Detailed information for compound 1041465

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 419.516 | Formula: C25H29N3O3
  • H donors: 1 H acceptors: 2 LogP: 4.26 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)Cc1cc(C)nn(c1=O)CC(=O)Nc1ccc(cc1)C(C)(C)C
  • InChi: 1S/C25H29N3O3/c1-17-13-19(14-18-7-6-8-22(15-18)31-5)24(30)28(27-17)16-23(29)26-21-11-9-20(10-12-21)25(2,3)4/h6-13,15H,14,16H2,1-5H3,(H,26,29)
  • InChiKey: IIUFGJSTLXSSDD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0476 0.0675
Brugia malayi Cyclin, N-terminal domain containing protein 0.0015 0.0074 0.0074
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0719 0.9292
Trichomonas vaginalis cyclins, putative 0.0063 0.1005 0.467
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0074 0.0333
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0229 0.0229
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.0476 0.0675
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0719 0.0719
Brugia malayi phosphofructokinase 0.011 0.1941 0.1941
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0581 0.0581
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.1389 0.1389
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0533 0.2474
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0158 0.0734
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0362 1
Echinococcus granulosus neuropeptide receptor 0.0036 0.0476 0.0675
Echinococcus granulosus cyclin dependent kinase 5 0.0051 0.0772 0.1096
Trichomonas vaginalis cyclins, putative 0.0121 0.215 1
Onchocerca volvulus 0.0014 0.0049 0.0098
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.0476 0.0703
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0104 0.0473
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.1549 0.2291
Plasmodium falciparum protein kinase 5 0.0051 0.0772 0.7646
Trichomonas vaginalis cyclin B, putative 0.0121 0.215 1
Leishmania major protein kinase, putative 0.0023 0.0233 0.1082
Trypanosoma cruzi CYC2-like cyclin, putative 0.0121 0.215 1
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0229 0.282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0104 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0158 0.0233
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1941 0.9028
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.0476 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0779 0.362
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0104 0.0478
Schistosoma mansoni intermediate filament proteins 0.0054 0.0846 0.1251
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.0476 0.0476
Onchocerca volvulus Cyclin L homolog 0.0015 0.0074 0.0169
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0229 0.0339
Brugia malayi Dopamine receptor 0.0036 0.0476 0.0476
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0362 0.4576
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0051 0.0772 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0049 0.0229
Echinococcus granulosus g-protein coupled receptor 0.0036 0.0476 0.0675
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0104 0.0482
Trichomonas vaginalis cyclin B, putative 0.0121 0.215 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.1091 0.1091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0772 0.3592
Brugia malayi Dopamine receptor protein 1 0.0036 0.0476 0.0476
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1941 0.9028
Echinococcus multilocularis Glycoside hydrolase, chitinase domain containing protein 1 0.0012 0.0016 0.0022
Schistosoma mansoni Cyclin fold protein 0.0015 0.0074 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.004 0.0184
Brugia malayi hypothetical protein 0.0113 0.2 0.2
Echinococcus multilocularis chromobox protein 2 0.0023 0.0229 0.0325
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0158 0.0734
Schistosoma mansoni amine GPCR 0.0036 0.0476 0.0703
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.0476 0.0476
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0065 0.0065
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0198 0.0912
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1941 0.9028
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0229 0.2967
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.1924 0.8893
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0229 0.0229
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0049 0.022
Onchocerca volvulus Protein CNPPD1 homolog 0.0015 0.0074 0.0169
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0051 0.0772 0.1096
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0049 0.0049
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0015 0.0074 0.0074
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0015 0.0074 0.0105
Entamoeba histolytica cyclin, domain containing protein 0.0015 0.0074 0.0333
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0846 0.0846
Brugia malayi G-protein coupled receptor 0.0036 0.0476 0.0476
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0476 0.0476
Echinococcus granulosus cyclins 0.0015 0.0074 0.0105
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0476 0.0675
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0229 0.1057
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0476 0.0675
Loa Loa (eye worm) hypothetical protein 0.0058 0.0922 0.0922
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0104 0.116
Schistosoma mansoni cyclins 0.0063 0.1005 0.1487
Loa Loa (eye worm) glycosyl hydrolase family 18 protein 0.0012 0.0016 0.0016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.0476 0.0476
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.0476 0.0703
Echinococcus granulosus cyclin G2 0.0015 0.0074 0.0105
Trypanosoma cruzi mitotic cyclin, putative 0.0015 0.0074 0.0342
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0229 0.1057
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0779 0.362
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0876 0.1244
Brugia malayi endochitinase 0.0012 0.0016 0.0016
Schistosoma mansoni amine GPCR 0.0036 0.0476 0.0703
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0476 0.0703
Brugia malayi cell division control protein 2 homolog 0.0051 0.0772 0.0772
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0002 0.0009
Echinococcus granulosus allatostatin A receptor 0.0036 0.0476 0.0675
Leishmania major chitinase 0.0012 0.0016 0.0073
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0362 0.1675
Loa Loa (eye worm) hypothetical protein 0.0025 0.0273 0.0273
Onchocerca volvulus 0.0113 0.2 0.581
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1941 0.897
