TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 589.612 | Formula: C32H41BrN6
H donors: 0 H acceptors: 0 LogP: 7.81 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: N=c1ncc(cn1CCCCCCCCCCCCn1cc(cnc1=N)c1ccccc1)c1ccccc1.Br
InChi: 1S/C32H40N6.BrH/c33-31-35-23-29(27-17-11-9-12-18-27)25-37(31)21-15-7-5-3-1-2-4-6-8-16-22-38-26-30(24-36-32(38)34)28-19-13-10-14-20-28;/h9-14,17-20,23-26,33-34H,1-8,15-16,21-22H2;1H
InChiKey: HOAIAXHOKZKSMI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0412821	0.267179	0.26016
Trichomonas vaginalis	tubulin alpha chain, putative	0.0170992	0.0928077	0.241892
Echinococcus multilocularis	tubulin alpha 3 chain	0.0412821	0.267179	0.69637
Leishmania major	gamma-tubulin	0.0302207	0.187421	0.488488
Trypanosoma brucei	alpha tubulin, putative	0.0170992	0.0928077	0.222669
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0131215	0.0641259	0.146017
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Leishmania major	beta tubulin	0.0574384	0.383675	1
Brugia malayi	Tubulin alpha chain	0.0131215	0.0641259	0.0551611
Loa Loa (eye worm)	tubulin beta chain	0.0131215	0.0641259	0.0551611
Echinococcus granulosus	Tubulin alpha 1 chain	0.0412821	0.267179	0.69637
Brugia malayi	Tubulin alpha chain	0.0412821	0.267179	0.26016
Trypanosoma cruzi	tubulin gamma chain	0.0302207	0.187421	0.488488
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Trichomonas vaginalis	tubulin beta chain, putative	0.0574384	0.383675	1
Echinococcus multilocularis	tubulin epsilon chain	0.0302207	0.187421	0.488488
Trichomonas vaginalis	tubulin beta chain, putative	0.0170992	0.0928077	0.241892
Trypanosoma brucei	epsilon tubulin	0.0302207	0.187421	0.475518
Schistosoma mansoni	alpha tubulin	0.0412821	0.267179	0.688671
Schistosoma mansoni	alpha tubulin	0.0412821	0.267179	0.688671
Loa Loa (eye worm)	tubulin beta chain	0.0574384	0.383675	0.377771
Schistosoma mansoni	alpha tubulin	0.0412821	0.267179	0.688671
Trichomonas vaginalis	tubulin gamma chain, putative	0.0574384	0.383675	1
Trypanosoma cruzi	zeta tubulin, putative	0.0131215	0.0641259	0.167136
Schistosoma mansoni	tubulin subunit beta	0.0574384	0.383675	1
Echinococcus granulosus	tubulin subunit TubB	0.0412821	0.267179	0.69637
Plasmodium falciparum	tubulin delta chain, putative	0.0131215	0.0641259	0.146017
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Loa Loa (eye worm)	tubulin beta-2A chain	0.0574384	0.383675	0.377771
Trichomonas vaginalis	tubulin alpha chain, putative	0.0574384	0.383675	1
Leishmania major	beta tubulin	0.0574384	0.383675	1
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Schistosoma mansoni	tubulin subunit alpha	0.0412821	0.267179	0.688671
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Trypanosoma brucei	zeta tubulin	0.0131215	0.0641259	0.146017
Toxoplasma gondii	alpha tubulin TUBA1	0.0412821	0.267179	0.688671
Loa Loa (eye worm)	beta-tubulin	0.0574384	0.383675	0.377771
Leishmania major	beta tubulin	0.0574384	0.383675	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0574384	0.383675	0.377771
Echinococcus granulosus	tubulin delta chain	0.0131215	0.0641259	0.167136
Echinococcus granulosus	tubulin alpha chain	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0574384	0.383675	1
Trichomonas vaginalis	tubulin, putative	0.0574384	0.383675	1
Echinococcus multilocularis	tubulin alpha chain	0.0412821	0.267179	0.69637
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Loa Loa (eye worm)	alpha-tubulin	0.0412821	0.267179	0.26016
Entamoeba histolytica	tubulin alpha-1 chain	0.0412821	0.267179	0.688671
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Leishmania major	delta tubulin, putative	0.0131215	0.0641259	0.167136
Plasmodium falciparum	alpha tubulin 1	0.0412821	0.267179	0.688671
