TDR Targets

Basic information

Technical information

TDR Targets ID: 1018967
Name: 2-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl ]amino]quinazolin-5-yl]oxy-2-methylpropanamid e
MW: 463.916 | Formula: C24H22ClN5O3
H donors: 2 H acceptors: 4 LogP: 3.98 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)C(Oc1cccc2c1c(ncn2)Nc1ccc(c(c1)Cl)OCc1ccccn1)(C)C
InChi: 1S/C24H22ClN5O3/c1-24(2,23(26)31)33-20-8-5-7-18-21(20)22(29-14-28-18)30-15-9-10-19(17(25)12-15)32-13-16-6-3-4-11-27-16/h3-12,14H,13H2,1-2H3,(H2,26,31)(H,28,29,30)
InChiKey: ZTDGISKEIHFQJM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]quinazolin-5-yl]oxy-2-methyl-propanamide
2-[[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-5-quinazolinyl]oxy]-2-methylpropanamide
2-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]quinazolin-5-yl]oxy-2-methyl-propionamide
2-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-5-yl]oxy-2-methyl-propanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	erb-b2 receptor tyrosine kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	neuropeptide s receptor	0.0463	0.0992	0.0992
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0191	0.0325	0.0325
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Schistosoma mansoni	tyrosine kinase	0.0096	0.0093	0.0093
Schistosoma mansoni	lipoxygenase	0.0118	0.0148	0.0148
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1596	0.3764	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.02	0.0349	0.0349
Brugia malayi	Protein-tyrosine phosphatase 1	0.0191	0.0325	0.0325
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0191	0.0325	0.0325
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1596	0.3764	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0362	0.0744	0.0744
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0191	0.0325	0.0325
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0258	0.049	0.2232
Onchocerca volvulus		0.0191	0.0325	0.0805
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Onchocerca volvulus		0.0191	0.0325	0.0805
Onchocerca volvulus		0.0191	0.0325	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 3	0.0068	0.0024	0.0024
Trypanosoma cruzi	hypothetical protein, conserved	0.0492	0.1063	1
Trypanosoma cruzi	endonuclease G, putative	0.0258	0.049	0.2232
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.02	0.0349	0.0349
Echinococcus granulosus	gpi ethanolamine phosphate transferase 3	0.0068	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0429	0.0909	0.0909
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1596	0.3764	1
Brugia malayi	hypothetical protein	0.0068	0.0024	0.0024
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0191	0.0325	0.0325
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0812	0.1846	0.1846
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.02	0.0349	0.0349
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0258	0.049	0.5
Onchocerca volvulus		0.0191	0.0325	0.0805
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0067	0.0024	0.0024
Mycobacterium leprae	hypothetical protein	0.0068	0.0024	0.5
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0191	0.0325	0.0325
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.02	0.0349	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0429	0.0909	0.0909
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.02	0.0349	0.0349
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.02	0.0349	0.0349
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.03	0.03
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0231	0.0231
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0191	0.0325	0.0325
Brugia malayi	hypothetical protein	0.0191	0.0325	0.0325
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0191	0.0325	0.0325
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0191	0.0325	0.0325
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0191	0.0325	0.0325
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0191	0.0325	0.0325
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0191	0.0325	0.0325
Schistosoma mansoni	tyrosine kinase	0.0097	0.0096	0.0096
Schistosoma mansoni	pcd6 interacting protein-related	0.0191	0.0325	0.0325
Schistosoma mansoni	tyrosine kinase	0.0097	0.0096	0.0096
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.03	0.03
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Brugia malayi	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.02	0.0349	0.0349
Schistosoma mansoni	hypothetical protein	0.017	0.0274	0.0274
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.02	0.0349	0.0349
Echinococcus granulosus	geminin	0.017	0.0274	0.0274
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0191	0.0325	0.0805
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.1596	0.3764	0.3764
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0191	0.0325	0.0325
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0492	0.1063	0.2145
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0024	0.0024
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.03	0.03
Schistosoma mansoni	endonuclease related	0.0258	0.049	0.049
Plasmodium falciparum	GPI ethanolamine phosphate transferase 3, putative	0.0068	0.0024	0.5
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0492	0.1063	1
Schistosoma mansoni	hypothetical protein	0.0068	0.0024	0.0024
Trypanosoma brucei	endonuclease G, putative	0.0258	0.049	0.4483
Echinococcus multilocularis		0.0191	0.0325	0.0325
Onchocerca volvulus	4.1 G protein, putative homolog	0.0191	0.0325	0.0805
Echinococcus granulosus	neuropeptide s receptor	0.0463	0.0992	0.0992
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0191	0.0325	0.0325
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.0096	0.0096
Onchocerca volvulus		0.0429	0.0909	0.2366
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0362	0.0744	0.0744
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Schistosoma mansoni	lipoxygenase	0.0083	0.0061	0.0061
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Brugia malayi	hypothetical protein	0.0068	0.0024	0.0024
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0258	0.049	0.4483
Giardia lamblia	Protein tyrosine phosphatase	0.0191	0.0325	0.0805
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.0096	0.0096
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.02	0.0349	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0191	0.0325	0.0325
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0191	0.0325	0.0325
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1596	0.3764	1
Onchocerca volvulus		0.0191	0.0325	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1596	0.3764	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.4146	1	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Onchocerca volvulus		0.0191	0.0325	0.0805
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0362	0.0744	0.0744
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0068	0.0024	0.0024
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Echinococcus multilocularis	ectonucleotide	0.0362	0.0744	0.0744
Echinococcus multilocularis	geminin	0.017	0.0274	0.0274
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0927	0.2125	0.2125
Onchocerca volvulus		0.0191	0.0325	0.0805
Schistosoma mansoni	protein tyrosine phosphatase	0.0191	0.0325	0.0325
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0068	0.0024	0.0024
Onchocerca volvulus		0.0191	0.0325	0.0805
