Detailed information for compound 1004669

Basic information

Technical information
  • TDR Targets ID: 1004669
  • Name: (3R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolid ine-1-carbonyl]heptanoic acid
  • MW: 343.42 | Formula: C19H25N3O3
  • H donors: 2 H acceptors: 4 LogP: 2.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@@H](C(=O)N1CCC[C@H]1c1nc2c([nH]1)cccc2)CC(=O)O
  • InChi: 1S/C19H25N3O3/c1-2-3-7-13(12-17(23)24)19(25)22-11-6-10-16(22)18-20-14-8-4-5-9-15(14)21-18/h4-5,8-9,13,16H,2-3,6-7,10-12H2,1H3,(H,20,21)(H,23,24)/t13-,16+/m1/s1
  • InChiKey: YZNULDWRNNKMJD-CJNGLKHVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3R)-3-[[(2S)-2-(1H-benzimidazol-2-yl)-1-pyrrolidinyl]-oxomethyl]heptanoic acid
  • (3R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidine-1-carbonyl]enanthic acid
  • (3R)-3-[(2S)-2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]carbonylheptanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) Get druggable targets OG5_128237 All targets in OG5_128237
Chlamydia trachomatis peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium vivax peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Treponema pallidum polypeptide deformylase (def) Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium yoelii polypeptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium falciparum peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium berghei peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium ulcerans peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Neospora caninum Peptide deformylase, related Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium knowlesi peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi surface protease GP63, putative Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 197 aa 171 aa 25.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0335 0.091
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.1137 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0082 0.04
Schistosoma mansoni zinc finger protein 0.0022 0.0114 0.0212
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0297 0.0297
Entamoeba histolytica hypothetical protein 0.0037 0.0297 0.0628
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0042 0.0357 0.1135
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0335 0.0801
Echinococcus multilocularis cpg binding protein 0.0036 0.0282 0.0282
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.006 0.0112
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0045 0.0005
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0673 0.5777
Loa Loa (eye worm) hypothetical protein 0.0028 0.0188 0.0525
Schistosoma mansoni hypothetical protein 0.005 0.0451 0.0837
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0082 0.04
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0673 0.1726
Onchocerca volvulus 0.004 0.0335 0.459
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.3506 1
Schistosoma mansoni hypothetical protein 0.0037 0.0297 0.0552
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0043 0.008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0082 0.04
Brugia malayi hypothetical protein 0.0244 0.2808 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0335 0.1054
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0045 0.0005
Loa Loa (eye worm) hypothetical protein 0.004 0.0335 0.1054
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.3506 1
Chlamydia trachomatis peptide deformylase 0.0279 0.3229 0.5
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0043 0.008
Brugia malayi Bromodomain containing protein 0.004 0.0326 0.1024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0673 0.5777
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.006 0.006
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0043 0.008
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0188 0.0455
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0043 0.008
Schistosoma mansoni cpg binding protein 0.0036 0.0282 0.0523
Loa Loa (eye worm) hypothetical protein 0.004 0.0327 0.1028
Schistosoma mansoni hypothetical protein 0.0175 0.1969 0.3655
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0188 0.1363
Loa Loa (eye worm) beta-lactamase 0.004 0.0335 0.1054
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0071
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0451 0.1474
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0673 0.0673
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0043 0.0043
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0673 0.125
Trypanosoma brucei Polypeptide deformylase 1 0.0106 0.1137 1
Schistosoma mansoni survival motor neuron protein 0.005 0.0451 0.0837
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0043 0.008
Echinococcus granulosus cpg binding protein 0.0036 0.0282 0.0523
Schistosoma mansoni hypothetical protein 0.0021 0.0105 0.0195
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0335 0.2694
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0188 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0335 0.2694
Loa Loa (eye worm) hypothetical protein 0.004 0.0335 0.1054
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0069 0.0128
Leishmania major hypothetical protein, conserved 0.0016 0.0043 0.0044
Mycobacterium tuberculosis Conserved protein 0.004 0.0335 0.091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0335 0.0621
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0188 0.0455
Brugia malayi hypothetical protein 0.0037 0.0297 0.0919
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0302 0.3506 1
Brugia malayi beta-lactamase family protein 0.004 0.0335 0.1054
Loa Loa (eye worm) hypothetical protein 0.004 0.0335 0.1054
Mycobacterium ulcerans lipase LipD 0.004 0.0335 0.0801
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.1137 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0236 0.0697
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0188 0.1363
Mycobacterium tuberculosis Conserved protein 0.004 0.0335 0.091
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0089 0.0089
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0188 0.1363
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.2808 0.5212
Onchocerca volvulus 0.004 0.0335 0.459
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0673 0.5777
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0043 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0335 0.2694
Brugia malayi beta-lactamase 0.004 0.0335 0.1054
Entamoeba histolytica hypothetical protein 0.0037 0.0297 0.0628
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.3506 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0082 0.0141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0093
Leishmania major polypeptide deformylase-like protein, putative 0.0106 0.1137 1
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0335 0.0621
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0082 0.0123
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0045 0.0083
Echinococcus multilocularis geminin 0.0175 0.1969 0.1969
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0335 0.0801
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0325 0.0604
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0335 0.0621
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0335 0.0335
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0302 0.3506 1
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.2808 0.2808
Leishmania major hypothetical protein, conserved 0.004 0.0335 0.2694
Giardia lamblia Fructose-bisphosphate aldolase 0.0302 0.3506 1
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0335 0.0736
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0082 0.0082
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0045
Mycobacterium tuberculosis Conserved protein 0.004 0.0335 0.091
Echinococcus granulosus lysine specific demethylase 5A 0.0064 0.0629 0.1168
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.006 0.0112