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1941 0.9029
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0772 0.3586
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1924 0.8893
Brugia malayi hypothetical protein 0.002 0.017 0.017
Loa Loa (eye worm) cyclin domain-containing protein 0.0193 0.357 0.357
Brugia malayi hypothetical protein 0.0015 0.0074 0.0074
Echinococcus multilocularis G1:S specific cyclin D1 0.0015 0.0074 0.0105
Trichomonas vaginalis cyclin A, putative 0.0121 0.215 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0362 0.1389
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0074 0.0764
Brugia malayi 6-phosphofructokinase 0.011 0.1941 0.1941
Toxoplasma gondii hypothetical protein 0.0015 0.0074 0.0953
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0229 0.1057
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0104 0.0887
Trypanosoma brucei cyclin 3 0.0015 0.0074 0.0342
Brugia malayi Cytochrome P450 family protein 0.0031 0.038 0.038
Giardia lamblia Cyclin A 0.0063 0.1005 0.4486
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trypanosoma brucei unspecified product 0.0019 0.0158 0.0734
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0476 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0158 0.0812
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0581 0.0825
Schistosoma mansoni cyclin k 0.0015 0.0074 0.0109
Onchocerca volvulus 0.0036 0.0476 0.1346
Echinococcus multilocularis RUN 0.002 0.017 0.0241
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0719 0.3321
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1941 0.897
Loa Loa (eye worm) hypothetical protein 0.0051 0.0779 0.0779
Trypanosoma brucei unspecified product 0.0013 0.004 0.0184
Loa Loa (eye worm) phosphofructokinase 0.011 0.1941 0.1941
Echinococcus granulosus cyclin B3 1 0.0063 0.1005 0.1427
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Brugia malayi Cyclin, N-terminal domain containing protein 0.0193 0.357 0.357
Schistosoma mansoni g1/s-specific cyclin C 0.0015 0.0074 0.0109
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.038 0.038
Schistosoma mansoni lamin 0.0054 0.0846 0.1251
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0015 0.0074 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0362 0.1675
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0015 0.0074 0.0953
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0049 0.022
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0016 0.0064
Trichomonas vaginalis chromobox protein, putative 0.0082 0.1389 0.6457
Brugia malayi Protein kinase domain containing protein 0.0051 0.0772 0.0772
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.0476 0.0675
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.0476 0.0703
Trichomonas vaginalis cyclins, putative 0.0121 0.215 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0846 0.0846
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.009 0.1549 0.2199
Echinococcus multilocularis sex peptide receptor 0.0036 0.0476 0.0675
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1941 0.9028
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1941 0.2871
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.0476 0.0703
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0362 0.1675
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0476 0.0703
Loa Loa (eye worm) hypothetical protein 0.0259 0.4862 0.4862
Echinococcus granulosus serotonin receptor 0.0036 0.0476 0.0675
Schistosoma mansoni cyclin B 0.0121 0.215 0.318
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0104 0.0482
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0362 1
Schistosoma mansoni hypothetical protein 0.0023 0.0229 0.0339
Schistosoma mansoni hypothetical protein 0.0053 0.0814 0.1205
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0362 0.1675
Loa Loa (eye worm) RecQ helicase 0.0021 0.0198 0.0198
Onchocerca volvulus 0.0054 0.0846 0.243
Brugia malayi cyclin fold protein 1 variant b 0.0015 0.0074 0.0074
Brugia malayi M-phase phosphoprotein, mpp8 0.0113 0.2 0.2
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0362 0.1675
Brugia malayi hypoxia-induced factor 1 0.0165 0.3015 0.3015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0229 0.0229
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0552 0.0552
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0104 0.0482
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0719 0.3342
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0552 0.2842
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.0476 0.0675
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.035 0.035
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Loa Loa (eye worm) hypothetical protein 0.0025 0.0273 0.0273
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.4862 0.6903
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0015 0.0074 0.0109
Loa Loa (eye worm) hypothetical protein 0.0113 0.2 0.2
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0229 0.1057
Schistosoma mansoni cyclin d 0.0015 0.0074 0.0109
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0062 0.0607
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.0476 0.0675
Trichomonas vaginalis chromobox protein, putative 0.0082 0.1389 0.6457
Echinococcus multilocularis cyclins 0.0063 0.1005 0.1427
Echinococcus granulosus somatostatin receptor 0.0036 0.0476 0.0675
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0229 0.1057
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0229 0.1057
Onchocerca volvulus 0.002 0.017 0.0451
Echinococcus multilocularis lamin dm0 0.0054 0.0846 0.1201
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0104 0.0482
Leishmania major mitotic cyclin, putative 0.0015 0.0074 0.0342
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1941 0.9028
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1941 1
Schistosoma mansoni hypothetical protein 0.0036 0.0476 0.0703
Trypanosoma brucei cdc2-related kinase 1 0.0051 0.0772 0.3592
Loa Loa (eye worm) cyclin domain-containing protein 0.0015 0.0074 0.0074
Loa Loa (eye worm) glutathione reductase 0.0048 0.0719 0.0719
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0051 0.0772 0.0772
Loa Loa (eye worm) hypothetical protein 0.0186 0.3431 0.3431
Onchocerca volvulus 0.0036 0.0476 0.1346
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.017 0.0241
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0104 0.0482
Plasmodium falciparum cyclin 0.0063 0.1005 1
Brugia malayi Serotonin receptor 0.0036 0.0476 0.0476
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Echinococcus multilocularis chromobox protein 1 0.0082 0.1389 0.1972
