TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 485.965 | Formula: C20H32ClN7O5
H donors: 5 H acceptors: 4 LogP: 1.78 Rotable bonds: 16
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)NC(=O)[C@H]1NC[C@H](C1)NC(=O)CCCCCNC(=N)N[N+](=O)[O-].Cl
InChi: 1S/C20H31N7O5.ClH/c1-2-32-16-9-7-14(8-10-16)25-19(29)17-12-15(13-23-17)24-18(28)6-4-3-5-11-22-20(21)26-27(30)31;/h7-10,15,17,23H,2-6,11-13H2,1H3,(H,24,28)(H,25,29)(H3,21,22,26);1H/t15-,17-;/m0./s1
InChiKey: ICVQAAFMJUZPJV-NBLXOJGSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.128	0.7675	1
Schistosoma mansoni	peter pan-related	0.0023	0.0045	0.0059
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0023	0.0045	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Echinococcus multilocularis	RING finger protein 185	0.0023	0.0045	0.0045
Onchocerca volvulus		0.0455	0.2669	0.3438
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0455	0.2669	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0455	0.2669	0.3477
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0018	0.5
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0018	0.0024
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0023	0.0045	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Giardia lamblia	Ser/Thr protein kinase	0.0023	0.0045	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0067	0.0088
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0018	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0196	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0455	0.2669	0.3477
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0018	0.0024
Echinococcus multilocularis	zinc finger protein Ran binding	0.0455	0.2669	0.2669
Toxoplasma gondii	hypothetical protein	0.0023	0.0045	0.0059
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0196	0.0256
Toxoplasma gondii	RING zinc finger protein	0.0023	0.0045	0.0059
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Leishmania major	hypothetical protein, conserved	0.0455	0.2669	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0023	0.0045	0.017
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0152	0.0826	0.1077
Onchocerca volvulus		0.005	0.0205	0.021
Trichomonas vaginalis	ankyrin, putative	0.0023	0.0045	0.0055
Schistosoma mansoni	hypothetical protein	0.0048	0.0196	0.0256
Echinococcus multilocularis	SWI:SNF matrix associated	0.128	0.7675	0.7675
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.0038	0.0136	0.0177
Echinococcus multilocularis	lamin	0.0027	0.0067	0.0067
Echinococcus multilocularis	musashi	0.0027	0.0067	0.0067
Echinococcus granulosus	GPCR family 2	0.0048	0.0196	0.0256
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.128	0.7675	1
Brugia malayi	hypothetical protein	0.0038	0.0134	0.0175
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0045	0.017
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0233	0.0303
Onchocerca volvulus		0.0455	0.2669	0.3438
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0023	0.0045	0.0059
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Entamoeba histolytica	zinc finger domain containing protein	0.0023	0.0045	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Echinococcus granulosus	zinc finger protein Ran binding	0.0455	0.2669	0.3477
Toxoplasma gondii	hypothetical protein	0.0023	0.0045	0.0059
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0045	0.017
Echinococcus multilocularis		0.0023	0.0045	0.0045
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Schistosoma mansoni	hypothetical protein	0.0023	0.0045	0.0059
Onchocerca volvulus		0.0054	0.0233	0.0246
Entamoeba histolytica	zinc finger domain containing protein	0.0023	0.0045	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0196	0.0256
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0455	0.2669	1
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0023	0.0045	0.0059
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Echinococcus granulosus	tumor protein p63	0.1149	0.6885	0.897
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0023	0.0045	0.0045
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0023	0.0045	0.017
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0045	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0023	0.0045	0.017
Leishmania major	DNA repair protein-like protein	0.0023	0.0045	0.017
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Echinococcus multilocularis	SWI:SNF matrix associated	0.128	0.7675	0.7675
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0023	0.0045	0.0055
Echinococcus multilocularis	SWI:SNF matrix associated	0.128	0.7675	0.7675
Echinococcus granulosus	Zinc finger RanBP2 type	0.0455	0.2669	0.3477
