Detailed information for compound 1033023

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 282.249 | Formula: C12H14N2O6
  • H donors: 1 H acceptors: 4 LogP: 0.81 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CNC(=O)OCOC(=O)c1cccnc1
  • InChi: 1S/C12H14N2O6/c1-2-18-10(15)7-14-12(17)20-8-19-11(16)9-4-3-5-13-6-9/h3-6H,2,7-8H2,1H3,(H,14,17)
  • InChiKey: QEDOAYCPYGKORW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0015 0.0004
Brugia malayi G protein-coupled receptor 0.0019 0.0015 0.0015
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0055 0.0349
Schistosoma mansoni amine GPCR 0.0019 0.0015 0.0018
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0474 0.0522
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0017 0.0005
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0072 0.0526
Schistosoma mansoni cpg binding protein 0.0121 0.0567 0.0648
Echinococcus multilocularis transcription factor eb 0.011 0.0506 0.0565
Onchocerca volvulus 0.002 0.0017 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0015 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0052 0.0141
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0015 0.0004
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.003 0.002
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0258 0.0312
Schistosoma mansoni opsin-like receptor 0.0019 0.0015 0.0018
Brugia malayi Melatonin receptor type 1A 0.0019 0.0015 0.0015
Brugia malayi Dopamine receptor 0.0019 0.0015 0.0015
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.003 0.0121
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0015 0.0018
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.002 0.0017 0.0016
Leishmania major importin beta-1 subunit, putative 0.0024 0.0042 0.0037
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0016
Schistosoma mansoni cpg binding protein 0.0121 0.0567 0.0648
Loa Loa (eye worm) LGC-31 protein 0.002 0.0017 0.0009
Echinococcus granulosus serotonin receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0221 0.1114 0.1386
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.1812 0.6437
Echinococcus granulosus glutamate receptor NMDA 0.0078 0.0334 0.0367
Chlamydia trachomatis protoporphyrinogen oxidase 0.0221 0.1114 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0055 0.0372
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0089 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0133 0.1064
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0418 0.0457
Loa Loa (eye worm) CXXC zinc finger family protein 0.0114 0.0532 0.0656
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis 0.0221 0.1114 0.126
Schistosoma mansoni amine oxidase 0.0221 0.1114 0.1272
Loa Loa (eye worm) Smad1 0.0033 0.0089 0.01
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0016
Schistosoma mansoni glutamate receptor kainate 0.004 0.0126 0.0144
Schistosoma mansoni neuropeptide receptor 0.0019 0.0015 0.0018
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0015 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.12 0.1358
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0017 0.0005
Schistosoma mansoni alpha-glucosidase 0.0145 0.0698 0.0796
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.005 0.0058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0015 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.12 0.1358
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0457 0.0522
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0052 0.0141
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0015 0.0015
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0015 0.0004
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0167 0.0177
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0114 0.0362
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0015 0.0015
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0114 0.8506
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0015 0.0004
Schistosoma mansoni opsin-like receptor 0.0019 0.0015 0.0018
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0457 0.0522
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0258 0.0319
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.12 0.1358
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.002 0.0017 0.0009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0221 0.1114 0.125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.005 0.0136
Brugia malayi G-protein coupled receptor 0.0019 0.0015 0.0015
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0015 0.0008
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0015 0.0018
Brugia malayi TAR-binding protein 0.0064 0.0258 0.0319
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0221 0.1114 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0217 0.1088 0.9438
Echinococcus multilocularis neuropeptide receptor A26 0.096 0.5128 0.5849
Trichomonas vaginalis ran, putative 0.0022 0.003 0.0062
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.002 0.0017 0.0005
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0015 0.0008
Echinococcus multilocularis serotonin receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.002 0.0017 0.0005
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0031 0.0023
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0015 0.0004
Echinococcus granulosus nmda type glutamate receptor 0.0085 0.0374 0.0414
Schistosoma mansoni hypothetical protein 0.0116 0.054 0.0616
Entamoeba histolytica hypothetical protein 0.0024 0.0042 0.2466
Trichomonas vaginalis glucosylceramidase, putative 0.0533 0.2808 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.12 0.137
Loa Loa (eye worm) hypothetical protein 0.0109 0.0503 0.062
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0015 0.0004
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0019
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0052 0.0141
