TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 704.16 | Formula: C18H20Cl6N2O2Pt++
H donors: 4 H acceptors: 2 LogP: 7.44 Rotable bonds: 2
Rule of 5 violations (Lipinski): 2
SMILES: Clc1cc(O)cc(c1C1CCC([NH+]([Pt]([NH+]1C)(Cl)Cl)C)c1c(Cl)cc(cc1Cl)O)Cl
InChi: 1S/C18H20Cl4N2O2.2ClH.Pt/c1-23-15(17-11(19)5-9(25)6-12(17)20)3-4-16(24-2)18-13(21)7-10(26)8-14(18)22;;;/h5-8,15-16,23-26H,3-4H2,1-2H3;2*1H;/q;;;+4/p-2
InChiKey: LCHPWPYNBIFVPJ-UHFFFAOYSA-L

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.017	0.1876	0.5408
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0173	0.9662
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0173	0.0218
Loa Loa (eye worm)	hypothetical protein	0.008	0.0784	0.3269
Echinococcus granulosus	RUN	0.002	0.0053	0.0157
Leishmania major	hypothetical protein, conserved	0.0025	0.0115	0.0989
Brugia malayi	Doublecortin family protein	0.002	0.0053	0.022
Brugia malayi	hypothetical protein	0.0073	0.0695	0.2895
Brugia malayi	hypothetical protein	0.002	0.0053	0.022
Loa Loa (eye worm)	MBCTL1	0.0056	0.0483	0.2015
Entamoeba histolytica	hypothetical protein	0.0073	0.0695	0.5876
Brugia malayi	C1-like domain containing protein	0.0019	0.0037	0.0152
Schistosoma mansoni	serine/threonine protein kinase	0.0167	0.1844	0.5314
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0018	0.003	0.003
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0053	0.0053
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0019	0.0037	0.0152
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0098	0.0997	0.4156
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0018	0.003	0.0124
Echinococcus granulosus	Protein kinase C brain isozyme	0.0167	0.1844	0.5488
Onchocerca volvulus		0.0084	0.0828	0.2926
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0026	0.0122	0.0122
Onchocerca volvulus		0.0022	0.0076	0.017
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.0828	0.345
Echinococcus multilocularis	protein kinase c iota type	0.0044	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.002	0.0053	0.022
Schistosoma mansoni	vav2	0.0018	0.003	0.0086
Echinococcus multilocularis	dnaJ subfamily C 6	0.0063	0.057	0.057
Onchocerca volvulus		0.0084	0.0828	0.2926
Brugia malayi	Bromodomain containing protein	0.003	0.017	0.0709
Onchocerca volvulus	Peroxidase homolog	0.0084	0.0828	0.2926
Echinococcus granulosus	6 phosphofructokinase	0.0111	0.1161	0.3455
Toxoplasma gondii	AGC kinase	0.0026	0.0122	0.6822
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0098	0.0996	0.2966
Brugia malayi	Protein kinase domain containing protein	0.0019	0.0037	0.0152
Brugia malayi	Ras association domain family 1 isoform A	0.0018	0.003	0.0124
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0122	0.0509
Echinococcus granulosus	unc 13 munc13	0.0022	0.0076	0.0226
Loa Loa (eye worm)	phosphofructokinase	0.0111	0.1161	0.4839
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0173	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.1265	0.5272
Schistosoma mansoni	hypothetical protein	0.0063	0.057	0.1643
Onchocerca volvulus	Matrilysin homolog	0.008	0.0784	0.2766
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0053	0.0157
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0026	0.0122	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.4156
Schistosoma mansoni	hypothetical protein	0.0073	0.0695	0.2002
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.1161	0.3958
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0076	0.0317
Brugia malayi	Pleckstrin Homology Domain	0.0018	0.003	0.0124
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.0828	0.345
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0122	0.0352
Echinococcus granulosus	Diacylglycerol kinase theta	0.0018	0.003	0.0089
Brugia malayi	Blistered cuticle protein 3	0.0084	0.0828	0.345
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0019	0.0037	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0366	0.1054
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.1161	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1483	0.6179
Brugia malayi	Matrixin family protein	0.008	0.0784	0.3269
Onchocerca volvulus		0.002	0.0053	0.0084
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0063	0.057	0.1721
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0247	0.0711
Entamoeba histolytica	protein kinase, putative	0.0026	0.0122	0.0816
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0179	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0098	0.0996	0.0996
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.017	0.0491
Mycobacterium ulcerans	6-phosphofructokinase	0.0111	0.1161	1
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.0828	0.345
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0053	0.2944
Trichomonas vaginalis	6-phosphofructokinase, putative	0.003	0.0173	0.0218
Brugia malayi	hypothetical protein	0.0025	0.0115	0.0479
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Brugia malayi	Pre-SET motif family protein	0.0031	0.0179	0.0746
Schistosoma mansoni	polycystin 1-related	0.002	0.0053	0.0152
