TDR Targets

Basic information

Technical information

TDR Targets ID: 1070745
Name: N-[(2,5-dimethoxyphenyl)methyl]quinolin-3-ami ne
MW: 294.348 | Formula: C18H18N2O2
H donors: 1 H acceptors: 1 LogP: 3.61 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1CNc1cnc2c(c1)cccc2)OC
InChi: 1S/C18H18N2O2/c1-21-16-7-8-18(22-2)14(10-16)11-19-15-9-13-5-3-4-6-17(13)20-12-15/h3-10,12,19H,11H2,1-2H3
InChiKey: MMOFZEGEDZSEPI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(2,5-dimethoxyphenyl)methyl]-3-quinolinamine
(2,5-dimethoxybenzyl)-(3-quinolyl)amine
MLS-0111667.0001

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	alkaline phosphatase, liver/bone/kidney	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	vacuolar alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Schistosoma mansoni	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Schistosoma japonicum	ko:K01077 alkaline phosphatase [EC3.1.3.1], putative	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus multilocularis	intestinal type alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus multilocularis	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Candida albicans	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Schistosoma mansoni	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus granulosus	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Candida albicans	alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	Get druggable targets OG5_126976	All targets in OG5_126976
Schistosoma japonicum	Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus granulosus	intestinal type alkaline phosphatase 1	Get druggable targets OG5_126976	All targets in OG5_126976
Candida albicans	vacuolar alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus granulosus	intestinal type alkaline phosphatase	Get druggable targets OG5_126976	All targets in OG5_126976
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	Get druggable targets OG5_126976	All targets in OG5_126976

