TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 389.404 | Formula: C22H19N3O4
H donors: 0 H acceptors: 2 LogP: 2.55 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=c1nc(oc2c1cc1cc(OCc3cccnc3)ccc1c2)N1CCOCC1
InChi: 1S/C22H19N3O4/c26-21-19-11-17-10-18(28-14-15-2-1-5-23-13-15)4-3-16(17)12-20(19)29-22(24-21)25-6-8-27-9-7-25/h1-5,10-13H,6-9,14H2
InChiKey: BGCWIXDMWKZVAP-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.08	0.9682
Echinococcus multilocularis	Polycystic kidney disease protein	0.0023	0.0277	0.0277
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.2535	0.3473
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0028	0.0404	0.0404
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0157	0.0157
Toxoplasma gondii	hypothetical protein	0.0047	0.0908	0.7485
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0212	0.0212
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.077	0.1054
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0078	0.0078
Brugia malayi	Bromodomain containing protein	0.0048	0.093	0.2728
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.077	0.2261
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0078	0.0228
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.002	0.0212	0.0212
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0248	0.034
Schistosoma mansoni	hypothetical protein	0.0396	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0067	0.1418	0.2039
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.0826	0.6811
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0751	0.1028
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0712	0.2089
Loa Loa (eye worm)	acetyltransferase	0.0143	0.3408	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0078	0.0107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Echinococcus granulosus	fetal alzheimer antigen falz	0.0028	0.0404	0.0404
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0078	0.0078
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0138	0.3286	0.4501
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.077	0.9324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0042	0.077	0.2261
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.3286	0.4501
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0078	0.0228
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0248	0.3101
Echinococcus multilocularis	zinc finger protein	0.0028	0.0403	0.0403
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.077	0.077
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Loa Loa (eye worm)	doublecortin family protein	0.0023	0.0277	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0812
Echinococcus multilocularis	ubiquitin specific protease 41	0.0043	0.08	0.08
Schistosoma mansoni	zinc finger protein	0.0028	0.0403	0.0403
Schistosoma mansoni	polycystin 1-related	0.0023	0.0277	0.0277
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.73	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0751	0.1028
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.0826	1
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0078	0.0228
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.077	0.9324
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0248	0.0236
Loa Loa (eye worm)	hypothetical protein	0.004	0.0712	0.2089
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.1213	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0078	0.0078
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.119	0.3492
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0028	0.0404	0.0404
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.3234	0.3234
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0157	0.0157
Schistosoma mansoni	hypothetical protein	0.0018	0.0157	0.0157
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.077	0.1054
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0751	0.1028
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.0826	0.6811
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0157	0.0461
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.73	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0078	0.0641
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0313	0.7846	0.7846
Schistosoma mansoni	hypothetical protein	0.0018	0.0157	0.0157
Echinococcus granulosus	zinc finger protein	0.0028	0.0403	0.0403
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0248	0.0248
Schistosoma mansoni	hypothetical protein	0.0018	0.0157	0.0157
Plasmodium falciparum	LCCL domain-containing protein	0.0023	0.0277	0.3389
Schistosoma mansoni	lipoxygenase	0.0023	0.0277	0.0277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0067	0.1418	0.1418
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.0826	1
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0078	0.0078
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0157	0.0157
Plasmodium vivax	multidomain scavenger receptor, putative	0.0023	0.0277	0.2658
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0037	0.0444
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0248	0.034
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.077	0.9253
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0043	0.08	0.08
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0277	0.0812
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0157	0.0461
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.077	0.2261
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.0826	0.0826
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.119	0.3492
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0248	0.0728
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1216	0.1216
Leishmania major	hypothetical protein, conserved	0.0114	0.2645	0.3554
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0043	0.08	1
Mycobacterium leprae	Probable lipase LipE	0.0042	0.077	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Brugia malayi	beta-lactamase family protein	0.0042	0.077	0.2261
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0042	0.077	0.2261
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0074	0.162	0.162
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.077	0.1054
Echinococcus multilocularis	cpg binding protein	0.0032	0.0503	0.0503
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0042	0.077	0.2261
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.1418	0.2216
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0067	0.1418	0.1418
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0248	0.0728
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0248	0.034
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0014	0.0037	0.0302
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.08	0.9682
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0042	0.077	0.2261
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.077	0.1054
Echinococcus granulosus	Polycystic kidney disease protein	0.0023	0.0277	0.0277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.08	0.2348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Echinococcus granulosus	geminin	0.0197	0.4816	0.4816
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0248	0.034
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0157	0.0461
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.077	0.1055
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0157	0.0157
Leishmania major	hypothetical protein, conserved	0.0042	0.077	0.0959
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0248	0.0236
Echinococcus granulosus	methyl CpG binding domain protein 2	0.002	0.0196	0.0196
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.002	0.0212	0.0212
Echinococcus multilocularis	geminin	0.0197	0.4816	0.4816
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0043	0.08	0.1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0067	0.1418	0.2216
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0078	0.0107
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0248	0.2044
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0248	0.0728
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0067	0.1418	0.1418
Loa Loa (eye worm)	bromodomain containing protein	0.0024	0.0304	0.0893
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0404	0.1185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Brugia malayi	hypothetical protein	0.0023	0.0277	0.0812
Brugia malayi	Bromodomain containing protein	0.0092	0.2083	0.6113
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	0.7846	0.7846