Schistosoma mansoni	unc-13 (munc13)	0.0024	0.0099	0.0287
Echinococcus granulosus	NDR protein kinase	0.0026	0.0122	0.0363
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0173	0.0218
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0056	0.0495	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Echinococcus granulosus	dnaJ subfamily C 6	0.0063	0.057	0.1697
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0026	0.0122	0.0122
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0111	0.1161	1
Brugia malayi	jmjC domain containing protein	0.0098	0.0996	0.4153
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0056	0.0483	0.2015
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0213	0.24	1
Onchocerca volvulus		0.0242	0.2758	1
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0019	0.0037	0.0152
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0063	0.057	0.2376
Entamoeba histolytica	hypothetical protein	0.0073	0.0695	0.5876
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0026	0.0122	0.0509
Brugia malayi	diacylglycerol kinase	0.0018	0.003	0.0124
Entamoeba histolytica	protein kinase, putative	0.0026	0.0122	0.0816
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0059	0.0522	0.4493
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0053	0.0157
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.003	0.0173	0.1265
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Echinococcus granulosus	protein kinase c iota type	0.0044	0.0345	0.1026
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0056	0.0495	0.1472
Loa Loa (eye worm)	matrix metalloproteinase	0.008	0.0784	0.3269
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0026	0.0122	0.0509
Brugia malayi	MH2 domain containing protein	0.012	0.1265	0.5272
Plasmodium falciparum	phd finger protein, putative	0.003	0.017	0.9847
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0022	0.0076	0.0226
Brugia malayi	p70 ribosomal S6 kinase beta	0.0026	0.0122	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0179	0.0746
Entamoeba histolytica	protein kinase, putative	0.0026	0.0122	0.0816
Brugia malayi	Peroxidasin	0.0084	0.0828	0.345
Echinococcus granulosus	peroxidasin	0.0084	0.0828	0.2464
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0115	0.0479
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0695	0.2067
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Echinococcus granulosus	geminin	0.017	0.1876	0.5584
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0483	0.2015
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0115	0.6645
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.0247	0.0734
Brugia malayi	diacylglycerol kinase	0.0018	0.003	0.0124
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0026	0.0122	0.0122
Schistosoma mansoni	peroxidasin	0.0084	0.0828	0.2386
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0179	0.0516
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0391	0.1127
Loa Loa (eye worm)	animal heme peroxidase	0.0084	0.0828	0.345
Brugia malayi	RhoGEF domain containing protein	0.0018	0.003	0.0124
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0292	0.336	1
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0053	0.0157
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0179	0.0532
Onchocerca volvulus		0.0084	0.0828	0.2926
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0173	0.9662
Onchocerca volvulus		0.0031	0.0179	0.0547
Echinococcus multilocularis	peroxidasin	0.0084	0.0828	0.0828
Brugia malayi	Protein kinase c protein 2	0.0142	0.1536	0.64
Echinococcus multilocularis	RNA directed DNA polymerase	0.0119	0.126	0.126
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0115	0.6421
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0179	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Trypanosoma brucei	RNA helicase, putative	0.0106	0.1096	0.9444
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0173	0.0218
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0366	0.1054
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.0522	0.2174
Echinococcus granulosus	polycomb protein SCMH1	0.0049	0.0401	0.1194
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0056	0.0483	0.1393
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0695	0.0695
Loa Loa (eye worm)	hypothetical protein	0.003	0.017	0.0709
Entamoeba histolytica	protein kinase, putative	0.0026	0.0122	0.0816
Echinococcus multilocularis	unc 13 (munc13)	0.0022	0.0076	0.0076
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0292	0.336	0.336
Onchocerca volvulus	Matrilysin homolog	0.0178	0.1975	0.7129
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0018	0.003	0.0124
Echinococcus multilocularis	protein kinase c epsilon type	0.0048	0.0391	0.0391
Echinococcus multilocularis	serine threonine protein kinase	0.0149	0.1621	0.1621
Onchocerca volvulus	Alhambra homolog	0.003	0.017	0.0515
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0026	0.0122	0.0509
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0019	0.0037	0.0109
