Detailed information for compound 104102

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 649.676 | Formula: C25H29N8O9S2+
  • H donors: 5 H acceptors: 9 LogP: -1.41 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: Nc1scc(n1)C(=NOCCN(C(=O)C)O)C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)C[n+]1ccc(cc1)CN(C(=O)C)O
  • InChi: 1S/C25H28N8O9S2/c1-13(34)31(40)7-8-42-29-18(17-12-44-25(26)27-17)21(36)28-19-22(37)33-20(24(38)39)16(11-43-23(19)33)10-30-5-3-15(4-6-30)9-32(41)14(2)35/h3-6,12,19,23,40-41H,7-11H2,1-2H3,(H3-,26,27,28,36,38,39)/p+1/b29-18-/t19-,23-/m1/s1
  • InChiKey: QTLXUMDZPKSRRW-KUINTPDISA-O  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0016 0.001
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0204 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0065 0.0168 0.1476
Toxoplasma gondii hypothetical protein 0.0047 0.0105 0.2811
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0056
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0049 0.0112 0.0389
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0047 0.0105 0.0368
Loa Loa (eye worm) voltage-gated potassium channel 0.0047 0.0105 0.0368
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0047 0.0105 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0204 0.0725
Leishmania major cathepsin L-like protease 0.0064 0.0163 0.0585
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0047 0.0105 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Echinococcus granulosus short transient receptor potential channel 6 0.0047 0.0105 0.0099
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0016 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0043 0.0152
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0135 0.0129
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0029 0.0045 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Loa Loa (eye worm) hypothetical protein 0.0065 0.0168 0.0587
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0006 0.0021
Schistosoma mansoni lipoxygenase 0.0055 0.0135 0.0129
Loa Loa (eye worm) hypothetical protein 0.0074 0.0197 0.0691
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0112 0.0238
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0836 0.2733 1
Echinococcus granulosus tumor protein p63 0.0337 0.1073 0.1067
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0116 0.0405
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0105 0.0099
Leishmania major hypothetical protein, conserved 0.0047 0.0105 0.0369
Schistosoma mansoni lipoxygenase 0.002 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0045 0.0158
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0346 0.1101 1
Echinococcus multilocularis two pore calcium channel protein 1 0.0047 0.0105 0.0099
Loa Loa (eye worm) ryanodine receptor 0.0047 0.0105 0.0368
Schistosoma mansoni hypothetical protein 0.002 0.0016 0.001
Echinococcus granulosus two pore calcium channel protein 2 0.0047 0.0105 0.0099
Leishmania major 4-coumarate:coa ligase-like protein 0.0065 0.0168 0.0602
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0049 0.0112 0.0238
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0114 0.0108
Echinococcus multilocularis transient receptor potential cation channel 0.0047 0.0105 0.0099
Echinococcus multilocularis hyperpolarization activated cyclic 0.0047 0.0105 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Echinococcus multilocularis potassium voltage gated channel protein 0.0047 0.0105 0.0099
Echinococcus granulosus short transient receptor potential channel 6 0.0047 0.0105 0.0099
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0047 0.0105 0.0099
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0197 0.0542
Leishmania major cathepsin L-like protease 0.0064 0.0163 0.0585
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0047 0.0105 0.0368
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0197 0.0691
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0112 0.0238
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0043 0.0152
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0049 0.0112 0.0396
Echinococcus multilocularis voltage dependent calcium channel 0.0047 0.0105 0.0099
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0074 0.0068
Trichomonas vaginalis antibiotic synthetase, putative 0.0049 0.0112 0.0968
Echinococcus granulosus transient receptor potential cation channel 0.0047 0.0105 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0116 0.011
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0049 0.0112 0.0396
Onchocerca volvulus 0.0049 0.0112 0.5541
Echinococcus multilocularis musashi 0.0028 0.0043 0.0037
Brugia malayi voltage-dependent calcium channel 0.0047 0.0105 0.0368
Trichomonas vaginalis antibiotic synthetase, putative 0.0049 0.0112 0.0968
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0065 0.0168 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.1101 1
Leishmania major fatty acid transporter protein-like protein 0.0824 0.2694 1
Echinococcus multilocularis survival motor neuron protein 1 0.028 0.0882 0.0876
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0047 0.0105 0.0099
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0197 0.9509
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0047 0.0105 0.2811
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus granulosus lamin 0.0028 0.0043 0.0037
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Trichomonas vaginalis esterase, putative 0.0074 0.0197 0.1748
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0047 0.0105 0.0368
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0047 0.0105 0.0099
Echinococcus multilocularis potassium voltage gated channel protein 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0016 0.0056
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0204 0.5605