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.0476 0.0703
Brugia malayi endochitinase 0.0012 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0113 0.2 0.2
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.0476 0.0476
Echinococcus multilocularis chromobox protein 1 0.0082 0.1389 0.1972
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0772 0.1142
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0229 0.1057
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0229 0.2967
Schistosoma mansoni polycystin 1-related 0.002 0.017 0.0251
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0581 0.0581
Echinococcus granulosus Glycoside hydrolase chitinase domain containing protein 1 0.0012 0.0016 0.0022
Echinococcus granulosus RUN 0.002 0.017 0.0241
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0049 0.022
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trichomonas vaginalis cyclins, putative 0.0121 0.215 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0017 0.0017
Echinococcus multilocularis cyclin b3 0.0063 0.1005 0.1427
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.2164 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0104 0.0482
Brugia malayi hypothetical protein 0.0012 0.0016 0.0016
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.0772 0.3592
Schistosoma mansoni hypothetical protein 0.0036 0.0476 0.0703
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0158 0.0729
Mycobacterium leprae Possible regulatory protein 0.0014 0.0049 0.0227
Echinococcus multilocularis allatostatin A receptor 0.0036 0.0476 0.0675
Trichomonas vaginalis cyclin B, putative 0.0015 0.0074 0.0333
Trichomonas vaginalis cyclin B, putative 0.0015 0.0074 0.0333
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0846 0.0846
Echinococcus multilocularis cyclins 0.0063 0.1005 0.1427
Loa Loa (eye worm) cyclin domain-containing protein 0.0015 0.0074 0.0074
Echinococcus multilocularis cyclin 0.0015 0.0074 0.0105
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.006 0.0278
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0772 0.1142
Brugia malayi GnHR receptor homolog 0.0036 0.0476 0.0476
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0188 0.0876
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.0476 0.0476
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.0476 0.0675
Echinococcus granulosus fmrfamide receptor 0.0036 0.0476 0.0675
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0476 0.0476
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0552 0.0783
Brugia malayi Cyclin, N-terminal domain containing protein 0.0121 0.215 0.215
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0772 0.3586
Echinococcus multilocularis cyclins 0.0063 0.1005 0.1427
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0188 0.0188
Plasmodium vivax glutathione reductase, putative 0.0048 0.0719 0.9292
Echinococcus granulosus cyclin y 0.0015 0.0074 0.0105
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0104 0.0153
Brugia malayi Protein cec-1. 0.0023 0.0229 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Brugia malayi Cytochrome P450 family protein 0.0021 0.0188 0.0188
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0015 0.0074 0.0764
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Schistosoma mansoni opsin-like receptor 0.0036 0.0476 0.0703
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0015 0.0074 0.0953
Onchocerca volvulus 0.0113 0.2 0.581
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0049 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0476 0.0675
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0104 0.0482
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1941 0.2756
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0049 0.0229
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0074
Echinococcus multilocularis cyclin B 0.0121 0.215 0.3052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1924 0.8893
Brugia malayi neuropeptide F receptor 0.0036 0.0476 0.0476
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0476 0.0703
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0158 0.0725
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0772 0.0772
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.2164 1
Echinococcus multilocularis cyclin dependent kinase 0.0051 0.0772 0.1096
Echinococcus multilocularis cyclins 0.0063 0.1005 0.1427
Schistosoma mansoni cyclin B3 0.0193 0.357 0.5281
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0109
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0049
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.0476 0.1346
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0476 0.0703
Brugia malayi hypothetical protein 0.0179 0.3287 0.3287
Trypanosoma brucei cdc2-related kinase 3 0.0051 0.0772 0.3592
Echinococcus granulosus cyclin b3 0.0063 0.1005 0.1427
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.0476 0.0675
Trypanosoma cruzi cyclin, putative 0.0121 0.215 1
Schistosoma mansoni lipoxygenase 0.002 0.017 0.0251
Echinococcus granulosus chromobox protein 2 0.0023 0.0229 0.0325
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0229 0.2156
Schistosoma mansoni hypothetical protein 0.0356 0.676 1
Schistosoma mansoni cyclin G2 0.0015 0.0074 0.0109
Onchocerca volvulus 0.0036 0.0476 0.1346
Echinococcus granulosus dna polymerase kappa 0.0019 0.0158 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Echinococcus granulosus cyclin A3 4 0.0015 0.0074 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Trichomonas vaginalis cyclin D, putative 0.0063 0.1005 0.467
Schistosoma mansoni biogenic amine receptor 0.0036 0.0476 0.0703
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.0476 0.1346
Brugia malayi G-protein coupled receptor 0.0036 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.002 0.017 0.017
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.0476 0.0476
Echinococcus multilocularis cyclin A3 4 0.0015 0.0074 0.0105
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0158 0.0224
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1924 0.8893
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1941 0.9029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0476 0.0703
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0779 0.2236
Loa Loa (eye worm) cyclin domain-containing protein 0.0015 0.0074 0.0074
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.0476 0.0703
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Loa Loa (eye worm) hypothetical protein 0.0023 0.0229 0.0229
Echinococcus granulosus cyclin B 0.0121 0.215 0.3052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Schistosoma mansoni lamin 0.0054 0.0846 0.1251
