Detailed information for compound 1054718

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.398 | Formula: C20H20N4O3
  • H donors: 2 H acceptors: 3 LogP: 3.05 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)Oc1nccc(c1)/C(=N/O)/NCc1ccccn1
  • InChi: 1S/C20H20N4O3/c1-2-26-17-6-8-18(9-7-17)27-19-13-15(10-12-22-19)20(24-25)23-14-16-5-3-4-11-21-16/h3-13,25H,2,14H2,1H3,(H,23,24)
  • InChiKey: NRWJHZAJRCMWJM-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0093 0.2085
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0023 0.0027 0.0045
Leishmania major hypothetical protein, conserved 0.0024 0.0036 0.0799
Plasmodium falciparum protoporphyrinogen oxidase 0.0023 0.0027 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0243 0.544
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0599 0.2961 0.3463
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0599 0.2961 0.3463
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0287 0.1372 0.3146
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0599 0.2961 0.3463
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0166 0.0166
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0599 0.2961 0.3463
Schistosoma mansoni nAChR subunit 0.0287 0.1372 0.4634
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0076 0.0076
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0599 0.2961 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0446 0.36
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0166 0.056
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0287 0.1372 0.1605
Schistosoma mansoni amine oxidase 0.0023 0.0027 0.0092
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.0446 0.2899
Schistosoma mansoni hypothetical protein 0.0129 0.0568 0.1919
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0053
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0232 0.0784
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0599 0.2961 1
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0182 0.1393
Brugia malayi ImpB/MucB/SamB family protein 0.0085 0.0347 0.0406
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0446 0.1508
Onchocerca volvulus 0.0287 0.1372 0.4584
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0004 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.0446 0.1429
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0004 0.0083
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0599 0.2961 1
Schistosoma mansoni amine oxidase 0.0023 0.0027 0.0092
Echinococcus granulosus glycine receptor subunit alpha 1 0.0599 0.2961 1
Schistosoma mansoni nAChR subunit 0.0287 0.1372 0.4634
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Brugia malayi SWIRM domain containing protein 0.0023 0.0027 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0004 0.0083
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0093 0.2085
Onchocerca volvulus 0.0599 0.2961 1
Onchocerca volvulus Putative endochitinase 0.0091 0.0375 0.1186
Schistosoma mansoni DNA polymerase eta 0.0085 0.0347 0.1173
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Onchocerca volvulus Putative endochitinase 0.0081 0.0326 0.1017
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0083 0.0333 0.7467
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0027 0.0191
Onchocerca volvulus 0.0599 0.2961 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0599 0.2961 0.2961
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0312 0.1502 0.1756
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.032 0.1542 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0083 0.0333 0.0545
Toxoplasma gondii hypothetical protein 0.0129 0.0568 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0027 0.0611
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0129 0.0568 0.1919
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Brugia malayi hypothetical protein 0.0287 0.1372 0.1605
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0599 0.2961 1
Echinococcus granulosus dna polymerase kappa 0.0087 0.0354 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0151 0.3381
Echinococcus granulosus glycine receptor subunit alpha 1 0.0599 0.2961 1
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0004 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.0058 0.0206 0.0241
Schistosoma mansoni hypothetical protein 0.0595 0.2941 0.9932
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0599 0.2961 1
Brugia malayi hypothetical protein 0.0078 0.0309 0.0361
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0232 0.0232
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0599 0.2961 0.3463
Mycobacterium ulcerans oxidoreductase 0.0023 0.0027 0.0153
Mycobacterium tuberculosis Possible chitinase 0.0069 0.0265 0.1855
Loa Loa (eye worm) hypothetical protein 0.0076 0.0298 0.0298
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0287 0.1372 0.1372
Onchocerca volvulus 0.0255 0.1212 0.4038
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0354 0.2275
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0058 0.0206 0.0473
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0232 0.1809