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0057
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0335 0.1054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0236 0.0697
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0069 0.0128
Onchocerca volvulus 0.005 0.0451 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0673 0.125
Schistosoma mansoni ap endonuclease 0.0019 0.0082 0.0153
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.006 0.0112
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0043 0.008
Brugia malayi PHD-finger family protein 0.0028 0.0181 0.0498
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0335 0.091
Loa Loa (eye worm) hypothetical protein 0.0073 0.0732 0.2493
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.3506 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1635 0.4933
Loa Loa (eye worm) hypothetical protein 0.004 0.0335 0.1054
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0617 0.1145
Brugia malayi hypothetical protein 0.0018 0.0067 0.0087
Schistosoma mansoni hypothetical protein 0.0175 0.1969 0.3655
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0082 0.0141
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0335 0.0736
Echinococcus granulosus zinc finger protein 0.0022 0.0114 0.0212
Brugia malayi jmjC domain containing protein 0.0064 0.0629 0.212
Brugia malayi Bromodomain containing protein 0.0079 0.0808 0.2767
Echinococcus granulosus dnaJ subfamily B 0.0457 0.5386 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0335 0.0736
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1635 0.4491
Toxoplasma gondii hypothetical protein 0.0279 0.3229 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.3506 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0082 0.0123
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0629 0.212
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0043 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.3506 1
Echinococcus multilocularis dnaJ subfamily B 0.0457 0.5386 0.5386
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0188 0.0455
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0335 0.091
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0043 0.0043
Mycobacterium ulcerans beta-lactamase 0.004 0.0335 0.0801
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.3506 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0297 0.0552
Brugia malayi beta-lactamase family protein 0.004 0.0335 0.1054
Plasmodium vivax peptide deformylase, putative 0.0279 0.3229 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0045 0.0057
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0089 0.0166
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0257 0.2962 0.9162
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0068 0.009
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0043 0.008
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0673 0.5777
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0105 0.0224
Echinococcus multilocularis zinc finger protein 0.0022 0.0114 0.0114
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0045 0.0045
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0043 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0335 0.0736
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0045 0.0057
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0069 0.0069
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0043 0.0043
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0082 0.04
Toxoplasma gondii ABC1 family protein 0.004 0.0335 0.0914
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0325 0.0325
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0335 0.0736
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0151 0.0281
Mycobacterium ulcerans peptide deformylase 0.0279 0.3229 1
Trichomonas vaginalis esterase, putative 0.004 0.0335 0.0736
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0672 0.1247
Entamoeba histolytica hypothetical protein 0.0037 0.0297 0.0628
Loa Loa (eye worm) hypothetical protein 0.0244 0.2808 1
Treponema pallidum fructose-bisphosphate aldolase 0.0302 0.3506 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0297 0.0552
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0043 0.0044
Toxoplasma gondii exonuclease III APE 0.0019 0.0082 0.0123
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0279 0.3229 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0617 0.0617
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0673 0.228
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0082 0.0118
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0279 0.3229 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0045
Brugia malayi hypothetical protein 0.0028 0.0188 0.0525
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0673 0.228
Treponema pallidum polypeptide deformylase (def) 0.0279 0.3229 0.919
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0583 0.1083
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0457 0.5386 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0629 0.1168
Schistosoma mansoni cpg binding protein 0.0032 0.0236 0.0438
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0279 0.3229 1
Plasmodium falciparum peptide deformylase 0.0279 0.3229 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.1137 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0005
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0057
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.1137 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0583 0.0583
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0302 0.3506 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0297 0.0297
Entamoeba histolytica hypothetical protein 0.0037 0.0297 0.0628
Schistosoma mansoni cpg binding protein 0.0036 0.0282 0.0523
Schistosoma mansoni ap endonuclease 0.0019 0.0082 0.0153
Leishmania major hypothetical protein, conserved 0.0028 0.0188 0.1363
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0583 0.1083
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0335 0.091
Schistosoma mansoni bromodomain containing protein 0.0067 0.0661 0.1228
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0613 0.179
Schistosoma mansoni jumonji/arid domain-containing protein 0.0064 0.0629 0.1168
Brugia malayi isocitrate dehydrogenase 0.0016 0.0045 0.0005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0335 0.091
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0151 0.0281
Brugia malayi jmjC domain containing protein 0.0061 0.0583 0.1953
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0335 0.091
Schistosoma mansoni zinc finger protein 0.0016 0.0038 0.0071
Echinococcus granulosus phd:f box containing protein 0.0016 0.0043 0.008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0297 0.0551
Loa Loa (eye worm) hypothetical protein 0.004 0.0335 0.1054
Plasmodium vivax hypothetical protein, conserved 0.004 0.0335 0.0914
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1635 0.4992
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0045 0.0005
Mycobacterium ulcerans hypothetical protein 0.004 0.0335 0.0801
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0045 0.0005
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0335 0.091
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0082 0.0153
Loa Loa (eye worm) hypothetical protein 0.004 0.0335 0.1054
Echinococcus granulosus geminin 0.0175 0.1969 0.3655
Trypanosoma brucei Peptide deformylase 2 0.0106 0.1137 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0403 0.1301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0069 0.0128
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0045 0.0045
Onchocerca volvulus 0.004 0.0335 0.459

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.202 uM Inhibition of Mycobacterium tuberculosis peptide deformylase expressed in Escherichia coli M15(pREp4) by microplate assay ChEMBL. 19008098

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.