Brugia malayi	6-phosphofructokinase	0.0111	0.1161	0.4839
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.0828	0.345
Schistosoma mansoni	serine/threonine protein kinase	0.0018	0.003	0.0086
Brugia malayi	phosphofructokinase	0.0111	0.1161	0.4839
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0173	1
Echinococcus granulosus	myotubularin protein 13	0.0018	0.003	0.0089
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.017	0.9514
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.003	0.0124
Schistosoma mansoni	hypothetical protein	0.002	0.0053	0.0152
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.1161	0.4839
Brugia malayi	RhoGAP domain containing protein	0.0018	0.003	0.0124
Schistosoma mansoni	hypothetical protein	0.0297	0.3419	0.9854
Loa Loa (eye worm)	matrixin family protein	0.0178	0.1975	0.8229
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0173	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.1161	0.3958
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0098	0.0997	0.8589
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.1161	1
Plasmodium vivax	hypothetical protein, conserved	0.003	0.017	0.9514
Echinococcus multilocularis	peregrin	0.003	0.017	0.017
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0179	0.0179
Brugia malayi	DnaJ domain containing protein	0.0063	0.057	0.2376
Schistosoma mansoni	rab6-interacting	0.002	0.0053	0.0152
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0018	0.003	0.0124
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.017	0.0507
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.1161	1
Echinococcus granulosus	serine:threonine protein kinase N2	0.0026	0.0122	0.0363
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0053	0.0053
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0026	0.0122	0.0509
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0122	0.0509
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Loa Loa (eye worm)	hypothetical protein	0.008	0.0784	0.3269
Schistosoma mansoni	diacylglycerol kinase theta	0.0018	0.003	0.0086
Schistosoma mansoni	hypothetical protein	0.0106	0.1096	0.316
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.0247	0.0711
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0124	0.1313	0.5472
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.1161	0.3346
Onchocerca volvulus	Dual oxidase homolog	0.0084	0.0828	0.2926
Loa Loa (eye worm)	animal heme peroxidase	0.0084	0.0828	0.345
Onchocerca volvulus		0.0114	0.1193	0.4263
Onchocerca volvulus	Chorion peroxidase homolog	0.0084	0.0828	0.2926
Echinococcus multilocularis	myotubularin protein 13	0.0018	0.003	0.003
Brugia malayi	Hr1 repeat family protein	0.0026	0.0122	0.0509
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.017	0.9514
Brugia malayi	6-phosphofructokinase	0.0111	0.1161	0.4839
Brugia malayi	hypothetical protein	0.0016	0.0006	0.0024
Brugia malayi	mbt repeat family protein	0.0049	0.0401	0.1672
Onchocerca volvulus		0.0049	0.0401	0.1362
Leishmania major	ATP-dependent phosphofructokinase	0.0111	0.1161	1
Brugia malayi	RhoGAP domain containing protein	0.0018	0.003	0.0124
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0026	0.0122	0.1051
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0522	0.1552
Echinococcus granulosus	Rac GTPase activating protein 1	0.0018	0.003	0.0089
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0401	0.1156
Echinococcus granulosus	N chimaerin	0.0018	0.003	0.0089
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0026	0.0122	0.0122
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0049	0.0401	0.0401
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0178	0.1975	0.7129
Echinococcus multilocularis	N chimaerin	0.0018	0.003	0.003
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0366	0.1088
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Onchocerca volvulus	Peroxidasin homolog	0.0084	0.0828	0.2926
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0179	0.0516
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0165	0.0492
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0053	0.022
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.1265	0.5272
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0401	0.1156
Entamoeba histolytica	hypothetical protein	0.0073	0.0695	0.5876
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0173	0.5
Loa Loa (eye worm)	hypothetical protein	0.0119	0.126	0.5251
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.0247	0.1028
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0115	0.6645
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0557	0.2321
Loa Loa (eye worm)	raf kinase	0.0018	0.003	0.0124
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0366	0.1054
Schistosoma mansoni	hypothetical protein	0.003	0.017	0.0491
Schistosoma mansoni	6-phosphofructokinase	0.0111	0.1161	0.3346
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0115	0.6421
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0122	0.0352
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0366	0.0366