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0261	0.0377	0.2892
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0049	0.0349
Entamoeba histolytica	DNA repair protein RAD51, putative	0.0093	0.0117	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0022	0.0009	0.0019
Mycobacterium ulcerans	dehydrogenase	0.0854	0.1293	0.1231
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0201	0.153
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0854	0.1293	1
Schistosoma mansoni	importin beta-1	0.0028	0.0018	0.0018
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0854	0.1293	0.1293
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0854	0.1293	0.1231
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0854	0.1293	1
Schistosoma mansoni	hypothetical protein	0.0352	0.0518	0.0518
Echinococcus granulosus	survival motor neuron protein 1	0.0261	0.0377	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0009	0.0036
Schistosoma mansoni	hypothetical protein	0.0049	0.0049	0.0049
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0048	0.0048
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0019	0.0019
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0035	0.0035
Echinococcus multilocularis	survival motor neuron protein 1	0.0261	0.0377	0.0377
Loa Loa (eye worm)	hypothetical protein	0.0854	0.1293	1
Plasmodium vivax	meiotic recombination protein DMC1, putative	0.003	0.002	0.0107
Brugia malayi	Bromodomain containing protein	0.0083	0.0102	0.0742
Trichomonas vaginalis	meiosis-specific recA homolog Dmc1	0.0093	0.0117	0.3382
Brugia malayi	Importin beta-1 subunit	0.0028	0.0018	0.009
Loa Loa (eye worm)	PHD-finger family protein	0.0023	0.0009	0.0039
Trypanosoma cruzi	meiotic recombination protein DMC1, putative	0.0093	0.0117	0.0863
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0071	0.0084	0.0603
Mycobacterium tuberculosis	Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO)	0.5633	0.8681	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.0854	0.1293	1
Echinococcus multilocularis	zinc finger protein	0.0022	0.0007	0.0007
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0854	0.1293	1
Schistosoma mansoni	alkaline phosphatase	0.0196	0.0277	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0084	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0094	0.0701
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0009	0.0026
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0039	0.0274
Brugia malayi	Pre-SET motif family protein	0.0029	0.0019	0.0102
Onchocerca volvulus		0.0854	0.1293	1
Toxoplasma gondii	meiotic recombination protein DMC1 family protein	0.0093	0.0117	0.0863
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0854	0.1293	0.1419
Schistosoma mansoni	hypothetical protein	0.0022	0.0009	0.0009
Mycobacterium ulcerans	monoamine oxidase	0.0854	0.1293	0.1231
Echinococcus multilocularis	snurportin 1	0.0303	0.0442	0.0442
Schistosoma mansoni	zinc finger protein	0.0022	0.0007	0.0007
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0048	0.0048
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0022	0.0009	0.0009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0048	0.0048
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0035	0.0027	0.0027
Schistosoma mansoni	excision repair cross-complementing 1 ercc1	0.0063	0.0071	0.0071
Schistosoma mansoni	survival motor neuron protein	0.0053	0.0056	0.0056
Brugia malayi	DNA repair protein RAD51 homolog 1	0.0093	0.0117	0.0863
Mycobacterium tuberculosis	Possible oxidoreductase	0.0854	0.1293	0.1419
Schistosoma mansoni	caspase-3 (C14 family)	0.0063	0.0072	0.0072
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.0291	0.2224
Brugia malayi	hypothetical protein	0.0261	0.0377	0.288
Plasmodium falciparum	importin beta, putative	0.0028	0.0018	0.009
Echinococcus granulosus	caspase 3	0.0046	0.0045	0.0052
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0854	0.1293	0.1231
Echinococcus granulosus	DNA excision repair protein ERCC 1	0.0063	0.0071	0.0082
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0035	0.0027	0.0032
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0019	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0047	0.033
Giardia lamblia	Dmc1b	0.003	0.002	0.2122
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0003	0.0003
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0035	0.0027	0.0032
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.0076	0.0087
Brugia malayi	SWIRM domain containing protein	0.0854	0.1293	1
Echinococcus granulosus	caspase	0.0063	0.0072	0.0083
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0035	0.0027	0.0027
Plasmodium falciparum	DNA repair protein RAD51	0.003	0.002	0.0107
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0006	0.0006
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0196	0.0277	0.032
Echinococcus multilocularis	caspase 3	0.0046	0.0045	0.0045
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0196	0.0277	0.0277
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0035	0.0027	0.0027
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0063	0.0072	0.0072
Schistosoma mansoni	hypothetical protein	0.0102	0.0132	0.0132
Echinococcus multilocularis	muscleblind protein 1	0.0147	0.0201	0.0201
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0035	0.0027	0.0165
Echinococcus granulosus	protoporphyrinogen oxidase	0.5633	0.8681	1
Schistosoma mansoni	ran	0.0021	0.0006	0.0006
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0854	0.1293	1
Wolbachia endosymbiont of Brugia malayi	Holliday junction DNA helicase RuvA	0.0063	0.0071	0.5
Schistosoma mansoni	hypothetical protein	0.0022	0.0009	0.0009
Leishmania major	UDP-galactopyranose mutase	0.0854	0.1293	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0049	0.0049	0.0333
Wolbachia endosymbiont of Brugia malayi	transcription elongation factor NusA	0.0063	0.0071	0.5
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0196	0.0277	0.0277
Brugia malayi	Meiotic recombination protein DMC1/LIM15 homolog, putative	0.003	0.002	0.0107
