Detailed information for compound 1025425

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 680.801 | Formula: C32H48N12O5
  • H donors: 10 H acceptors: 5 LogP: -1.43 Rotable bonds: 26
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=N)NCCC[C@@H](C(=O)NCc1ccc(cc1)C(=N)N)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)Cc1ccccc1)CCCNC(=N)N
  • InChi: 1S/C32H48N12O5/c1-19(45)26(44-29(48)24(10-6-16-40-32(37)38)42-25(46)17-20-7-3-2-4-8-20)30(49)43-23(9-5-15-39-31(35)36)28(47)41-18-21-11-13-22(14-12-21)27(33)34/h2-4,7-8,11-14,19,23-24,26,45H,5-6,9-10,15-18H2,1H3,(H3,33,34)(H,41,47)(H,42,46)(H,43,49)(H,44,48)(H4,35,36,39)(H4,37,38,40)/t19-,23+,24+,26+/m1/s1
  • InChiKey: VGIHFFCRMFMXDJ-ITAOHFDISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens furin (paired basic amino acid cleaving enzyme) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Proprotein convertase subtilisin/kexin type 6 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi endoprotease bli-4 precursor Get druggable targets OG5_127788 All targets in OG5_127788
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Brugia malayi celfurPC protein Get druggable targets OG5_127788 All targets in OG5_127788
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus granulosus furin Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Endoprotease bli-4 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) endoprotease bli-4 Get druggable targets OG5_127788 All targets in OG5_127788
Giardia lamblia High cysteine membrane protein Group 2 Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Furin-like protease 1, isoforms 1/1-X/2 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.0368 0.0359
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0594 0.1353
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0023 0.004
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0042 0.0678 0.1946
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0023 0.0014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.147 0.6946
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0368 0.1701
Schistosoma mansoni hypothetical protein 0.0012 0.0067 0.0168
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0023 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0023 0.0014
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0253 0.068
Onchocerca volvulus 0.0024 0.0305 0.0282
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0142 0.0385
Echinococcus granulosus FTZ F1 alpha 0.001 0.0023 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0023 0.0051
Onchocerca volvulus 0.0035 0.0538 0.0516
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0027 0.0371 0.1826
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0538 0.0529
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0023 0.0014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0213 0.0534
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0023 0.004
Brugia malayi follicle stimulating hormone receptor 0.0229 0.4503 0.4497
Onchocerca volvulus 0.0498 1 1
Onchocerca volvulus 0.0443 0.888 0.8878
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0852 0.6694
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0031 0.0071
Schistosoma mansoni ap endonuclease 0.0019 0.0213 0.0592
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0023 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0023 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0023 0.0014
Toxoplasma gondii ABC1 family protein 0.0035 0.0538 0.3276
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0023 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0538 0.0529
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0023 0.0051
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.4393 1
Echinococcus multilocularis 0.0143 0.2743 1
Mycobacterium ulcerans polyketide synthase 0.0027 0.0371 0.1585
Schistosoma mansoni furin-1 (S08 family) 0.0077 0.1397 0.4042
Brugia malayi hypothetical protein 0.0443 0.888 0.8879
Echinococcus multilocularis inositol monophosphatase 1 0.0081 0.147 0.5344
Echinococcus granulosus Furin 1 0.0042 0.0678 0.1946
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0142 0.0132
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0368 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.147 0.6946
Loa Loa (eye worm) hypothetical protein 0.0498 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0081 0.147 1
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0108 0.2023 0.7367
Loa Loa (eye worm) inositol-1 0.0081 0.147 0.1462
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0142 0.042
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0081 0.147 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0027 0.0371 0.0845
Loa Loa (eye worm) hypothetical protein 0.0035 0.0538 0.0529
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0339 0.0772
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0157 0.0534
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0023 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0538 0.1796
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.147 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0023 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0023 0.0014
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0116 0.0264
Loa Loa (eye worm) hypothetical protein 0.0443 0.888 0.8879
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0023 0.0014
Brugia malayi beta-lactamase family protein 0.0035 0.0538 0.0529
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0538 0.1224
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0852 0.5347
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0852 0.5347
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0852 0.2454
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0852 0.3532
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0371 0.0845
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0072 0.1297 0.2954
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0023 0.004
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.019 0.0769
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.2566 0.2559
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0852 0.5347
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0023 0.0014
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.147 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0852 0.2454
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0023 0.0014
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.147 1
Brugia malayi neuroendocrine convertase 1 precursor 0.0111 0.2098 0.209
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0213 0.179
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0023 0.004
Schistosoma mansoni inositol monophosphatase 0.0081 0.147 0.4254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0023 0.0014
