Detailed information for compound 1053594

Basic information

Technical information
  • TDR Targets ID: 1053594
  • Name: (3R,6S,7aS)-6-amino-6-cyclohexyl-5-oxo-2,3,7, 7a-tetrahydropyrrolo[5,1-b][1,3]thiazole-3-ca rbonitrile hydrochloride
  • MW: 301.835 | Formula: C13H20ClN3OS
  • H donors: 1 H acceptors: 2 LogP: 2.38 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H]1CS[C@@H]2N1C(=O)[C@@](C2)(N)C1CCCCC1.Cl
  • InChi: 1S/C13H19N3OS.ClH/c14-7-10-8-18-11-6-13(15,12(17)16(10)11)9-4-2-1-3-5-9;/h9-11H,1-6,8,15H2;1H/t10-,11+,13+;/m1./s1
  • InChiKey: OLXUDTYEYQHTGQ-CHZGQIEOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R,6S,7aS)-6-amino-6-cyclohexyl-5-oxo-2,3,7,7a-tetrahydropyrrolo[5,1-b]thiazole-3-carbonitrile hydrochloride
  • (3R,6S,7aS)-6-amino-6-cyclohexyl-5-keto-2,3,7,7a-tetrahydropyrrolo[5,1-b]thiazole-3-carbonitrile hydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References
Homo sapiens fibroblast activation protein, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis Dipeptidyl peptidase 9 fibroblast activation protein, alpha 735 aa 597 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0197 0.0492 0.12
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0141 0.0332 0.0332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0001 0.0001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0159 0.0384 0.0936
Echinococcus multilocularis prolyl endopeptidase 0.0033 0.0029 0.0029
Brugia malayi putative neuropeptide receptor NPR1 0.0197 0.0492 0.12
Onchocerca volvulus 0.0197 0.0492 0.1198
Loa Loa (eye worm) prolyl oligopeptidase 0.0033 0.0029 0.0029
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0056 0.0609
Schistosoma mansoni voltage-gated potassium channel 0.0174 0.0425 0.0425
Echinococcus granulosus g protein coupled receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Loa Loa (eye worm) serotonin transporter b 0.1475 0.4098 0.4098
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0197 0.0492 0.0492
Brugia malayi G-protein coupled receptor 0.0197 0.0492 0.12
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni hypothetical protein 0.0197 0.0492 0.0492
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0085 0.0085
Brugia malayi AKH receptor 0.0197 0.0492 0.12
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Echinococcus granulosus neuropeptides capa receptor 0.0197 0.0492 0.0492
Echinococcus granulosus neuropeptide s receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.1475 0.4098 0.4098
Trichomonas vaginalis glutaminase, putative 0.0318 0.0833 1
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0001 0.0002
Toxoplasma gondii ribonuclease HI protein 0.0043 0.0056 0.088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0085 0.0085
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0085 0.0208
Loa Loa (eye worm) glutaminase 2 0.0318 0.0833 0.0833
Schistosoma mansoni hypothetical protein 0.0041 0.0052 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.0404 0.4363
Echinococcus multilocularis sex peptide receptor 0.0197 0.0492 0.0492
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0033 0.0029 0.0308
Loa Loa (eye worm) hypothetical protein 0.025 0.0642 0.0642
Schistosoma mansoni phosphoglucomutase 0.0043 0.0056 0.0056
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Echinococcus granulosus G protein coupled receptor 139 0.0197 0.0492 0.0492
Echinococcus granulosus serotonin transporter 0.1475 0.4098 0.4098
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.0024 0.0024
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.025 0.0642 0.0642
Schistosoma mansoni sodium/chloride dependent transporter 0.1475 0.4098 0.4098
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0001 0.0001
Echinococcus granulosus voltage gated potassium channel 0.0046 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0056 0.0609
Echinococcus granulosus dro:myosuppressin receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.025 0.0642 0.0642
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0197 0.0492 0.0492
Entamoeba histolytica hypothetical protein 0.0041 0.0052 1
Schistosoma mansoni hypothetical protein 0.0195 0.0485 0.0485
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.0024 0.0024
Brugia malayi hypothetical protein 0.0041 0.0052 0.0126
Onchocerca volvulus 0.0197 0.0492 0.1198
Schistosoma mansoni amine GPCR 0.0197 0.0492 0.0492
Echinococcus multilocularis serotonin receptor 0.3566 1 1
Trypanosoma cruzi prolyl endopeptidase 0.0033 0.0029 0.0308
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.3566 1 1
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.025 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.0065 0.0158