Brugia malayi	Tubulin alpha-2 chain	0.0412821	0.267179	0.26016
Trichomonas vaginalis	tubulin beta chain, putative	0.0412821	0.267179	0.69637
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0412821	0.267179	0.69637
Echinococcus multilocularis	tubulin beta 1 chain	0.0574384	0.383675	1
Echinococcus granulosus	tubulin subunit beta	0.0574384	0.383675	1
Plasmodium vivax	tubulin gamma chain, putative	0.0302207	0.187421	0.475518
Loa Loa (eye worm)	hypothetical protein	0.142914	1	1
Leishmania major	beta tubulin	0.0574384	0.383675	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0281607	0.172567	0.449773
Schistosoma mansoni	tubulin subunit gamma	0.0302207	0.187421	0.475518
Plasmodium falciparum	tubulin gamma chain	0.0302207	0.187421	0.475518
Trypanosoma brucei	epsilon tubulin	0.0302207	0.187421	0.475518
Leishmania major	beta tubulin	0.0574384	0.383675	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0412821	0.267179	0.69637
Echinococcus granulosus	Tubulin beta 2C chain	0.0574384	0.383675	1
Brugia malayi	alpha-tubulin	0.0412821	0.267179	0.26016
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Schistosoma mansoni	tubulin subunit alpha	0.0131215	0.0641259	0.146017
Loa Loa (eye worm)	tubulin alpha 2	0.0281607	0.172567	0.164641
Loa Loa (eye worm)	hypothetical protein	0.13913	0.972714	0.972453
Loa Loa (eye worm)	alpha-tubulin	0.0412821	0.267179	0.26016
Trypanosoma cruzi	epsilon tubulin, putative	0.0302207	0.187421	0.488488
Schistosoma mansoni	tubulin subunit beta	0.0574384	0.383675	1
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Schistosoma mansoni	tubulin subunit alpha	0.0412821	0.267179	0.688671
Brugia malayi	Tubulin beta-1 chain	0.0574384	0.383675	0.377771
Echinococcus granulosus	Tubulin beta 2C chain	0.0574384	0.383675	1
Echinococcus granulosus	tubulin epsilon chain	0.0302207	0.187421	0.488488
Mycobacterium ulcerans	cell division protein FtsZ	0.0131215	0.0641259	1
Leishmania major	beta tubulin	0.0574384	0.383675	1
Trypanosoma cruzi	Heat shock protein 83, putative	0.00554399	0.00948817	0.0247297
Toxoplasma gondii	beta-tubulin, putative	0.0574384	0.383675	1
Leishmania major	beta tubulin	0.0574384	0.383675	1
Leishmania major	beta tubulin	0.0574384	0.383675	1
Plasmodium vivax	tubulin alpha chain, putative	0.0412821	0.267179	0.688671
Echinococcus multilocularis	tubulin gamma 1 chain	0.0302207	0.187421	0.488488
Brugia malayi	Tubulin beta chain	0.0170992	0.0928077	0.0841177
Plasmodium falciparum	tubulin beta chain	0.0574384	0.383675	1
Trypanosoma brucei	zeta tubulin, putative	0.0131215	0.0641259	0.146017
Onchocerca volvulus		0.0170992	0.0928077	0.5
Echinococcus granulosus	tubulin beta 1 chain	0.0574384	0.383675	1
Loa Loa (eye worm)	tubulin alpha 2	0.0281607	0.172567	0.164641
Brugia malayi	Tubulin gamma chain	0.0302207	0.187421	0.179637
Trichomonas vaginalis	tubulin, putative	0.0170992	0.0928077	0.241892
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0412821	0.267179	0.69637
Echinococcus multilocularis	tubulin alpha 3 chain	0.0412821	0.267179	0.69637
Loa Loa (eye worm)	tubulin alpha chain	0.0412821	0.267179	0.26016
Echinococcus multilocularis	beta tubulin	0.0574384	0.383675	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0574384	0.383675	1
Plasmodium falciparum	alpha tubulin 2	0.0412821	0.267179	0.688671
Brugia malayi	Cell division protein ftsZ	0.0131215	0.0641259	0.0551611
Trichomonas vaginalis	tubulin, putative	0.0131215	0.0641259	0.167136
Trichomonas vaginalis	tubulin gamma chain, putative	0.0302207	0.187421	0.488488
Trypanosoma brucei	alpha tubulin	0.0412821	0.267179	0.688671
Echinococcus granulosus	heat shock protein 90	0.00554399	0.00948817	0.0247297
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0281607	0.172567	0.164641