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0038	0.0136	0.0177
Schistosoma mansoni	hypothetical protein	0.0048	0.0196	0.0256
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0455	0.2669	0.3477
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0018	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Echinococcus multilocularis	ring finger protein 113a	0.0023	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0455	0.2669	0.3477
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0152	0.0826	0.1077
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0003	0.0004
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0455	0.2669	0.3477
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0455	0.2669	1
Plasmodium vivax	RING zinc finger protein, putative	0.0023	0.0045	0.0059
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0023	0.0045	0.0055
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Echinococcus granulosus	SWI:SNF matrix associated	0.128	0.7675	1
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0023	0.0045	0.0059
Schistosoma mansoni	hypothetical protein	0.0023	0.0045	0.0059
Brugia malayi	PAS domain containing protein	0.0016	0.0003	0.0004
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0054	0.0234	0.0234
Schistosoma mansoni	survival motor neuron protein	0.005	0.0205	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Schistosoma mansoni	mind bomb	0.0023	0.0045	0.0059
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0455	0.2669	0.3477
Giardia lamblia	Hypothetical protein	0.0023	0.0045	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0175
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0023	0.0045	0.0055
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0455	0.2669	0.3477
Giardia lamblia	Hypothetical protein	0.0023	0.0045	1
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0067	0.0088
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0003	0.0012
Brugia malayi	hypothetical protein	0.0023	0.0045	0.0059
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Trichomonas vaginalis	hypothetical protein	0.0023	0.0045	0.0055
Trypanosoma cruzi	WLM domain containing protein, putative	0.0455	0.2669	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0018	0.0069
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trypanosoma brucei	predicted zinc finger protein	0.0023	0.0045	0.017
Schistosoma mansoni	single-minded	0.0016	0.0003	0.0004
Onchocerca volvulus		0.015	0.0817	0.1012
Schistosoma mansoni	zinc finger protein	0.0455	0.2669	0.3477
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0196	0.0256
Brugia malayi	latrophilin 2 splice variant baaae	0.0104	0.0535	0.0697
Schistosoma mansoni	RNA binding protein	0.0455	0.2669	0.3477
Entamoeba histolytica	zinc finger domain containing protein	0.0023	0.0045	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0455	0.2669	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0018	0.002
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0023	0.0045	0.0045
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0023	0.0045	0.0059
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Onchocerca volvulus		0.0455	0.2669	0.3438
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0067	0.0088
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0023	0.0045	0.0059
Giardia lamblia	Kinase	0.0023	0.0045	1
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0023	0.0045	0.0059
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Schistosoma mansoni	hypothetical protein	0.128	0.7675	1
Plasmodium falciparum	zinc finger protein, putative	0.0023	0.0045	0.0059
Echinococcus granulosus	RING finger protein 185	0.0023	0.0045	0.0059
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Giardia lamblia	Zinc finger domain	0.0023	0.0045	1
Brugia malayi	RING zinc finger protein	0.0023	0.0045	0.0059
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0023	0.0045	0.0055
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0023	0.0045	0.0059
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0003	0.0012
Plasmodium vivax	hypothetical protein, conserved	0.128	0.7675	1
Brugia malayi	intermediate filament protein	0.0027	0.0067	0.0088
Giardia lamblia	Hypothetical protein	0.0023	0.0045	1
Echinococcus granulosus	survival motor neuron protein 1	0.0243	0.1379	0.1797
Schistosoma mansoni	hypothetical protein	0.0048	0.0196	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0455	0.2669	0.3477
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0023	0.0045	0.0045
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Brugia malayi	Neuralized family protein	0.0023	0.0045	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0175
