Detailed information for compound 1045219

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.197 | Formula: C14H15BrN4O4
  • H donors: 2 H acceptors: 6 LogP: 2.49 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc2nc(O)c(nc2cc1CN1CCC=CC1)O.Br
  • InChi: 1S/C14H14N4O4.BrH/c19-13-14(20)16-11-7-12(18(21)22)9(6-10(11)15-13)8-17-4-2-1-3-5-17;/h1-2,6-7H,3-5,8H2,(H,15,19)(H,16,20);1H
  • InChiKey: LSUZWHJKUFQRKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate receptors; NMDA/AMPA Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Probable ClpP-like protease 0.0157 0.0179 0.0454
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0222 0.0264 0.0669
Leishmania major hypothetical protein, conserved 0.0081 0.0079 0.02
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0081 0.0079 0.02
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0358 0.0441 0.1118
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Brugia malayi hypothetical protein 0.0033 0.0016 0.0041
Brugia malayi Pre-SET motif family protein 0.0059 0.0051 0.0129
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0021 0.0104
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0082 0.008 0.895
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0021 0.0021
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.3038 0.3942 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0021 0.0021
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0006 0.0006
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.008 0.0203
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0052
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.2957 0.3836 0.9732
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0081 0.0079 0.4242
Brugia malayi Importin beta-1 subunit 0.0029 0.0012 0.0029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.0178 0.045
Onchocerca volvulus 0.0358 0.0441 0.261
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.0004
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0052
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0006 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0021 0.0052
Brugia malayi jmjC domain containing protein 0.0124 0.0135 0.0342
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0006 0.0006
Onchocerca volvulus 0.0222 0.0264 0.1554
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0057 0.0145
Echinococcus granulosus phd:f box containing protein 0.0033 0.0016 0.0016
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0016 0.0016
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0089 0.0089 0.0227
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0071 0.0066 0.0167
Loa Loa (eye worm) hypothetical protein 0.0033 0.0016 0.0042
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0358 0.0441 0.1118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0222 0.0264 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0036 0.0609
Schistosoma mansoni hypothetical protein 0.0049 0.0038 0.0038
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0005 0.0005
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0021 0.1311
Schistosoma mansoni hypothetical protein 0.0023 0.0003 0.0003
Onchocerca volvulus 0.0025 0.0006 0.0016
Mycobacterium ulcerans transcriptional regulator 0.0081 0.0079 0.02
Schistosoma mansoni neuropeptide receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0157 0.0179 0.0454
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.008 0.1358
Schistosoma mansoni opsin-like receptor 0.0025 0.0006 0.0006
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0038 0.0038
Mycobacterium tuberculosis Probable reductase 0.0113 0.012 0.0305
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.3038 0.3942 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0001 0.0004
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0003 0.0003
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0089 0.0089 0.5579
Brugia malayi beta-lactamase 0.0222 0.0264 0.0669
Brugia malayi Dopamine receptor protein 1 0.0025 0.0006 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.0222 0.0264 0.0264
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0157 0.0397
Brugia malayi steroid hormone receptor 0.0036 0.0021 0.0052
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0025 0.0006 0.0006
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0016 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0006 0.0006
Onchocerca volvulus 0.0025 0.0006 0.0016
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0081 0.0079 0.8823
Echinococcus multilocularis snurportin 1 0.0312 0.0381 0.0381
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0082 0.008 0.4993
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.008 0.0203
Onchocerca volvulus 0.0025 0.0006 0.0016
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0081 0.0079 0.0079
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Schistosoma mansoni peptidase Clp (S14 family) 0.0157 0.0179 0.0179
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0025 0.0006 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0006 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0036 0.0611
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Onchocerca volvulus 0.0025 0.0006 0.0016
Brugia malayi intermediate filament protein 0.0055 0.0045 0.0114
Echinococcus multilocularis beta LACTamase domain containing family member 0.0222 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0012 0.003
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Echinococcus granulosus g protein coupled receptor 0.0025 0.0006 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0409 0.0507 0.0507
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0021 0.0021
Schistosoma mansoni biogenic amine receptor 0.0025 0.0006 0.0006
Leishmania major guanosine monophosphate reductase 0.3038 0.3942 1
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.0222 0.0264 0.0669
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0089 0.0227
Mycobacterium leprae Probable lipase LipE 0.0222 0.0264 0.0662
Loa Loa (eye worm) loechrig isoform VII 0.0081 0.0079 0.02
Echinococcus multilocularis tumor protein p63 0.0986 0.1261 0.1261
Loa Loa (eye worm) hypothetical protein 0.0051 0.004 0.0101
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.3038 0.3942 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0038 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0052
Schistosoma mansoni chloride channel protein 0.0081 0.0079 0.0079
Trypanosoma brucei hypothetical protein, conserved 0.0222 0.0264 0.0669
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0137 0.0339
Trypanosoma cruzi phospholipase A1, putative 0.0358 0.0441 0.1118