Echinococcus granulosus	heat shock protein	0.00554399	0.00948817	0.0247297
Mycobacterium leprae	cell division protein FtsZ	0.0131215	0.0641259	1
Leishmania major	epsilon tubulin, putative	0.0302207	0.187421	0.488488
Echinococcus multilocularis	Tubulin beta 2C chain	0.0574384	0.383675	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0412821	0.267179	0.688671
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Loa Loa (eye worm)	BEN-1 protein	0.0574384	0.383675	0.377771
Loa Loa (eye worm)	hypothetical protein	0.0281607	0.172567	0.164641
Echinococcus multilocularis	tubulin alpha	0.0302207	0.187421	0.488488
Trypanosoma brucei	epsilon tubulin	0.0302207	0.187421	0.475518
Leishmania major	beta tubulin	0.0574384	0.383675	1
Schistosoma mansoni	tubulin subunit beta	0.0131215	0.0641259	0.146017
Leishmania major	beta tubulin	0.0574384	0.383675	1
Echinococcus multilocularis	heat shock protein	0.00554399	0.00948817	0.0247297
Giardia lamblia	Beta tubulin	0.0574384	0.383675	1
Entamoeba histolytica	tubulin gamma chain	0.0302207	0.187421	0.475518
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Schistosoma mansoni	tubulin subunit alpha	0.0412821	0.267179	0.688671
Plasmodium vivax	tubulin beta chain, putative	0.0574384	0.383675	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0574384	0.383675	1
Echinococcus granulosus	tubulin alpha chain	0.0412821	0.267179	0.69637
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Trypanosoma cruzi	epsilon tubulin, putative	0.0302207	0.187421	0.488488
Trypanosoma brucei	beta tubulin	0.0574384	0.383675	1
Leishmania major	beta tubulin	0.0574384	0.383675	1
Echinococcus granulosus	beta tubulin	0.0574384	0.383675	1
Echinococcus granulosus	alpha tubulin	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin beta chain, putative	0.0412821	0.267179	0.69637
Schistosoma mansoni	tubulin subunit epsilon	0.0302207	0.187421	0.475518
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Trypanosoma cruzi	tubulin delta chain	0.0131215	0.0641259	0.167136
Trypanosoma cruzi	heat shock protein 85, putative	0.00554399	0.00948817	0.0247297
Echinococcus multilocularis	tubulin alpha chain	0.0412821	0.267179	0.69637
Loa Loa (eye worm)	hypothetical protein	0.0412821	0.267179	0.26016
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0574384	0.383675	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0131215	0.0641259	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0302207	0.187421	0.475518
Echinococcus multilocularis	tubulin delta chain	0.0131215	0.0641259	0.167136
Treponema pallidum	cell division protein FtsZ	0.0131215	0.0641259	1
Giardia lamblia	Alpha-tubulin	0.0412821	0.267179	0.69637
Trypanosoma cruzi	beta tubulin, putative	0.0574384	0.383675	1
Echinococcus granulosus	beta tubulin	0.0574384	0.383675	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin beta chain, putative	0.0412821	0.267179	0.69637
Schistosoma mansoni	tubulin subunit beta	0.0574384	0.383675	1
Trypanosoma brucei	beta tubulin	0.0302207	0.187421	0.475518
Echinococcus multilocularis	tubulin subunit TubB	0.0412821	0.267179	0.69637
Loa Loa (eye worm)	tubulin gamma chain	0.0302207	0.187421	0.179637
Loa Loa (eye worm)	tubulin alpha 2	0.0110614	0.0492719	0.0401648
Entamoeba histolytica	tubulin family protein	0.0574384	0.383675	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0302207	0.187421	0.475518
Echinococcus granulosus	tubulin alpha chain	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin gamma chain, putative	0.0131215	0.0641259	0.167136
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0412821	0.267179	0.69637
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Echinococcus multilocularis	hypothetical protein	0.0412821	0.267179	0.69637
Leishmania major	beta tubulin	0.0574384	0.383675	1