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0023	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0064	0.0084
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Schistosoma mansoni	brg-1 associated factor	0.128	0.7675	1
Brugia malayi	brahma associated protein 60 kDa	0.128	0.7675	1
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0023	0.0045	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0243	0.1379	0.1797
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Onchocerca volvulus		0.128	0.7675	1
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Brugia malayi	brahma associated protein 60 kDa	0.128	0.7675	1
Giardia lamblia	Hypothetical protein	0.0023	0.0045	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0045	0.017
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0018	0.0069
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0016	0.0003	0.0012
Trichomonas vaginalis	ion channel nompc, putative	0.0023	0.0045	0.0055
Toxoplasma gondii	hypothetical protein	0.0023	0.0045	0.0059
Toxoplasma gondii	helicase, putative	0.0023	0.0045	0.0059
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0018	0.0018
Trichomonas vaginalis	ankyrin, putative	0.0023	0.0045	0.0055
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Schistosoma mansoni	hypothetical protein	0.0104	0.0535	0.0697
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.128	0.7675	1
Brugia malayi	hypothetical protein	0.0243	0.1379	0.1797
Giardia lamblia	Ribonuclease	0.0023	0.0045	1
Plasmodium falciparum	trophozoite exported protein 1	0.0023	0.0045	0.0059
Leishmania major	hypothetical protein, conserved	0.0455	0.2669	1
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Plasmodium falciparum	RING zinc finger protein, putative	0.0023	0.0045	0.0059
Giardia lamblia	Hypothetical protein	0.0023	0.0045	1
Chlamydia trachomatis	DNA topoisomerase I	0.128	0.7675	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0535	0.0697
Brugia malayi	hypothetical protein	0.0023	0.0045	0.0059
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0023	0.0045	0.0055
Loa Loa (eye worm)	RiNg Finger protein family member	0.0023	0.0045	0.0059
Loa Loa (eye worm)	hypothetical protein	0.015	0.0817	0.1065
Schistosoma mansoni	TRABID protein (C64 family)	0.0455	0.2669	0.3477
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0455	0.2669	1
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0016	0.0003	0.0012
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Schistosoma mansoni	ap endonuclease	0.0019	0.0018	0.0024
Trichomonas vaginalis	ankyrin, putative	0.0023	0.0045	0.0055
Brugia malayi	hypothetical protein	0.0023	0.0045	0.0059
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0455	0.2669	0.2669
Echinococcus multilocularis	survival motor neuron protein 1	0.0243	0.1379	0.1379
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0016	0.0003	0.0012
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0023	0.0045	0.0055
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0067	0.0067
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Giardia lamblia	Hypothetical protein	0.0023	0.0045	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0175
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0023	0.0045	0.0055
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0023	0.0045	0.0045
Trypanosoma cruzi	WLM domain containing protein, putative	0.0455	0.2669	1
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0023	0.0045	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Schistosoma mansoni	hypothetical protein	0.0048	0.0196	0.0256
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Brugia malayi	B-box zinc finger family protein	0.0023	0.0045	0.0059
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0045	0.017
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Brugia malayi	hypothetical protein	0.0023	0.0045	0.0059
Schistosoma mansoni	cellular tumor antigen P53	0.0168	0.0926	0.1207
Onchocerca volvulus		0.0168	0.0926	0.1155
Brugia malayi	SWIB/MDM2 domain containing protein	0.128	0.7675	1
Entamoeba histolytica	zinc finger domain containing protein	0.0023	0.0045	1
Schistosoma mansoni	lamin	0.0027	0.0067	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0134	0.0175
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Brugia malayi	Zinc finger, C2H2 type family protein	0.0023	0.0045	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Echinococcus multilocularis	geminin	0.0173	0.0957	0.0957
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0023	0.0045	0.017
Schistosoma mansoni	hypothetical protein	0.005	0.0205	0.0268
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0018	0.0024
Schistosoma mansoni	ring finger protein 151	0.0023	0.0045	0.0059