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.0514 0.1305
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0038 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.0222 0.0264 0.4479
Mycobacterium ulcerans lipase LipD 0.0222 0.0264 0.0669
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0021 0.0021
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0089 0.0089 0.0089
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0003 0.0008
Brugia malayi G-protein coupled receptor 0.0025 0.0006 0.0015
Schistosoma mansoni transcription factor LCR-F1 0.0143 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0055 0.0045 0.0114
Trypanosoma brucei phospholipase A1, putative 0.0358 0.0441 0.1118
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0223 0.0223
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0006 0.0015
Leishmania major inosine-5-monophosphate dehydrogenase 0.3038 0.3942 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0021 0.0021
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0005 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0089 0.0089 0.0227
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0006 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0021 0.0052
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0005 0.0013
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0036 0.0611
Echinococcus granulosus H:Cl exchange transporter 3 0.0081 0.0079 0.0079
Plasmodium vivax JmjC domain containing protein 0.0033 0.0016 0.0043
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.004 0.0104
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.0223 0.0566
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0157 0.0179 1
Brugia malayi ecdysteroid receptor 0.0036 0.0021 0.0052
Brugia malayi Dopamine receptor protein 2 0.0025 0.0006 0.0015
Schistosoma mansoni intermediate filament proteins 0.0055 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0143 0.016 0.016
Loa Loa (eye worm) chloride channel protein 7 0.0081 0.0079 0.02
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.0135 0.0342
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0006 0.0015
Echinococcus multilocularis transcription factor btf3 0.0037 0.0021 0.0021
Schistosoma mansoni amine GPCR 0.0025 0.0006 0.0006
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0006 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0012 0.0208
Mycobacterium tuberculosis Probable esterase LipL 0.0222 0.0264 0.0669
Loa Loa (eye worm) beta-lactamase 0.0222 0.0264 0.0669
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0012 0.0031
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0025 0.0006 0.0006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0008 0.0008
Echinococcus multilocularis lamin 0.0055 0.0045 0.0045
Echinococcus multilocularis serotonin receptor 0.0025 0.0006 0.0006
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0006 0.0006
Trypanosoma cruzi phospholipase A1, putative 0.0358 0.0441 0.1118
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0038 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0021 0.0052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0222 0.0264 0.0669
Schistosoma mansoni glutamate receptor NMDA 0.0024 0.0005 0.0005
Schistosoma mansoni lamin 0.0055 0.0045 0.0045
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0003 0.0008
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0081 0.0079 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0089 0.1517
Loa Loa (eye worm) glutathione reductase 0.0049 0.0038 0.0096
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0037 0.0022 0.0055
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0005 0.0013
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0113 0.0287
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0003 0.0008
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0157 0.0179 0.0454
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0012 0.0029
Onchocerca volvulus 0.0222 0.0264 0.1554
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0006 0.0016
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.0004
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0089 0.0089 0.0227
Mycobacterium tuberculosis Conserved protein 0.0081 0.0079 0.02
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0012 0.0208
Schistosoma mansoni hypothetical protein 0.0372 0.046 0.046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0021 0.0052
Onchocerca volvulus Phospholipase A2 homolog 0.0643 0.0813 0.483
Giardia lamblia GTOR 0.0089 0.0089 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0006 0.0006
Trichomonas vaginalis esterase, putative 0.0222 0.0264 0.4479
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Loa Loa (eye worm) GMP reductase 0.1307 0.168 0.4262
Brugia malayi jmjC domain containing protein 0.0124 0.0135 0.0342
Brugia malayi ancient conserved domain protein 4 0.0081 0.0079 0.02
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0023 0.2541
Brugia malayi chloride channel protein 7 0.0081 0.0079 0.02
Trichomonas vaginalis ran, putative 0.0022 0.0001 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0052
Onchocerca volvulus 0.0025 0.0006 0.0016
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0082 0.008 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0222 0.0264 0.0669
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0082 0.008 0.1358
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0053 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0222 0.0264 0.4479
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0087 0.0087
Brugia malayi neuropeptide F receptor 0.0025 0.0006 0.0015
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0038 0.0038
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0016 0.0016
Onchocerca volvulus Phospholipase A2 homolog 0.0198 0.0232 0.1365
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0081 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0004 0.0073
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0001 0.0004
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0006 0.0006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0021 0.0021
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0016 0.0042
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0372 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0004 0.0011
Echinococcus granulosus geminin 0.0344 0.0423 0.0423
Entamoeba histolytica hypothetical protein 0.0037 0.0021 0.1311
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0222 0.0264 0.0669
Echinococcus granulosus neuropeptide receptor A26 0.0525 0.0659 0.0659
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0089 0.1517
