TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 394.374 | Formula: C22H18O7
H donors: 5 H acceptors: 6 LogP: 3.4 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)Cc1c(O)cc(c2c1O[C@H](c1ccc(cc1)O)[C@H](C2=O)O)O
InChi: 1S/C22H18O7/c23-13-5-1-11(2-6-13)9-15-16(25)10-17(26)18-19(27)20(28)21(29-22(15)18)12-3-7-14(24)8-4-12/h1-8,10,20-21,23-26,28H,9H2/t20-,21+/m0/s1
InChiKey: HELLEJINRNHBKU-LEWJYISDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1679	0.1679
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0069	0.0102	0.0102
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0083	0.0183	0.0183
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0078	0.0157	0.0157
Schistosoma mansoni	alpha-glucosidase	0.0158	0.0613	0.0613
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0069	0.0102	0.0102
Echinococcus multilocularis	Alkaline phosphatase, core domain	0.0054	0.0022	0.0022
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0054	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0054	0.0022	0.0022
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0078	0.0157	0.0223
Brugia malayi	Protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.0102	0.0102
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0078	0.0157	0.0936
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0157	0.0157
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0157	0.0157
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1119	0.6074	1
Onchocerca volvulus	4.1 G protein, putative homolog	0.0078	0.0157	0.0223
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.1119	0.6074	0.6074
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0157	0.0157
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1809	1	1
Brugia malayi	hypothetical protein	0.0054	0.0022	0.0022
Leishmania major	endonuclease G, putative	0.0208	0.0894	0.5341
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0124	0.0124
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1119	0.6074	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1809	1	1
Schistosoma mansoni	hypothetical protein	0.0054	0.0022	0.0022
Brugia malayi	hypothetical protein	0.0078	0.0157	0.0157
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0346	0.1679	0.1679
Onchocerca volvulus		0.0078	0.0157	0.0223
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0345	0.1673	0.2563
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1809	1	1
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0346	0.1679	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1679	0.1679
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0083	0.0183	0.0183
Onchocerca volvulus		0.1119	0.6074	1
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Leishmania major	hypothetical protein, conserved	0.0345	0.1673	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0083	0.0183	0.0183
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0157	0.0157
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0078	0.0157	0.0157
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0069	0.0102	0.0612
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Echinococcus multilocularis	Endonuclease G	0.0208	0.0894	0.0894
Trypanosoma cruzi	endonuclease G, putative	0.0208	0.0894	0.5341
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0208	0.0894	0.5341
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0078	0.0157	0.0223
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1119	0.6074	1
Echinococcus granulosus	transferase	0.0054	0.0022	0.0022
Onchocerca volvulus		0.0078	0.0157	0.0223
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0078	0.0157	0.0157
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0208	0.0894	1
Plasmodium falciparum	GPI ethanolamine phosphate transferase 3, putative	0.0054	0.0022	0.5
Onchocerca volvulus		0.0078	0.0157	0.0223
Brugia malayi	hypothetical protein	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0747	0.3957	0.6503
Onchocerca volvulus		0.0346	0.1679	0.2738
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Trypanosoma brucei	endonuclease G, putative	0.0208	0.0894	0.5341
Schistosoma mansoni	endonuclease related	0.0208	0.0894	0.0894
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0345	0.1673	0.2563
Loa Loa (eye worm)	type I phosphodiesterase/nucleotide pyrophosphatase	0.0054	0.0022	0.0022
Schistosoma mansoni	protein tyrosine phosphatase	0.0078	0.0157	0.0157
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Brugia malayi	Thrombospondin type 1 domain containing protein	0.0747	0.3957	0.3957
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0083	0.0183	0.0183
Echinococcus multilocularis	hypothetical protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase	0.0155	0.0595	0.0595
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Leishmania major	ethanolamine phosphotransferase, putative	0.0054	0.0022	0.013
Echinococcus multilocularis	transferase	0.0054	0.0022	0.0022
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 3	0.0054	0.0022	0.0022
Onchocerca volvulus		0.0078	0.0157	0.0223
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0346	0.1679	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0157	0.0157
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0291	0.137	0.137
Echinococcus multilocularis	geminin	0.0191	0.0801	0.0801
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1119	0.6074	1
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1119	0.6074	1
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0078	0.0157	0.0936
Echinococcus granulosus	ectonucleotide	0.0291	0.137	0.137
Brugia malayi	hypothetical protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0078	0.0157	0.0157
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1119	0.6074	0.6074
Onchocerca volvulus		0.0078	0.0157	0.0223
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0054	0.0022	0.0022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Onchocerca volvulus		0.0078	0.0157	0.0223
Schistosoma mansoni	hypothetical protein	0.0191	0.0801	0.0801
Onchocerca volvulus		0.0078	0.0157	0.0223
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0124	0.0124
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0083	0.0183	0.0183
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Echinococcus granulosus	lysosomal alpha glucosidase	0.0184	0.0759	0.0759
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0157	0.0157
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0157	0.0157
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0102	0.0133
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0078	0.0157	0.0157
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0083	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Schistosoma mansoni	protein tyrosine phosphatase	0.0083	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0569	0.0569
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0083	0.0183	0.0183
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0083	0.0183	0.0183
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Schistosoma mansoni	alpha-glucosidase	0.0158	0.0613	0.0613
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0078	0.0157	0.0157