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0362 0.4687
Brugia malayi intermediate filament protein 0.0054 0.0846 0.0846
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0476 0.0703
Echinococcus granulosus G1:S specific cyclin D1 0.0015 0.0074 0.0105
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0476 0.0675
Leishmania major cyclin 9, putative 0.0015 0.0074 0.0342
Brugia malayi Glycosyl hydrolases family 18 protein 0.0012 0.0016 0.0016
Mycobacterium tuberculosis Probable reductase 0.0109 0.1924 0.8893
Echinococcus granulosus cyclin y 0.0015 0.0074 0.0105
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0476 0.0703
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0198 0.0198
Loa Loa (eye worm) chitinase I 0.0012 0.0016 0.0016
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0051 0.0772 0.3592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0476 0.0703
Schistosoma mansoni rab6-interacting 0.002 0.017 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0074 0.0333
Echinococcus granulosus cyclins 0.0063 0.1005 0.1427
Echinococcus granulosus cyclin 0.0015 0.0074 0.0105
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0065 0.0096
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0476 0.0675
Loa Loa (eye worm) cyclin domain-containing protein 0.0015 0.0074 0.0074
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.1091 0.5076
Brugia malayi 6-phosphofructokinase 0.011 0.1941 0.1941
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0074
Entamoeba histolytica cyclin, domain containing protein 0.0015 0.0074 0.0333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0193 0.357 0.5069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0053 0.0826 0.0826
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Brugia malayi putative neuropeptide receptor 0.0036 0.0476 0.0476
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0476 0.0675
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0476 0.0703
Brugia malayi neuropeptide F receptor 0.0036 0.0476 0.0476
Plasmodium vivax cyclin 4, putative 0.0015 0.0074 0.0764
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.0476 0.0675
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0158 0.0812
Echinococcus multilocularis musashi 0.0054 0.0846 0.1201
Onchocerca volvulus 0.0036 0.0476 0.1346
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.0476 0.0675
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.0476 0.0675
Trichomonas vaginalis cyclins, putative 0.0121 0.215 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0229 0.1057
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0104 0.0887
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.2164 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.0476 0.0675
Schistosoma mansoni neuropeptide receptor 0.0036 0.0476 0.0703
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0051 0.0772 0.3592
Loa Loa (eye worm) cuticular endochitinase 0.0012 0.0016 0.0016
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.0476 0.0703
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0229 0.0339
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0104 0.0482
Echinococcus multilocularis cyclin t1 0.0015 0.0074 0.0105
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1924 0.8893
Onchocerca volvulus 0.0054 0.0846 0.243
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Plasmodium falciparum thioredoxin reductase 0.0017 0.0104 0.0887
Echinococcus multilocularis serotonin receptor 0.0036 0.0476 0.0675
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0023 0.0229 0.0325
Echinococcus multilocularis cyclin y 0.0015 0.0074 0.0105
Loa Loa (eye worm) CYL-1 protein 0.0015 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0109 0.0162
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0362 0.4687
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.0476 0.0675
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0362 0.3499
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0476 0.0675
Echinococcus granulosus chromobox protein 1 0.0082 0.1389 0.1972
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0198 0.0912
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0362 0.1675
Trichomonas vaginalis cyclins, putative 0.0015 0.0074 0.0333
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.0476 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0074 0.0333
Echinococcus multilocularis geminin 0.0356 0.676 0.9599
Loa Loa (eye worm) doublecortin family protein 0.002 0.017 0.017
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0772 0.3364
Brugia malayi AKH receptor 0.0036 0.0476 0.0476
Echinococcus granulosus hypothetical protein 0.0036 0.0476 0.0675
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0229 0.1057
Schistosoma mansoni cyclin G 0.0015 0.0074 0.0109
Onchocerca volvulus 0.0036 0.0476 0.1346
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.017 0.0241
Loa Loa (eye worm) hypothetical protein 0.0121 0.215 0.215
Entamoeba histolytica cyclin family protein 0.0063 0.1005 0.467
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.1091 0.1091
Trypanosoma cruzi cyclin 9, putative 0.0015 0.0074 0.0342
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0476 0.0675
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0476 0.0675
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0772 0.3586
Brugia malayi larval opioid receptor 0.0036 0.0476 0.0476
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1941 0.2871
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0019 0.0158 0.0158
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0015 0.0074 0.0584
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0476 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.004 0.0184
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0188 0.0971
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0772 0.1096
Mycobacterium ulcerans PE-PGRS family protein 0.0012 0.0016 0.0081
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0362 0.1406
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0229 0.0339
Echinococcus granulosus cyclins 0.0063 0.1005 0.1427
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0074 0.0342
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0015 0.0074 0.0105
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0476 0.0675
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Schistosoma mansoni amine GPCR 0.0036 0.0476 0.0703
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1941 0.9029
Onchocerca volvulus 0.0031 0.0387 0.1086
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.0476 0.0675
