Detailed information for compound 100978

Basic information

Technical information
  • TDR Targets ID: 100978
  • Name: N-(2-dimethylaminoethyl)-4-[3-(trifluoromethy l)phenyl]piperazine-1-carboxamide
  • MW: 344.375 | Formula: C16H23F3N4O
  • H donors: 1 H acceptors: 1 LogP: 2.07 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)N1CCN(CC1)c1cccc(c1)C(F)(F)F)C
  • InChi: 1S/C16H23F3N4O/c1-21(2)7-6-20-15(24)23-10-8-22(9-11-23)14-5-3-4-13(12-14)16(17,18)19/h3-5,12H,6-11H2,1-2H3,(H,20,24)
  • InChiKey: WASYRHBBAWLJIJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-dimethylaminoethyl)-4-[3-(trifluoromethyl)phenyl]-1-piperazinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0093 0.0342
Leishmania major cathepsin L-like protease 0.0058 0.0534 0.6437
Toxoplasma gondii NADPH-glutathione reductase 0.0012 0.0016 0.0024
Plasmodium vivax CDK-related protein kinase 6, putative 0.0899 1 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0034 0.0269 0.3112
Leishmania major cathepsin L-like protease 0.0015 0.0053 0.0637
Schistosoma mansoni glucose transport protein 0.0212 0.2265 1
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0413 0.4983
Plasmodium falciparum hexose transporter 0.0212 0.2265 0.2253
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0255 0.1125
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0217 0.0327
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Loa Loa (eye worm) hypothetical protein 0.0033 0.0255 0.1063
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0053 0.0233
Schistosoma mansoni protein kinase 0.0065 0.0614 0.2662
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0217 0.5239
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0597 0.7134
Echinococcus multilocularis cysteine protease 0.0015 0.0053 0.0049
Echinococcus granulosus thioredoxin glutathione reductase 0.0035 0.0274 0.1147
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0348 0.1536
Brugia malayi Sugar transporter family protein 0.003 0.0217 0.0894
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0053 0.0233
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0615 0.06
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Brugia malayi major facilitator superfamily protein 0.003 0.0217 0.0894
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0078 0.0764 0.8858
Plasmodium falciparum thioredoxin reductase 0.0012 0.0016 0.0000026642
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0016 0.0188
Loa Loa (eye worm) thioredoxin reductase 0.0034 0.0269 0.1124
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0534 0.6437
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2265 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0374 0.1651
Leishmania major glucose transporter, lmgt1 0.0066 0.0621 0.7479
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0621 0.274
Schistosoma mansoni hypothetical protein 0.0041 0.0343 0.1453
Plasmodium vivax sugar transporter, putative 0.003 0.0217 0.0201
Echinococcus multilocularis chromobox protein 1 0.0059 0.0547 0.0698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Onchocerca volvulus 0.003 0.0217 0.1639
Brugia malayi Cathepsin L-like precursor 0.0015 0.0053 0.0165
Loa Loa (eye worm) ctsf protein 0.0015 0.0053 0.0165
Brugia malayi Cathepsin L-like precursor 0.0015 0.0053 0.0165
Brugia malayi major facilitator superfamily protein 0.003 0.0217 0.0894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0614 0.0786
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0413 0.1769
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0084 0.083 0.362
Schistosoma mansoni chromobox protein 0.0059 0.0547 0.2364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0093 0.0077
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0615 0.06
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Plasmodium falciparum thioredoxin reductase 0.0034 0.0269 0.0253
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0286 0.3441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Brugia malayi Heterochromatin protein 1 0.0059 0.0547 0.2364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.0787 0.3428
Schistosoma mansoni protein kinase 0.0065 0.0614 0.2662
Onchocerca volvulus Putative transporter 0.003 0.0217 0.1639
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0413 1
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0134 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Plasmodium falciparum glutathione reductase 0.0012 0.0016 0.0000026642
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0217 0.2511
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0413 0.0625
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Onchocerca volvulus 0.003 0.0217 0.1639
Toxoplasma gondii exonuclease III APE 0.0019 0.0093 0.014
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0343 0.3736 0.5645
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trypanosoma brucei glucose transporter 1E 0.0066 0.0621 0.7479
Leishmania major cathepsin L-like protease 0.0058 0.0534 0.6437
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0566 0.2448
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2265 0.2953
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0053 0.0233
Plasmodium vivax vivapain-2 0.0015 0.0053 0.0037
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0615 0.06
Treponema pallidum NADH oxidase 0.0012 0.0016 0.0002
Trypanosoma cruzi sugar transporter, putative 0.003 0.0217 0.261
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0715 0.108
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0217 1
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0053 0.0165
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0012 0.0016 0.0000026642
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0078 0.0764 0.8858
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0894
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0614 0.2662
Schistosoma mansoni hypothetical protein 0.0031 0.0225 0.0933
Mycobacterium tuberculosis Probable dehydrogenase 0.0078 0.0764 0.8858