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0044 0.0115
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0021 0.0052
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0081 0.0079 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0021 0.0052
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0005 0.0013
Schistosoma mansoni jumonji/arid domain-containing protein 0.0124 0.0135 0.0135
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0012 0.0012
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0023 0.0059
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0053 0.0135
Schistosoma mansoni hypothetical protein 0.0025 0.0006 0.0006
Loa Loa (eye worm) acetyltransferase 0.014 0.0157 0.0397
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.006 0.1012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0052
Echinococcus granulosus sex peptide receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) RNA binding protein 0.0061 0.0053 0.0135
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.3038 0.3942 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.006 0.1012
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.0161
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Brugia malayi nuclear receptor NHR-88 0.0036 0.0021 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0043 0.0724
Mycobacterium ulcerans esterase/lipase LipP 0.0222 0.0264 0.0669
Brugia malayi CLC chloride channel protein 0.0081 0.0079 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0021 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0021 0.0021
Echinococcus granulosus orexin receptor type 2 0.0025 0.0006 0.0006
Chlamydia trachomatis Mg++ transporter 0.0081 0.0079 0.4242
Echinococcus granulosus lamin 0.0055 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0103 0.0108 0.0266
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0021 0.0104
Leishmania major importin beta-1 subunit, putative 0.0024 0.0004 0.0011
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0003 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Treponema pallidum Mg2+ transport protein (mgtE) 0.0081 0.0079 0.441
Onchocerca volvulus 0.0055 0.0045 0.0249
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0222 0.0264 0.0264
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0006 0.0006
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.004 0.0104
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0381 0.0967
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0038 0.0038
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0006 0.0015
Echinococcus multilocularis peptidase Clp (S14 family) 0.0103 0.0108 0.0108
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0157 0.0179 0.0179
Echinococcus multilocularis neuropeptide s receptor 0.0525 0.0659 0.0659
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.0072 0.1229
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0081 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0021 0.0021
Echinococcus granulosus peptidase Clp S14 family 0.0103 0.0108 0.0108
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0081 0.0079 0.8823
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0021 0.0053
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0016 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0045 0.0114
Plasmodium falciparum glutathione reductase 0.0049 0.0038 0.0099
Brugia malayi nuclear hormone receptor 0.0036 0.0021 0.0052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0038 0.0096
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0124 0.0135 0.0135
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0006 0.0006
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.3038 0.3942 0.3942
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0057 0.0145
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0001 0.0004
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0006 0.0006
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Onchocerca volvulus 0.0222 0.0264 0.1554
Echinococcus granulosus g protein coupled receptor 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Probable lipase LipE 0.0222 0.0264 0.0669
Echinococcus granulosus fmrfamide receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0081 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0222 0.0264 0.0669
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0006 0.0006
Onchocerca volvulus 0.0025 0.0006 0.0016
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0006 0.0006
Schistosoma mansoni transcription factor btf3 0.0037 0.0021 0.0021
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.012 0.0305
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0003 0.0202
Schistosoma mansoni biogenic amine receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0156 0.0178 0.045
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0012 0.0208
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0045 0.0114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0003 0.0008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0006 0.0006
Onchocerca volvulus 0.0025 0.0006 0.0016
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0222 0.0264 0.0669
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0051 0.004 0.0101
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0003 0.0008
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0089 0.0089 0.5579
Schistosoma mansoni hypothetical protein 0.0025 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0021 0.0052
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1651 0.2129 0.5403
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0043 0.0724
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0051 0.0051
Schistosoma mansoni thyroid hormone receptor 0.0409 0.0507 0.0507
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0016 0.0042
Toxoplasma gondii hypothetical protein 0.0054 0.0044 0.0112
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0081 0.0079 0.02
Echinococcus multilocularis lamin dm0 0.0055 0.0045 0.0045
Plasmodium vivax SET domain protein, putative 0.0059 0.0051 0.0133
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0049 0.0038 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.0178 0.045
Mycobacterium ulcerans cystathionine beta-synthase 0.0081 0.0079 0.02
Echinococcus granulosus tar DNA binding protein 0.0061 0.0053 0.0053
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0038 0.0096
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0081 0.0079 0.02
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0157 0.0179 1
Trypanosoma cruzi GMP reductase 0.3038 0.3942 1