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.0476 0.0675
Loa Loa (eye worm) CHromoDomain protein family member 0.0023 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.0476 0.0675
Brugia malayi chromobox protein homolog 3 0.0051 0.0779 0.0779
Brugia malayi Cyclin, N-terminal domain containing protein 0.0015 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0023 0.0229 0.0229
Echinococcus granulosus dna polymerase eta 0.0019 0.0158 0.0224
Echinococcus granulosus cyclin t1 0.0015 0.0074 0.0105
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0476 0.0675
Echinococcus multilocularis cyclin dependent kinase 5 0.0051 0.0772 0.1096
Loa Loa (eye worm) hypothetical protein 0.0121 0.215 0.215
Echinococcus multilocularis cyclin G2 0.0015 0.0074 0.0105
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0188 0.0876
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1941 0.9028
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0158 0.0725
Schistosoma mansoni chromobox protein 0.0082 0.1389 0.2054
Onchocerca volvulus 0.0121 0.215 0.6248
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0104 0.0482
Echinococcus granulosus chromobox protein 1 0.0082 0.1389 0.1972
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1941 0.2756
Trichomonas vaginalis chromobox protein, putative 0.0054 0.0838 0.3895
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.009 0.1549 0.2291
Entamoeba histolytica chitinase, putative 0.0012 0.0016 0.0064
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0229 0.282
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.0476 0.0675
Toxoplasma gondii thioredoxin reductase 0.0048 0.0719 0.9306
Plasmodium falciparum thioredoxin reductase 0.0048 0.0719 0.7105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Echinococcus granulosus cyclins 0.0063 0.1005 0.1427
Trichomonas vaginalis cyclin D, putative 0.0063 0.1005 0.467
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0158 0.0734
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0158 0.0158
Schistosoma mansoni biogenic amine receptor 0.0036 0.0476 0.0703
Loa Loa (eye worm) hypothetical protein 0.005 0.0761 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0476 0.0675
Echinococcus multilocularis orexin receptor type 2 0.0036 0.0476 0.0675
Entamoeba histolytica hypothetical protein 0.0023 0.0229 0.1057
Brugia malayi hypothetical protein 0.0012 0.0016 0.0016
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0015 0.0065 0.0092
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0362 0.4576
Schistosoma mansoni neuropeptide receptor 0.0036 0.0476 0.0703
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.1091 0.5072
Entamoeba histolytica cyclin, putative 0.0121 0.215 1
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0193 0.357 0.5069
Schistosoma mansoni adenoreceptor 0.0036 0.0476 0.0703
Schistosoma mansoni chromobox protein 0.0023 0.0229 0.0339
Onchocerca volvulus 0.0036 0.0476 0.1346
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus granulosus tumor protein p63 0.037 0.7043 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0387 0.0387
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0521 1 1
Brugia malayi Endochitinase 0.0012 0.0016 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0229 0.1057
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0719 0.102
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0049 0.022
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0147 0.1325
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.0476 0.0476
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0158 0.0158
Onchocerca volvulus 0.0053 0.0814 0.2338
Trypanosoma brucei unspecified product 0.0013 0.004 0.0184
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0229 0.1057
Brugia malayi hypothetical protein 0.002 0.017 0.017
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0581 0.0825
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0876 0.1244
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0049 0.022
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0533 0.2474
Schistosoma mansoni hypothetical protein 0.0036 0.0476 0.0703
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Schistosoma mansoni rab6-interacting 0.002 0.017 0.0251
Echinococcus granulosus g protein coupled receptor 0.0036 0.0476 0.0675
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0104 0.0482
Trichomonas vaginalis cyclin B3, putative 0.0063 0.1005 0.467
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0049 0.007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0158 0.0233
Schistosoma mansoni loxhd1 0.002 0.017 0.0251
Brugia malayi N-terminal motif family protein 0.0186 0.3431 0.3431
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0229 0.1057
Entamoeba histolytica cyclin family protein 0.0063 0.1005 0.467
Loa Loa (eye worm) hypothetical protein 0.0032 0.0408 0.0408
Trichomonas vaginalis cyclin B, putative 0.0063 0.1005 0.467
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Brugia malayi Cyclin, N-terminal domain containing protein 0.0015 0.0074 0.0074
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0158 0.0729
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Schistosoma mansoni opsin-like receptor 0.0036 0.0476 0.0703
Echinococcus multilocularis voltage gated potassium channel 0.0015 0.0065 0.0092
Trypanosoma cruzi cyclin 6, putative 0.0121 0.215 1
Trypanosoma brucei trypanothione reductase 0.0048 0.0719 0.3342
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0015 0.0074 0.0584
Brugia malayi Cyclin, N-terminal domain containing protein 0.0015 0.0074 0.0074
Onchocerca volvulus 0.0036 0.0476 0.1346
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0179 0.3287 0.3287
Onchocerca volvulus 0.0023 0.0229 0.0624
Brugia malayi hypothetical protein 0.0015 0.0074 0.0074
Echinococcus granulosus intermediate filament protein 0.0054 0.0846 0.1201
Toxoplasma gondii cyclin dependent kinase binding protein 0.0015 0.0074 0.0953
Echinococcus multilocularis serotonin receptor 0.0036 0.0476 0.0675
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0823 0.1218
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0362 0.3499
Onchocerca volvulus 0.0036 0.0476 0.1346
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.0476 0.0703
Echinococcus granulosus cyclin dependent kinase 1 0.0051 0.0772 0.1096
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.0476 0.0675
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.006 0.0278
Echinococcus granulosus orexin receptor type 2 0.0036 0.0476 0.0675
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1091 0.5076
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0015 0.0074 0.0105
