TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.546 | Formula: C22H26N6O2S
H donors: 1 H acceptors: 5 LogP: 2.32 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#CC1(CC1)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1nc2c(s1)cccn2
InChi: 1S/C22H26N6O2S/c23-14-22(7-8-22)26-19(29)15-4-1-2-5-16(15)20(30)27-10-12-28(13-11-27)21-25-18-17(31-21)6-3-9-24-18/h3,6,9,15-16H,1-2,4-5,7-8,10-13H2,(H,26,29)/t15-,16-/m1/s1
InChiKey: AOXOTPFMIVMRQI-HZPDHXFCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0537	0.1296
Schistosoma mansoni	cpg binding protein	0.0031	0.0537	0.0537
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0216	0.0216
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0768	0.5507
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0768	0.1894
Echinococcus granulosus	cathepsin l1	0.0059	0.1179	0.1179
Brugia malayi	cathepsin F-like cysteine proteinase	0.0015	0.0166	0.0328
Giardia lamblia	Cathepsin B precursor	0.0065	0.1312	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0125	0.2704	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1179	0.8899
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1179	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Loa Loa (eye worm)	ctsf protein	0.0059	0.1179	0.2966
Loa Loa (eye worm)	cysteine protease	0.0059	0.1179	0.2966
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0216	0.0437
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0216	0.0216
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1179	0.2971
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0059	0.1179	0.2966
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0577	0.3923
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0577	0.3923
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0216	0.0303
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0015	0.0166	0.0166
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0065	0.1312	1
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0112	0.0185
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0216	0.0303
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.029	0.1557
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0059	0.1179	0.1179
Trypanosoma cruzi	major cysteine proteinase, putative	0.0015	0.0166	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0166	0.053
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.029	0.029
Toxoplasma gondii	cathepsin CPL	0.0059	0.1179	0.8838
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0044
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.029	1
Onchocerca volvulus		0.0059	0.1179	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0033	0.0577	0.0577
Leishmania major	cathepsin L-like protease	0.0059	0.1179	0.8785
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0015	0.0166	0.032
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.1179	0.2857
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1179	0.8899
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.1179	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0216	0.0944
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0033	0.0577	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1179	0.2971
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0216	0.0495
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Schistosoma mansoni	tsg101-related	0.006	0.1214	0.1214
Schistosoma mansoni	tsg101-related	0.006	0.1214	0.1214
Leishmania major	cathepsin L-like protease	0.0059	0.1179	0.8785
Entamoeba histolytica	cysteine proteinase 2	0.0033	0.0577	0.4408
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1179	0.2971
Schistosoma mansoni	cpg binding protein	0.0033	0.0578	0.0578
Trypanosoma cruzi	trypanothione reductase, putative	0.0049	0.0959	0.2274
Plasmodium vivax	glutathione reductase, putative	0.0049	0.0959	0.7828
Mycobacterium tuberculosis	Probable reductase	0.0113	0.2415	0.8837
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1179	0.8899
Plasmodium vivax	vivapain-2	0.0059	0.1179	1
Onchocerca volvulus		0.0031	0.0537	0.3663
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1338	0.1338
Brugia malayi	cathepsin L precursor	0.0015	0.0166	0.0328
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0015	0.0166	0.032
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.0577	0.0577
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.029	0.1557
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0041	0.0768	0.1768
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1179	0.8899
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.1179	0.1179
Echinococcus multilocularis	dnaJ subfamily B	0.0442	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0033	0.0577	0.126
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0166	0.032
Schistosoma mansoni	hypothetical protein	0.0442	1	1
Entamoeba histolytica	cysteine protease, putative	0.0015	0.0166	0.0596
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0015	0.0166	0.032
Plasmodium vivax	unspecified product	0.0018	0.0233	0.066
Trypanosoma brucei	trypanothione reductase	0.0049	0.0959	0.7082
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0216	0.0944
Toxoplasma gondii	thioredoxin reductase	0.0049	0.0959	0.6919
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.1179	0.2857
Brugia malayi	cathepsin L-like precursor	0.0041	0.0768	0.19
Leishmania major	trypanothione reductase	0.0049	0.0959	0.6778
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0216	0.0437
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.029	0.1227
Trypanosoma cruzi	cruzipain precursor, putative	0.0059	0.1179	0.2857
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0018	0.0233	0.0502