Plasmodium falciparum serine/threonine protein kinase, putative 0.0063 0.0232 0.4086
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0046 0.0145 0.2547
Loa Loa (eye worm) hypothetical protein 0.0069 0.0265 0.0265
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0309 0.1044
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0446 1
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0166 0.056
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0058 0.0206 0.0697
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.1218 0.6116 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.0446 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0027 0.0092
Schistosoma mansoni flap endonuclease-1 0.0026 0.0043 0.0145
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0016 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0076 0.0258
Brugia malayi hypothetical protein 0.0023 0.0027 0.0032
Onchocerca volvulus 0.0312 0.1502 0.5025
Brugia malayi excitatory GABA receptor EXP-1A 0.0599 0.2961 0.3463
Entamoeba histolytica protein kinase domain containing protein 0.0063 0.0232 0.1457
Giardia lamblia Aurora kinase 0.0063 0.0232 0.516
Schistosoma mansoni acetylcholine receptor-related 0.0287 0.1372 0.4634
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0599 0.2961 0.679
Loa Loa (eye worm) hypothetical protein 0.0312 0.1502 0.1502
Echinococcus granulosus aurora kinase A 0.0063 0.0232 0.0784
Schistosoma mansoni kinase 0.0054 0.0189 0.0639
Toxoplasma gondii RNA-directed DNA polymerase 0.0083 0.0333 0.5866
Schistosoma mansoni neurotransmitter gated ion channel 0.0287 0.1372 0.4634
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0057 0.127
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0024 0.0036 0.0799
Brugia malayi Cation transporter family protein 0.0599 0.2961 0.3463
Leishmania major DNA polymerase kappa, putative 0.0018 0.0004 0.0083
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.007 0.0237
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0057 0.013
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Schistosoma mansoni nAChR subunit 0.0599 0.2961 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0599 0.2961 0.679
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0595 0.2941 0.2941
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0023 0.0027 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0097 0.0683
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Trichomonas vaginalis hypothetical protein 0.0037 0.01 0.0705
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.0243 0.1702
Echinococcus granulosus expressed protein 0.0036 0.0097 0.0329
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.0206 0.0697
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0287 0.1372 0.1605
Loa Loa (eye worm) chitinase I 0.0081 0.0326 0.0326
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0027 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0152 0.3398
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0287 0.1372 0.1605
Brugia malayi hypothetical protein 0.0287 0.1372 0.1605
Schistosoma mansoni survival motor neuron protein 0.0052 0.0177 0.0598
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0076 0.0258
Schistosoma mansoni nAChR subunit 0.0599 0.2961 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.0243 0.544
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0599 0.2961 0.679
Onchocerca volvulus 0.0129 0.0568 0.1844
Echinococcus multilocularis nAChR subunit 0.0312 0.1502 0.3443
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0076 0.0175
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0063 0.0232 0.1457
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0057 0.0343
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0174 0.0797 0.2692
Leishmania major protein kinase, putative 0.0063 0.0232 0.52
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0023 0.0027 0.0092
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0599 0.2961 0.679
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0873 0.4361 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0312 0.1502 0.1756
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0354 0.2275
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0076 0.0175
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0063 0.0232 0.1457
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.121 0.4086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0166 0.056
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Echinococcus granulosus flap endonuclease 1 0.0028 0.0057 0.0191
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0023 0.0027 0.0063
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0098 0.0412 0.9235
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0093 0.1638
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0287 0.1372 0.1605
Schistosoma mansoni neurotransmitter gated ion channel 0.0287 0.1372 0.4634
Brugia malayi hypothetical protein 0.0076 0.0298 0.0348
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0599 0.2961 0.3463
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0004 0.0066