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.1091 0.1614
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Schistosoma mansoni single-minded 0.0053 0.0823 0.1218
Entamoeba histolytica hypothetical protein 0.0015 0.0074 0.0333
Toxoplasma gondii hypothetical protein 0.0047 0.0709 0.9178
Echinococcus granulosus g protein coupled receptor 0.0036 0.0476 0.0675
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0054 0.0838 0.2409
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0229 0.282
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.0476 0.0675
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0476 0.0675
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1091 0.5076
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0158 0.0224
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0476 0.0675
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.006 0.0278
Echinococcus granulosus g protein coupled receptor 0.0036 0.0476 0.0675
Trichomonas vaginalis cyclin B3, putative 0.0015 0.0074 0.0333
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0015 0.0065 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0229 0.1057
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0476 0.0476
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0648 0.0958
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0476 0.0675
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0362 0.1675
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0104 0.0104
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0121 0.215 1
Echinococcus granulosus geminin 0.0356 0.676 0.9599
Brugia malayi glutathione reductase 0.0048 0.0719 0.0719
Echinococcus granulosus cyclin G2 0.0015 0.0074 0.0105
Echinococcus multilocularis cyclins 0.0063 0.1005 0.1427
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.017 0.2037
Entamoeba histolytica cyclin C, putative 0.0015 0.0074 0.0333
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0476 0.0675
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1941 0.1941
Echinococcus multilocularis cyclins 0.0063 0.1005 0.1427
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Brugia malayi Doublecortin family protein 0.002 0.017 0.017
Echinococcus multilocularis cyclins 0.0063 0.1005 0.1427
Onchocerca volvulus 0.0036 0.0476 0.1346
Onchocerca volvulus Cyclin L homolog 0.0015 0.0074 0.0169
Brugia malayi CHD4 protein 0.0023 0.0229 0.0229
Leishmania major protein kinase, putative 0.0014 0.006 0.0278
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0772 0.3586
Echinococcus granulosus lamin dm0 0.0054 0.0846 0.1201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0719 0.102
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0104 0.0533
Schistosoma mansoni survival motor neuron protein 0.0053 0.0814 0.1205
Echinococcus granulosus single minded 2 0.0043 0.0618 0.0878
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus granulosus Chromo domain 0.0023 0.0229 0.0325
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Onchocerca volvulus 0.0036 0.0476 0.1346
Brugia malayi Endochitinase 0.0012 0.0016 0.0016
Onchocerca volvulus 0.0054 0.0841 0.2416
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0229 0.1057
Schistosoma mansoni hypothetical protein 0.0015 0.0074 0.0109
Loa Loa (eye worm) hypothetical protein 0.0026 0.0293 0.0293
Schistosoma mansoni neuropeptide receptor 0.0036 0.0476 0.0703
Brugia malayi hypothetical protein 0.0259 0.4862 0.4862
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0023 0.0229 0.0325
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0104 0.5
Brugia malayi Glycosyl hydrolases family 18 protein 0.0012 0.0016 0.0016
Plasmodium falciparum LCCL domain-containing protein 0.002 0.017 0.1557
Leishmania major cyclin 0.0121 0.215 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0476 0.0703
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0104 0.0147
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.0476 0.0675
Schistosoma mansoni DNA polymerase eta 0.0019 0.0158 0.0233
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0049 0.007
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0104 0.0473
Onchocerca volvulus 0.0039 0.0552 0.1569
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0476 0.0476
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0229 0.0325
Plasmodium falciparum cyclin 1 0.0015 0.0074 0.0584
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1941 0.1941
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0476 0.0703
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.0476 0.0675
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0476 0.0675
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0648 0.0958
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.017 0.0241
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.0476 0.0476
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0229 0.0325
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1941 1
Onchocerca volvulus 0.0036 0.0476 0.1346
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Schistosoma mansoni hypothetical protein 0.0356 0.676 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0229 0.1057
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.0476 0.0703
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0188 0.0188
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.0476 0.0476
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0229 0.2967
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0104 0.1737
Trypanosoma cruzi cyclin, putative 0.0121 0.215 1
Schistosoma mansoni lipoxygenase 0.0056 0.0876 0.1296
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0188 0.0876
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.0476 0.0476
Brugia malayi SET domain containing protein 0.0023 0.0229 0.0229
Onchocerca volvulus 0.0036 0.0476 0.1346
Loa Loa (eye worm) hypothetical protein 0.0023 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0538 0.0764
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0229 0.0339
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Leishmania major mitotic cyclin, putative 0.0015 0.0074 0.0342
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0049 0.022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0476 0.0703
Echinococcus granulosus neuropeptide s receptor 0.0036 0.0476 0.0675
Onchocerca volvulus 0.0036 0.0476 0.1346
Entamoeba histolytica hypothetical protein 0.0023 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0229 0.0229
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0476 0.0675
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.0476 0.0675