Echinococcus multilocularis	ectonucleotide	0.0291	0.137	0.137
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0083	0.0183	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0078	0.0157	0.0157
Giardia lamblia	Protein tyrosine phosphatase	0.0078	0.0157	0.0223
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1119	0.6074	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0078	0.0157	0.0157
Leishmania major	tyrosine specific protein phosphatase, putative	0.0078	0.0157	0.0936
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0774	0.4113	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0747	0.3957	0.3957
Trypanosoma cruzi	hypothetical protein, conserved	0.0345	0.1673	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0078	0.0157	0.0157
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0078	0.0157	0.0157
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0291	0.137	0.137
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Schistosoma mansoni	hypothetical protein	0.0054	0.0022	0.0022
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0083	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Schistosoma mansoni	hypothetical protein	0.0054	0.0022	0.0022
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0157	0.0157
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 1	0.0054	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0054	0.0022	0.0022
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0078	0.0157	0.0157
Brugia malayi	hypothetical protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0078	0.0157	0.0157
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0083	0.0183	0.0183
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0208	0.0894	0.5341
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0124	0.0124
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0083	0.0183	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Trypanosoma cruzi	endonuclease G, putative	0.0208	0.0894	0.5341
Schistosoma mansoni	pcd6 interacting protein-related	0.0078	0.0157	0.0157
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0346	0.1679	0.1679
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0184	0.0759	0.0759
Brugia malayi	Protein-tyrosine phosphatase 1	0.0078	0.0157	0.0157
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0083	0.0183	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Schistosoma mansoni	hypothetical protein	0.0191	0.0801	0.0801
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0078	0.0157	0.0157
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0184	0.0759	0.0759
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0157	0.0157
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0078	0.0157	0.0936
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0078	0.0157	0.0223
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0157	0.0157
Brugia malayi	endonuclease G, mitochondrial precursor	0.0208	0.0894	0.0894
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0078	0.0157	0.0157
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0078	0.0157	0.0157
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0054	0.0022	0.0022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Mycobacterium leprae	hypothetical protein	0.0054	0.0022	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1809	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.0102	0.0102
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.0747	0.3957	0.3957
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0022	0.0022
Echinococcus granulosus	gpi ethanolamine phosphate transferase 3	0.0054	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Echinococcus granulosus	Endonuclease G	0.0208	0.0894	0.0894
Trypanosoma cruzi	hypothetical protein, conserved	0.0345	0.1673	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0157	0.0157
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0184	0.0759	0.0759
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0106	0.0318	0.0489
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0078	0.0157	0.0936
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0157	0.0157
Brugia malayi	hypothetical protein	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0345	0.1673	1
Onchocerca volvulus		0.0078	0.0157	0.0223
Brugia malayi	AEL166Cp	0.0054	0.0022	0.0022
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0083	0.0183	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Echinococcus multilocularis		0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0291	0.137	0.137
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0078	0.0157	0.0936
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0346	0.1679	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Trypanosoma brucei	endonuclease G, putative	0.0208	0.0894	0.5341
Echinococcus granulosus	geminin	0.0191	0.0801	0.0801
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0077	0.0151	0.0213
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0078	0.0157	0.0157
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0184	0.0759	0.0759
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Trypanosoma brucei	GPI ethanolamine phosphate transferase 3, putative	0.0054	0.0022	0.013
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0054	0.0022	0.0022
Trypanosoma brucei	endonuclease G, putative	0.0208	0.0894	0.5341
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1119	0.6074	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0102	0.0133
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0208	0.0894	0.5341
Onchocerca volvulus		0.0078	0.0157	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0346	0.1679	0.1679
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0083	0.0183	0.0183
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0083	0.0183	0.0183
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1119	0.6074	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Onchocerca volvulus		0.0078	0.0157	0.0223
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1119	0.6074	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Schistosoma mansoni	protein tyrosine phosphatase	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0346	0.1679	0.2738
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0054	0.0022	0.0022
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0346	0.1679	0.1679
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0157	0.0157
Onchocerca volvulus		0.0078	0.0157	0.0223
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0078	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0157	0.0157
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0157	0.0157
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1119	0.6074	1
Onchocerca volvulus		0.0078	0.0157	0.0223
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0102	0.0133

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 50 uM	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells by Griess assay	ChEMBL.	19113968

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL563192

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1065002