Leishmania major hypothetical protein, conserved 0.003 0.0217 0.261
Trichomonas vaginalis chromobox protein, putative 0.0059 0.0547 0.2417
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0016 0.0188
Toxoplasma gondii protein kinase, putative 0.0599 0.6618 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0084 0.083 0.362
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0413 0.4983
Toxoplasma gondii sugar transporter ST1 0.003 0.0217 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Echinococcus granulosus cathepsin l1 0.0015 0.0053 0.0165
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Leishmania major cathepsin L-like protease 0.0015 0.0053 0.0637
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0078 0.0764 0.8858
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0015 0.0053 0.0037
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0615 0.0929
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0069
Trypanosoma cruzi polo-like protein kinase, putative 0.0084 0.083 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.1052 0.461
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) heterochromatin protein 1 0.0059 0.0547 0.2364
Leishmania major cathepsin L-like protease 0.0015 0.0053 0.0637
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0597 0.2583
Brugia malayi hypothetical protein 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Schistosoma mansoni hypothetical protein 0.0144 0.1501 0.6604
Trypanosoma cruzi polo-like protein kinase, putative 0.0084 0.083 1
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0413 0.4886
Entamoeba histolytica protein kinase, putative 0.0065 0.0614 0.7352
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0413 0.1769
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0012 0.0016 0.0378
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0217 0.5239
Loa Loa (eye worm) fibroinase 0.0015 0.0053 0.0165
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0134 0.3243
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0012 0.0016 0.0188
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0217 0.0264
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0333 0.3863
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Entamoeba histolytica hypothetical protein 0.0031 0.0225 0.2576
Leishmania major protein kinase, putative 0.0065 0.0614 0.7402
Brugia malayi Cathepsin L-like precursor 0.0015 0.0053 0.0165
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0031 0.0225 0.0275
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0016 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0093 0.0946
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0413 0.1769
Trypanosoma brucei sugar transporter, putative 0.003 0.0217 0.261
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0087 0.0863 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0621 0.7479
Onchocerca volvulus 0.003 0.0217 0.1639
Giardia lamblia Kinase, PLK 0.0084 0.083 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0413 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0597 0.6914
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0615 0.06
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.7479
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0093 0.1116
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0621 0.7479
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0614 0.0786
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0188
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0615 0.06
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.7479
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0093 0.1116
Leishmania major cathepsin L-like protease 0.0015 0.0053 0.0637
Onchocerca volvulus 0.003 0.0217 0.1639
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0615 0.06
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0614 0.2662
Leishmania major cathepsin L-like protease 0.0015 0.0053 0.0637
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0016 0.0181
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0012 0.0016 0.0024
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0093 0.0342
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0012 0.0016 0.0378
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0053 0.0049
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0093 0.0946
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0087 0.0863 1
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0269 0.3236
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0016 0.0188
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0715 0.8616
Onchocerca volvulus 0.003 0.0217 0.1639
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0621 0.274
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0053 0.0457
Leishmania major cathepsin L-like protease 0.0058 0.0534 0.6437
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0053 0.0637
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0283 0.125
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0597 0.7134
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0614 0.2712
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0012 0.0016 0.0188
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0264
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0015 0.0053 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0053 0.0233
Echinococcus granulosus geminin 0.0144 0.1501 0.6604
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0036 0.0283 0.2304
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0093 0.0077
Entamoeba histolytica hypothetical protein 0.0031 0.0225 0.2576
Brugia malayi hypothetical protein 0.003 0.0217 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2265 0.2953
Loa Loa (eye worm) hypothetical protein 0.0047 0.0413 0.1769
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Brugia malayi Cathepsin L-like precursor 0.0015 0.0053 0.0165
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0217 0.0894
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.008 0.0787 0.3428
Mycobacterium tuberculosis Probable oxidoreductase 0.0087 0.0863 1