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0015 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0258 0.0295
Echinococcus granulosus glutamate receptor 2 0.0047 0.0167 0.0177
Entamoeba histolytica SWIRM domain protein 0.0041 0.0131 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0604 0.3192 0.3993
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0016
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.003 0.0152
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0019
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.005 0.018 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0015 0.0008
Plasmodium falciparum glutathione reductase 0.0041 0.0133 0.1064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0366 0.1899 0.2376
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0089 0.0087
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0015 0.0004
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0133 0.0133
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0258 0.0295
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0015 0.0018
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.002 0.0017 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0052 0.0141
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0015 0.0004
Schistosoma mansoni hypothetical protein 0.0713 0.3784 0.4321
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0015 0.0004
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0015 0.0004
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0072 0.0075
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.005 0.018 0.1494
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0167 0.0177
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.0825 0.0929
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.002 0.0017 0.0005
Echinococcus granulosus neuropeptide receptor 0.0019 0.0015 0.0004
Plasmodium falciparum thioredoxin reductase 0.0041 0.0133 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0131 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0114 0.0127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0243 0.1228 0.1403
Leishmania major UDP-galactopyranose mutase 0.0221 0.1114 0.1383
Schistosoma mansoni amine GPCR 0.0019 0.0015 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.1812 0.6437
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0015 0.0008
Trypanosoma brucei glucosidase, putative 0.0037 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0116 0.054 0.0666
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0042 0.0037
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0167 0.0177
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0114 0.0889
Schistosoma mansoni opsin-like receptor 0.0019 0.0015 0.0018
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0016 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0052 0.0141
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.002 0.0017 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.1812 0.6437
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0126 0.0144
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0041 0.0131 0.0153
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0065 0.006
Brugia malayi MH2 domain containing protein 0.0481 0.2522 0.3158
Giardia lamblia hypothetical protein 0.0041 0.0131 1
Echinococcus granulosus nmda type glutamate receptor 0.0092 0.0413 0.0458
Echinococcus multilocularis sex peptide receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0016 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0366 0.1899 0.2376
Echinococcus granulosus somatostatin receptor 0.0019 0.0015 0.0004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0116 0.054 0.0603
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Brugia malayi MH1 domain containing protein 0.0018 0.0009 0.0007
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.018 0.0211
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.011 0.0506 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0052 0.0141
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0221 0.1114 1
Brugia malayi Serotonin receptor 0.0019 0.0015 0.0015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0457 0.0522
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.002 0.0017 0.0005
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0533 0.2808 1
Echinococcus granulosus tm gpcr rhodopsin 0.0574 0.3027 0.3447
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0221 0.1114 0.1099
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0221 0.1114 0.1272
Brugia malayi hypothetical protein 0.0026 0.0055 0.0064
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0042 0.0105
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0015 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0052 0.0141
Entamoeba histolytica Ran family GTPase 0.0022 0.003 0.1452
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.1485 0.7978 1
Echinococcus multilocularis isocitrate dehydrogenase 0.005 0.018 0.0192
Schistosoma mansoni hypothetical protein 0.0116 0.054 0.0616
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0015 0.0018
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0228 0.1152 1
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0015 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0114 0.0362
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.005 0.0043
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0015 0.0008
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.002 0.0017 0.0009
Echinococcus multilocularis dnaJ subfamily B 0.1629 0.8758 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0167 0.0177
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0017 0.0005
Brugia malayi excitatory GABA receptor EXP-1A 0.002 0.0017 0.0016
Echinococcus granulosus g protein coupled receptor 0.0019 0.0015 0.0004