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0167	0.1844	0.1844
Brugia malayi	jmjC domain containing protein	0.0036	0.0247	0.1028
Echinococcus multilocularis	geminin	0.017	0.1876	0.1876
Echinococcus multilocularis	polycomb protein SCMH1	0.0049	0.0401	0.0401
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0026	0.0122	0.0363
Echinococcus multilocularis	protein kinase c eta type	0.0018	0.003	0.003
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0173	0.0218
Schistosoma mansoni	protein kinase C mu	0.0018	0.003	0.0086
Schistosoma mansoni	rac gtpase activating protein	0.0018	0.003	0.0086
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0018	0.003	0.0086
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0048	0.0391	0.163
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0247	0.0247
Onchocerca volvulus		0.002	0.0053	0.0084
Onchocerca volvulus	Peroxidase homolog	0.0084	0.0828	0.2926
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0192	0.2149	0.6394
Schistosoma mansoni	peroxidasin	0.0084	0.0828	0.2386
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0366	0.1524
Schistosoma mansoni	unc-13 (munc13)	0.0022	0.0076	0.0219
Echinococcus multilocularis	6 phosphofructokinase	0.0111	0.1161	0.1161
Brugia malayi	PHD-finger family protein	0.003	0.017	0.0709
Echinococcus granulosus	histone acetyltransferase MYST2	0.0056	0.0483	0.1439
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0312	0.0312
Echinococcus multilocularis	conserved hypothetical protein	0.0299	0.3446	0.3446
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0022	0.0076	0.0076
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0018	0.003	0.0086
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0366	0.1088
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0474	0.1974
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0026	0.0122	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Schistosoma mansoni	hypothetical protein	0.0018	0.003	0.0086
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0366	0.0366
Toxoplasma gondii	phosphofructokinase PFKII	0.003	0.0173	0.9662
Trichomonas vaginalis	set domain proteins, putative	0.0242	0.2758	1
Echinococcus granulosus	protein kinase c epsilon type	0.0048	0.0391	0.1164
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0056	0.0483	0.1439
Loa Loa (eye worm)	animal heme peroxidase	0.0084	0.0828	0.345
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Loa Loa (eye worm)	6-phosphofructokinase	0.0111	0.1161	0.4839
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0056	0.0483	0.0483
Brugia malayi	Protein kinase domain containing protein	0.0026	0.0122	0.0509
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0018	0.003	0.0124
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0695	0.2002
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0312	0.093
Schistosoma mansoni	lipoxygenase	0.0056	0.0495	0.1426
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0122	0.0352
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0056	0.0483	0.0483
Loa Loa (eye worm)	matrixin family protein	0.0194	0.217	0.9043
Loa Loa (eye worm)	hypothetical protein	0.002	0.0053	0.022
Schistosoma mansoni	serine/threonine protein kinase	0.0167	0.1844	0.5314
Echinococcus granulosus	protein kinase c eta type	0.0018	0.003	0.0089
Loa Loa (eye worm)	animal heme peroxidase	0.0084	0.0828	0.345
Onchocerca volvulus		0.008	0.0784	0.2766
Brugia malayi	protein kinase C3,putative	0.0019	0.0037	0.0152
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0026	0.0122	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0026	0.0122	0.0509
Schistosoma mansoni	atypical protein kinase C	0.0044	0.0345	0.0994
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0122	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Brugia malayi	hypothetical protein	0.0084	0.0828	0.345
Schistosoma mansoni	glucose-6-phosphatase	0.0301	0.347	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0179	0.0516
Loa Loa (eye worm)	hypothetical protein	0.008	0.0784	0.3269
Brugia malayi	Matrixin family protein	0.008	0.0784	0.3269
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0059	0.0522	0.1503
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0059	0.0522	0.4493
Brugia malayi	Matrixin family protein	0.008	0.0784	0.3269
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.017	0.017
Schistosoma mansoni	hypothetical protein	0.017	0.1876	0.5408
Schistosoma mansoni	jumonji domain containing protein	0.0078	0.0752	0.2167
Schistosoma mansoni	rab6-interacting	0.002	0.0053	0.0152
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Onchocerca volvulus	Peroxidasin homolog	0.0084	0.0828	0.2926
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0111	0.1161	1
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0037	0.0105
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0049	0.0401	0.1362
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0037	0.0105
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0192	0.2149	0.2149
Loa Loa (eye worm)	hypothetical protein	0.0018	0.003	0.0124