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0049 0.0112 0.0396
Loa Loa (eye worm) hypothetical protein 0.0074 0.0197 0.0691
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0047 0.0105 0.0368
Onchocerca volvulus 0.0065 0.0168 0.8447
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0047 0.0105 0.0099
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0047 0.0105 0.0099
Schistosoma mansoni voltage-gated ion channel 0.0047 0.0105 0.0099
Entamoeba histolytica acyl-CoA synthetase, putative 0.0065 0.0168 0.1476
Onchocerca volvulus 0.0057 0.014 0.7001
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0047 0.0105 0.0364
Echinococcus multilocularis sodium channel protein 0.0047 0.0105 0.0099
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0065 0.0168 0.0436
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0204 0.0198
Brugia malayi Doublecortin family protein 0.002 0.0016 0.0056
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0112 0.0396
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0197 0.1748
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0346 0.1101 1
Echinococcus granulosus voltage dependent calcium channel 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0112 0.0396
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Leishmania major cathepsin L-like protease 0.0064 0.0163 0.0585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0047 0.0105 0.0099
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0169 0.0513 0.1662
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0145 0.0509
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0197 0.0192
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0047 0.0105 0.0906
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0168 0.0587
Schistosoma mansoni ryanodine receptor related 0.0047 0.0105 0.0099
Loa Loa (eye worm) ctsf protein 0.0017 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0045 0.0158
Onchocerca volvulus 0.002 0.0016 0.0519
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0197 0.0192
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0197 0.0702
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0197 0.1748
Loa Loa (eye worm) cysteine protease 0.0017 0.0006 0.0021
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0112 0.0393
Schistosoma mansoni transient receptor potential channel 0.0047 0.0105 0.0099
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0047 0.0105 0.2426
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0197 0.0713
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Loa Loa (eye worm) inositol-1 0.0076 0.0204 0.0714
Loa Loa (eye worm) hypothetical protein 0.0074 0.0197 0.0691
Plasmodium vivax acetyl-CoA synthetase, putative 0.0049 0.0112 0.5541
Echinococcus granulosus hypothetical protein 0.0047 0.0105 0.0099
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0047 0.0105 0.0368
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0197 0.1748
Loa Loa (eye worm) voltage-gated potassium channel 0.0047 0.0105 0.0368
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0047 0.0105 0.0368
Schistosoma mansoni calcium-activated potassium channel 0.0047 0.0105 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0047 0.0105 0.0099
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.0073 0.0249
Mycobacterium ulcerans hypothetical protein 0.0074 0.0197 0.0542
Toxoplasma gondii transporter, cation channel family protein 0.0047 0.0105 0.2811
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.0105 0.0099
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0074 0.0197 0.0691
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0197 0.0713
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0105 0.0099
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0047 0.0105 0.0368
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0065 0.0168 0.0436
Mycobacterium leprae Probable lipase LipE 0.0074 0.0197 0.0331
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0047 0.0105 0.0099
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0047 0.0105 0.0099
Brugia malayi beta-lactamase family protein 0.0074 0.0197 0.0691
Schistosoma mansoni lamin 0.0028 0.0043 0.0037
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0836 0.2733 1
Echinococcus multilocularis transient receptor potential cation channel 0.0047 0.0105 0.0099
Echinococcus granulosus long chain fatty acid transport protein 4 0.0836 0.2733 0.2729
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0047 0.0105 0.0364
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0049 0.0112 0.0396
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0197 0.1748
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0049 0.0112 0.0396
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0873 0.2856 1
Schistosoma mansoni voltage-gated cation channel 0.0047 0.0105 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0168 0.0436
Brugia malayi hypothetical protein 0.002 0.0016 0.0056
Echinococcus multilocularis transient receptor potential gamma protein 0.0047 0.0105 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0163 0.0576
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0168 0.0436
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0047 0.0105 0.0099
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0197 0.0542
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Toxoplasma gondii MAPEG family protein 0.0123 0.0359 1
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0049 0.0114 0.0401
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Brugia malayi ion channel NompC 0.0047 0.0105 0.0368
Schistosoma mansoni vesicular amine transporter 0.0047 0.0105 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Loa Loa (eye worm) hypothetical protein 0.0049 0.0112 0.0393
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0049 0.0112 0.3005