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.0024 0.0024
Schistosoma mansoni neuropeptide f receptor 76f 0.0197 0.0492 0.0492
Onchocerca volvulus 0.0057 0.0095 0.0231
Loa Loa (eye worm) hypothetical protein 0.025 0.0642 0.0642
Onchocerca volvulus 0.0197 0.0492 0.1198
Trypanosoma cruzi oligopeptidase b 0.0033 0.0029 0.0308
Echinococcus multilocularis neuropeptide receptor 0.0197 0.0492 0.0492
Schistosoma mansoni neuropeptide receptor 0.0197 0.0492 0.0492
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0033 0.0029 0.0308
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0001 0.0001
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0141 0.0332 0.3583
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0029 0.0308
Echinococcus multilocularis neuropeptide Y receptor 0.0197 0.0492 0.0492
Echinococcus multilocularis acylamino acid releasing enzyme 0.0033 0.0029 0.0029
Schistosoma mansoni myosin xvIII 0.0197 0.0492 0.0492
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0197 0.0492 0.0492
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0001 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0001 0.0001
Toxoplasma gondii hypothetical protein 0.0033 0.0029 0.0445
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0029 0.5526
Echinococcus granulosus serotonin receptor 0.0197 0.0492 0.0492
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0046 0.0065 0.0065
Trypanosoma brucei oligopeptidase b 0.0033 0.0029 0.0308
Schistosoma mansoni sodium-dependent amino acid transporter 0.025 0.0642 0.0642
Brugia malayi steroid hormone receptor 0.0023 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Mycobacterium ulcerans hypothetical protein 0.0185 0.0457 0.5333
Schistosoma mansoni neuropeptide receptor 0.0197 0.0492 0.0492
Echinococcus granulosus g protein coupled receptor 0.0197 0.0492 0.0492
Onchocerca volvulus 0.0197 0.0492 0.1198
Echinococcus granulosus rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0197 0.0492 0.0492
Loa Loa (eye worm) G-protein coupled receptor 0.0197 0.0492 0.0492
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0197 0.0492 0.0492
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1475 0.4098 0.4098
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Echinococcus granulosus rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0001 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0197 0.0492 0.0492
Echinococcus granulosus somatostatin receptor 0.0197 0.0492 0.0492
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0001 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0197 0.0492 0.0492
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0074 0.0803
Toxoplasma gondii hypothetical protein 0.025 0.0642 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0033 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.025 0.0642 0.0642
Echinococcus multilocularis g protein coupled receptor 0.0197 0.0492 0.0492
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0033 0.0029 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0001 0.0002
Onchocerca volvulus Prolyl endopeptidase homolog 0.0033 0.0029 0.0067
Toxoplasma gondii hypothetical protein 0.0057 0.0095 0.1479
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0029 0.007
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.025 0.0642 0.0642
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0024 0.0024
Plasmodium falciparum peptidase, putative 0.0033 0.0029 0.0445
Brugia malayi nuclear receptor NHR-88 0.0023 0.0001 0.0002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0197 0.0492 0.0492
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0001 0.0001
Brugia malayi ecdysteroid receptor 0.0023 0.0001 0.0002
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0033 0.0029 0.0343
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0197 0.0492 0.0492
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0197 0.0492 0.1198
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0197 0.0492 0.0492
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0033 0.0029 0.0308
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.025 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni biogenic amine (5HT) receptor 0.0197 0.0492 0.0492
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0001 0.0002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0197 0.0492 0.1198
Onchocerca volvulus 0.1475 0.4098 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Onchocerca volvulus 0.025 0.0642 0.1564
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0029 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0085 0.0085
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0001 0.0001