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0922	0.0922
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0216	0.0303
Onchocerca volvulus		0.0059	0.1179	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0922	0.2295
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0125	0.2704	1
Echinococcus multilocularis	cathepsin L	0.0033	0.0577	0.0577
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0065	0.1312	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0216	0.0944
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0065	0.1312	0.321
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0216	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0176	0.3871	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Leishmania major	cathepsin L-like protease	0.0059	0.1179	0.8785
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0216	0.0303
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1179	0.8899
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.029	0.0677
Entamoeba histolytica	cysteine protease, putative	0.0015	0.0166	0.0596
Schistosoma mansoni	cathepsin F (C01 family)	0.0041	0.0768	0.0768
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1179	0.8899
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Plasmodium vivax	unspecified product	0.0033	0.0577	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0233	0.0495
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.0577	0.3923
Leishmania major	cathepsin L-like protease	0.0059	0.1179	0.8785
Brugia malayi	cathepsin B-like cysteine proteinase	0.0176	0.3871	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0768	0.1894
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0216	0.0495
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.0577	0.126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0113	0.2415	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0015	0.0166	0.053
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Trichomonas vaginalis	hypothetical protein	0.0035	0.0637	0.4418
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0537	0.129
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0059	0.1179	0.1179
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.029	0.0645
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.029	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0015	0.0166	0.0166
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0216	0.0303
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0059	0.1179	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0166	0.032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.1179	0.8899
Echinococcus granulosus	cathepsin L	0.0033	0.0577	0.0577
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Echinococcus multilocularis	cathepsin L	0.0015	0.0166	0.0166
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0233	0.0502
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0049	0.0959	0.2985
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.029	0.175
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.029	0.1227
Echinococcus multilocularis	cpg binding protein	0.0033	0.0578	0.0578
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0125	0.2704	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.029	0.05
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.1179	0.2971
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0768	0.1894
Toxoplasma gondii	cathepsin B	0.0065	0.1312	1
Loa Loa (eye worm)	glutathione reductase	0.0049	0.0959	0.2392
Brugia malayi	fibroinase precursor	0.0015	0.0166	0.0328
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.1179	0.1179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0166	0.053
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Onchocerca volvulus		0.0059	0.1179	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0166	0.053
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0015	0.0166	0.0166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.1176	0.8816
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0216	0.0944
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0176	0.3871	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0044	0.0044
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0015	0.0166	0.053
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0059	0.1179	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0166	0.0166
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.029	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0113	0.2415	0.8837
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Schistosoma mansoni	tsg101-related	0.0049	0.0959	0.0959
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.029	0.0298
Loa Loa (eye worm)	thioredoxin reductase	0.0049	0.0959	0.2392
Echinococcus multilocularis	cysteine protease	0.0059	0.1179	0.1179
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1179	0.2971
Brugia malayi	Cathepsin L-like precursor	0.0041	0.0768	0.19
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.029	0.05
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.3871	0.3871
Leishmania major	cathepsin L-like protease	0.0059	0.1179	0.8785
Echinococcus granulosus	thioredoxin glutathione reductase	0.0049	0.0959	0.0959
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.3871	0.3871
Entamoeba histolytica	cysteine protease, putative	0.0015	0.0166	0.0596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0166	0.053
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0015	0.0166	0.053
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0922	0.0922
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0216	0.0495