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.017	0.0709
Echinococcus granulosus	peregrin	0.003	0.017	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0401	0.1672
Mycobacterium ulcerans	hydrolase	0.0098	0.0997	0.7439
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0119	0.126	0.126
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.1161	0.3958
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0018	0.003	0.0089
Schistosoma mansoni	loxhd1	0.002	0.0053	0.0152
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0018	0.003	0.003
Brugia malayi	hypothetical protein	0.002	0.0053	0.022
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0173	0.0218
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0049	0.0401	0.1156
Toxoplasma gondii	diacylglycerol kinase, putative	0.0018	0.003	0.1664
Schistosoma mansoni	diacylglycerol kinase theta	0.0018	0.003	0.0086
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0522	0.0522
Loa Loa (eye worm)	blistered cuticle protein 3	0.0084	0.0828	0.345
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0026	0.0122	0.0509
Brugia malayi	Hemopexin family protein	0.0114	0.1193	0.497
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0018	0.003	0.003
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0115	0.0989
Plasmodium vivax	SET domain protein, putative	0.0031	0.0179	1
Echinococcus multilocularis	conserved hypothetical protein	0.0299	0.3446	0.3446
Brugia malayi	Pre-SET motif family protein	0.0213	0.24	1
Entamoeba histolytica	phosphofructokinase, putative	0.0111	0.1161	1
Entamoeba histolytica	hypothetical protein	0.0073	0.0695	0.5876
Brugia malayi	Matrixin family protein	0.008	0.0784	0.3269
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0111	0.1161	1
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.003	0.0173	1
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Brugia malayi	mbt repeat family protein	0.0049	0.0401	0.1672
Echinococcus granulosus	RNA directed DNA polymerase	0.0119	0.126	0.375
Brugia malayi	Animal haem peroxidase family protein	0.0084	0.0828	0.345
Schistosoma mansoni	hypothetical protein	0.0114	0.1193	0.3437
Echinococcus granulosus	SAM and MBT domain containing protein	0.0049	0.0401	0.1194
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0111	0.1161	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0053	0.0053
Toxoplasma gondii	6-phosphofructokinase	0.003	0.0173	0.9662
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0179	0.0179
Schistosoma mansoni	lipoxygenase	0.002	0.0053	0.0152
Loa Loa (eye worm)	mbt repeat family protein	0.0049	0.0401	0.1672
Brugia malayi	Matrixin family protein	0.0194	0.217	0.9043
Brugia malayi	protein kinase C II.	0.0048	0.0391	0.163
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.003	0.0173	0.9662
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0026	0.0122	0.0122
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0115	0.0989
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0085	0.0839	0.2417
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0018	0.003	0.003
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0026	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0051	0.043	0.1791
Schistosoma mansoni	serine/threonine kinase	0.0026	0.0122	0.0352
Schistosoma mansoni	protein kinase C mu	0.0019	0.0037	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0828	0.345
Echinococcus multilocularis	RUN	0.002	0.0053	0.0053
Echinococcus granulosus	raf serine:threonine protein kinase	0.0018	0.003	0.0089
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.008	0.0784	0.226
Trichomonas vaginalis	phosphofructokinase, putative	0.0111	0.1161	0.3958
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0019	0.0037	0.0037
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0053	0.3047
Echinococcus granulosus	protein kinase C gamma type	0.0149	0.1621	0.4825
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0366	0.1524
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0115	0.0989
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0122	0.0026
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0173	0.0218
Schistosoma mansoni	serine/threonine protein kinase	0.0026	0.0122	0.0352
Schistosoma mansoni	protein kinase C	0.0022	0.0076	0.0219

Activities

Activity type	Activity value	Assay description	Source	Reference
Estrogenic effect (functional)	= 0 nM	Estrogenic effect in uterotrophic assay in mice at 0.1 nM/animal dose	ChEMBL.	7783138
Estrogenic effect (functional)	= 0 nM	Estrogenic effect in uterotrophic assay in mice at 1 nM/animal dose	ChEMBL.	7783138
Estrogenic effect (functional)	= 0 nM	Estrogenic effect in uterotrophic assay in mice at 10 nM/animal dose	ChEMBL.	7783138
Estrogenic effect (functional)	= 28 nM	Estrogenic effect in uterotrophic assay in mice at 100 nM/animal dose	ChEMBL.	7783138
Estrogenic effect (functional)	= 88 nM	Estrogenic effect in uterotrophic assay in mice at 1000 nM/animal dose	ChEMBL.	7783138

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 200924

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 104746