P450 0.0018 0.011 0.0188
Brugia malayi vesicular acetylcholine transporter unc-17 0.0216 0.2968 0.5085
Brugia malayi 6-phosphofructokinase 0.023 0.3171 0.5433
Brugia malayi nuclear receptor NHR-88 0.0018 0.0107 0.0183
Loa Loa (eye worm) hypothetical protein 0.0018 0.0107 0.0088
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.023 0.3171 1
Mycobacterium leprae putative cytochrome p450 0.0018 0.011 0.0347
Brugia malayi Pre-SET motif family protein 0.0414 0.5836 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0107 0.0183
Schistosoma mansoni intermediate filament proteins 0.003 0.0292 0.0292
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0266 0.0802
Echinococcus multilocularis geminin 0.0368 0.5163 0.5163
Echinococcus multilocularis musashi 0.003 0.0292 0.0292
Echinococcus granulosus pyruvate kinase 0.0017 0.0104 0.0104
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0082 0.0429
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.011 0.0271
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0107 0.0183
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0181
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0161 0.1531
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.011 0.0271
Echinococcus multilocularis 6 phosphofructokinase 0.023 0.3171 0.3171

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 8.4921 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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