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.1179	0.8899
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.029	0.029
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0166	0.032
Echinococcus granulosus	cathepsin l1	0.0041	0.0768	0.0768
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.029	0.0652
Plasmodium vivax	vivapain-3	0.0033	0.0577	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0015	0.0166	0.053
Trypanosoma brucei	Vps23 core domain containing protein, putative	0.0023	0.0357	0.2107
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0577	0.4408
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.3871	0.3871
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1179	0.8899
Entamoeba histolytica	cysteine proteinase 1, putative	0.0033	0.0577	0.4408
Mycobacterium tuberculosis	Probable dehydrogenase	0.0113	0.2415	0.8837
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0059	0.1179	1
Entamoeba histolytica	cysteine protease, putative	0.0015	0.0166	0.0596
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.0577	0.0577
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0922	0.0922
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0166	0.053
Schistosoma mansoni	ap endonuclease	0.002	0.029	0.029
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Leishmania major	cysteine peptidase A (CPA)	0.0059	0.1179	0.8785
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0216	0.0944
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0166	0.053
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.1179	0.1179
Loa Loa (eye worm)	cathepsin B	0.0065	0.1312	0.3314
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1179	0.2971
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.029	0.1557
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0041	0.0768	0.19
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0015	0.0166	0.0166
Entamoeba histolytica	hypothetical protein	0.0015	0.0166	0.0596
Schistosoma mansoni	cathepsin C	0.0015	0.0166	0.0166
Trypanosoma cruzi	cysteine proteinase, putative	0.0033	0.0577	0.126
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.1179	0.1179
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1494	0.3789
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.029	0.1084
Giardia lamblia	Cathepsin B precursor	0.0065	0.1312	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0015	0.0166	0.053
Toxoplasma gondii	exonuclease III APE	0.002	0.029	0.1084
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0216	0.0458
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0015	0.0166	0.053
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.1179	0.2857
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0033	0.0577	0.126
Echinococcus multilocularis	cysteine protease	0.0059	0.1179	0.1179
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0922	0.23
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0166	0.053
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0015	0.0166	0.053
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1179	0.8899
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0166	0.053
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0216	0.0303
Leishmania major	cathepsin L-like protease	0.0059	0.1179	0.8785
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Schistosoma mansoni	cpg binding protein	0.0033	0.0578	0.0578
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0922	0.0922
Onchocerca volvulus		0.0059	0.1179	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0015	0.0166	0.0596
Entamoeba histolytica	cysteine protease, putative	0.0015	0.0166	0.0596
Leishmania major	cathepsin L-like protease	0.0059	0.1179	0.8785
Onchocerca volvulus		0.0059	0.1179	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0233	0.0347
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Trypanosoma cruzi	major cysteine proteinase, putative	0.0015	0.0166	0.017
Onchocerca volvulus		0.0041	0.0768	0.5946
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0922	0.0922
Entamoeba histolytica	cysteine proteinase, putative	0.0041	0.0768	0.6188
Brugia malayi	Papain family cysteine protease containing protein	0.0015	0.0166	0.0328
Giardia lamblia	Cathepsin B precursor	0.0065	0.1312	1
Brugia malayi	Papain family cysteine protease containing protein	0.0015	0.0166	0.0328
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0216	0.0495
Mycobacterium tuberculosis	Probable oxidoreductase	0.0125	0.2704	1
Loa Loa (eye worm)	fibroinase	0.0059	0.1179	0.2966
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0015	0.0166	0.053
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0577	0.1399
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0216	0.0495
Brugia malayi	Thioredoxin reductase	0.0049	0.0959	0.2397
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Leishmania major	hypothetical protein, conserved	0.0023	0.0357	0.1284
Echinococcus granulosus	cysteine protease	0.0033	0.0577	0.0577
Brugia malayi	hypothetical protein	0.0073	0.1494	0.3794
Entamoeba histolytica	tumor susceptibility gene 101 protein, putative	0.0049	0.0959	0.7962
Echinococcus granulosus	cathepsin b	0.0176	0.3871	0.3871
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.0233	0.0502
Echinococcus multilocularis	cathepsin b	0.0176	0.3871	0.3871
Brugia malayi	cathepsin L-like cysteine proteinase	0.0015	0.0166	0.0328
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.1179	0.1179
Echinococcus granulosus	cathepsin L	0.0015	0.0166	0.0166
Echinococcus multilocularis	tumor susceptibility gene 101 protein	0.0073	0.1494	0.1494