Brugia malayi Dopamine receptor protein 2 0.0036 0.0476 0.0476
Schistosoma mansoni amine GPCR 0.0036 0.0476 0.0703
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0476 0.0703
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0049 0.022
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0065 0.0096
Echinococcus granulosus sex peptide receptor 0.0036 0.0476 0.0675
Brugia malayi Heterochromatin protein 1 0.0082 0.1389 0.1389
Echinococcus multilocularis somatostatin receptor 0.0036 0.0476 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0229 0.1057
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.0476 0.0703
Trichomonas vaginalis cyclin B3, putative 0.0015 0.0074 0.0333
Onchocerca volvulus 0.002 0.017 0.0451
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0229 0.0339
Loa Loa (eye worm) hypothetical protein 0.002 0.017 0.017
Giardia lamblia Kinase, CMGC CDK 0.0051 0.0772 0.3364
Trypanosoma brucei cyclin 9 0.0015 0.0074 0.0342
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.0772 0.1096
Entamoeba histolytica hypothetical protein 0.0023 0.0229 0.1057
Trichomonas vaginalis chromobox protein, putative 0.0054 0.0838 0.3895
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0229 0.0229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0229 0.1057
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.3431 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0476 0.0675
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0229 0.1057
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0158 0.0734
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0104 0.0482
Echinococcus multilocularis dna polymerase eta 0.0019 0.0158 0.0224
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0049 0.022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus granulosus voltage gated potassium channel 0.0015 0.0065 0.0092
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0229 0.2156
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0104 0.116
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0158 0.0734
Leishmania major trypanothione reductase 0.0048 0.0719 0.3342
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0814 0.0814
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0293 0.0416
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0476 0.0703
Trichomonas vaginalis hypothetical protein 0.0023 0.0229 0.1057
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.0476 0.0675
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) cyclin domain-containing protein 0.0015 0.0074 0.0074
Loa Loa (eye worm) helicase 0.0023 0.0229 0.0229
Brugia malayi Cytochrome P450 family protein 0.0021 0.0188 0.0188
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.0772 0.3586
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0476 0.0675
Echinococcus multilocularis cyclin B3 1 0.0063 0.1005 0.1427
Plasmodium falciparum glutathione reductase 0.0048 0.0719 0.7105
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0198 0.0281
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0158 0.0725
Loa Loa (eye worm) cyclin C 0.0015 0.0074 0.0074
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0188 0.0188
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.0476 0.0476
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0049 0.022
Brugia malayi Cyclin, N-terminal domain containing protein 0.0015 0.0074 0.0074
Brugia malayi Cyclin C 0.0015 0.0074 0.0074
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.017 0.0241
Echinococcus multilocularis Cyclin L1 0.0015 0.0074 0.0105
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trichomonas vaginalis cyclins, putative 0.0073 0.1218 0.5664
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0229 0.0325
Onchocerca volvulus 0.0036 0.0476 0.1346
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.2164 1
Trypanosoma brucei mitotic cyclin 6 0.0121 0.215 1
Schistosoma mansoni chromobox protein 0.0082 0.1389 0.2054
Echinococcus multilocularis cyclin G2 0.0015 0.0074 0.0105
Trichomonas vaginalis cyclins, putative 0.0015 0.0074 0.0333
Echinococcus multilocularis cyclin k 0.0015 0.0074 0.0105
Schistosoma mansoni neuropeptide receptor 0.0036 0.0476 0.0703
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0104 0.0482
Echinococcus multilocularis tumor protein p63 0.037 0.7043 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0015 0.0074 0.0074
Schistosoma mansoni biogenic amine receptor 0.0036 0.0476 0.0703
Trichomonas vaginalis cyclin D, putative 0.0015 0.0074 0.0333
Leishmania major DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Entamoeba histolytica cyclin, putative 0.0063 0.1005 0.467
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0841 0.1244
Trypanosoma brucei mitotic cyclin 0.0015 0.0074 0.0342
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.0476 0.0703
Trypanosoma cruzi mitotic cyclin, putative 0.0015 0.0074 0.0342
Echinococcus granulosus cyclin dependent kinase 0.0051 0.0772 0.1096
Brugia malayi Cyclin, N-terminal domain containing protein 0.0121 0.215 0.215
Brugia malayi ORL1-like opioid receptor 0.0036 0.0476 0.0476
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.0476 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0328 0.1517
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0476 0.0675
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0476 0.0675
Echinococcus granulosus Ankyrin repeat domain containing protein 0.009 0.1549 0.2199
Loa Loa (eye worm) hypothetical protein 0.0054 0.0841 0.0841
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0015 0.0065 0.0092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0229 0.1057
Echinococcus granulosus Chromobox protein 3 0.0023 0.0229 0.0325
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0104 0.0482
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0017 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0476 0.0703
Echinococcus granulosus neuropeptide receptor 0.0036 0.0476 0.0675
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.0476 0.0675
Giardia lamblia DINP protein human, muc B family 0.0019 0.0158 0.0405
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.1091 0.5076
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0158 0.0158
Schistosoma mansoni histamine h1 receptor 0.0036 0.0476 0.0703
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0772 0.3592
Brugia malayi hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.0772 0.0772
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.006 0.0278
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0362 0.4687
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.0476 0.0675
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.0476 0.0476