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0021
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0021
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0177 0.0638
Giardia lamblia Fructose-bisphosphate aldolase 0.0346 0.1101 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0116 0.011
Brugia malayi cation channel family protein 0.0047 0.0105 0.0368
Echinococcus granulosus potassium voltage gated channel protein 0.0047 0.0105 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0112 0.0238
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0116 0.011
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0074 0.0252
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0112 0.0238
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0836 0.2733 0.2729
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0047 0.0105 0.0099
Schistosoma mansoni hypothetical protein 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Conserved protein 0.0074 0.0197 0.0713
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0049 0.0112 0.0968
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0204 0.0725
Mycobacterium tuberculosis Conserved protein 0.0074 0.0197 0.0713
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0047 0.0105 0.2426
Onchocerca volvulus 0.002 0.0016 0.0519
Loa Loa (eye worm) voltage-gated calcium channel 0.0047 0.0105 0.0368
Toxoplasma gondii transporter, cation channel family protein 0.0047 0.0105 0.2811
Echinococcus granulosus potassium voltage gated channel protein 0.0047 0.0105 0.0099
Onchocerca volvulus 0.0028 0.0043 0.1947
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0112 0.0396
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0047 0.0105 0.0099
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0049 0.0112 0.0393
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0049 0.0112 0.0389
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus multilocularis transient receptor potential cation channel 0.0047 0.0105 0.0099
Echinococcus multilocularis potassium voltage gated channel protein 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0049 0.0112 0.0396
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Plasmodium falciparum acyl-CoA synthetase 0.0029 0.0045 0.3697
Echinococcus granulosus voltage gated hydrogen channel 1 0.0047 0.0105 0.0099
Schistosoma mansoni polycystin 1-related 0.002 0.0016 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0204 0.1806
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Schistosoma mansoni survival motor neuron protein 0.0057 0.014 0.0134
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0105 0.0099
Mycobacterium ulcerans acyl-CoA synthetase 0.0065 0.0168 0.0436
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0016 0.001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0204 0.0564
Brugia malayi hypothetical protein 0.0047 0.0105 0.0368
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0047 0.0105 0.0099
Schistosoma mansoni intermediate filament proteins 0.0028 0.0043 0.0037
Onchocerca volvulus 0.0074 0.0197 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0047 0.0105 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0197 0.0702
Echinococcus granulosus transient receptor potential cation channel 0.0047 0.0105 0.0099
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0118 0.0409
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0074 0.0617
Schistosoma mansoni microsomal glutathione s-transferase 0.0123 0.0359 0.0353
Entamoeba histolytica acyl-CoA synthetase, putative 0.0065 0.0168 0.1476
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0047 0.0105 0.0099
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0065 0.0168 0.0436
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0074 0.0068
Echinococcus multilocularis lamin dm0 0.0028 0.0043 0.0037
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Echinococcus granulosus potassium voltage gated channel protein 0.0047 0.0105 0.0099
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0021
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Mycobacterium ulcerans acetyl-CoA synthetase 0.0049 0.0112 0.0238
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0049 0.0112 0.0389
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0047 0.0105 0.0099
Schistosoma mansoni transient receptor potential channel 0.0047 0.0105 0.0099
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0824 0.2694 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0047 0.0105 0.0099
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0049 0.0112 0.0238
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0197 0.0713
Brugia malayi beta-lactamase 0.0074 0.0197 0.0691
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0168 0.0587
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0177 0.0252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.1101 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0047 0.0105 0.0099
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0204 0.1806
Echinococcus granulosus calcium activated potassium channel 0.0047 0.0105 0.0099
Echinococcus granulosus potassium voltage gated channel protein 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0045 0.0158
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.014 0.049
Schistosoma mansoni FFA transport protein 0.0836 0.2733 0.2729
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0016 0.0519
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0049 0.0112 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0016 0.001
Schistosoma mansoni inositol monophosphatase 0.0076 0.0204 0.0198
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0047 0.0105 0.0368
Mycobacterium ulcerans hypothetical protein 0.0065 0.0168 0.0436
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0116 0.011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0116 0.0405