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.005 0.018 0.0206
Entamoeba histolytica hypothetical protein 0.0026 0.005 0.318
Mycobacterium tuberculosis Probable reductase 0.0093 0.0418 0.0457
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.002 0.0017 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0369 0.1914 0.6803
Echinococcus granulosus cpg binding protein 0.0121 0.0567 0.0635
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0019
Brugia malayi MH2 domain containing protein 0.0033 0.0089 0.0107
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0015 0.0004
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.0018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0016 0.0005
Leishmania major C-8 sterol isomerase-like protein 0.1485 0.7978 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.1114 0.1386
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1615 0.8682 0.9914
Schistosoma mansoni neuropeptide receptor 0.0019 0.0015 0.0018
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0167 0.0177
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.002 0.0017 0.0005
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0457 0.3906
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.1812 0.6437
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0089 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0052 0.0141
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0012 0.0011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0017 0.0016
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0258 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0052 0.0141
Schistosoma mansoni hypothetical protein 0.1629 0.8758 1
Brugia malayi Melibiase family protein 0.0067 0.0275 0.0341
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0016
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1857 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0237 0.12 0.1494
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.0474 0.0522
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0221 0.1114 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.002 0.0017 0.0016
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0016 0.0016
Echinococcus granulosus smad 0.0033 0.0089 0.0087
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0016 0.5
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0015 0.0015
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0015 0.0018
Echinococcus granulosus orexin receptor type 2 0.0019 0.0015 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0042 0.0105
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.005 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0015 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0015 0.0018
Trichomonas vaginalis helicase, putative 0.0026 0.0052 0.0141
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0258 0.0295
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0015 0.0008
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0017 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0052 0.0141
Loa Loa (eye worm) hypothetical protein 0.0174 0.0858 0.1065
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0418 0.0457
Echinococcus granulosus neuropeptide s receptor 0.096 0.5128 0.5849
Schistosoma mansoni ATP-binding cassette transporter 0.004 0.0126 0.0144
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0167 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Schistosoma mansoni smad1 5 8 and 0.0033 0.0089 0.0101
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.003 0.0026
Brugia malayi N-terminal motif family protein 0.0174 0.0858 0.1072
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0065 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0015 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0052 0.0141
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0825 0.0929
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0015 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0533 0.2808 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1485 0.7978 1
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.003 0.0121
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.002 0.0017 0.0009
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0015 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0533 0.2808 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0055 0.0349
Brugia malayi Dopamine receptor protein 1 0.0019 0.0015 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0114 0.0127
Echinococcus granulosus GPCR family 2 0.0116 0.054 0.0603
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.018 0.0192
Brugia malayi Serotonin receptor 0.0019 0.0015 0.0015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.0825 0.1023
Trypanosoma brucei trypanothione reductase 0.0041 0.0133 0.0152
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0087 0.0086
Brugia malayi MH2 domain containing protein 0.0033 0.0089 0.0107
Echinococcus granulosus neuropeptide receptor A26 0.096 0.5128 0.5849
Brugia malayi putative neuropeptide receptor 0.0019 0.0015 0.0015
Schistosoma mansoni alpha-glucosidase 0.0145 0.0698 0.0796
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0457 0.0522
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0016 0.034
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) latrophilin receptor protein 2 0.0116 0.054 0.0666
Echinococcus multilocularis glutamate receptor NMDA 0.0078 0.0334 0.0367
Leishmania major GTP-binding protein, putative 0.0022 0.003 0.0022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.1633 0.2038
Echinococcus multilocularis nAChR subunit 0.002 0.0017 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.025 0.127 0.1587
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.002 0.0017 0.0005
Brugia malayi SWIRM domain containing protein 0.0041 0.0131 0.016