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0104 0.1341
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0476 0.0675
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0293 0.0416
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0058 0.0756
Echinococcus granulosus lamin 0.0054 0.0846 0.1201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0846 0.0846
Brugia malayi PAS domain containing protein 0.0053 0.0823 0.0823
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.0476 0.0476
Echinococcus granulosus cyclins 0.0063 0.1005 0.1427
Brugia malayi Thioredoxin reductase 0.0048 0.0719 0.0719
Echinococcus granulosus cyclins 0.0063 0.1005 0.1427
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0104 0.0533
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0104 0.0147
Brugia malayi Cyclin, N-terminal domain containing protein 0.0015 0.0074 0.0074
Brugia malayi G protein-coupled receptor 0.0036 0.0476 0.0476
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0476 0.0675
Schistosoma mansoni myosin xvIII 0.0036 0.0476 0.0703
Plasmodium falciparum glutathione reductase 0.0017 0.0104 0.0887
Plasmodium vivax protein kinase Crk2 0.0051 0.0772 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.3015 0.3015
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus granulosus Cyclin L1 0.0015 0.0074 0.0105
Onchocerca volvulus 0.0015 0.0074 0.0169
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.1091 0.155
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0104 0.5
Schistosoma mansoni cyclin l 0.0015 0.0074 0.0109
Echinococcus granulosus bloom syndrome protein 0.0021 0.0198 0.0281
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0229 0.1057
Giardia lamblia G2/mitotic-specific cyclin B 0.0121 0.215 1
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.1005 0.467
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0538 0.0764
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1924 0.8893
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.4862 0.6903
Brugia malayi Serotonin receptor 0.0036 0.0476 0.0476
Schistosoma mansoni chitinase 0.0012 0.0016 0.0023
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1941 0.9028
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0229 0.1057
Leishmania major DNA polymerase eta, putative 0.0019 0.0158 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0074 0.0333
Plasmodium vivax cyclin homologue, putative 0.0015 0.0074 0.0764
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0476 0.0675
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0229 0.1057
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0229 0.1057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Schistosoma mansoni hypothetical protein 0.0036 0.0476 0.0703
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0328 0.1517
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0476 0.0675
Giardia lamblia Hypothetical protein 0.0063 0.1005 0.4486
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0104 0.0482
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0002 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0104 0.0482
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0104 0.0533
Echinococcus multilocularis cyclin y 0.0015 0.0074 0.0105
Trichomonas vaginalis cyclin B, putative 0.0121 0.215 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0476 0.0703
Leishmania major cytochrome p450-like protein 0.0021 0.0188 0.0876
Echinococcus multilocularis Chromo domain 0.0023 0.0229 0.0325
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0362 0.1675
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0476 0.0675
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0229 0.2156
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0049 0.022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Echinococcus multilocularis lamin 0.0054 0.0846 0.1201
Loa Loa (eye worm) cyclin domain-containing protein 0.0015 0.0074 0.0074
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.017 0.0241
Schistosoma mansoni amine GPCR 0.0036 0.0476 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.004 0.0184
Loa Loa (eye worm) hypothetical protein 0.0036 0.0476 0.0476
Brugia malayi RE15519p 0.0036 0.0476 0.0476
Schistosoma mansoni chromobox protein 0.0023 0.0229 0.0339
Trichomonas vaginalis chitinase, putative 0.0012 0.0016 0.0064
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.035 0.035
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Onchocerca volvulus 0.0036 0.0476 0.1346
Schistosoma mansoni opsin-like receptor 0.0036 0.0476 0.0703
Trichomonas vaginalis cyclin B, putative 0.0121 0.215 1
Schistosoma mansoni hypothetical protein 0.002 0.017 0.0251
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Trichomonas vaginalis cyclin A, putative 0.0015 0.0074 0.0333
Onchocerca volvulus 0.0036 0.0476 0.1346
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0015 0.0074 0.0342
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0104 0.0144
Toxoplasma gondii cyclin 4, putative 0.0015 0.0074 0.0953
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0229 0.1057
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0049 0.0229
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0158 0.0734
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.017 0.0241
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0049 0.022
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0049 0.007
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.1091 0.155
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0476 0.0675
Brugia malayi Melatonin receptor type 1A 0.0036 0.0476 0.0476
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0104 0.0482
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0158 0.0734
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.0772 0.3592
Echinococcus granulosus cyclin k 0.0015 0.0074 0.0105
Brugia malayi sulfakinin receptor protein 0.0036 0.0476 0.0476
Onchocerca volvulus 0.0036 0.0476 0.1346
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0476 0.0675
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0104 0.1341
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.0476 0.0675
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0158 0.0224

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay ChEMBL. 19639995
EC50 (functional) Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay ChEMBL. 19639995
EC50 (functional) Agonist activity at FPRL2 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay ChEMBL. 19639995

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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