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0095 0.0095
Echinococcus granulosus acylamino acid releasing enzyme 0.0033 0.0029 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0138 0.0324 0.0324
Schistosoma mansoni glutaminase 0.0318 0.0833 0.0833
Echinococcus multilocularis sodium and chloride dependent glycine 0.025 0.0642 0.0642
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0001 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0197 0.0492 0.0492
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Onchocerca volvulus 0.0197 0.0492 0.1198
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0065 0.0065
Echinococcus multilocularis fmrfamide receptor 0.0197 0.0492 0.0492
Echinococcus multilocularis tumor protein p63 0.0388 0.1031 0.1031
Echinococcus granulosus Dipeptidyl peptidase 9 0.0141 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0197 0.0492 0.0492
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0029 0.5526
Echinococcus granulosus tm gpcr rhodopsin 0.0197 0.0492 0.0492
Echinococcus granulosus rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0074 0.0803
Schistosoma mansoni 60S ribosomal protein L21 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Echinococcus granulosus geminin 0.0195 0.0485 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0001 0.0002
Onchocerca volvulus 0.0197 0.0492 0.1198
Loa Loa (eye worm) hypothetical protein 0.0108 0.0238 0.0238
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0001 0.0001
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0085 0.0085
Echinococcus granulosus rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Trypanosoma brucei ingi protein (ORF1) 0.0047 0.0067 0.0721
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0065 0.0065
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0141 0.0332 0.3583
Trypanosoma brucei ingi protein (ORF1) 0.0047 0.0067 0.0721
Echinococcus granulosus uncharacterized sodium dependent transporter 0.025 0.0642 0.0642
Echinococcus granulosus g-protein coupled receptor 0.0197 0.0492 0.0492
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0149 0.0354 0.4253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Echinococcus granulosus fmrfamide receptor 0.0197 0.0492 0.0492
Schistosoma mansoni biogenic amine receptor 0.0197 0.0492 0.0492
Schistosoma mansoni phosphoglucomutase 0.0043 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0001 0.0002
Echinococcus granulosus g protein coupled receptor 0.0197 0.0492 0.0492
Schistosoma mansoni sodium/chloride dependent transporter 0.025 0.0642 0.0642
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0197 0.0492 0.0492
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0197 0.0492 0.12
Echinococcus granulosus sodium and chloride dependent glycine 0.025 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0001 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0159 0.0384 0.0384
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0197 0.0492 0.0492
Echinococcus granulosus tm gpcr rhodopsin 0.0197 0.0492 0.0492
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.025 0.0642 0.0642
Entamoeba histolytica hypothetical protein 0.0041 0.0052 1
Schistosoma mansoni opsin-like receptor 0.0197 0.0492 0.0492
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0001 0.0002
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.025 0.0642 0.0642
Brugia malayi neuropeptide F receptor 0.0197 0.0492 0.12
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0001 0.0001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0197 0.0492 0.0492
Brugia malayi Melatonin receptor type 1A 0.0197 0.0492 0.12
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.025 0.0642 0.0642
Echinococcus multilocularis rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0001 0.0002
Echinococcus multilocularis neuropeptides capa receptor 0.0197 0.0492 0.0492
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0001 0.0001
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.025 0.0642 0.0642
Echinococcus granulosus neuropeptides capa receptor 0.0197 0.0492 0.0492
Onchocerca volvulus Neuropeptide F receptor homolog 0.0197 0.0492 0.1198
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Echinococcus granulosus tachykinin peptides receptor 99D 0.0197 0.0492 0.0492
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Echinococcus multilocularis rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0024 0.0285
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0033 0.0029 0.0308
Loa Loa (eye worm) glutaminase 0.0318 0.0833 0.0833
Loa Loa (eye worm) melatonin receptor type 1A 0.0197 0.0492 0.0492
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.025 0.0642 0.0642