Trypanosoma brucei	tubulin gamma chain	0.0302207	0.187421	0.475518
Brugia malayi	Tubulin alpha-2 chain	0.0412821	0.267179	0.26016
Echinococcus granulosus	tubulin beta 4A class IVa	0.0574384	0.383675	1
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0131215	0.0641259	0.167136
Trypanosoma brucei	alpha tubulin	0.0412821	0.267179	0.688671
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Leishmania major	beta tubulin	0.0574384	0.383675	1
Brugia malayi	tubulin alpha-2 chain	0.0412821	0.267179	0.26016
Leishmania major	beta tubulin	0.0574384	0.383675	1
Giardia lamblia	Gamma tubulin	0.0302207	0.187421	0.488488
Loa Loa (eye worm)	BEN-1 protein	0.0574384	0.383675	0.377771
Trypanosoma brucei	beta tubulin	0.0574384	0.383675	1
Giardia lamblia	Heat shock protein HSP 90-alpha	0.00554399	0.00948817	0.0247297
Echinococcus multilocularis	tubulin alpha 1C chain	0.0412821	0.267179	0.69637
Trypanosoma cruzi	alpha tubulin, putative	0.0412821	0.267179	0.69637
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Giardia lamblia	Beta tubulin	0.0574384	0.383675	1
Leishmania major	beta tubulin	0.0574384	0.383675	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0412821	0.267179	0.688671
Echinococcus granulosus	tubulin alpha 1C chain	0.0412821	0.267179	0.69637
Leishmania major	zeta tubulin, putative	0.0131215	0.0641259	0.167136
Echinococcus granulosus	peroxisome assembly protein 26	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin alpha chain, putative	0.0302207	0.187421	0.488488
Trypanosoma cruzi	heat shock protein 85, putative	0.00554399	0.00948817	0.0247297
Echinococcus granulosus	tubulin alpha chain	0.0412821	0.267179	0.69637
Entamoeba histolytica	tubulin family protein	0.0574384	0.383675	1
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Loa Loa (eye worm)	tubulin alpha chain	0.0412821	0.267179	0.26016
Brugia malayi	tubulin alpha chain - mouse	0.0412821	0.267179	0.26016
Loa Loa (eye worm)	hypothetical protein	0.0241829	0.143885	0.135684
Echinococcus granulosus	tubulin alpha 1C chain	0.0412821	0.267179	0.69637
Leishmania major	beta tubulin	0.0574384	0.383675	1
Echinococcus multilocularis	tubulin alpha chain	0.0412821	0.267179	0.69637
Trypanosoma brucei	beta tubulin	0.0574384	0.383675	1
Echinococcus multilocularis	beta tubulin	0.0574384	0.383675	1
Giardia lamblia	Epsilon tubulin	0.0131215	0.0641259	0.167136
Trichomonas vaginalis	tubulin gamma chain, putative	0.0302207	0.187421	0.488488
Echinococcus multilocularis	tubulin alpha 1C chain	0.0412821	0.267179	0.69637
Trypanosoma brucei	alpha tubulin	0.0412821	0.267179	0.688671
Echinococcus granulosus	tubulin alpha chain	0.0412821	0.267179	0.69637
Schistosoma mansoni	tubulin subunit beta	0.0574384	0.383675	1
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Leishmania major	beta tubulin	0.0574384	0.383675	1
Trichomonas vaginalis	conserved hypothetical protein	0.0131215	0.0641259	0.167136
Trypanosoma cruzi	heat shock protein 90, putative	0.00554399	0.00948817	0.0247297
Leishmania major	beta tubulin	0.0574384	0.383675	1
Trypanosoma cruzi	tubulin delta chain	0.0131215	0.0641259	0.167136
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0241829	0.143885	0.375018
Toxoplasma gondii	beta-1 tubulin, putative	0.0574384	0.383675	1
Echinococcus granulosus	tubulin alpha	0.0302207	0.187421	0.488488
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Brugia malayi	beta-tubulin, identical	0.0574384	0.383675	0.377771
Trypanosoma brucei	alpha tubulin	0.0412821	0.267179	0.688671
Plasmodium vivax	tubulin alpha chain, putative	0.0412821	0.267179	0.688671
Echinococcus multilocularis	Tubulin beta 2C chain	0.0574384	0.383675	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0412821	0.267179	0.69637
Loa Loa (eye worm)	tubulin beta-4 chain	0.0574384	0.383675	0.377771