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0049 0.0112 0.0389
Plasmodium vivax acyl-CoA synthetase, putative 0.0029 0.0045 0.2048
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus multilocularis transient receptor potential cation channel 0.0047 0.0105 0.0099
Echinococcus granulosus sodium channel protein 0.0047 0.0105 0.0099
Echinococcus granulosus TRP transient receptor potential channel 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0824 0.2694 1
Onchocerca volvulus 0.0049 0.0112 0.5541
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0204 0.0736
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0112 0.0396
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0047 0.0105 0.0368
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0047 0.0105 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0006 0.0021
Leishmania major acetyl-CoA synthetase, putative 0.0049 0.0112 0.0395
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0047 0.0105 0.0368
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0163 0.0576
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0016 0.0936
Echinococcus multilocularis voltage dependent calcium channel 0.0047 0.0105 0.0099
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0047 0.0105 0.5182
Echinococcus multilocularis microtubule associated protein 2 0.3019 1 1
Echinococcus multilocularis transfer RNA-Gly 0.0047 0.0105 0.0099
Schistosoma mansoni lamin 0.0028 0.0043 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0112 0.0238
Leishmania major 4-coumarate:coa ligase-like protein 0.0065 0.0168 0.0602
Loa Loa (eye worm) hypothetical protein 0.0037 0.0074 0.0258
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0047 0.0105 0.0099
Schistosoma mansoni 60S ribosomal protein L21 0.0047 0.0105 0.0099
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0043 0.0152
Leishmania major hypothetical protein, unknown function 0.0047 0.0105 0.0369
Echinococcus granulosus transient receptor potential cation channel 0.0047 0.0105 0.0099
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0006 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0146
Echinococcus multilocularis lamin 0.0028 0.0043 0.0037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0065 0.0168 0.0603
Echinococcus granulosus hyperpolarization activated cyclic 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0049 0.0112 0.0393
Echinococcus granulosus intermediate filament protein 0.0028 0.0043 0.0037
Loa Loa (eye worm) ion channel NompC 0.0047 0.0105 0.0368
Brugia malayi intermediate filament protein 0.0028 0.0043 0.0152
Echinococcus multilocularis short transient receptor potential channel 6 0.0047 0.0105 0.0099
Brugia malayi Transient-receptor-potential like protein 0.0047 0.0105 0.0368
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0169 0.0513 0.1551
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0152
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0047 0.0105 0.0368
Echinococcus granulosus hyperpolarization activated cyclic 0.0047 0.0105 0.0099
Echinococcus granulosus lamin dm0 0.0028 0.0043 0.0037
Echinococcus multilocularis ryanodine receptor 44f 0.0047 0.0105 0.0099
Onchocerca volvulus 0.0047 0.0105 0.5182
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0112 0.0393
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0074 0.0617
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0074 0.0617
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.1101 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0074 0.0248
Brugia malayi Cyclic-nucleotide gated cation channel 0.0047 0.0105 0.0368
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0536 0.1735 0.173
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0047 0.0105 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Schistosoma mansoni voltage-dependent calcium channel 0.0047 0.0105 0.0099
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0074 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0116 0.011
Echinococcus multilocularis two pore calcium channel protein 2 0.0047 0.0105 0.0099
Brugia malayi olfactory channel protein osm-9 0.0047 0.0105 0.0368
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Mycobacterium ulcerans beta-lactamase 0.0074 0.0197 0.0542
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0197 0.1748
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0049 0.0112 0.0238
Echinococcus multilocularis potassium voltage gated channel protein 0.0047 0.0105 0.0099
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0123 0.0359 0.0353
Echinococcus granulosus transient receptor potential gamma protein 0.0047 0.0105 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Echinococcus multilocularis tumor protein p63 0.0337 0.1073 0.1067
Brugia malayi hypothetical protein 0.002 0.0016 0.0056
Echinococcus granulosus voltage gated potassium channel 0.0047 0.0105 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0016 0.001
Schistosoma mansoni transient receptor potential channel 4 0.0047 0.0105 0.0099
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0197 0.0192
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0047 0.0105 0.0368
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0021
Schistosoma mansoni acetyl-CoA synthetase 0.0049 0.0112 0.0106
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0049 0.0112 0.0238
Echinococcus granulosus RUN 0.002 0.0016 0.001
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0074 0.0068
Leishmania major 4-coumarate:coa ligase-like protein 0.0065 0.0168 0.0602
Echinococcus granulosus transient receptor potential cation channel 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0074 0.0617
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0112 0.0238
Loa Loa (eye worm) fibroinase 0.0017 0.0006 0.0021
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0204 0.5