Trypanosoma brucei RNA helicase, putative 0.0161 0.0391 0.4217
Leishmania major mitochondrial DNA polymerase beta 0.0351 0.0927 1
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0141 0.0332 0.3583
Schistosoma mansoni hypothetical protein 0.0195 0.0485 0.0485
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0085 0.0085
Onchocerca volvulus 0.0197 0.0492 0.1198
Loa Loa (eye worm) solute carrier family 6 member 4 0.1475 0.4098 0.4098
Echinococcus granulosus neuropeptide Y receptor 0.0197 0.0492 0.0492
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.025 0.0642 0.0642
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0197 0.0492 0.0492
Entamoeba histolytica hypothetical protein 0.0041 0.0052 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0029 0.5526
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0052 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0197 0.0492 0.0492
Echinococcus multilocularis serotonin receptor 0.3566 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0197 0.0492 0.0492
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0031 0.0024 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.025 0.0642 0.0642
Echinococcus multilocularis neuropeptide Y receptor 0.0197 0.0492 0.0492
Schistosoma mansoni biogenic amine receptor 0.0197 0.0492 0.0492
Onchocerca volvulus 0.0197 0.0492 0.1198
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Trypanosoma brucei prolyl oligopeptidase, putative 0.0033 0.0029 0.0308
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.0404 0.4363
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0001 0.0001
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.000000000029643 0.00000000046197
Loa Loa (eye worm) hypothetical protein 0.1475 0.4098 0.4098
Trichomonas vaginalis ribonuclease H1, putative 0.0043 0.0056 0.0678
Schistosoma mansoni hypothetical protein 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0197 0.0492 0.0492
Echinococcus granulosus 7TM GPCR rhodopsin 0.0197 0.0492 0.0492
Entamoeba histolytica hypothetical protein, conserved 0.0033 0.0029 0.5526
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0197 0.0492 0.0492
Echinococcus multilocularis somatostatin receptor 0.0197 0.0492 0.0492
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.025 0.0642 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Onchocerca volvulus 0.025 0.0642 0.1564
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0197 0.0492 0.0492
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0141 0.0332 0.3583
Echinococcus granulosus neuropeptide receptor A26 0.0197 0.0492 0.0492
Onchocerca volvulus Ribonuclease H1 homolog 0.0043 0.0056 0.0136
Brugia malayi G-protein coupled receptor 0.0197 0.0492 0.12
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni neuropeptide receptor 0.0197 0.0492 0.0492
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0031 0.0024 0.0024
Brugia malayi G protein-coupled receptor F59B2.13 0.0197 0.0492 0.12
Brugia malayi RE15519p 0.0197 0.0492 0.12
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0001 0.0001
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0029 0.5053
Echinococcus granulosus 7tm_1 domain containing protein 0.0197 0.0492 0.0492
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0149 0.0354 0.4253
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0197 0.0492 0.1198
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Echinococcus multilocularis rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.0065 0.0065
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0141 0.0332 0.3583
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0029 0.0029
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0932 0.2566 0.2566
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Echinococcus granulosus alpha 1A adrenergic receptor 0.0197 0.0492 0.0492
Schistosoma mansoni hypothetical protein 0.0161 0.0391 0.0391
Loa Loa (eye worm) neuropeptide F receptor 0.0197 0.0492 0.0492
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0197 0.0492 0.12
Echinococcus multilocularis rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Brugia malayi larval opioid receptor 0.0197 0.0492 0.12
Loa Loa (eye worm) hypothetical protein 0.025 0.0642 0.0642
Giardia lamblia Ribonuclease H 0.0043 0.0056 1
Toxoplasma gondii prolyl endopeptidase 0.0033 0.0029 0.0445
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0197 0.0492 0.0492
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0418 0.1116 0.2722
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0001 0.0002
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0141 0.0332 0.0332
Brugia malayi hypothetical protein 0.025 0.0642 0.1566