Brugia malayi	Tubulin beta chain	0.0131215	0.0641259	0.0551611
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0241829	0.143885	0.135684
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Echinococcus multilocularis	Tubulin beta 2C chain	0.0574384	0.383675	1
Schistosoma mansoni	tubulin subunit beta	0.0574384	0.383675	1
Schistosoma mansoni	tubulin subunit beta	0.0574384	0.383675	1
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Toxoplasma gondii	beta tubulin	0.0574384	0.383675	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin beta chain, putative	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin beta chain, putative	0.0412821	0.267179	0.69637
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Echinococcus granulosus	tubulin alpha 3 chain	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0170992	0.0928077	0.241892
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0131215	0.0641259	0.167136
Echinococcus multilocularis	Tubulin beta 2C chain	0.0574384	0.383675	1
Trypanosoma brucei	tubulin delta chain	0.0131215	0.0641259	0.146017
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0412821	0.267179	0.69637
Echinococcus multilocularis	tubulin alpha chain	0.0412821	0.267179	0.69637
Echinococcus granulosus	Tubulin beta 2C chain	0.0574384	0.383675	1
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Giardia lamblia	Delta tubulin	0.0131215	0.0641259	0.167136
Trypanosoma cruzi	zeta tubulin, putative	0.0131215	0.0641259	0.167136
Echinococcus granulosus	tubulin gamma 1 chain	0.0302207	0.187421	0.488488
Trichomonas vaginalis	tubulin, putative	0.0170992	0.0928077	0.241892
Trichomonas vaginalis	conserved hypothetical protein	0.0131215	0.0641259	0.167136
Trypanosoma brucei	beta tubulin	0.0574384	0.383675	1
Giardia lamblia	Beta tubulin	0.0574384	0.383675	1
Leishmania major	alpha tubulin	0.0412821	0.267179	0.69637
Plasmodium vivax	delta tubulin, putative	0.0131215	0.0641259	0.146017
Giardia lamblia	Alpha-tubulin	0.0412821	0.267179	0.69637
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.142914	1	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0131215	0.0641259	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0170992	0.0928077	0.241892
Trichomonas vaginalis	heat shock protein, putative	0.00554399	0.00948817	0.0247297
Echinococcus multilocularis	peroxisome assembly protein 26	0.0412821	0.267179	0.69637
Trypanosoma cruzi	heat shock protein 85, putative	0.00554399	0.00948817	0.0247297
Echinococcus granulosus	Tubulin beta 2C chain	0.0574384	0.383675	1
Echinococcus multilocularis	tubulin alpha chain	0.0412821	0.267179	0.69637
Trichomonas vaginalis	tubulin alpha chain, putative	0.0170992	0.0928077	0.241892
Leishmania major	heat shock protein 83-1	0.00554399	0.00948817	0.0247297
Echinococcus multilocularis	tubulin subunit beta	0.0574384	0.383675	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0302207	0.187421	0.475518
Echinococcus multilocularis	heat shock protein 90	0.00554399	0.00948817	0.0247297
Echinococcus granulosus	tubulin alpha 3 chain	0.0412821	0.267179	0.69637
Schistosoma mansoni	tubulin subunit delta	0.0131215	0.0641259	0.146017
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0131215	0.0641259	0.146017
Echinococcus multilocularis	Tubulin beta 2C chain	0.0574384	0.383675	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0412821	0.267179	0.69637

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 12.3 nM	Antimalarial activity against Plasmodium falciparum Nigerian in human erythrocytes after 48 hrs	ChEMBL.	18004799

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	18004799

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL536528

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1032520