Schistosoma mansoni	hypothetical protein	0.0927	0.2125	0.2125
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Trypanosoma brucei	endonuclease G, putative	0.0258	0.049	0.4483
Leishmania major	hypothetical protein, conserved	0.0492	0.1063	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0191	0.0325	0.0325
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0118	0.0148	0.0148
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.02	0.0349	0.0349
Schistosoma mansoni	hypothetical protein	0.0068	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0191	0.0325	0.0325
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0429	0.0909	0.0909
Echinococcus multilocularis	transferase	0.0068	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0429	0.0909	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0024	0.0024
Brugia malayi	Protein-tyrosine phosphatase	0.0352	0.0721	0.0721
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0068	0.0024	0.0024
Echinococcus granulosus	transferase	0.0068	0.0024	0.0024
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.4146	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Echinococcus multilocularis	neuropeptide receptor A26	0.0463	0.0992	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0024	0.0024
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0191	0.0325	0.0325
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.02	0.0349	0.0349
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0191	0.0325	0.0325
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.02	0.0349	0.0349
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0429	0.0909	0.0909
Onchocerca volvulus		0.1596	0.3764	1
Echinococcus granulosus	neuropeptide receptor A26	0.0463	0.0992	0.0992
Trypanosoma brucei	endonuclease G, putative	0.0258	0.049	0.4483
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0191	0.0325	0.0325
Leishmania major	endonuclease G, putative	0.0258	0.049	0.4483
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0068	0.0024	0.0024
Echinococcus granulosus	Endonuclease G	0.0258	0.049	0.049
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0231	0.0231
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0068	0.0024	0.0024
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.4146	1	1
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Brugia malayi	Protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0191	0.0325	0.0325
Trypanosoma cruzi	endonuclease G, putative	0.0258	0.049	0.2232
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0191	0.0325	0.0325
Schistosoma mansoni	protein tyrosine phosphatase	0.02	0.0349	0.0349
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1596	0.3764	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1596	0.3764	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0191	0.0325	0.0325
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 1	0.0068	0.0024	0.0024
Brugia malayi	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus granulosus	ectonucleotide	0.0362	0.0744	0.0744
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0429	0.0909	0.0909
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Schistosoma mansoni	tyrosine kinase	0.0096	0.0093	0.0093
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.1104	0.256	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0118	0.0148	0.0148
Onchocerca volvulus		0.0429	0.0909	0.2366
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0191	0.0325	0.0325
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1596	0.3764	1
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0343	0.0697	0.0697
Brugia malayi	AEL166Cp	0.0068	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0191	0.0325	0.0325
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0429	0.0909	0.0909
Echinococcus multilocularis	Endonuclease G	0.0258	0.049	0.049
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0191	0.0325	0.0325
Brugia malayi	endonuclease G, mitochondrial precursor	0.0258	0.049	0.049
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.03	0.03
Onchocerca volvulus		0.0191	0.0325	0.0805
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0191	0.0325	0.2897
Schistosoma mansoni	tyrosine kinase	0.018	0.03	0.03
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0191	0.0325	0.2897
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Schistosoma mansoni	hypothetical protein	0.017	0.0274	0.0274
Onchocerca volvulus		0.0927	0.2125	0.5619
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0258	0.049	0.2232
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.02	0.0349	0.0349
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1596	0.3764	0.3764
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1596	0.3764	1
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.02	0.0349	0.0349
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0191	0.0325	0.0325
Schistosoma mansoni	hypothetical protein	0.0068	0.0024	0.0024
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0067	0.0024	0.0024
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0191	0.0325	0.0325
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0191	0.0325	0.0805
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0429	0.0909	0.0909
Onchocerca volvulus		0.0191	0.0325	0.0805
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0927	0.2125	0.2125
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.4146	1	1
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Echinococcus multilocularis	hypothetical protein	0.0191	0.0325	0.0325
Brugia malayi	hypothetical protein	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.02	0.0349	0.0349
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0191	0.0325	0.0805
Onchocerca volvulus		0.0162	0.0255	0.0618
Schistosoma mansoni	hypothetical protein	0.0068	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.0096	0.0096
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0492	0.1063	0.2145
Onchocerca volvulus		0.0191	0.0325	0.0805
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0231	0.0231
Leishmania major	tyrosine specific protein phosphatase, putative	0.0191	0.0325	0.2897
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0191	0.0325	0.0325
Onchocerca volvulus		0.0191	0.0325	0.0805
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0191	0.0325	0.0325
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0191	0.0325	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0024	0.0024
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0191	0.0325	0.0325
Echinococcus multilocularis	Alkaline phosphatase, core domain	0.0068	0.0024	0.0024
Brugia malayi	hypothetical protein	0.0191	0.0325	0.0325
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.02	0.0349	0.0349
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0191	0.0325	0.0325
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0429	0.0909	0.0909
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1596	0.3764	1
Loa Loa (eye worm)	type I phosphodiesterase/nucleotide pyrophosphatase	0.0068	0.0024	0.0024
Schistosoma mansoni	tyrosine kinase	0.0096	0.0093	0.0093
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0191	0.0325	0.0325
Trypanosoma cruzi	hypothetical protein, conserved	0.0492	0.1063	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2 nM	Inhibition of HER2	ChEMBL.	18500794

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL518750

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1018967