Loa Loa (eye worm) neuropeptide F receptor 0.0197 0.0492 0.0492
Mycobacterium tuberculosis Conserved hypothetical protein 0.0185 0.0457 1
Echinococcus granulosus sex peptide receptor 0.0197 0.0492 0.0492
Schistosoma mansoni alpha-1 adrenergic receptor 0.0197 0.0492 0.0492
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.025 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0197 0.0492 0.0492
Onchocerca volvulus 0.0197 0.0492 0.1198
Schistosoma mansoni biogenic amine receptor 0.0197 0.0492 0.0492
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0024 0.0024
Brugia malayi Dopamine receptor protein 2 0.0197 0.0492 0.12
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0001 0.0001
Loa Loa (eye worm) prolyl oligopeptidase 0.0418 0.1116 0.1116
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0197 0.0492 0.0492
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0159 0.0384 0.0384
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0001 0.0002
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) norepinephrine transporter 0.1475 0.4098 0.4098
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0197 0.0492 0.0492
Trypanosoma brucei unspecified product 0.0047 0.0067 0.0721
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.0029
Echinococcus granulosus neuropeptide Y receptor 0.0197 0.0492 0.0492
Brugia malayi Tachykinin-like peptides receptor 99D 0.0197 0.0492 0.12
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0197 0.0492 0.0492
Echinococcus multilocularis rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.025 0.0642 1
Onchocerca volvulus 0.0197 0.0492 0.1198
Brugia malayi Cyclic-nucleotide gated cation channel 0.0031 0.0024 0.0058
Echinococcus multilocularis orexin receptor type 2 0.0197 0.0492 0.0492
Schistosoma mansoni neuropeptide receptor 0.0197 0.0492 0.0492
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0074 0.0803
Brugia malayi prolyl oligopeptidase family protein 0.0418 0.1116 0.2724
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0006 0.0006
Echinococcus granulosus allatostatin A receptor 0.0197 0.0492 0.0492
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0085 0.0085
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0029 0.007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0001 0.0001
Brugia malayi Serotonin receptor 0.0197 0.0492 0.12
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.025 0.0642 0.0642
Echinococcus granulosus hypothetical protein 0.0197 0.0492 0.0492
Loa Loa (eye worm) G-protein coupled receptor 0.0197 0.0492 0.0492
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0031 0.0024 0.0024
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0031 0.0024 0.0024
Onchocerca volvulus 0.025 0.0642 0.1564
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0105 0.1132
Brugia malayi Serotonin receptor 0.0197 0.0492 0.12
Schistosoma mansoni amine GPCR 0.0197 0.0492 0.0492
Trypanosoma brucei prolyl endopeptidase 0.0033 0.0029 0.0308
Onchocerca volvulus 0.0197 0.0492 0.1198
Loa Loa (eye worm) hypothetical protein 0.3566 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0001 0.0001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0197 0.0492 0.0492
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0001 0.0001
Onchocerca volvulus 0.0197 0.0492 0.1198
Loa Loa (eye worm) hypothetical protein 0.025 0.0642 0.0642
Loa Loa (eye worm) TYRA-2 protein 0.0197 0.0492 0.0492
Brugia malayi hypothetical protein 0.0108 0.0238 0.0582
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0033 0.0029 0.0343
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0024 0.0024
Plasmodium vivax hypothetical protein, conserved 0.025 0.0642 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Plasmodium vivax amine transporter, putative 0.025 0.0642 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.025 0.0642 0.0642
Schistosoma mansoni amine GPCR 0.0197 0.0492 0.0492
Toxoplasma gondii hypothetical protein 0.025 0.0642 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0197 0.0492 0.0492
Treponema pallidum sodium- and chloride- dependent transporter 0.1475 0.4098 1
Mycobacterium ulcerans glutaminase 0.0318 0.0833 1
Schistosoma mansoni opsin-like receptor 0.0197 0.0492 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0001 0.0002
Brugia malayi sulfakinin receptor protein 0.0197 0.0492 0.12
Schistosoma mansoni amine GPCR 0.0197 0.0492 0.0492
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0033 0.0029 0.0445
Brugia malayi RNase H family protein 0.0043 0.0056 0.0138
Echinococcus multilocularis fmrfamide receptor 0.0197 0.0492 0.0492
Echinococcus multilocularis G protein coupled receptor 139 0.0197 0.0492 0.0492
Brugia malayi Sodium:neurotransmitter symporter family protein 0.025 0.0642 0.1566