Toxoplasma gondii propionate-CoA ligase 0.0049 0.0112 0.3005
Loa Loa (eye worm) doublecortin family protein 0.002 0.0016 0.0056
Loa Loa (eye worm) hypothetical protein 0.0065 0.0168 0.0587
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0197 0.0713
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0047 0.0105 0.0099
Onchocerca volvulus 0.0074 0.0197 1
Brugia malayi AMP-binding enzyme family protein 0.0873 0.2856 1
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Echinococcus granulosus transient receptor potential cation channel 0.0047 0.0105 0.0099
Echinococcus multilocularis sodium leak channel non selective protein 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0065 0.0168 0.0587
Echinococcus granulosus microsomal glutathione S transferase 3 0.0123 0.0359 0.0353
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0873 0.2856 1
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0047 0.0105 0.0099
Echinococcus multilocularis hyperpolarization activated cyclic 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0168 0.0603
Toxoplasma gondii transporter, cation channel family protein 0.0047 0.0105 0.2811
Schistosoma mansoni loxhd1 0.002 0.0016 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.1101 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0047 0.0105 0.2811
Onchocerca volvulus 0.0028 0.0043 0.1947
Loa Loa (eye worm) hypothetical protein 0.0074 0.0197 0.0691
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0047 0.0105 0.0368
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0047 0.0105 0.0099
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0045 0.0158
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus multilocularis conserved hypothetical protein 0.0047 0.0105 0.0099
Onchocerca volvulus 0.0074 0.0197 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0047 0.0105 0.0099
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0065 0.0168 0.0216
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0204 0.0198
Echinococcus multilocularis potassium large conductance calcium activated 0.0047 0.0105 0.0099
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0049 0.0112 0.0238
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0049 0.0112 0.0238
Schistosoma mansoni rab6-interacting 0.002 0.0016 0.001
Schistosoma mansoni hypothetical protein 0.0057 0.014 0.0134
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0047 0.0105 0.0099
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0135 0.0129
Schistosoma mansoni inositol monophosphatase 0.0076 0.0204 0.0198
Leishmania major hypothetical protein, conserved 0.0074 0.0197 0.0712
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.1531 0.5673
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0204 0.1806
Onchocerca volvulus 0.0049 0.0114 0.566
Mycobacterium tuberculosis Conserved protein 0.0074 0.0197 0.0713
Echinococcus granulosus voltage dependent calcium channel 0.0047 0.0105 0.0099
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0047 0.0105 0.0099
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Loa Loa (eye worm) beta-lactamase 0.0074 0.0197 0.0691
Schistosoma mansoni transient receptor potential channel 0.0047 0.0105 0.0099
Loa Loa (eye worm) calcium channel 0.0047 0.0105 0.0368
Echinococcus multilocularis transient receptor potential cation channel 0.0047 0.0105 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.1101 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0112 0.0238
Echinococcus granulosus potassium large conductance calcium activated 0.0047 0.0105 0.0099
Onchocerca volvulus 0.0049 0.0112 0.5541
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0197 0.0691
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0049 0.0112 0.0106
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0047 0.0105 0.5182
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.1101 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0197 0.0713
Echinococcus multilocularis shaker cognate 0.0047 0.0105 0.0099
Echinococcus granulosus sodium leak channel non selective protein 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0197 0.0713
Brugia malayi cation channel family protein 0.0047 0.0105 0.0368
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus multilocularis calcium activated potassium channel 0.0047 0.0105 0.0099
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0047 0.0105 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0197 0.0192
Echinococcus multilocularis short transient receptor potential channel 6 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0197 0.0713
Echinococcus granulosus potassium voltage gated channel protein 0.0047 0.0105 0.0099
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0047 0.0105 0.0099
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0029 0.0045 0.5
Echinococcus granulosus two pore calcium channel protein 1 0.0047 0.0105 0.0099
Echinococcus granulosus transient receptor potential cation channel 0.0047 0.0105 0.0099
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0049 0.0112 0.0395
Schistosoma mansoni rab6-interacting 0.002 0.0016 0.001
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0112 0.0238
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0047 0.0105 0.0368
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0197 0.0331
Mycobacterium ulcerans lipase LipD 0.0074 0.0197 0.0542
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0065 0.0168 0.0436
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0074 0.0068
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0047 0.0105 0.0906
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0047 0.0105 0.0368
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0049 0.0112 0.0393
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0049 0.0112 0.2953
Echinococcus multilocularis transient receptor potential cation channel 0.0047 0.0105 0.0099