Echinococcus multilocularis Furin 1 0.0042 0.0678 0.2445
Schistosoma mansoni thyroid hormone receptor 0.001 0.0023 0.004
Brugia malayi beta-lactamase 0.0035 0.0538 0.0529
Loa Loa (eye worm) hypothetical protein 0.0035 0.0538 0.0529
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.2566 0.2559
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0238 0.0653
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0213 0.0534
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.4503 0.4497
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0142 0.042
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0339 0.1543
Loa Loa (eye worm) runx1 0.0062 0.1099 0.1091
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0142 0.0484
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0081 0.147 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0067 0.0211
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0538 0.1539
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0023 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0538 0.1796
Brugia malayi MAP kinase sur-1 0.005 0.0852 0.0844
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0852 0.5543
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0067 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0023 0.004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0538 0.0529
Brugia malayi celfurPC protein 0.0143 0.2743 0.2736
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0323 0.0735
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0594 0.3797
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0081 0.147 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0852 0.3083
Mycobacterium ulcerans hypothetical protein 0.0035 0.0538 0.2862
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0023 0.0014
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0339 0.1339
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Giardia lamblia Furin precursor putative serine protease 0.0034 0.0523 0.3247
Schistosoma mansoni ap endonuclease 0.0019 0.0213 0.0592
Schistosoma mansoni coup transcription factor 0.001 0.0023 0.004
Loa Loa (eye worm) acyl carrier protein 0.0012 0.006 0.0051
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0339 0.0772
Brugia malayi ecdysteroid receptor 0.001 0.0023 0.0014
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0048 0.0801 0.0793
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0213 0.3137
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0538 0.2862
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0678 0.2568
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0594 0.1353
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0023 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0538 0.0529
Loa Loa (eye worm) proprotein convertase 2 0.0042 0.0678 0.0669
Brugia malayi isocitrate dehydrogenase 0.0016 0.0142 0.0132
Loa Loa (eye worm) hypothetical protein 0.0035 0.0538 0.0529
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0253 0.0784
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0023 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0538 0.1796
Onchocerca volvulus 0.0035 0.0538 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Trichomonas vaginalis hypothetical protein 0.0034 0.0523 0.1714
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0213 0.0744
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0678 0.2568
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0852 0.5347
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0108 0.2023 0.5864
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0678 0.2568
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0023 0.0014
Brugia malayi proprotein convertase 2 0.0111 0.2098 0.209
Giardia lamblia High cysteine membrane protein Group 2 0.0066 0.1168 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0538 0.3298
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0538 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0238 0.0567
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0142 0.0385
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0177 0.3443 1
Brugia malayi MH2 domain containing protein 0.0134 0.2566 0.2559
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0213 0.0534
Echinococcus multilocularis Protein lozenge 0.0062 0.1099 0.3987
Leishmania major hypothetical protein, conserved 0.0027 0.0368 0.1701
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0371 0.1585
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0323 0.0735
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.2023 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0538 0.2982
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0023 0.0051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0213 0.0203
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0253 0.0576
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0332 0.0323
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0023 0.004
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0027 0.0371 0.1585
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0213 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0538 0.1224
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0538 0.1224
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0193 0.044
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0014
Schistosoma mansoni nuclear hormone receptor 0.001 0.0023 0.004
Mycobacterium ulcerans polyketide synthase 0.0025 0.0339 0.1339
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0538 0.2982
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0852 0.5347
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0852 0.0844
Mycobacterium leprae Probable polyketide synthase Pks1 0.0027 0.0371 0.1826
Loa Loa (eye worm) hypothetical protein 0.0042 0.069 0.0681
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0594 0.3295
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0023 0.0014
Mycobacterium tuberculosis Conserved protein 0.0035 0.0538 0.1224
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0142 0.0323
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0538 0.1224
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0678 0.2568
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0023 0.0051
Echinococcus granulosus inositol monophosphatase 1 0.0081 0.147 0.4254
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0023 0.0051
Onchocerca volvulus Fatty acid synthase homolog 0.0046 0.0753 0.0732
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0024 0.0305 0.0296
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0678 0.2568
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0142 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0852 0.3532
Loa Loa (eye worm) hypothetical protein 0.0014 0.0112 0.0103