Loa Loa (eye worm) ACC-1 protein 0.002 0.0017 0.0009
Schistosoma mansoni ran 0.0022 0.003 0.0034
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0017 0.0005
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0015 0.0015
Brugia malayi AKH receptor 0.0019 0.0015 0.0015
Onchocerca volvulus 0.002 0.0017 0.0004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0237 0.12 0.15
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0015 0.0004
Toxoplasma gondii thioredoxin reductase 0.0041 0.0133 0.106
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0015 0.0004
Onchocerca volvulus 0.002 0.0017 0.0004
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0015 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0114 0.0362
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.003 0.0022
Loa Loa (eye worm) transcription factor SMAD2 0.0481 0.2522 0.3153
Schistosoma mansoni histamine h1 receptor 0.0019 0.0015 0.0018
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0017 0.0016
Brugia malayi Isocitrate dehydrogenase 0.005 0.018 0.0222
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0131 0.0426
Brugia malayi Glutamate receptor 2 precursor 0.004 0.0126 0.0153
Echinococcus multilocularis glycine receptor subunit beta 0.002 0.0017 0.0005
Schistosoma mansoni adenoreceptor 0.0019 0.0015 0.0018
Echinococcus granulosus hypothetical protein 0.0019 0.0015 0.0004
Brugia malayi G-protein coupled receptor 0.0019 0.0015 0.0015
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0055 0.0349
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0275 0.0314
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0114 0.0116
Brugia malayi Cation transporter family protein 0.002 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis serotonin receptor 0.0019 0.0015 0.0004
Schistosoma mansoni SWI/SNF complex-related 0.0041 0.0131 0.015
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0016 0.0005
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0015 0.0004
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0017 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Brugia malayi Cation transporter family protein 0.002 0.0017 0.0016
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0221 0.1114 1
Brugia malayi Smad1 0.0033 0.0089 0.0107
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0016 0.0014
Loa Loa (eye worm) ACC-1 protein 0.002 0.0017 0.0009
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0016
Brugia malayi GnHR receptor homolog 0.0019 0.0015 0.0015
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0015 0.0004
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0167 0.0177
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0089 0.0087
Loa Loa (eye worm) hypothetical protein 0.0366 0.1899 0.2371
Schistosoma mansoni biogenic amine receptor 0.0019 0.0015 0.0018
Echinococcus granulosus lysine specific histone demethylase 1A 0.0604 0.3192 0.3635
Echinococcus granulosus geminin 0.0713 0.3784 0.4313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.005 0.018 0.0192
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0457 0.0509
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0016 0.5
Schistosoma mansoni importin beta-1 0.003 0.0072 0.0082
Schistosoma mansoni biogenic amine receptor 0.0019 0.0015 0.0018
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0136 0.0141
Schistosoma mansoni myosin xvIII 0.0019 0.0015 0.0018
Onchocerca volvulus 0.002 0.0017 0.0004
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0015 0.0004
Trypanosoma cruzi UDP-galactopyranose mutase 0.0221 0.1114 0.1383
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0015 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.12 0.1358
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0015 0.0018
Brugia malayi larval opioid receptor 0.0019 0.0015 0.0015
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0015 0.0018
Entamoeba histolytica hypothetical protein 0.0041 0.0131 1
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0015 0.0018
Brugia malayi neuropeptide F receptor 0.0019 0.0015 0.0015
Echinococcus granulosus serine protein kinase ATM 0.0026 0.005 0.0043
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0015 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0114 0.0362
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Brugia malayi Importin beta-1 subunit 0.003 0.0072 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0035 0.0103 0.0104
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0089 0.01
Brugia malayi Dopamine receptor protein 2 0.0019 0.0015 0.0015
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0015 0.0004
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0089 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.1812 0.6437
Mycobacterium ulcerans dehydrogenase 0.0221 0.1114 0.1099
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0017 0.0005
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.002 0.0017 0.0005
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Brugia malayi SWIRM domain containing protein 0.0645 0.3412 0.4274
Echinococcus multilocularis nmda type glutamate receptor 0.0092 0.0413 0.0458
Echinococcus granulosus transcription factor eb 0.011 0.0506 0.0565
Loa Loa (eye worm) glutamate receptor 1 0.004 0.0126 0.0146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis glycine receptor subunit alpha 1 0.002 0.0017 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.1812 0.6437
Brugia malayi MH1 domain containing protein 0.0033 0.0089 0.0107
Echinococcus granulosus g protein coupled receptor 0.0019 0.0015 0.0004
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0017 0.0016
Toxoplasma gondii SWIRM domain-containing protein 0.0041 0.0131 0.1046
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0116 0.054 0.0603
Schistosoma mansoni glutamate receptor kainate 0.004 0.0126 0.0144