Trypanosoma cruzi aurora B kinase, putative 0.0063 0.0232 0.52
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0057 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0446 0.36
Loa Loa (eye worm) hypothetical protein 0.0096 0.04 0.04
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0098 0.0412 0.9235
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0166 0.038
Echinococcus multilocularis dual specificity 0.0098 0.0412 0.0945
Entamoeba histolytica hypothetical protein 0.0078 0.0309 0.1974
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0004 0.0013
Brugia malayi Telomerase reverse transcriptase 0.022 0.1032 0.1207
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0287 0.1372 0.1605
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0309 0.0709
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.1054 0.1054
Schistosoma mansoni hypothetical protein 0.0367 0.178 0.6012
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Onchocerca volvulus Putative endochitinase 0.0091 0.0375 0.1186
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0057 0.127
Plasmodium vivax hypothetical protein, conserved 0.0129 0.0568 0.0929
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0354 0.7919
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0174 0.0797 0.0932
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0027 0.048
Entamoeba histolytica protein kinase, putative 0.0063 0.0232 0.1457
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0023 0.0027 0.048
Plasmodium falciparum flap endonuclease 1 0.0028 0.0057 0.0998
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0599 0.2961 0.679
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Trichomonas vaginalis rotamase, putative 0.0035 0.0093 0.0647
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0016 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0354 0.7919
Toxoplasma gondii aurora kinase 0.0063 0.0232 0.4086
Loa Loa (eye worm) hypothetical protein 0.0312 0.1502 0.1502
Onchocerca volvulus 0.0312 0.1502 0.5025
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0057 0.0998
Mycobacterium ulcerans chitinase/cellulase 0.0069 0.0265 0.1697
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0599 0.2961 0.679
Loa Loa (eye worm) GABA receptor subunit 0.0312 0.1502 0.1502
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0599 0.2961 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0599 0.2961 0.3463
Onchocerca volvulus 0.0599 0.2961 1
Schistosoma mansoni hypothetical protein 0.0595 0.2941 0.9932
Entamoeba histolytica hypothetical protein 0.0078 0.0309 0.1974
Entamoeba histolytica hypothetical protein 0.0312 0.1502 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.0446 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0058 0.0206 0.1283
Echinococcus multilocularis glycine receptor subunit beta 0.0599 0.2961 0.679
Onchocerca volvulus 0.0599 0.2961 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.0352
Loa Loa (eye worm) hypothetical protein 0.0085 0.0347 0.0347
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0599 0.2961 0.3463
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0599 0.2961 0.3463
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0232 0.1809
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0599 0.2961 0.2961
Loa Loa (eye worm) hypothetical protein 0.0312 0.1502 0.1502
Echinococcus multilocularis dna polymerase eta 0.0085 0.0347 0.0796
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0093 0.0521
Onchocerca volvulus Putative endochitinase 0.0091 0.0375 0.1186
Onchocerca volvulus 0.0287 0.1372 0.4584
Schistosoma mansoni nAChR subunit 0.0599 0.2961 1
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0024 0.0036 0.0799
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0312 0.1502 0.5071
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0027 0.0045
Trypanosoma brucei aurora B kinase 0.0063 0.0232 0.52
Echinococcus multilocularis dna polymerase kappa 0.0087 0.0354 0.0811
Entamoeba histolytica hypothetical protein 0.0078 0.0309 0.1974
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0312 0.1502 0.1756
Brugia malayi Protein kinase domain containing protein 0.0174 0.0797 0.0932
Schistosoma mansoni hypothetical protein 0.0052 0.0177 0.0598
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0093 0.2085
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0063 0.0232 0.0784
Trichomonas vaginalis rotamase, putative 0.0036 0.0097 0.0683
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0309 0.1044
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Schistosoma mansoni ap endonuclease 0.002 0.0016 0.0053
Loa Loa (eye worm) ACC-1 protein 0.0599 0.2961 0.2961
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0599 0.2961 0.679
Trypanosoma brucei unspecified product 0.0079 0.0317 0.7101
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0317 0.7101
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0412 0.1392
Trypanosoma brucei unspecified product 0.004 0.0115 0.2579
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0599 0.2961 1
Schistosoma mansoni rotamase 0.0036 0.0097 0.0329