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0538 0.1933
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0368 0.1701
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0142 0.0484
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0238 0.0567
Mycobacterium ulcerans beta-lactamase 0.0035 0.0538 0.2862
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0023 0.0014
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0538 0.1224
Mycobacterium leprae Probable lipase LipE 0.0035 0.0538 0.3298
Mycobacterium ulcerans lipase LipD 0.0035 0.0538 0.2862
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0339 0.1339
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0023 0.004
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0852 0.3083
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0213 0.0203
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0142 0.0484
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0023 0.0014
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0072 0.1297 1
Echinococcus granulosus neuroendocrine convertase 2 0.0111 0.2098 0.6082
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0852 0.3532
Brugia malayi nuclear receptor NHR-88 0.001 0.0023 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Loa Loa (eye worm) hypothetical protein 0.0498 1 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0142 0.0484
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0023 0.004
Echinococcus multilocularis neuroendocrine convertase 2 0.0111 0.2098 0.764
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0852 0.5347
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0305 0.0296
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0034 0.0523 0.1714
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0371 0.2073
Loa Loa (eye worm) beta-lactamase 0.0035 0.0538 0.0529
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0142 0.0484
Brugia malayi beta-lactamase family protein 0.0035 0.0538 0.0529
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0023 0.004
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0034 0.0523 0.1714
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0523 0.1714
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0213 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0042 0.0678 0.2568
Brugia malayi hypothetical protein 0.0017 0.0174 0.0165
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0021 0.0245 0.0557
Loa Loa (eye worm) hypothetical protein 0.0069 0.1243 0.1235
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0213 0.0534
Trypanosoma brucei protein kinase, putative 0.005 0.0852 0.5347
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0368 0.205
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0023 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0852 0.3532
Schistosoma mansoni lozenge 0.0062 0.1099 0.3174
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0538 0.1224
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0538 0.1796
Toxoplasma gondii exonuclease III APE 0.0019 0.0213 0.0931
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0023 0.0014
Brugia malayi Inositol-1 0.0081 0.147 0.1462
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0027 0.0371 0.0845
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0368 0.5706
Brugia malayi steroid hormone receptor 0.001 0.0023 0.0014
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0368 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0538 0.1539
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0213 0.0372
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0023 0.0051
Onchocerca volvulus 0.0044 0.0721 0.07
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0538 0.1796
Trichomonas vaginalis esterase, putative 0.0035 0.0538 0.1796
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0024 0.0305 0.0694
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0023 0.004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0023 0.0014
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0339 0.1339
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0213 0.0592
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0339 0.1543
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0023 0.004
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0852 0.2454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0023 0.0014
Schistosoma mansoni inositol monophosphatase 0.0081 0.147 0.4254
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0538 0.2982
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0023 0.004
Leishmania major hypothetical protein, conserved 0.0035 0.0538 0.2982
Loa Loa (eye worm) hypothetical protein 0.0177 0.3443 0.3437
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.2023 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0538 0.0529
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0023 0.0014
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0027 0.0371 0.1826
Mycobacterium ulcerans thioesterase 0.0021 0.0253 0.068
Echinococcus granulosus furin 0.0177 0.3443 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0852 0.5347
Schistosoma mansoni thyroid hormone receptor 0.001 0.0023 0.004
Mycobacterium tuberculosis Conserved protein 0.0035 0.0538 0.1224
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0023 0.004
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0339 0.1339
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0538 0.2862
Loa Loa (eye worm) endoprotease bli-4 0.0177 0.3443 0.3437
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0023 0.0014
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0339 0.033
Brugia malayi hypothetical protein 0.0027 0.0368 0.0359
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.147 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0538 0.1224
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0339 0.0772
Brugia malayi endoprotease bli-4 precursor 0.0177 0.3443 0.3437
Onchocerca volvulus 0.0035 0.0538 0.0516
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0023 0.004
Brugia malayi nuclear hormone receptor 0.001 0.0023 0.0014
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0034 0.0523 0.1714
Mycobacterium tuberculosis Conserved protein 0.0035 0.0538 0.1224
Trichomonas vaginalis inositol monophosphatase, putative 0.0081 0.147 0.6946
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0538 0.1539
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0368 0.1701
Schistosoma mansoni hypothetical protein 0.0034 0.0523 0.1495
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0023 0.0014

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 6 nM Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins ChEMBL. 21757345

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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