Loa Loa (eye worm)	brahma associated protein	0.128	0.7675	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.128	0.7675	0.7675
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.128	0.7675	1
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0023	0.0045	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0455	0.2669	0.3477
Leishmania major	hypothetical protein, conserved	0.0455	0.2669	1
Trypanosoma brucei	hypothetical protein, conserved	0.0455	0.2669	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0003	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0067	0.0088
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Brugia malayi	hypothetical protein	0.0023	0.0045	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Leishmania major	hypothetical protein, conserved	0.0455	0.2669	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Leishmania major	hypothetical protein, unknown function	0.0023	0.0045	0.017
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0023	0.0045	0.0055
Trypanosoma cruzi	hypothetical protein	0.0023	0.0045	0.017
Schistosoma mansoni	aryl hydrocarbon receptor nuclear translocator homolog (darnt)	0.0038	0.0136	0.0177
Schistosoma mansoni	aryl hydrocarbon receptor	0.0016	0.0005	0.0006
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0455	0.2669	0.2669
Entamoeba histolytica	zinc finger domain containing protein	0.0023	0.0045	1
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0455	0.2669	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0196	0.0196
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0018	0.5
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0018	0.002
Leishmania major	protein kinase, putative	0.0016	0.0003	0.0012
Chlamydia trachomatis	SWIB complex protein	0.128	0.7675	1
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.128	0.7675	1
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Entamoeba histolytica	zinc finger domain containing protein	0.0023	0.0045	1
Giardia lamblia	Kinase, NEK	0.0023	0.0045	1
Loa Loa (eye worm)	RING finger protein 20	0.0023	0.0045	0.0059
Echinococcus multilocularis	tumor protein p63	0.1149	0.6885	0.6885
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0018	0.0069
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0023	0.0045	0.0059
Leishmania major	hypothetical protein, conserved	0.0455	0.2669	1
Brugia malayi	hypothetical protein	0.015	0.0817	0.1065
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0018	0.5
Echinococcus granulosus	ring and YY1 binding protein	0.0455	0.2669	0.3477
Echinococcus granulosus	ring finger protein 170	0.0023	0.0045	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Brugia malayi	Zinc finger protein 183 homolog	0.0023	0.0045	0.0059
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Schistosoma mansoni	fusion	0.0455	0.2669	0.3477
Toxoplasma gondii	hypothetical protein	0.0023	0.0045	0.0059
Echinococcus granulosus	geminin	0.0173	0.0957	0.1247
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Giardia lamblia	Kinase, NEK	0.0023	0.0045	1
Schistosoma mansoni	zinc finger protein	0.0023	0.0045	0.0059
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0023	0.0045	0.0059
Echinococcus granulosus	intermediate filament protein	0.0027	0.0067	0.0088
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0054	0.0234	0.0305
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0003	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Schistosoma mansoni	hypothetical protein	0.0173	0.0957	0.1247
Trypanosoma cruzi	hypothetical protein	0.0023	0.0045	0.017
Loa Loa (eye worm)	hypothetical protein	0.0455	0.2669	0.3477
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0455	0.2669	0.3477
Plasmodium vivax	zinc finger protein, putative	0.0023	0.0045	0.0059
Schistosoma mansoni	rnf5	0.0023	0.0045	0.0059
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0045	0.017
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0023	0.0045	0.0059
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0455	0.2669	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0455	0.2669	0.3477
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0023	0.0045	0.0055
Schistosoma mansoni	lamin	0.0027	0.0067	0.0088
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0196	0.0256
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0016	0.0005	0.0006
Echinococcus multilocularis	ring and YY1 binding protein	0.0455	0.2669	0.2669
Onchocerca volvulus	Protein cycle homolog	0.0038	0.0136	0.0119
Schistosoma mansoni	hypothetical protein	0.0173	0.0957	0.1247
Brugia malayi	YY1-associated factor 2	0.0455	0.2669	0.3477
Trypanosoma brucei	ring finger containing protein	0.0023	0.0045	0.017