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0016 0.0016
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0021 0.0104
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Onchocerca volvulus 0.0025 0.0006 0.0016
Giardia lamblia Hypothetical protein 0.0081 0.0079 0.8823
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Mycobacterium tuberculosis Probable hydrolase 0.0222 0.0264 0.0669
Schistosoma mansoni jumonji/arid domain-containing protein 0.0124 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0643 0.0813 0.2063
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.0081 0.0079 0.02
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0081 0.0079 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0036 0.0609
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.3038 0.3942 1
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.3038 0.3942 0.3942
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0006 0.0006
Brugia malayi Serotonin receptor 0.0025 0.0006 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0223 0.0223
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0089 0.0089 0.0227
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0001 0.0004
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0089 0.0089 0.0089
Trypanosoma brucei trypanothione reductase 0.0049 0.0038 0.0096
Onchocerca volvulus 0.0025 0.0006 0.0016
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.2957 0.3836 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0008
Onchocerca volvulus 0.0025 0.0006 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0222 0.0264 0.4479
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0005 0.0291
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0081 0.0079 0.02
Loa Loa (eye worm) hypothetical protein 0.0049 0.0038 0.0096
Brugia malayi G protein-coupled receptor 0.0025 0.0006 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0021 0.0052
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0157 0.0157
Brugia malayi Thioredoxin reductase 0.0049 0.0038 0.0096
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Entamoeba histolytica hypothetical protein 0.0143 0.016 1
Schistosoma mansoni chloride channel protein 0.0081 0.0079 0.0079
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0021 0.0053
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0081 0.0079 0.02
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0016 0.0042
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0847 0.1079 0.1079
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.012 0.0298
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0027 0.0462
Onchocerca volvulus 0.0358 0.0441 0.261
Brugia malayi beta-lactamase family protein 0.0222 0.0264 0.0669
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0006 0.0016
Echinococcus multilocularis somatostatin receptor 0.0025 0.0006 0.0006
Leishmania major chloride channel protein, putative 0.0081 0.0079 0.02
Onchocerca volvulus 0.0036 0.0021 0.0104
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0006 0.0015
Toxoplasma gondii CBS domain-containing protein 0.0081 0.0079 0.02
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0223 0.0223
Brugia malayi AKH receptor 0.0025 0.0006 0.0015
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0089 0.0089 0.0089
Schistosoma mansoni adenoreceptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Brugia malayi hypothetical protein 0.0143 0.016 0.0406
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0003 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0006 0.0006
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0005 0.0013
Echinococcus granulosus lamin dm0 0.0055 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0021 0.0357
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0089 0.0227
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1421 0.1829 0.4641
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0223 0.0223
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0005 0.0013
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0006 0.0006
Echinococcus granulosus intermediate filament protein 0.0055 0.0045 0.0045
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0005 0.0005
Onchocerca volvulus Putative GMP reductase 0.1307 0.168 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0004 0.0073
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0082 0.008 0.0203
Onchocerca volvulus 0.0025 0.0006 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0042 0.0713
Trichomonas vaginalis D-aminoacylase, putative 0.0222 0.0264 0.4479
Brugia malayi glutathione reductase 0.0049 0.0038 0.0096
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Echinococcus granulosus snurportin 1 0.0312 0.0381 0.0381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0006 0.0006
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0006 0.0015
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0006 0.0006
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1307 0.168 0.4262
Echinococcus granulosus allatostatin A receptor 0.0025 0.0006 0.0006
Brugia malayi Serotonin receptor 0.0025 0.0006 0.0015
Onchocerca volvulus 0.0358 0.0441 0.261
Trypanosoma cruzi chloride channel protein, putative 0.0081 0.0079 0.02
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0005 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0036 0.0611
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0043 0.0724
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Echinococcus granulosus importin subunit beta 1 0.0029 0.0012 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0107 0.0113 0.0113
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0372 0.046 0.046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0222 0.0264 0.0669
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0087 0.0087
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0052
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0081 0.0079 0.02
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0057 0.0057
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0048 0.0048
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0008 0.0008
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0021 0.0055
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0023 0.1418
Entamoeba histolytica Ran family GTPase 0.0022 0.0001 0.009
Onchocerca volvulus 0.0059 0.0051 0.0284
Loa Loa (eye worm) IMP dehydrogenase 1 0.3038 0.3942 1
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.004 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0021 0.0052
Echinococcus granulosus neuropeptide receptor 0.0025 0.0006 0.0006