Brugia malayi hypothetical protein 0.0287 0.1372 0.1605
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0129 0.0568 0.0664
Toxoplasma gondii histone lysine-specific demethylase 0.0023 0.0027 0.048
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0004 0.0083
Loa Loa (eye worm) hypothetical protein 0.0255 0.121 0.121
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0027 0.0045
Brugia malayi indoleamine 2,3-dioxygenase 0.0595 0.2941 0.344
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0599 0.2961 0.679
Loa Loa (eye worm) ACC-1 protein 0.0599 0.2961 0.2961
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0599 0.2961 0.2961
Schistosoma mansoni nAChR subunit 0.0599 0.2961 1
Echinococcus granulosus glycine receptor subunit beta 0.0599 0.2961 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0004 0.0083
Schistosoma mansoni hypothetical protein 0.0367 0.178 0.6012
Mycobacterium ulcerans dehydrogenase 0.0023 0.0027 0.0153
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0599 0.2961 0.2961
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0166 0.0194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0166 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0152 0.3398
Plasmodium vivax SET domain protein, putative 0.0032 0.0076 0.0125
Entamoeba histolytica protein kinase, putative 0.0063 0.0232 0.1457
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.121 0.2774
Loa Loa (eye worm) hypothetical protein 0.0312 0.1502 0.1502
Brugia malayi N-terminal motif family protein 0.0196 0.0912 0.1066
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0599 0.2961 0.2961
Loa Loa (eye worm) microfilarial chitinase 0.0079 0.0315 0.0315
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.0446 0.1024
Entamoeba histolytica protein kinase, putative 0.0098 0.0412 0.2669
Brugia malayi Pre-SET motif family protein 0.0224 0.1054 0.1233
Leishmania major DNA damage repair protein, putative 0.0018 0.0004 0.0083
Onchocerca volvulus Putative endochitinase 0.0081 0.0326 0.1017
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0063 0.0232 0.038
Schistosoma mansoni neurotransmitter gated ion channel 0.0312 0.1502 0.5071
Brugia malayi hypothetical protein 0.0255 0.121 0.1415
Onchocerca volvulus 0.0032 0.0076 0.0167
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0016 0.5
Entamoeba histolytica hypothetical protein 0.0098 0.0412 0.2669
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0016 0.0016
Chlamydia trachomatis protoporphyrinogen oxidase 0.0023 0.0027 0.5
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Loa Loa (eye worm) hypothetical protein 0.0096 0.04 0.04
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0182 0.1393
Brugia malayi hypothetical protein 0.0287 0.1372 0.1605
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0023 0.0027 0.0153
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.0446 0.0446
Entamoeba histolytica protein kinase domain containing protein 0.0098 0.0412 0.2669
Brugia malayi Endochitinase 0.0091 0.0375 0.0439
Schistosoma mansoni protein kinase 0.0063 0.0232 0.0784
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0076 0.0298 0.0682
Echinococcus granulosus nAChR subunit 0.0599 0.2961 1
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0287 0.1372 0.4634
Loa Loa (eye worm) acetylcholine receptor protein 0.0287 0.1372 0.1372
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0027 0.048
Echinococcus multilocularis nAChR subunit 0.0599 0.2961 0.679
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0599 0.2961 0.3463
Onchocerca volvulus 0.0052 0.0177 0.0511
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.0027 0.0191
Loa Loa (eye worm) hypothetical protein 0.0196 0.0912 0.0912
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0446 0.36
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0599 0.2961 0.2961
Onchocerca volvulus Putative nachr subunit 0.0599 0.2961 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0023 0.0027 0.0045
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Brugia malayi endochitinase 0.0091 0.0375 0.0439
Schistosoma mansoni nAChR subunit 0.0599 0.2961 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0085 0.0347 0.7781
Brugia malayi Protein kinase domain containing protein 0.0098 0.0412 0.0482
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0174 0.0797 0.1828
Schistosoma mansoni tsg101-related 0.0063 0.0233 0.0787
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0004 0.0083
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0174 0.0797 0.0797
Trypanosoma brucei telomerase reverse transcriptase 0.0083 0.0333 0.7467
Echinococcus granulosus geminin 0.0367 0.178 0.6012
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0023 0.0027 0.5
Loa Loa (eye worm) hypothetical protein 0.0312 0.1502 0.1502
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.0446 0.1508
Toxoplasma gondii exonuclease III APE 0.002 0.0016 0.0277
Entamoeba histolytica protein kinase , putative 0.0063 0.0232 0.1457
Schistosoma mansoni hypothetical protein 0.0078 0.0309 0.1044
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0287 0.1372 0.1372