Plasmodium vivax hexose transporter 0.0212 0.2265 0.2253
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2265 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0053 0.0233
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0264
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0597 0.2583
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0093 0.1116
Trypanosoma brucei trypanothione reductase 0.0034 0.0269 0.3236
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0614 0.2662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.0787 0.3428
Loa Loa (eye worm) sugar transporter 0.0212 0.2265 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.083 0.3664
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.7479
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0012 0.0016 0.0000034926
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0146 0.0644
Entamoeba histolytica hypothetical protein 0.0031 0.0225 0.2576
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0093 0.224
Schistosoma mansoni hypothetical protein 0.0212 0.2265 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0615 0.06
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0134 0.2978
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0621 0.7479
Entamoeba histolytica protein kinase, putative 0.0065 0.0614 0.7352
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0217 0.261
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0217 0.0894
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0217 0.0201
Schistosoma mansoni glucose transport protein 0.0212 0.2265 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0212 0.2265 0.3422
Onchocerca volvulus 0.003 0.0217 0.1639
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.7479
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0264
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0093 0.0409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Onchocerca volvulus 0.003 0.0217 0.1639
Mycobacterium tuberculosis Probable reductase 0.0078 0.0764 0.8858
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.7479
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0016 0.0188
Leishmania major glucose transporter, lmgt3 0.0066 0.0621 0.7479
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0016 0.0188
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0217 0.0894
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0093 0.0409
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0621 0.274
Schistosoma mansoni ap endonuclease 0.0019 0.0093 0.0342
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Giardia lamblia Hexose transporter 0.003 0.0217 0.2469
Schistosoma mansoni kinase 0.0045 0.0386 0.1646
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0188
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0534 0.6437
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0413 0.0522
Loa Loa (eye worm) hypothetical protein 0.0201 0.2142 0.9452
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.0343 0.1453
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0016 0.0188
Brugia malayi glutathione reductase 0.0034 0.0269 0.1124
Onchocerca volvulus 0.0026 0.0174 0.1214
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.083 0.3664
Toxoplasma gondii cathepsin CPL 0.0015 0.0053 0.008
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0413 0.0399
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0217 0.2511
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2265 1
Trypanosoma cruzi hexose transporter 0.0066 0.0621 0.7479
Echinococcus granulosus cathepsin l cysteine peptidase 0.0015 0.0053 0.0165
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0053 0.0165
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0705
Loa Loa (eye worm) hypothetical protein 0.0064 0.0597 0.2583
Entamoeba histolytica hypothetical protein 0.0047 0.0413 0.4886
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0093 0.0342
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0217 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Brugia malayi hypothetical protein 0.003 0.0217 0.0894
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0012 0.0016 0.0188
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0283 0.125
Plasmodium falciparum mitogen-activated protein kinase 2 0.0343 0.3736 0.3726
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0621 0.7479
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0715 0.8616
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0033 0.0255 0.202
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0093 0.3831
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.083 0.3664
Trichomonas vaginalis chromobox protein, putative 0.0059 0.0547 0.2417
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0188
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0012 0.0016 0.0181
Schistosoma mansoni ap endonuclease 0.0019 0.0093 0.0342
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0621 0.7479
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0621 0.274
Echinococcus multilocularis survival motor neuron protein 1 0.0201 0.2142 0.2791
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0413 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0621 0.274
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0053 0.0457
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0715 0.8616
Toxoplasma gondii thioredoxin reductase 0.0034 0.0269 0.0406
Brugia malayi hypothetical protein 0.0201 0.2142 0.9452
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0615 0.06
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0084 0.083 0.1069
Mycobacterium ulcerans sugar transporter 0.003 0.0217 0.5239
Onchocerca volvulus 0.003 0.0217 0.1639
Entamoeba histolytica serine/threonine protein kinase, putative 0.0084 0.083 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0015 0.0053 0.0165
Brugia malayi Sugar transporter family protein 0.003 0.0217 0.0894
Trypanosoma cruzi hexose transporter, putative 0.003 0.0217 0.261
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0621 0.7479
