Detailed information for compound 1064849

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 202.249 | Formula: C13H14O2
  • H donors: 0 H acceptors: 1 LogP: 3 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1OC(=O)C(=C)[C@H]1c1ccc(cc1)C
  • InChi: 1S/C13H14O2/c1-8-4-6-11(7-5-8)12-9(2)13(14)15-10(12)3/h4-7,10,12H,2H2,1,3H3/t10-,12-/m1/s1
  • InChiKey: CAIHXFUMFXDTBZ-ZYHUDNBSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0028 0.0209 0.057
Schistosoma mansoni tar DNA-binding protein 0.0062 0.064 0.1748
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0132 0.0416
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0464 0.1672
Loa Loa (eye worm) beta-lactamase 0.0043 0.0396 0.1083
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0132 0.0361
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0141 0.1991
Echinococcus granulosus muscleblind protein 0.0164 0.1941 0.5304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0132 0.0132
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0079 0.0215
Brugia malayi hypothetical protein 0.005 0.0487 0.1533
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0132 0.0361
Echinococcus granulosus expressed protein 0.0038 0.0331 0.0905
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0132 0.0361
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0396 0.1083
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0413 0.0863
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0089 0.0281
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0321 0.3949 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0043 0.0396 0.1083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0132 0.0361
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.032 0.6135
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0105 0.1185 0.3237
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0132 0.0361
Schistosoma mansoni hypothetical protein 0.0299 0.366 1
Brugia malayi Importin beta-1 subunit 0.0028 0.0209 0.0656
Trichomonas vaginalis rotamase, putative 0.0037 0.032 0.1031
Brugia malayi Cytochrome P450 family protein 0.0059 0.0603 0.1898
Brugia malayi hypothetical protein 0.0041 0.0368 0.1159
Echinococcus multilocularis muscleblind protein 0.0164 0.1941 0.1941
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0331 0.1081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0132 0.0416
Leishmania major hypothetical protein, conserved 0.005 0.0487 1
Brugia malayi beta-lactamase family protein 0.0043 0.0396 0.1248
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0079 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0132 0.0416
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0209 0.3553
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0132 0.0361
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0141 0.0231
Brugia malayi Cytochrome P450 family protein 0.0026 0.0181 0.0569
Echinococcus granulosus snurportin 1 0.0299 0.366 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0132 0.0361
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0132 0.0361
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0603 0.1648
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0079 0.0079
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0089 0.0089
Schistosoma mansoni hypothetical protein 0.0031 0.0245 0.0669
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.366 1
Entamoeba histolytica hypothetical protein 0.0041 0.0368 0.8627
Loa Loa (eye worm) hypothetical protein 0.0043 0.0396 0.1083
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0079 0.0546
Loa Loa (eye worm) hypothetical protein 0.0022 0.0132 0.0361
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0487 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0368 0.1007
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.2329 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0031 0.0245 0.0669
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0132 0.0416
Schistosoma mansoni ap endonuclease 0.0019 0.0089 0.0244
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0396 0.0877
Onchocerca volvulus 0.0043 0.0396 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0132 0.0361
Schistosoma mansoni ran 0.0021 0.0114 0.0312
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0396 0.1083
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0132 0.0361
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0209 0.3553
Schistosoma mansoni tar DNA-binding protein 0.0062 0.064 0.1748
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0396 0.0877
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.1373
Echinococcus multilocularis snurportin 1 0.0299 0.366 0.366
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0089 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.1185 0.3237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.1185 0.1185
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0089 0.0791
Loa Loa (eye worm) hypothetical protein 0.0164 0.1941 0.5304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0132 0.0132
Mycobacterium tuberculosis Conserved protein 0.0043 0.0396 0.0877
Brugia malayi follicle stimulating hormone receptor 0.0261 0.3177 1
Trichomonas vaginalis esterase, putative 0.0043 0.0396 0.1372
Schistosoma mansoni importin beta-1 0.0028 0.0209 0.057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0132 0.0416
Brugia malayi TAR-binding protein 0.0062 0.064 0.2013
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0181 0.2912
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0464 0.9462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0132 0.0361
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0089 0.0244
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0089 0.0791
Entamoeba histolytica hypothetical protein 0.0041 0.0368 0.8627
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0396 0.0877
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0132 0.0361
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0079 0.0546
Leishmania major cytochrome p450-like protein 0.0026 0.0181 0.2912
Mycobacterium ulcerans beta-lactamase 0.0043 0.0396 0.0877
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0487 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0132 0.0361
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0132 0.0361
Loa Loa (eye worm) hypothetical protein 0.0164 0.1941 0.5304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0132 0.0361
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.032 0.6135
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.032 0.6135
Entamoeba histolytica hypothetical protein 0.0041 0.0368 0.8627
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0137 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.1185 0.3237
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0079 0.0215
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0132 0.0361