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0024 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0012 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0066 0.1114
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0081 0.0079 0.8823
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0029
Entamoeba histolytica hypothetical protein 0.0143 0.016 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0003 0.0202
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0082 0.008 0.008
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0057 0.0057
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0066 0.1114
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0151 0.0151
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.012 0.0305
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0124 0.0135 0.0135
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0082 0.008 0.008
Schistosoma mansoni histamine h1 receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0081 0.0079 0.0079
Mycobacterium tuberculosis Probable lipase LipD 0.0222 0.0264 0.0669
Brugia malayi G-protein coupled receptor 0.0025 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Trypanosoma cruzi target of rapamycin kinase 3 0.0071 0.0066 0.0167
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0005 0.0005
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0012 0.0029
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0006 0.0006
Schistosoma mansoni myosin xvIII 0.0025 0.0006 0.0006
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0157 0.0179 0.0466
Onchocerca volvulus 0.0055 0.0045 0.0249
Leishmania major phospholipase A1, putative 0.0358 0.0441 0.1118
Schistosoma mansoni neuropeptide receptor 0.0025 0.0006 0.0006
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0157 0.0179 0.0454
Echinococcus granulosus ubiquitin specific protease 41 0.0082 0.008 0.008
Trypanosoma cruzi GMP reductase 0.3038 0.3942 1
Echinococcus granulosus serotonin receptor 0.0025 0.0006 0.0006
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0016 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.004 0.0101
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0157 0.0179 0.0446
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.1387 0.1785 0.4525
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0016 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0066 0.1114
Plasmodium vivax glutathione reductase, putative 0.0049 0.0038 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Plasmodium falciparum importin beta, putative 0.0029 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0222 0.0264 0.0669
Echinococcus multilocularis musashi 0.0055 0.0045 0.0045
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0081 0.0079 0.02
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.3038 0.3942 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0079 0.02
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0344 0.0423 0.0423
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0051 0.0051
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0082 0.008 0.0203
Trypanosoma cruzi chloride channel protein, putative 0.0081 0.0079 0.02
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0021 0.0021
Schistosoma mansoni importin beta-1 0.0029 0.0012 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0006 0.0006
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0006 0.0006
Plasmodium falciparum protein MAM3, putative 0.0081 0.0079 0.0206
Loa Loa (eye worm) hypothetical protein 0.0054 0.0044 0.0111
Schistosoma mansoni opsin-like receptor 0.0025 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0049 0.0826
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0028 0.0072
Echinococcus multilocularis thyroid hormone receptor alpha 0.0409 0.0507 0.0507
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0006 0.0006
Echinococcus granulosus lysine specific demethylase 5A 0.0124 0.0135 0.0135
Mycobacterium tuberculosis Conserved protein 0.0222 0.0264 0.0669
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0051 0.0129
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0006 0.0015
Echinococcus multilocularis ubiquitin specific protease 41 0.0082 0.008 0.008
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0003 0.0202
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Brugia malayi ancient conserved domain protein 2 0.0081 0.0079 0.02
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0005 0.0014
Toxoplasma gondii ABC1 family protein 0.0222 0.0264 0.0669
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0089 0.0089 0.0227
Plasmodium falciparum thioredoxin reductase 0.0049 0.0038 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0021 0.0052
Onchocerca volvulus 0.0081 0.0079 0.0451
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0051 0.0051
Trypanosoma cruzi chloride channel protein, putative 0.0081 0.0079 0.02
Echinococcus multilocularis lysine specific demethylase 5A 0.0124 0.0135 0.0135
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0008
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0027 0.0071
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0003 0.0003
Treponema pallidum hemolysin (tlyC) 0.0081 0.0079 0.441
Toxoplasma gondii IMP dehydrogenas 0.3038 0.3942 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0021 0.0052
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0003 0.0008
Echinococcus granulosus tumor protein p63 0.0986 0.1261 0.1261
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0081 0.0079 0.02
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0021 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.008 0.1358
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0057 0.0057
Mycobacterium ulcerans hypothetical protein 0.0023 0.0003 0.0008
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0016 0.0016
Brugia malayi larval opioid receptor 0.0025 0.0006 0.0015
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0005 0.0014
Brugia malayi beta-NAC-like protein 0.0037 0.0021 0.0053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0222 0.0264 0.0669
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0006 0.0006
Schistosoma mansoni ran 0.0022 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0021 0.0021
Mycobacterium ulcerans hypothetical protein 0.0081 0.0079 0.02
Echinococcus granulosus H:Cl exchange transporter 7 0.0081 0.0079 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0021 0.0052
Onchocerca volvulus 0.0144 0.0162 0.0946
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0021 0.0052
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.006 0.1012
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0081 0.0079 0.0079