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0599 0.2961 1
Giardia lamblia DINP protein human, muc B family 0.0065 0.0243 0.5402
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0004 0.0083
Brugia malayi Cation transporter family protein 0.0599 0.2961 0.3463
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0446 0.36
Echinococcus multilocularis aurora kinase A 0.0063 0.0232 0.0532
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Echinococcus multilocularis 0.0023 0.0027 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0177 0.0207
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0093 0.2085
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0446 0.36
Echinococcus multilocularis expressed protein 0.0036 0.0097 0.0223
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0599 0.2961 0.3463
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0287 0.1372 0.1605
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0446 0.36
Loa Loa (eye worm) hypothetical protein 0.1696 0.8551 0.8551
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0599 0.2961 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.0277
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0196 0.0912 0.3015
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0097 0.0114
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0174 0.0797 0.0797
Loa Loa (eye worm) hypothetical protein 0.0312 0.1502 0.1502
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0302 0.1453 0.486
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0076 0.0258
Entamoeba histolytica protein kinase, putative 0.0098 0.0412 0.2669
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0151 0.3381
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0287 0.1372 0.3146
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0152 0.3398
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0016 0.0018
Onchocerca volvulus 0.0287 0.1372 0.4584
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0098 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0129 0.0568 0.0568
Leishmania major DNA polymerase kappa, putative 0.0065 0.0243 0.544
Echinococcus granulosus nAChR subunit 0.0312 0.1502 0.5071
Plasmodium falciparum telomerase reverse transcriptase 0.0083 0.0333 0.5866
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Echinococcus multilocularis geminin 0.0367 0.178 0.4082
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0016 0.0036
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0599 0.2961 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0297 0.1427 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0599 0.2961 0.3463
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0057 0.0276
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Brugia malayi serine/threonine-protein kinase 6 0.0063 0.0232 0.0271
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0057 0.127
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0063 0.0232 0.1457
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0599 0.2961 0.3463
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.0446 0.36
Onchocerca volvulus 0.0599 0.2961 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0016 0.0352
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0016 0.0271
Loa Loa (eye worm) hypothetical protein 0.0312 0.1502 0.1502
Schistosoma mansoni acetylcholine receptor subunit beta 0.0287 0.1372 0.4634
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0004 0.0083
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0599 0.2961 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.1502 0.1502
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0599 0.2961 1
Leishmania major UDP-galactopyranose mutase 0.0023 0.0027 0.0611
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0097 0.0097
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0063 0.0232 0.0532
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0027
Mycobacterium ulcerans monoamine oxidase 0.0023 0.0027 0.0153
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0076 0.0258
Loa Loa (eye worm) hypothetical protein 0.0129 0.0568 0.0568
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0599 0.2961 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0166 0.056
Echinococcus multilocularis protoporphyrinogen oxidase 0.0023 0.0027 0.0063
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0145 0.3242
Leishmania major DNA polymerase eta, putative 0.0046 0.0145 0.3242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0076 0.0258
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.0446 0.0522
Entamoeba histolytica chitinase, putative 0.0081 0.0326 0.2085
Echinococcus granulosus glycine receptor subunit alpha 1 0.0599 0.2961 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0058 0.0206 0.0206
Giardia lamblia Kinase, PLK 0.0105 0.0446 1
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0129 0.0568 0.1303
Schistosoma mansoni tsg101-related 0.0063 0.0233 0.0787
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0027 0.0611
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0004 0.0083