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.128	0.7675	1
Brugia malayi	RING finger protein 20	0.0023	0.0045	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0038	0.0136	0.0177
Schistosoma mansoni	ap endonuclease	0.0019	0.0018	0.0024
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Brugia malayi	aryl hydrocarbon receptor AHR-1	0.0038	0.0134	0.0175
Echinococcus granulosus	ring finger protein 113a	0.0023	0.0045	0.0059
Leishmania major	hypothetical protein	0.0023	0.0045	0.017
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0045	0.0059
Brugia malayi	hypothetical protein	0.0038	0.0136	0.0177
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.128	0.7675	1
Plasmodium vivax	DNA repair protein RAD5, putative	0.0023	0.0045	0.0059
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0018	0.0024
Entamoeba histolytica	zinc finger domain containing protein	0.0023	0.0045	1
Entamoeba histolytica	SPRY domain protein	0.0023	0.0045	1
Plasmodium vivax	trophozoite exported protein 1, putative	0.0023	0.0045	0.0059
Trypanosoma cruzi	hypothetical protein, conserved	0.0455	0.2669	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0023	0.0045	0.0059
Giardia lamblia	Zinc finger domain	0.0023	0.0045	1
Trichomonas vaginalis	conserved hypothetical protein	0.128	0.7675	1
Echinococcus granulosus	aryl hydrocarbon receptor	0.0054	0.0234	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Toxoplasma gondii	exonuclease III APE	0.0019	0.0018	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0045	0.0059
Trypanosoma brucei	DNA repair protein, putative	0.0023	0.0045	0.017
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Echinococcus multilocularis	ring finger protein 170	0.0023	0.0045	0.0045
Entamoeba histolytica	hypothetical protein	0.0023	0.0045	1
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Onchocerca volvulus		0.0027	0.0067	0.0029
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0455	0.2669	1
Onchocerca volvulus		0.0455	0.2669	0.3438
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0016	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.128	0.7675	1
Giardia lamblia	Hypothetical protein	0.0023	0.0045	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0018	0.0024
Schistosoma mansoni	hypothetical protein	0.0023	0.0045	0.0059
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.128	0.7675	1
Echinococcus granulosus	lamin dm0	0.0027	0.0067	0.0088
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0067	0.0088
Leishmania major	protein kinase, putative	0.0016	0.0003	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0023	0.0045	0.0059
Onchocerca volvulus		0.0027	0.0067	0.0029
Leishmania major	hypothetical protein, conserved	0.0023	0.0045	0.017
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0455	0.2669	0.3438
Brugia malayi	hypothetical protein	0.0023	0.0045	0.0059
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0023	0.0045	0.017
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0826	0.1077
Entamoeba histolytica	hypothetical protein	0.0023	0.0045	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0152	0.0826	0.1077
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0023	0.0045	0.0059
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0205	0.0268
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0023	0.0045	0.0059
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Brugia malayi	hypothetical protein	0.0054	0.0233	0.0303
Trypanosoma brucei	hypothetical protein, conserved	0.0455	0.2669	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0196	0.0256
Trypanosoma cruzi	hypothetical protein, conserved	0.0455	0.2669	1
Echinococcus granulosus	lamin	0.0027	0.0067	0.0088
Giardia lamblia	Protein 21.1	0.0023	0.0045	1
Entamoeba histolytica	zinc finger domain containing protein	0.0023	0.0045	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0023	0.0045	0.017
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Schistosoma mansoni	hypothetical protein	0.0455	0.2669	0.3477
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0196	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0045	0.0055
Toxoplasma gondii	ran binding protein	0.0455	0.2669	0.3477
Mycobacterium leprae	Possible regulatory protein	0.0016	0.0003	0.5
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0926	0.1207
Schistosoma mansoni	peter pan-related	0.0023	0.0045	0.0059

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 162 uM	Inhibition of inducible NOS mediated nitric oxide production in LPS-activated Kunming mouse macrophages	ChEMBL.	17937988

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL559190

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1051363