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0157 0.0179 0.0454
Schistosoma mansoni amine GPCR 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0052
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0044 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0006 0.0006
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0157 0.0179 0.0454
Chlamydia trachomatis CBS domain-containing protein 0.0081 0.0079 0.4242
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0006 0.0006
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0082 0.008 0.008
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0137 0.0347
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0005 0.0013
Onchocerca volvulus 0.0025 0.0006 0.0016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0038 0.0096
Schistosoma mansoni microtubule-associated protein tau 0.7676 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0003 0.0008
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0087 0.0087 0.022
Entamoeba histolytica hypothetical protein 0.0024 0.0004 0.0269
Echinococcus multilocularis microtubule associated protein 2 0.7676 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.006 0.1012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0012 0.0031
Echinococcus granulosus H:Cl exchange transporter 4 0.0081 0.0079 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0021 0.0052
Schistosoma mansoni biogenic amine receptor 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Brugia malayi RNA, U transporter 1 0.0083 0.0082 0.0208
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0003 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1387 0.1785 0.453
Toxoplasma gondii target of rapamycin (TOR), putative 0.0066 0.006 0.0151
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0021 0.0021
Echinococcus multilocularis sex peptide receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0012 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0223 0.0223
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0021 0.0021
Onchocerca volvulus 0.0025 0.0006 0.0016
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0016 0.0043
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0157 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0006 0.0006
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.3038 0.3942 1
Mycobacterium tuberculosis Conserved protein 0.0222 0.0264 0.0669
Schistosoma mansoni hypothetical protein 0.0344 0.0423 0.0423
Plasmodium vivax hypothetical protein, conserved 0.0222 0.0264 0.0688
Echinococcus granulosus neuropeptide s receptor 0.0525 0.0659 0.0659
Loa Loa (eye worm) hypothetical protein 0.0222 0.0264 0.0669
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0006 0.0015
Brugia malayi hypothetical protein 0.0025 0.0006 0.0015
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.012 0.0305
Brugia malayi Phospholipase A2 family protein 0.0643 0.0813 0.2063
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0081 0.0079 0.0079
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0006 0.0006
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0006 0.0006
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0025 0.0006 0.0015
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0081 0.0079 0.02
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0016 0.0016
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0006 0.0015
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0081 0.0079 0.02
Brugia malayi TAR-binding protein 0.0061 0.0053 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0021 0.0052
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0087 0.022
Leishmania major chloride channel protein, putative 0.0081 0.0079 0.02
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0312 0.0381 0.0381
Brugia malayi RNA binding protein 0.0061 0.0053 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0021 0.0357
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0005 0.0013
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0033 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0223 0.0223
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0006 0.0006
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0044 0.0104
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0006 0.0006
Trypanosoma brucei GMP reductase 0.3038 0.3942 1
Brugia malayi GMP reductase 0.1307 0.168 0.4262
Echinococcus granulosus transcription factor btf3 0.0037 0.0021 0.0021
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0012 0.0031
Leishmania major trypanothione reductase 0.0049 0.0038 0.0096
Mycobacterium ulcerans beta-lactamase 0.0222 0.0264 0.0669
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0021 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0051 0.0051
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0006 0.0006
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0081 0.0079 0.0079
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.0223 0.0566
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0164 0.0188 0.0476
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.004 0.0101
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0087 0.0087
Echinococcus multilocularis serotonin receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0082 0.008 0.008
Onchocerca volvulus 0.0087 0.0087 0.0498
Schistosoma mansoni protein kinase subunit gamma 0.0081 0.0079 0.0079
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0016 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0004 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0143 0.016 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0222 0.0264 0.0669
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0021 0.0021
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0005 0.0005
Plasmodium vivax importin-beta 2, putative 0.0029 0.0012 0.003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0057 0.0145
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0038 0.0038
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0071 0.0066 0.0167
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0024 0.0005 0.0005
Echinococcus granulosus GPCR family 2 0.0049 0.0038 0.0038
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0006 0.0006
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0006 0.0015
Schistosoma mansoni cellular tumor antigen P53 0.0144 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0033 0.0016 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.006 0.1012
Echinococcus granulosus g protein coupled receptor 0.0025 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0021 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0021 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0012 0.0208