Loa Loa (eye worm) TAR-binding protein 0.0062 0.064 0.1748
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0396 0.0877
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0321 0.3949 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0089 0.0791
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0396 0.1372
Treponema pallidum hypothetical protein 0.0321 0.3949 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0413 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0132 0.0361
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0181 0.2912
Plasmodium falciparum importin beta, putative 0.0028 0.0209 0.0336
Brugia malayi steroid hormone receptor 0.0022 0.0132 0.0416
Echinococcus multilocularis GPCR, family 2 0.0031 0.0245 0.0245
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.032 0.6135
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0089 0.0027
Schistosoma mansoni hypothetical protein 0.0022 0.0137 0.0374
Schistosoma mansoni ap endonuclease 0.0019 0.0089 0.0244
Schistosoma mansoni hypothetical protein 0.0041 0.0368 0.1007
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.032 0.7135
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0132 0.0361
Trichomonas vaginalis rotamase, putative 0.0038 0.0331 0.1081
Plasmodium vivax importin-beta 2, putative 0.0028 0.0209 0.0336
Schistosoma mansoni hypothetical protein 0.0031 0.0245 0.0669
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0396 0.0396
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0114 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0132 0.0361
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0132 0.0416
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0396 0.0877
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0368 0.0368
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0089 0.0791
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0181 0.2912
Loa Loa (eye worm) hypothetical protein 0.0022 0.0132 0.0361
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0396 0.7902
Brugia malayi RNA, U transporter 1 0.008 0.0866 0.2726
Schistosoma mansoni ran 0.0021 0.0114 0.0312
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0132 0.0132
Mycobacterium ulcerans lipase LipD 0.0043 0.0396 0.0877
Loa Loa (eye worm) hypothetical protein 0.005 0.0487 0.1331
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.02 0.2398 0.7549
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.1185 0.3237
Echinococcus granulosus tar DNA binding protein 0.0062 0.064 0.1748
Loa Loa (eye worm) hypothetical protein 0.0022 0.0132 0.0361
Mycobacterium leprae Probable lipase LipE 0.0043 0.0396 0.0877
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0396 0.7902
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0089 0.0088
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0413 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0132 0.0361
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0132 0.0361
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0396 0.1083
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0079 0.0061
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0487 0.1055
Brugia malayi nuclear receptor NHR-88 0.0022 0.0132 0.0416
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.1185 0.1185
Brugia malayi Cytochrome P450 family protein 0.0026 0.0181 0.0569
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0079 0.0546
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0312
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0132 0.0132
Trichomonas vaginalis ran, putative 0.0021 0.0114 0.0112
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0132 0.0132
Onchocerca volvulus 0.0043 0.0396 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0137 0.0374
Entamoeba histolytica hypothetical protein 0.0023 0.0141 0.1602
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1094 0.299
Schistosoma mansoni tar DNA-binding protein 0.0062 0.064 0.1748
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1094 0.3445
Schistosoma mansoni hypothetical protein 0.0067 0.0701 0.1916
Loa Loa (eye worm) hypothetical protein 0.0043 0.0396 0.1083
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0464 0.1267
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0396 0.1372
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0464 0.1672
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0132 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0487 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0132 0.0361
Entamoeba histolytica Ran family GTPase 0.0021 0.0114 0.0777
Brugia malayi RNA binding protein 0.0062 0.064 0.2013
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.1373
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0079 0.0079
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0089 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0132 0.0416
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0701 0.2207
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0331 0.1043
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0079 0.0079
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0396 0.1083
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0464 0.0995
Mycobacterium tuberculosis Conserved protein 0.0043 0.0396 0.0877
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0132 0.0361
Schistosoma mansoni coup transcription factor 0.0022 0.0132 0.0361
Loa Loa (eye worm) hypothetical protein 0.0022 0.0132 0.0361
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0079 0.0546
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0114 0.1373
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0132 0.0416
Brugia malayi ecdysteroid receptor 0.0022 0.0132 0.0416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.1185 0.3237
Brugia malayi nuclear hormone receptor 0.0022 0.0132 0.0416
Schistosoma mansoni hypothetical protein 0.0016 0.0055 0.015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0396 0.1083
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0245 0.0669
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0321 0.3949 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0132 0.0132
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0245 0.0669
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0132 0.0361
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0079 0.0546
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.1933 0.5281
Brugia malayi beta-lactamase 0.0043 0.0396 0.1248
Schistosoma mansoni tar DNA-binding protein 0.0062 0.064 0.1748
Loa Loa (eye worm) hypothetical protein 0.0067 0.0701 0.1916
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0132 0.0416
Loa Loa (eye worm) acetyltransferase 0.0163 0.1933 0.5281
Leishmania major GTP-binding protein, putative 0.0021 0.0114 0.1373
Leishmania major hypothetical protein, conserved 0.0043 0.0396 0.7902