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0016 0.0005
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0015 0.0018
Schistosoma mansoni amine GPCR 0.0019 0.0015 0.0018
Onchocerca volvulus 0.0114 0.0532 0.1521
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0015 0.0004
Schistosoma mansoni amine GPCR 0.0019 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1485 0.7978 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0015 0.0018
Schistosoma mansoni hypothetical protein 0.025 0.127 0.145
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0015 0.0008
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0015 0.0004
Echinococcus multilocularis smad 0.0033 0.0089 0.0087
Brugia malayi CXXC zinc finger family protein 0.0114 0.0532 0.0663
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0574 0.3027 0.3447
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0012 0.0004
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.002 0.0017 0.0019
Brugia malayi ORL1-like opioid receptor 0.0019 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0052 0.0141
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.002 0.0017 0.0005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.003 0.0022
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0418 0.0457
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0015 0.0004
Schistosoma mansoni neuropeptide receptor 0.0019 0.0015 0.0018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0035 0.0103 0.0104
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.005 0.0057
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0012 0.0014
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0015 0.0018
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0457 0.0509
Brugia malayi sulfakinin receptor protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0604 0.3192 0.3993
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0055 0.0053
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0012 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0221 0.1114 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0015 0.0004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0015 0.0018
Schistosoma mansoni glutamate receptor NMDA 0.0094 0.0422 0.0482
Leishmania major trypanothione reductase 0.0041 0.0133 0.0152
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Trypanosoma cruzi UDP-galactopyranose mutase 0.0221 0.1114 0.1383
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0016 0.0005
Schistosoma mansoni hypothetical protein 0.0317 0.1633 0.1865
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.0825 0.0929
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0015 0.0004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0136 0.0141
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0072 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0055 0.0057
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0041 0.0131 0.0136
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.002 0.0017 0.0005
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0015 0.0008
Schistosoma mansoni glutamate receptor kainate 0.004 0.0126 0.0144
Schistosoma mansoni ap endonuclease 0.0019 0.0016 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0052 0.0141
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.0825 0.103
Plasmodium falciparum protoporphyrinogen oxidase 0.0221 0.1114 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0052 0.0141
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.0018
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0041 0.0131 0.0136
Toxoplasma gondii exonuclease III APE 0.0019 0.0016 0.0036
Echinococcus multilocularis geminin 0.0713 0.3784 0.4313
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0759 0.4034 0.5051
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0114 0.0116
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0258 0.0281
Schistosoma mansoni neuropeptide receptor 0.0019 0.0015 0.0018
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.018 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0015 0.0018
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0114 0.0127
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Schistosoma mansoni cpg binding protein 0.0114 0.0532 0.0608
Brugia malayi RE15519p 0.0019 0.0015 0.0015
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0017 0.0005
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.018 0.1475
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0015 0.0004
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1636 0.8797 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.002 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0031 0.0027
Brugia malayi hypothetical protein 0.0221 0.1114 0.1392
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0015 0.0004
Echinococcus multilocularis GPCR, family 2 0.0116 0.054 0.0603
Brugia malayi Latrophilin receptor protein 2 0.0116 0.054 0.0672
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.002 0.0017 0.0009
Brugia malayi amine oxidase, flavin-containing family protein 0.0262 0.1335 0.1669
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0015 0.0018
Onchocerca volvulus Glucosylceramidase homolog 0.035 0.1812 0.5289
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0015 0.0004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0065 0.006
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0457 0.0509
Plasmodium falciparum importin beta, putative 0.003 0.0072 0.0509
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0221 0.1114 1
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) glutamate receptor 2 0.004 0.0126 0.0146
Echinococcus granulosus g protein coupled receptor 0.0019 0.0015 0.0004
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.002 0.0017 0.0005
Toxoplasma gondii histone lysine-specific demethylase 0.0221 0.1114 0.9668