Schistosoma mansoni hypothetical protein 0.0049 0.0038 0.0038
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1307 0.168 0.4262
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0006 0.0015
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0027 0.0008 0.0008
Brugia malayi RE15519p 0.0025 0.0006 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0003 0.0008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0006 0.0015
Mycobacterium ulcerans hypothetical protein 0.0081 0.0079 0.02
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0006 0.0006
Onchocerca volvulus 0.0025 0.0006 0.0016
Toxoplasma gondii CBS family protein 0.0081 0.0079 0.02
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0081 0.0079 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0089 0.1517
Brugia malayi Melatonin receptor type 1A 0.0025 0.0006 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Schistosoma mansoni amine GPCR 0.0025 0.0006 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.004 0.0101
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0051 0.0051
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0027 0.0462
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0081 0.0079 0.02
Echinococcus granulosus biogenic amine 5HT receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0006 0.0015
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0004 0.0073
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0222 0.0264 0.0669
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Schistosoma mansoni hypothetical protein 0.0025 0.0006 0.0006
Schistosoma mansoni neuropeptide receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0016 0.0016
Brugia malayi putative neuropeptide receptor 0.0025 0.0006 0.0015
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0081 0.0079 0.02
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0006 0.0006
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0006 0.0015
Brugia malayi Pre-SET motif family protein 0.0414 0.0514 0.1305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0042 0.0713
Leishmania major CBS domain protein, conserved 0.0081 0.0079 0.02
Brugia malayi CBS domain containing protein 0.0081 0.0079 0.02
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0021 0.0357
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0027 0.0027
Schistosoma mansoni amine GPCR 0.0025 0.0006 0.0006
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0021 0.0053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0079 0.0192
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0006 0.0006
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0157 0.0179 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0082 0.008 0.0203
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0164 0.0188 0.0476
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0027 0.0069
Brugia malayi loechrig isoform VII 0.0081 0.0079 0.02
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0137 0.0347
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.0178 0.045
Echinococcus granulosus somatostatin receptor 0.0025 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0021 0.0052
Entamoeba histolytica hypothetical protein 0.0143 0.016 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0021 0.0021
Brugia malayi ORL1-like opioid receptor 0.0025 0.0006 0.0015
Schistosoma mansoni jumonji domain containing protein 0.0124 0.0135 0.0135
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0006 0.0006
Schistosoma mansoni coup transcription factor 0.0036 0.0021 0.0021
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0051 0.0051
Brugia malayi hypothetical protein 0.0051 0.004 0.0101
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0103 0.0108 0.0274
Mycobacterium tuberculosis Conserved protein 0.0081 0.0079 0.02
Toxoplasma gondii thioredoxin reductase 0.0049 0.0038 0.0096
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0045 0.0114
Brugia malayi neuropeptide F receptor 0.0025 0.0006 0.0015
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0021 0.0021
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0046 0.0117
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0157 0.0179 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0051 0.0869
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.006 0.1012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0001 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.004 0.0104
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0033 0.0016 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0021 0.0052
Echinococcus multilocularis geminin 0.0344 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0025 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Leishmania major hypothetical protein, conserved 0.0033 0.0016 0.0042
Brugia malayi Voltage gated chloride channel family protein 0.0081 0.0079 0.02
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0223 0.0223
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0081 0.0079 0.02
Entamoeba histolytica hypothetical protein 0.0024 0.0005 0.0325
Echinococcus multilocularis GPCR, family 2 0.0049 0.0038 0.0038
Brugia malayi beta-lactamase family protein 0.0222 0.0264 0.0669
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.3038 0.3942 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0222 0.0264 0.0669
Echinococcus multilocularis neuropeptide receptor A26 0.0525 0.0659 0.0659
Schistosoma mansoni opsin-like receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0033 0.0016 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0057 0.0145
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0006 0.0006
Schistosoma mansoni ran 0.0022 0.0001 0.0001
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.2957 0.3836 1
Mycobacterium ulcerans hypothetical protein 0.0081 0.0079 0.02
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0089 0.0089 0.0227
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0006 0.0015
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.3038 0.3942 1
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0038 0.0096
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0006 0.0015
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0006 0.0006
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0006 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0006 0.0006
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0038 0.0038
Echinococcus granulosus neuropeptide receptor 0.0025 0.0006 0.0006
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0081 0.0079 0.02