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.1179	0.1179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0216	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0065	0.1312	0.1312
Entamoeba histolytica	cysteine protease, putative	0.0015	0.0166	0.0596
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0113	0.2415	0.8837
Onchocerca volvulus		0.0059	0.1179	1
Plasmodium falciparum	glutathione reductase	0.0017	0.0216	0.0495
Brugia malayi	Cathepsin L-like precursor	0.0059	0.1179	0.2971
Echinococcus granulosus	tumor susceptibility gene 101 protein	0.0073	0.1494	0.1494
Schistosoma mansoni	ap endonuclease	0.002	0.029	0.029
Leishmania major	cathepsin L-like protease	0.0059	0.1179	0.8785
Echinococcus granulosus	cathepsin b	0.0176	0.3871	0.3871
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.1179	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.1179	0.8899
Schistosoma mansoni	cathepsin S (C01 family)	0.0015	0.0166	0.0166
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0113	0.2415	0.8837
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0166	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0166	0.053
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.0577	0.1399
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0112	0.0185
Schistosoma mansoni	cathepsin s	0.0018	0.0233	0.0233
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0049	0.0959	0.0959
Brugia malayi	glutathione reductase	0.0049	0.0959	0.2397
Plasmodium falciparum	thioredoxin reductase	0.0049	0.0959	0.7828
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0166	0.032
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.1179	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0033	0.0577	0.126
Entamoeba histolytica	cysteine protease, putative	0.0059	0.1179	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0015	0.0166	0.0166
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0922	0.0922
Brugia malayi	Cathepsin L-like precursor	0.0041	0.0768	0.19
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0216	0.0944
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.1179	0.2857
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.0768	0.5507
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0577	0.4408
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0216	0.0303
Plasmodium vivax	vivapain-1	0.0033	0.0577	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0577	0.4408
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0015	0.0166	0.0328
Entamoeba histolytica	cysteine protease, putative	0.0033	0.0577	0.4408
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0176	0.3871	0.3871
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0015	0.0166	0.0328
Plasmodium falciparum	glutathione reductase	0.0049	0.0959	0.7828
Onchocerca volvulus	Cathepsin F homolog	0.0059	0.1179	1
Trypanosoma cruzi	Vps23 core domain containing protein, putative	0.0023	0.0357	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1179	0.2966
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0166	0.0166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.0577	0.3923
Onchocerca volvulus		0.0059	0.1179	1
Plasmodium vivax	vivapain-2	0.0059	0.1179	1
Plasmodium vivax	thioredoxin reductase, putative	0.0049	0.0959	0.7828
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0059	0.1179	0.2966
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0015	0.0166	0.053
Brugia malayi	Papain family cysteine protease containing protein	0.0015	0.0166	0.0328
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.1179	0.8899
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0216	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0166	0.032
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0233	0.0495
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.0577	0.0577
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0216	0.0437
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.0577	0.4408
Trypanosoma cruzi	cruzipain precursor, putative	0.0018	0.0233	0.0347
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0015	0.0166	0.0328
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0216	0.0216
Echinococcus granulosus	cpg binding protein	0.0033	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0233	0.0495
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0015	0.0166	0.0596
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0065	0.1312	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0233	0.0495
Echinococcus multilocularis	cathepsin b	0.0176	0.3871	0.3871
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0166	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0015	0.0166	0.053
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0015	0.0166	0.0166
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0922	0.0922
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.1179	0.8899
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0166	0.032

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 4	Inhibition of human recombinant cathepsin L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay	ChEMBL.	22858142
IC50 (binding)	> 4	Inhibition of human ERG	ChEMBL.	22858142
IC50 (binding)	= 5.4	Inhibition of human recombinant cathepsin B using Z-Arg-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay	ChEMBL.	22858142
IC50 (binding)	= 5.8	Inhibition of human recombinant cathepsin S using Z-Val-Val-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay	ChEMBL.	22858142
IC50 (binding)	= 7.3	Inhibition of human recombinant cathepsin K using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay	ChEMBL.	22858142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2071095

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1007770