Trichomonas vaginalis glucosylceramidase, putative 0.0369 0.1914 0.6803
Schistosoma mansoni hypothetical protein 0.0116 0.054 0.0616
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.1812 0.6437
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.002 0.0017 0.0016
Schistosoma mansoni smad1 5 8 and 0.0033 0.0089 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Loa Loa (eye worm) glutathione reductase 0.0041 0.0133 0.0155
Echinococcus multilocularis importin subunit beta 1 0.003 0.0072 0.0068
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.0474 0.0522
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0042 0.0105
Mycobacterium ulcerans oxidoreductase 0.0221 0.1114 0.1099
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Echinococcus granulosus glutamate receptor 2 0.0032 0.0087 0.0086
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.002 0.0017 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0533 0.2808 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0114 0.0362
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0019
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.018 0.1475
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0604 0.3192 0.3635
Schistosoma mansoni smad 0.0033 0.0089 0.0101
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0114 0.0362
Echinococcus granulosus neuropeptide receptor 0.0019 0.0015 0.0004
Plasmodium vivax importin-beta 2, putative 0.003 0.0072 0.0509
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0015 0.0015
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0015 0.0015
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0604 0.3192 0.3644
Plasmodium vivax glutathione reductase, putative 0.0041 0.0133 0.1064
Echinococcus multilocularis Smad4 0.0033 0.0089 0.0087
Loa Loa (eye worm) hypothetical protein 0.003 0.0072 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0015 0.0018
Toxoplasma gondii FATC domain-containing protein 0.0026 0.005 0.0333
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0015 0.0004
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0065 0.006
Schistosoma mansoni Smad4 0.0033 0.0089 0.0101
Trypanosoma brucei C-8 sterol isomerase, putative 0.1485 0.7978 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0015 0.0004
Echinococcus granulosus sex peptide receptor 0.0019 0.0015 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0052 0.0141
Brugia malayi Cation transporter family protein 0.002 0.0017 0.0016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0116 0.054 0.0603
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0015 0.0004
Onchocerca volvulus Putative nachr subunit 0.002 0.0017 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0052 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0258 0.0295
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0101 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0015 0.0018
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0015 0.0004
Echinococcus multilocularis snurportin 1 0.0317 0.1633 0.1853
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.005 0.018 0.1494
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0017 0.0019
Echinococcus granulosus Smad4 0.0033 0.0089 0.0087
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0067 0.0275 0.0334
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0015 0.0004
Onchocerca volvulus 0.0645 0.3412 1
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0015 0.0004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0116 0.054 0.0603
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.002 0.0017 0.0016
Schistosoma mansoni ran 0.0022 0.003 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0015 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0114 0.0362
Echinococcus granulosus lysine specific histone demethylase 1A 0.0221 0.1114 0.126
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0167 0.0177
Schistosoma mansoni hypothetical protein 0.0116 0.054 0.0616
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0114 0.0131
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0012 0.0004
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0126 0.0144
Echinococcus granulosus glycine receptor subunit alpha 1 0.002 0.0017 0.0005
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0174 0.0858 0.2481
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0015 0.0018
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.0474 0.0813
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0275 0.0941
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.005 0.0048
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0133 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Leishmania major hypothetical protein, conserved 0.0026 0.0055 0.0053
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0015 0.0004
Onchocerca volvulus 0.002 0.0017 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0133 0.0152
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0015 0.0004
Onchocerca volvulus 0.0097 0.0439 0.1248
Schistosoma mansoni hypothetical protein 0.0713 0.3784 0.4321
Echinococcus multilocularis cpg binding protein 0.0121 0.0567 0.0635
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.018 0.0211
Echinococcus granulosus importin subunit beta 1 0.003 0.0072 0.0068
Entamoeba histolytica SWIRM domain protein 0.0041 0.0131 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0055 0.0053
Echinococcus granulosus glutamate NMDA receptor subunit 0.0094 0.0422 0.0468
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.018 0.0192
Echinococcus granulosus allatostatin A receptor 0.0019 0.0015 0.0004
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0114 0.0362
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0533 0.2808 0.3512
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.002 0.0017 0.0005