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0049 0.0112 0.3005
Brugia malayi hypothetical protein 0.028 0.0882 0.3087
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0016 0.001
Schistosoma mansoni microtubule-associated protein tau 0.3019 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.1101 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0074 0.0248
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0112 0.0238
Leishmania major acetyl-CoA synthetase, putative 0.0049 0.0112 0.0395
Brugia malayi AMP-binding enzyme family protein 0.0065 0.0168 0.0587
Echinococcus granulosus ryanodine receptor 44f 0.0047 0.0105 0.0099
Treponema pallidum fructose-bisphosphate aldolase 0.0346 0.1101 0.5
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0074 0.0068
Schistosoma mansoni two-pore calcium channel 0.0047 0.0105 0.0099
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0047 0.0105 0.0099
Toxoplasma gondii hypothetical protein 0.0047 0.0105 0.2811
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0047 0.0105 0.0099
Brugia malayi Inositol-1 0.0076 0.0204 0.0714
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0047 0.0105 0.0368
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0047 0.0105 0.0368
Brugia malayi beta-lactamase family protein 0.0074 0.0197 0.0691
Loa Loa (eye worm) voltage-dependent calcium channel 0.0047 0.0105 0.0368
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0047 0.0105 0.0099
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0197 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0049 0.0112 0.0396
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.0105 0.0099
Loa Loa (eye worm) oxidoreductase 0.0049 0.0112 0.0393
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0163 0.688
Echinococcus granulosus survival motor neuron protein 1 0.028 0.0882 0.0876
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0047 0.0105 0.0099
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0074 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0116 0.011
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0112 0.0393
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0204 0.1806
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0047 0.0105 0.0099
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0105 0.0099
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0049 0.0112 0.0393
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0047 0.0105 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0116 0.011
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0049 0.0112 0.2953
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0047 0.0105 0.0368
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.0105 0.0099
Loa Loa (eye worm) hypothetical protein 0.0074 0.0197 0.0691
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.1101 1
Toxoplasma gondii ABC1 family protein 0.0074 0.0197 0.5424
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0047 0.0105 0.0368
Echinococcus multilocularis RUN 0.002 0.0016 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0163 0.0576
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0105 0.0099
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0047 0.0105 0.0099
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0074 0.0068
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0047 0.0105 0.0099
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0169 0.0513 0.1885
Loa Loa (eye worm) hypothetical protein 0.028 0.0882 0.3087
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0074 0.0258
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0163 0.0576
Loa Loa (eye worm) hypothetical protein 0.0029 0.0045 0.0158
Onchocerca volvulus 0.0049 0.0112 0.5541
Echinococcus granulosus shaker cognate 0.0047 0.0105 0.0099
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0049 0.0112 0.0106
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0047 0.0105 0.0099

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.007 ug ml-1 Compound was evaluated for antibacterial activity against S. pyogenes A77. ChEMBL. No reference
MIC (functional) = 0.049 ug ml-1 Compound was evaluated for antibacterial activity against S. pneumoniae type I. ChEMBL. No reference
MIC (functional) = 0.391 ug ml-1 Compound was evaluated for antibacterial activity against E. coli DC 2. ChEMBL. No reference
MIC (functional) = 0.781 ug ml-1 Compound was evaluated for antibacterial activity against K. pneumoniae NCTC 9632. ChEMBL. No reference
MIC (functional) = 6.25 ug ml-1 Compound was evaluated for antibacterial activity against P. aeruginosa 1771M. ChEMBL. No reference
MIC (functional) = 6.25 ug ml-1 Compound was evaluated for antibacterial activity against P. vulgaris GN76. ChEMBL. No reference
MIC (functional) = 12.5 ug ml-1 Compound was evaluated for antibacterial activity against S. aureus Smith. ChEMBL. No reference
MIC (functional) = 12.5 ug ml-1 Compound was evaluated for antibacterial activity against E. coli DC 0. ChEMBL. No reference
MIC (functional) = 12.5 ug ml-1 Compound was evaluated for antibacterial activity against S. marcescens IFO 12648. ChEMBL. No reference
MIC (functional) = 25 ug ml-1 Compound was evaluated for antibacterial activity against P. aeruginosa 1771. ChEMBL. No reference
MIC (functional) = 50 ug ml-1 Compound was evaluated for antibacterial activity against S. aureus C2379 (MRSA). ChEMBL. No reference
MIC (functional) = 50 ug ml-1 Compound was evaluated for antibacterial activity against P. aeruginosa 9027. ChEMBL. No reference
MIC (functional) = 50 ug ml-1 Compound was evaluated for antibacterial activity against E. cloacae P99. ChEMBL. No reference
MIC (functional) > 100 ug ml-1 Compound was evaluated for antibacterial activity against P. aeruginosa C-1198. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.