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0001 0.0001
Schistosoma mansoni neuropeptide F-like receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0057 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0197 0.0492 0.0492
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0043 0.0056 0.5
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.025 0.0642 0.1566
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0033 0.0029 0.0308
Echinococcus multilocularis dro:myosuppressin receptor 0.0197 0.0492 0.0492
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0033 0.0029 0.0029
Echinococcus multilocularis G-protein coupled receptor, putative 0.0197 0.0492 0.0492
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0197 0.0492 0.0492
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0351 0.0927 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0197 0.0492 0.0492
Onchocerca volvulus 0.0197 0.0492 0.1198
Leishmania major oligopeptidase b 0.0033 0.0029 0.0308
Echinococcus multilocularis ribonuclease H1 0.0043 0.0056 0.0056
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.0024 0.0024
Echinococcus granulosus prolyl endopeptidase 0.0033 0.0029 0.0029
Onchocerca volvulus 0.0197 0.0492 0.1198
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1475 0.4098 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0024
Brugia malayi Dopamine receptor protein 1 0.0197 0.0492 0.12
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.025 0.0642 0.5
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0351 0.0927 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0001 0.0001
Echinococcus granulosus ribonuclease H1 0.0043 0.0056 0.0056
Schistosoma mansoni amine GPCR 0.0197 0.0492 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0029 0.0343
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0074 0.0803
Echinococcus multilocularis g protein coupled receptor 0.0197 0.0492 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0001 0.0002
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0159 0.0384 0.0384
Brugia malayi putative neuropeptide receptor 0.0197 0.0492 0.12
Echinococcus granulosus biogenic amine 5HT receptor 0.0197 0.0492 0.0492
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0141 0.0332 0.5175
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0001 0.0001
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0418 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Echinococcus multilocularis g-protein coupled receptor 0.0197 0.0492 0.0492
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0351 0.0927 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0001 0.0002
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0418 0.1116 0.1116
Echinococcus multilocularis neuropeptide receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0197 0.0492 0.0492
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0001 0.0001
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0197 0.0492 0.0492
Schistosoma mansoni histamine h1 receptor 0.0197 0.0492 0.0492
Entamoeba histolytica prolyl oligopeptidase family protein 0.0033 0.0029 0.5526
Echinococcus granulosus tm gpcr rhodopsin 0.0197 0.0492 0.0492
Echinococcus multilocularis sodium and chloride dependent glycine 0.025 0.0642 0.0642
Brugia malayi nuclear hormone receptor 0.0023 0.0001 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0197 0.0492 0.0492
Schistosoma mansoni hypothetical protein 0.0197 0.0492 0.0492
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Brugia malayi GnHR receptor homolog 0.0197 0.0492 0.12
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Brugia malayi follicle stimulating hormone receptor 0.0197 0.0492 0.12
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0001 0.0001
Brugia malayi neuropeptide F receptor 0.0197 0.0492 0.12
Entamoeba histolytica hypothetical protein 0.0041 0.0052 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0001 0.0001
Plasmodium falciparum amino acid transporter, putative 0.025 0.0642 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.025 0.0642 0.0642
Schistosoma mansoni opsin-like receptor 0.0197 0.0492 0.0492
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.0024 0.0024
Giardia lamblia Alanyl dipeptidyl peptidase 0.0033 0.0029 0.5053
Echinococcus granulosus peptide allatostatin:somatostatin 0.0197 0.0492 0.0492
Echinococcus multilocularis g protein coupled receptor 0.0197 0.0492 0.0492
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0418 0.1116 0.1116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.025 0.0642 0.0642
Brugia malayi hypothetical protein 0.0197 0.0492 0.12
Brugia malayi RNase H family protein 0.0043 0.0056 0.0138