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0016 0.0078
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0599 0.2961 0.679
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0057 0.0057
Trypanosoma brucei DNA polymerase eta, putative 0.0085 0.0347 0.7781
Leishmania major telomerase reverse transcriptase, putative 0.0083 0.0333 0.7467
Echinococcus multilocularis glycine receptor subunit beta 0.0599 0.2961 0.679
Brugia malayi polk-prov protein 0.0047 0.0151 0.0177
Giardia lamblia Telomerase catalytic subunit 0.0083 0.0333 0.7445
Schistosoma mansoni terminal deoxycytidyl transferase 0.0058 0.0206 0.0697
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0232 0.1809
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Onchocerca volvulus 0.0129 0.0568 0.1844
Loa Loa (eye worm) hypothetical protein 0.1409 0.7091 0.7091
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.0412 0.9235
Trypanosoma brucei unspecified product 0.004 0.0115 0.2579
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0076 0.0298 0.1005
Leishmania major DNA polymerase eta, putative 0.0085 0.0347 0.7781
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0083 0.0333 0.7467
Loa Loa (eye worm) hypothetical protein 0.0047 0.0151 0.0151
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0599 0.2961 0.3463
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0595 0.2941 0.9932
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Trichomonas vaginalis DNA polymerase eta, putative 0.0087 0.0354 0.2824
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0016 0.0352
Loa Loa (eye worm) LGC-31 protein 0.0599 0.2961 0.2961
Brugia malayi amine oxidase, flavin-containing family protein 0.0023 0.0027 0.0032
Mycobacterium ulcerans chitinase/cellulase 0.0069 0.0265 0.1697
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0287 0.1372 0.4634
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0354 0.7919
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0166 0.038
Schistosoma mansoni serine/threonine protein kinase 0.0174 0.0797 0.2692
Echinococcus granulosus glycine receptor subunit beta 0.0599 0.2961 1
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0016 0.011
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0312 0.1502 0.5071
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.032 0.1542 1
Loa Loa (eye worm) hypothetical protein 0.0599 0.2961 0.2961
Trichomonas vaginalis AGC family protein kinase 0.0063 0.0232 0.1809
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0016 0.0026
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0051 0.0174 0.1068
Brugia malayi serine/threonine protein kinase 6 0.0063 0.0232 0.0271
Brugia malayi hypothetical protein 0.0287 0.1372 0.1605
Leishmania major chitinase 0.0081 0.0326 0.7292
Schistosoma mansoni nAChR subunit 0.0599 0.2961 1
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.004 0.0708
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0595 0.2941 0.6744
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0287 0.1372 0.3146
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0312 0.1502 0.1756
Schistosoma mansoni tsg101-related 0.0051 0.0174 0.0589
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0599 0.2961 0.3463
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.1696 0.8551 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0599 0.2961 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0016 0.0352
Plasmodium falciparum conserved protein, unknown function 0.0129 0.0568 1
Brugia malayi Flap endonuclease-1 0.0028 0.0057 0.0066
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0174 0.0797 0.2624
Onchocerca volvulus 0.0599 0.2961 1
Echinococcus granulosus dna polymerase eta 0.0085 0.0347 0.1173
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0004 0.0083
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0087 0.0354 0.2824
Loa Loa (eye worm) cuticular endochitinase 0.0081 0.0326 0.0326
Brugia malayi endochitinase 0.0081 0.0326 0.0381
Loa Loa (eye worm) hypothetical protein 0.0287 0.1372 0.1372
Trypanosoma brucei polo-like protein kinase 0.0105 0.0446 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0206 0.1446
Trichomonas vaginalis set domain proteins, putative 0.0255 0.1212 1
Brugia malayi Cation transporter family protein 0.0599 0.2961 0.3463
Echinococcus granulosus dual specificity 0.0098 0.0412 0.1392
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0057 0.1197
Entamoeba histolytica hypothetical protein 0.0078 0.0309 0.1974
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0076 0.1343
Schistosoma mansoni nAChR subunit 0.0599 0.2961 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0098 0.0412 0.9235
Brugia malayi Pre-SET motif family protein 0.0032 0.0076 0.0089
Loa Loa (eye worm) AUR protein kinase 0.0063 0.0232 0.0232
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0599 0.2961 0.679
Brugia malayi serine/threonine kinase 12 0.0063 0.0232 0.0271

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 26 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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