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0273 0.3331 0.8413
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0396 0.1372
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0487 0.1055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0132 0.0361
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0396 0.1372
Brugia malayi hypothetical protein 0.0032 0.0262 0.0824
Echinococcus multilocularis expressed protein 0.0038 0.0331 0.0331
Leishmania major importin beta-1 subunit, putative 0.0023 0.0141 0.1991
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0132 0.0416
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0114 0.0312
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0181 0.0494
Echinococcus granulosus GPCR family 2 0.0031 0.0245 0.0669
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0396 0.0877
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0089 0.0088
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0245 0.0669
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0209 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0132 0.0416
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0368 0.1007
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0396 0.0877
Brugia malayi beta-lactamase family protein 0.0043 0.0396 0.1248
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0261 0.3177 0.8681
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0331 0.0905
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0055 0.015
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0181 0.0494
Loa Loa (eye worm) cytochrome P450 0.0016 0.0055 0.015
Brugia malayi cytochrome P450 0.0016 0.0055 0.0173
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0396 0.0877
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0245 0.0771
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0396 0.0821
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0181 0.0323
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0487 0.1055
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0141 0.0231
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.064 0.1748
Toxoplasma gondii ABC1 family protein 0.0043 0.0396 0.7902
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0114 0.1373
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0079 0.0248
Schistosoma mansoni hypothetical protein 0.0031 0.0245 0.0669
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1094 0.3445
Echinococcus granulosus importin subunit beta 1 0.0028 0.0209 0.057
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0245 0.0771
Onchocerca volvulus 0.0043 0.0396 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0132 0.0416
Brugia malayi isocitrate dehydrogenase 0.0018 0.0079 0.0248
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0396 0.1083
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0132 0.0132
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.1933 0.1933
Loa Loa (eye worm) hypothetical protein 0.0022 0.0132 0.0361
Toxoplasma gondii exonuclease III APE 0.0019 0.0089 0.0791
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.032 0.6135
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0132 0.0416
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0396 0.0877
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0132 0.0361
Loa Loa (eye worm) hypothetical protein 0.02 0.2398 0.6553
Schistosoma mansoni cytochrome P450 0.0016 0.0055 0.015
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0396 0.0877
Echinococcus multilocularis muscleblind protein 1 0.0164 0.1941 0.1941
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0079 0.0546
Mycobacterium tuberculosis Conserved protein 0.0043 0.0396 0.0877
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0181 0.0494
Loa Loa (eye worm) hypothetical protein 0.0097 0.1094 0.299
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.1933 0.6083
Mycobacterium ulcerans hypothetical protein 0.0043 0.0396 0.0877
Schistosoma mansoni tar DNA-binding protein 0.0062 0.064 0.1748
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0114 0.0777
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0321 0.3949 1
Echinococcus multilocularis 0.0016 0.0055 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0132 0.0416
Schistosoma mansoni rotamase 0.0038 0.0331 0.0905
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0321 0.3949 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0141 0.0231
Loa Loa (eye worm) hypothetical protein 0.0022 0.0132 0.0361
Schistosoma mansoni hypothetical protein 0.0031 0.0245 0.0669
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0132 0.0361
Brugia malayi Muscleblind-like protein 0.0164 0.1941 0.611
Loa Loa (eye worm) hypothetical protein 0.0022 0.0132 0.0361
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.064 0.2013
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0132 0.0416
Brugia malayi Cytochrome P450 family protein 0.0016 0.0055 0.0173
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0396 0.1248
Loa Loa (eye worm) RNA binding protein 0.0062 0.064 0.1748
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0209 0.3553
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0079 0.0215
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0132 0.0361
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0464 0.9462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.1185 0.3237
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0114 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0396 0.1372
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0132 0.0361
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0089 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0132 0.0416
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0105 0.1185 0.3729
Echinococcus granulosus histone acetyltransferase KAT2B 0.0159 0.1874 0.5122
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0396 0.7902
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0132 0.0361
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0079 0.0546
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0043 0.0396 0.1083
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0245 0.0245
Entamoeba histolytica hypothetical protein 0.0041 0.0368 0.8627
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0132 0.0132

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.5 microM Cytotoxicity against mouse L1210 cells after 48 hrs by MTT assay ChEMBL. 19962797
IC50 (functional) = 5.62 microM Cytotoxicity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 19962797
IC50 (functional) = 5.97 microM Cytotoxicity against human NALM6 cells after 48 hrs by MTT assay ChEMBL. 19962797

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 19962797
Homo sapiens ChEMBL23 19962797

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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