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0024 0.0285
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0197 0.0492 0.0492
Echinococcus granulosus rhodopsin orphan GPCR 0.0197 0.0492 0.0492
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0085 0.0085
Leishmania major ribonuclease H1, putative 0.0043 0.0056 0.0609
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0197 0.0492 0.0492
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0197 0.0492 0.0492
Echinococcus granulosus neuropeptide receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Trypanosoma cruzi oligopeptidase b 0.0033 0.0029 0.0308
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.025 0.0642 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.025 0.0642 0.0642
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0001
Brugia malayi G protein-coupled receptor 0.0197 0.0492 0.12
Schistosoma mansoni adenoreceptor 0.0197 0.0492 0.0492
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0197 0.0492 0.0492
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.0024 0.0024
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0197 0.0492 0.0492
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0031 0.0024 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0067 0.0721
Echinococcus granulosus neuropeptide FF receptor 2 0.0197 0.0492 0.0492
Schistosoma mansoni sodium/chloride dependent transporter 0.025 0.0642 0.0642
Brugia malayi Sodium:neurotransmitter symporter family protein 0.025 0.0642 0.1566
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0197 0.0492 0.12
Brugia malayi prolyl oligopeptidase family protein 0.0033 0.0029 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0029 0.0308
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni neuropeptide F-like receptor 0.0197 0.0492 0.0492
Echinococcus granulosus orexin receptor type 2 0.0197 0.0492 0.0492
Plasmodium falciparum transporter, putative 0.025 0.0642 1
Brugia malayi prolyl oligopeptidase family protein 0.0141 0.0332 0.081
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0047 0.0067 0.0721
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0065 0.0065
Brugia malayi Dopamine receptor 0.0197 0.0492 0.12
Brugia malayi glutaminase DH11.1 0.0318 0.0833 0.2032
Schistosoma mansoni coup transcription factor 0.0023 0.0001 0.0001
Brugia malayi RNase H family protein 0.0043 0.0056 0.0138
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0197 0.0492 0.12
Echinococcus granulosus tumor protein p63 0.0388 0.1031 0.1031
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Echinococcus granulosus sodium and chloride dependent glycine 0.025 0.0642 0.0642
Brugia malayi Sodium:neurotransmitter symporter family protein 0.025 0.0642 0.1566
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0197 0.0492 0.0492
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.0404 0.4363
Echinococcus multilocularis allatostatin A receptor 0.0197 0.0492 0.0492
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0033 0.0029 0.0308
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.0024 0.0024
Schistosoma mansoni growth hormone secretagogue receptor 0.0197 0.0492 0.0492
Echinococcus multilocularis geminin 0.0195 0.0485 0.0485
Trypanosoma brucei ribonuclease H1 0.0043 0.0056 0.0609
Echinococcus granulosus neuropeptide receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni voltage-gated potassium channel 0.0174 0.0425 0.0425
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.1475 0.4098 0.4098
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0065 0.0065
Echinococcus multilocularis serotonin transporter 0.1475 0.4098 0.4098
Onchocerca volvulus 0.0197 0.0492 0.1198
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0197 0.0492 0.0492
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Schistosoma mansoni phosphoglucomutase 0.0043 0.0056 0.0056
Brugia malayi ORL1-like opioid receptor 0.0197 0.0492 0.12
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0197 0.0492 0.0492
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0001 0.0001
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0033 0.0029 0.5526
Loa Loa (eye worm) hypothetical protein 0.0197 0.0492 0.0492
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0052 0.0052
Schistosoma mansoni biogenic amine (5HT) receptor 0.3566 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 59 nM Inhibition of human recombinant DPP4 by fluorescence assay ChEMBL. 19482472
IC50 (binding) > 10 uM Inhibition of human recombinant FAP expressed in Sf9 cells by fluorescence assay ChEMBL. 19482472

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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