Loa Loa (eye worm) hypothetical protein 0.0645 0.3412 0.427
Schistosoma mansoni smad1 5 8 and 0.0033 0.0089 0.0101
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0017 0.0019
Echinococcus multilocularis somatostatin receptor 0.0019 0.0015 0.0004
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0055 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0481 0.2522 0.3153
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0167 0.0177
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0015 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0052 0.0141
Mycobacterium tuberculosis Possible oxidoreductase 0.0221 0.1114 0.125
Loa Loa (eye worm) histone methyltransferase 0.0035 0.0103 0.0118
Echinococcus multilocularis protoporphyrinogen oxidase 0.0221 0.1114 0.126
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Brugia malayi RNA binding protein 0.0064 0.0258 0.0319
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0418 0.0457
Brugia malayi isocitrate dehydrogenase 0.005 0.018 0.0222
Echinococcus multilocularis glutamate receptor 2 0.004 0.0126 0.013
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0015 0.0008
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0089 0.0087
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0065 0.0074
Brugia malayi Glutamate receptor 1 precursor 0.004 0.0126 0.0153
Schistosoma mansoni nAChR subunit 0.002 0.0017 0.0019
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.002 0.0017 0.0016
Brugia malayi RNA, U transporter 1 0.0084 0.037 0.0459
Brugia malayi Thioredoxin reductase 0.0041 0.0133 0.0162
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0262 0.1335 0.1663
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0015 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0015 0.0018
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0221 0.1114 1
Schistosoma mansoni biogenic amine receptor 0.0019 0.0015 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Brugia malayi neuropeptide F receptor 0.0019 0.0015 0.0015
Schistosoma mansoni amine GPCR 0.0019 0.0015 0.0018
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0015 0.0004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0114 0.0138
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Brugia malayi MH1 domain containing protein 0.0033 0.0089 0.0107
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.003 0.0032
Brugia malayi glutathione reductase 0.0041 0.0133 0.0162
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.002 0.0017 0.0009
Schistosoma mansoni amine oxidase 0.0221 0.1114 0.1272
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0275 0.0314
Onchocerca volvulus 0.002 0.0017 0.0004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0418 0.0457
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.0018
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0015 0.0004
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0015 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0116 0.054 0.0672
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0533 0.2808 0.3517
Schistosoma mansoni glutamate receptor NMDA 0.0125 0.0589 0.0673
Echinococcus granulosus glycine receptor subunit beta 0.002 0.0017 0.0005
Loa Loa (eye worm) isocitrate dehydrogenase 0.005 0.018 0.0215
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.002 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus granulosus tar DNA binding protein 0.0064 0.0258 0.0281
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.002 0.0017 0.0005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0012 0.0011
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0017 0.0019
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0114 0.8506
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0114 0.0362
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Mycobacterium ulcerans monoamine oxidase 0.0221 0.1114 0.1099
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.003 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0009
Echinococcus granulosus dnaJ subfamily B 0.1629 0.8758 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0094 0.0422 0.0468
Loa Loa (eye worm) RNA binding protein 0.0064 0.0258 0.0312
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0015 0.0004
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0109 0.0503 0.062
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0015 0.0015
Echinococcus granulosus snurportin 1 0.0317 0.1633 0.1853
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.018 0.0211
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.003 0.1452
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.005 0.018 0.0187
Echinococcus granulosus nAChR subunit 0.002 0.0017 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.12 0.137
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.005 0.018 0.0211
Brugia malayi hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0015 0.0018
Echinococcus multilocularis nmda type glutamate receptor 0.0085 0.0374 0.0414
Trypanosoma brucei isocitrate dehydrogenase, putative 0.005 0.018 0.0211
Echinococcus granulosus fmrfamide receptor 0.0019 0.0015 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.12 0.137
Schistosoma mansoni alpha glucosidase 0.0037 0.0114 0.013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0366 0.1899 0.2371
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0015 0.0004
Loa Loa (eye worm) hypothetical protein 0.025 0.127 0.1582
Echinococcus multilocularis neuropeptide s receptor 0.096 0.5128 0.5849
Trichomonas vaginalis glucosylceramidase, putative 0.0533 0.2808 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0258 0.0295

Activities

Activity type Activity value Assay description Source Reference
T1/2 (ADMET) = 0.43 min Half life in human plasma ChEMBL. 19398207

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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