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0196	0.0196
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.08	0.08
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0842	0.2471
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.077	0.9324
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.077	0.077
Loa Loa (eye worm)	hypothetical protein	0.002	0.0212	0.0622
Leishmania major	hypothetical protein, conserved	0.0018	0.0143	0.009
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0078	0.0107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.077	0.5
Schistosoma mansoni	rab6-interacting	0.0023	0.0277	0.0277
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0078	0.0078
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.08	0.08
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.002	0.0196	0.0196
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0985	0.1349
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.08	0.9682
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0157	0.0461
Echinococcus granulosus	ubiquitin specific protease 41	0.0043	0.08	0.08
Schistosoma mansoni	hypothetical protein	0.004	0.0712	0.0712
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0064	0.1353	0.1353
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0277	0.0277
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.119	0.3492
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0248	0.034
Onchocerca volvulus		0.0042	0.077	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.077	0.1054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0067	0.1418	0.4161
Trichomonas vaginalis	esterase, putative	0.0042	0.077	0.9324
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.077	0.077
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0277	0.0277
Brugia malayi	beta-lactamase	0.0042	0.077	0.2261
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0248	0.034
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0751	0.1028
Trypanosoma brucei	ISWI complex protein	0.0018	0.0143	0.0196
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.077	0.1054
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0078	0.0078
Echinococcus granulosus	histone lysine methyltransferase setb	0.002	0.0212	0.0212
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0248	0.034
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.077	0.9324
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0062	0.1301	0.3817
Brugia malayi	beta-lactamase family protein	0.0042	0.077	0.2261
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0074	0.162	0.162
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0248	0.0248
Schistosoma mansoni	zinc finger protein	0.0018	0.0143	0.0143
Mycobacterium ulcerans	hypothetical protein	0.0154	0.3693	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.08	0.1096
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.077	0.1055
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0064	0.1353	0.1353
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1823	0.5349
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0305	0.0894
Loa Loa (eye worm)	beta-lactamase	0.0042	0.077	0.2261
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0138	0.3286	0.4442
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0248	0.034
Leishmania major	mitochondrial DNA polymerase beta	0.0293	0.73	1
Schistosoma mansoni	cpg binding protein	0.0032	0.0503	0.0503
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.0826	1
Echinococcus granulosus	cpg binding protein	0.0032	0.0503	0.0503
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.3408	0.3408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Schistosoma mansoni	cpg binding protein	0.0028	0.0404	0.0404
Echinococcus multilocularis	RUN	0.0023	0.0277	0.0277
Schistosoma mansoni	loxhd1	0.0023	0.0277	0.0277
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.077	0.1055
Brugia malayi	Doublecortin family protein	0.0023	0.0277	0.0812
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0043	0.08	0.2348
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0665	0.8312
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0043	0.08	0.08
Schistosoma mansoni	lipoxygenase	0.0064	0.1353	0.1353
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0037	0.0444
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0248	0.034
Echinococcus granulosus	GPCR family 2	0.0018	0.0157	0.0157
Onchocerca volvulus		0.0042	0.077	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0043	0.08	0.08
Onchocerca volvulus		0.0042	0.077	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0248	0.3101
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0042	0.0768	0.0768
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.077	0.1054
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0043	0.08	0.08
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0143	0.0196
Schistosoma mansoni	hypothetical protein	0.0197	0.4816	0.4816
Brugia malayi	PHD-finger family protein	0.0034	0.0565	0.1658
Schistosoma mansoni	methyl-cpg binding protein mbd	0.002	0.0196	0.0196
Echinococcus granulosus	RUN	0.0023	0.0277	0.0277
Schistosoma mansoni	hypothetical protein	0.0023	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1103	0.3236
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.08	0.1096
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0404	0.1185
Schistosoma mansoni	hypothetical protein	0.0018	0.0143	0.0143
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0665	0.7554
Echinococcus multilocularis	dnaJ subfamily B	0.0396	1	1
Schistosoma mansoni	hypothetical protein	0.0024	0.0305	0.0305
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0078	0.0641
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0248	0.0248
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.08	0.1096
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.077	0.9324
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0248	0.0236
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0248	0.0236
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0293	0.73	1
Schistosoma mansoni	rab6-interacting	0.0023	0.0277	0.0277
Mycobacterium tuberculosis	Conserved protein	0.0042	0.077	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0248	0.0236
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Mycobacterium tuberculosis	Conserved protein	0.0042	0.077	0.1054
Onchocerca volvulus		0.0028	0.0404	0.2573
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0014	0.0037	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Schistosoma mansoni	bromodomain containing protein	0.0079	0.1728	0.1728
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0248	0.0728
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.3408	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0248	0.0248
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0078	0.0078
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0078	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0042	0.077	0.2261
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0248	0.034
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0268	0.6652	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Schistosoma mansoni	hypothetical protein	0.0018	0.0157	0.0157
Toxoplasma gondii	ABC1 family protein	0.0042	0.077	0.635
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0042	0.077	0.2261
Schistosoma mansoni	hypothetical protein	0.0197	0.4816	0.4816
Mycobacterium tuberculosis	Conserved protein	0.0042	0.077	0.1054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0043	0.08	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0248	0.3002
Trypanosoma cruzi	ISWI complex protein	0.0018	0.0143	0.0196
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.3408	0.3408
Brugia malayi	hypothetical protein	0.0023	0.0277	0.0812
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0067	0.1418	0.1856
Loa Loa (eye worm)	hypothetical protein	0.0058	0.119	0.3492
Schistosoma mansoni	cpg binding protein	0.0032	0.0503	0.0503
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0277	0.0277
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.3693	0.55
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0042	0.0768	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1004	0.2945
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0665	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.7 uM	Inhibition of purified DNA-PK by ADP-Glo Kinase assay	ChEMBL.	21664823

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1795748

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1024749