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0413 0.1769
Giardia lamblia Sugar-proton symporter 0.003 0.0217 0.2469
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0621 0.274
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.7479
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0146 0.0644
Onchocerca volvulus 0.003 0.0217 0.1639
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0093 0.0101
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0413 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0615 0.0929
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0053 0.0049
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0015 0.0053 0.0037
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0016 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0053 0.0233
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0597 0.2583
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0614 0.2662
Brugia malayi Cathepsin L-like precursor 0.0015 0.0053 0.0165
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0615 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.2265 1
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0217 0.261
Schistosoma mansoni survival motor neuron protein 0.0041 0.0343 0.1453
Echinococcus multilocularis General substrate transporter 0.0182 0.193 0.2513
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.008 0.0787 0.1012
Loa Loa (eye worm) sugar transporter 0.003 0.0217 0.0894
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0597 0.0763
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0016 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Echinococcus granulosus survival motor neuron protein 1 0.0201 0.2142 0.9452
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0534 0.6437
Entamoeba histolytica cysteine protease, putative 0.0015 0.0053 0.0457
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0016 0.0188
Onchocerca volvulus Huntingtin homolog 0.0104 0.1052 1
Brugia malayi chromobox protein homolog 3 0.0033 0.0255 0.1063
Brugia malayi Cathepsin L-like precursor 0.0015 0.0053 0.0165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Plasmodium falciparum protein kinase 7 0.0599 0.6618 0.6613
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0264
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0012 0.0016 0.0188
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0217 0.0956
Echinococcus multilocularis chromobox protein 1 0.0059 0.0547 0.0698
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0016 0.0188
Onchocerca volvulus 0.003 0.0217 0.1639
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0715 0.0701
Onchocerca volvulus Huntingtin homolog 0.0104 0.1052 1
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0217 0.0956
Brugia malayi Sugar transporter family protein 0.0212 0.2265 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0614 0.0786
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0333 0.3863
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0053 0.0233
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0053 0.0165
Schistosoma mansoni glucose transporter 0.003 0.0217 0.0894
Schistosoma mansoni protein kinase 0.0065 0.0614 0.2662
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0104 0.1052 0.461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0016 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0016 0.0188
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0065 0.0614 0.2662
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0395 0.4754
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0012 0.0016 0.0000026642
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0621 0.274
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0175 0.0709
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0217 0.5239
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0615 0.0929
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.008 0.0787 0.3428
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Brugia malayi hypothetical protein 0.0031 0.0225 0.0933
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0087 0.0863 1
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0534 0.6437
Plasmodium vivax thioredoxin reductase, putative 0.0034 0.0269 0.0253
Echinococcus multilocularis geminin 0.0144 0.1501 0.195
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0217 0.0894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0012 0.0016 0.0001
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0614 0.2662
Brugia malayi Cam kinase protein 1 0.0065 0.0614 0.2662
Onchocerca volvulus 0.003 0.0217 0.1639
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0012 0.0016 0.0378
Onchocerca volvulus 0.003 0.0217 0.1639
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Loa Loa (eye worm) cysteine protease 0.0015 0.0053 0.0165
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0031 0.0225 0.0933
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.083 0.3664
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.083 0.3664
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Loa Loa (eye worm) glutathione reductase 0.0034 0.0269 0.1124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0016 0.0181
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0212 0.2265 0.2953
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0084 0.083 0.362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Echinococcus granulosus chromobox protein 1 0.0059 0.0547 0.2364
Schistosoma mansoni chromobox protein 0.0059 0.0547 0.2364
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0217 0.0894
Trichomonas vaginalis glucose transporter, putative 0.003 0.0217 0.0956
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0715 0.0701
Echinococcus multilocularis thioredoxin glutathione reductase 0.0035 0.0274 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0016 0.0188
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0053 0.0233
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0621 0.7479
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0093 0.1116