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0016 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0222 0.0264 0.4479
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.1651 0.2129 0.5399
Onchocerca volvulus 0.0471 0.0589 0.3494
Brugia malayi sulfakinin receptor protein 0.0025 0.0006 0.0015
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0006 0.0006
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0006 0.0006
Schistosoma mansoni lamin 0.0055 0.0045 0.0045
Mycobacterium ulcerans hypothetical protein 0.0222 0.0264 0.0669
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0005 0.0005
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0036 0.0611
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Brugia malayi Dopamine receptor 0.0025 0.0006 0.0015
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0081 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0107 0.0113 0.0287
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0157 0.0179 0.0466
Loa Loa (eye worm) hypothetical protein 0.0026 0.0008 0.002
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0082 0.008 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0021 0.0021
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0222 0.0264 0.0669
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0036 0.0609
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0021 0.0021
Echinococcus granulosus glutamate receptor 2 0.0024 0.0005 0.0005
Trypanosoma cruzi chloride channel protein, putative 0.0081 0.0079 0.02
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0012 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0006 0.0006
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0012 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0143 0.016 0.016
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0006 0.0006
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0021 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0021 0.0052
Trichomonas vaginalis set domain proteins, putative 0.0471 0.0589 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0021 0.0021
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0081 0.0079 0.02
Mycobacterium leprae conserved hypothetical protein 0.0222 0.0264 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0066 0.1114
Leishmania major basic transcription factor 3a, putative 0.0037 0.0021 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0006 0.0006
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.012 0.0305
Loa Loa (eye worm) hypothetical protein 0.0144 0.0162 0.0411
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0198 0.0232 0.0589
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0027 0.0069
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0222 0.0264 0.0669
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0051 0.0051
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0049 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0081 0.0079 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0021 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0006 0.0006
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0021 0.0053
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0006 0.0006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0038 0.0038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0057 0.0145
Loa Loa (eye worm) hypothetical protein 0.0059 0.0051 0.0129
Brugia malayi jmjC domain containing protein 0.0033 0.0016 0.0042
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0012 0.0012
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0081 0.0079 0.02
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0006 0.0006
Onchocerca volvulus 0.0025 0.0006 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0021 0.0052
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0021 0.0053
Schistosoma mansoni chloride channel protein 0.0081 0.0079 0.0079
Brugia malayi GnHR receptor homolog 0.0025 0.0006 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.006 0.1012
Brugia malayi jmjC domain containing protein 0.0033 0.0016 0.0042
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0001 0.0004
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0044 0.2467
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0016 0.0042
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0016 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0053 0.0053
Loa Loa (eye worm) chloride channel 3 0.0081 0.0079 0.02
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0016 0.0016
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0081 0.0079 0.02
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.0066 0.1114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0021 0.0052
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0021 0.0055
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0006 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0137 0.0347
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0006 0.0006
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0082 0.008 0.008
Echinococcus granulosus hypothetical protein 0.0025 0.0006 0.0006
Onchocerca volvulus 0.0025 0.0006 0.0016
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0053 0.0135
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0006 0.0006
Schistosoma mansoni amine GPCR 0.0025 0.0006 0.0006
Brugia malayi jmjC domain containing protein 0.0033 0.0016 0.0042
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0012 0.003
Onchocerca volvulus 0.0025 0.0006 0.0016
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.3038 0.3942 0.3942
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0021 0.0021
Toxoplasma gondii CBS domain-containing protein 0.0081 0.0079 0.02
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0012 0.0031
Leishmania major GTP-binding protein, putative 0.0022 0.0001 0.0004
Entamoeba histolytica hypothetical protein 0.0143 0.016 1
Brugia malayi jmjC domain containing protein 0.0033 0.0016 0.0042
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.012 0.0305
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0103 0.0108 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0012 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0015
Schistosoma mansoni neuropeptide receptor 0.0025 0.0006 0.0006

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.36 uM In vitro binding affinity to the AMPA receptor using [3H]-AMPA binding assay ChEMBL. 9871630
Inhibition (binding) = 40 % In vitro binding affinity against glycine-bining site of NMDA receptor at a concentration of 1 uM using [3H]-MDL-105,519 binding assay ChEMBL. 9871630

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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