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0012 0.0016 0.0000026642
Onchocerca volvulus 0.003 0.0217 0.1639
Echinococcus multilocularis cysteine protease 0.0015 0.0053 0.0049
Onchocerca volvulus 0.003 0.0217 0.1639
Entamoeba histolytica hypothetical protein 0.0031 0.0225 0.2576
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0333 0.3863
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis glutathione reductase, putative 0.0012 0.0016 0.0069
Onchocerca volvulus 0.0041 0.0343 0.2898
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0016 0.0188
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0413 0.1826
Trypanosoma brucei glucose transporter 2A 0.0066 0.0621 0.7479
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0217 0.0264
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.008 0.0787 0.3428
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0597 0.2634
Schistosoma mansoni transcription factor LCR-F1 0.0031 0.0225 0.0933
Echinococcus granulosus chromobox protein 1 0.0059 0.0547 0.2364
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0566 0.0723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0715 0.8616
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0212 0.2265 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0093 0.1073
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0012 0.0016 0.0000026642
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0053 0.0165
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0413 0.4792
Trichomonas vaginalis mercuric reductase, putative 0.0012 0.0016 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0614 0.7402
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.008 0.0787 0.1012
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0165
Leishmania major glucose transporter, lmgt2 0.0066 0.0621 0.7479
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0413 0.4983
Schistosoma mansoni glucose transport protein 0.0212 0.2265 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0689 0.7632 1
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.083 0.362
Onchocerca volvulus Serine\/threonine kinase homolog 0.0084 0.083 0.7774
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0053 0.0233
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0084 0.083 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Onchocerca volvulus 0.003 0.0217 0.1639
Brugia malayi hypothetical protein 0.0104 0.1052 0.461
Loa Loa (eye worm) hypothetical protein 0.0052 0.0462 0.1987
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0078 0.0764 0.8858
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0016 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0374 0.1651
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0188
Loa Loa (eye worm) hypothetical protein 0.0064 0.0597 0.2583
Plasmodium vivax glutathione reductase, putative 0.0034 0.0269 0.0253
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0078 0.0764 0.8858
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0053 0.0233
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0093 0.65
Leishmania major cysteine peptidase A (CPA) 0.0015 0.0053 0.0637
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0597 0.2583
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0053 0.0049
Trypanosoma cruzi trypanothione reductase, putative 0.0012 0.0016 0.0188
Plasmodium vivax vivapain-2 0.0015 0.0053 0.0037
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0614 0.2662
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0016 0.0377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.008 0.0787 0.3428
Plasmodium falciparum glutathione reductase 0.0034 0.0269 0.0253
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0053 0.0478 0.5754
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0534 0.6437
Plasmodium falciparum cysteine proteinase falcipain 3 0.0015 0.0053 0.0037
Brugia malayi Thioredoxin reductase 0.0034 0.0269 0.1124
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Onchocerca volvulus 0.003 0.0217 0.1639
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0597 0.2583
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.083 0.3664
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0614 0.2662
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0343 0.3736 0.3726
Trypanosoma brucei polo-like protein kinase 0.0084 0.083 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0016 0.0024
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0217 0.0894
Toxoplasma gondii sugar transporter ST3 0.003 0.0217 0.0327
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0012 0.0016 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0255 0.1125
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0614 0.2662
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0053 0.0233
Trichomonas vaginalis CAMK family protein kinase 0.0084 0.083 0.3664
Echinococcus granulosus General substrate transporter 0.0182 0.193 0.851
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0053 0.0233
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.7479
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.7479
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.008 0.0787 0.3428
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0212 0.2265 0.2953
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0715 0.8616
Trypanosoma cruzi glucose transporter, putative 0.003 0.0217 0.261
Schistosoma mansoni hypothetical protein 0.0144 0.1501 0.6604
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0614 0.0786
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0053 0.0049
Toxoplasma gondii sugar transporter ST2 0.003 0.0217 0.0327
Leishmania major trypanothione reductase 0.0034 0.0269 0.3236

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -18 % Oral antiallergic activity in rat passive foot anaphylaxis (PFA) assay as percent change in volume of foot edema at a dose 31.6 mg/kg compared to -61% of aminophylline at 100 mg/kg ChEMBL. 1972965

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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