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0854	0.1293	1
Onchocerca volvulus	Meiotic recombination protein DMC1\/LIM15 homolog	0.003	0.002	0.0005
Echinococcus granulosus	hypothetical protein	0.0772	0.1167	0.1344
Schistosoma mansoni	bromodomain containing protein	0.007	0.0082	0.0082
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0854	0.1293	0.1293
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0018	0.8409
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.0442	0.3401
Echinococcus multilocularis	caspase	0.0063	0.0072	0.0072
Schistosoma mansoni	ran	0.0021	0.0006	0.0006
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0003	0.0003
Echinococcus multilocularis	alkaline phosphatase	0.0196	0.0277	0.0277
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0018	0.002
Echinococcus multilocularis	GPCR, family 2	0.0022	0.0009	0.0009
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0196	0.0277	0.032
Toxoplasma gondii	DNA repair protein RAD51, putative	0.003	0.002	0.0107
Treponema pallidum	Holliday junction DNA helicase (ruvA)	0.0063	0.0071	0.5
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0201	0.153
Brugia malayi	RNA, U transporter 1	0.0081	0.0099	0.0719
Echinococcus granulosus	zinc finger protein	0.0022	0.0007	0.0008
Schistosoma mansoni	hypothetical protein	0.0023	0.0009	0.0009
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0854	0.1293	1
Echinococcus multilocularis		0.0854	0.1293	0.1293
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0035	0.0027	0.0027
Schistosoma mansoni	DNA repair protein RAD51	0.0093	0.0117	0.0117
Echinococcus multilocularis	DNA excision repair protein ERCC 1	0.0063	0.0071	0.0071
Toxoplasma gondii	histone lysine-specific demethylase	0.0854	0.1293	1
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0018	0.002
Brugia malayi	Pre-SET motif family protein	0.0205	0.0291	0.2211
Trypanosoma cruzi	DNA repair protein RAD51, putative	0.0093	0.0117	0.0863
Trypanosoma brucei	DNA repair protein RAD51	0.003	0.002	1
Onchocerca volvulus		0.0053	0.0056	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0854	0.1293	1
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0854	0.1293	0.149
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0048	0.0056
Schistosoma mansoni	hypothetical protein	0.0022	0.0009	0.0009
Echinococcus granulosus	GPCR family 2	0.0022	0.0009	0.001
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0065	0.0074	0.0074
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0009	0.0026
Echinococcus granulosus	dna repair protein rad51 1	0.0093	0.0117	0.0135
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0071	0.0084	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0043	0.0305
Schistosoma mansoni	amine oxidase	0.0854	0.1293	0.1293
Echinococcus multilocularis	dna repair protein rad51 1	0.0093	0.0117	0.0117
Brugia malayi	hypothetical protein	0.0854	0.1293	1
Entamoeba histolytica	Meiotic recombination protein DMC1, putative	0.003	0.002	0.1241
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0012	0.0014
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0063	0.0072	0.0083
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0003	0.0003
Echinococcus multilocularis	geminin	0.0352	0.0518	0.0518
Giardia lamblia	hypothetical protein	0.0063	0.0071	1
Plasmodium vivax	SET domain protein, putative	0.0029	0.0019	0.0102
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0012	0.0012
Brugia malayi	Serotonin receptor	0.0517	0.0773	0.5959
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0035	0.0027	0.0027
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0018	0.8409
Loa Loa (eye worm)	hypothetical protein	0.0854	0.1293	1
Brugia malayi	Bromodomain containing protein	0.0042	0.0039	0.0256
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0854	0.1293	0.149
Entamoeba histolytica	hypothetical protein	0.0023	0.0009	0.0296
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0022	0.0009	0.0036
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0018	0.009
Schistosoma mansoni	hypothetical protein	0.0352	0.0518	0.0518
Giardia lamblia	DNA repair protein RAD51	0.003	0.002	0.2122
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0035	0.0027	0.0182
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.0076	0.0076
Trypanosoma brucei	meiotic recombination protein DMC1, putative	0.003	0.002	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0022	0.0009	0.001
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0009	0.01
Plasmodium vivax	hypothetical protein, conserved	0.0854	0.1293	1
Mycobacterium ulcerans	oxidoreductase	0.0854	0.1293	0.1231
Plasmodium falciparum	protoporphyrinogen oxidase	0.0854	0.1293	1
Schistosoma mansoni	hypothetical protein	0.0053	0.0056	0.0056
Toxoplasma gondii	DNA repair protein rad10 subfamily protein	0.0063	0.0071	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0854	0.1293	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0035	0.004
Loa Loa (eye worm)	rad51	0.0093	0.0117	0.0878
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0006	0.0007
Schistosoma mansoni	alkaline phosphatase	0.0196	0.0277	0.0277
Brugia malayi	PHD-finger family protein	0.0027	0.0016	0.0079
Trichomonas vaginalis	recombinase Rad51 (recA homolog)	0.003	0.002	0.042
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0071	0.0084	0.0603
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0196	0.0277	0.032
Trypanosoma cruzi	meiotic recombination protein DMC1, putative	0.0093	0.0117	0.0863
Plasmodium falciparum	meiotic recombination protein DMC1, putative	0.003	0.002	0.0107
Schistosoma mansoni	caspase-7 (C14 family)	0.0063	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0018	0.0107
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0196	0.0277	0.0277
Leishmania major	RAD51/dmc1 protein	0.0093	0.0117	0.0863
Echinococcus multilocularis	conserved hypothetical protein	0.0764	0.1154	0.1154
Onchocerca volvulus		0.0233	0.0334	0.2474
Loa Loa (eye worm)	meiotic recombination protein DMC1/LIM15	0.003	0.002	0.0124
Echinococcus granulosus	snurportin 1	0.0303	0.0442	0.051
Brugia malayi	Latrophilin receptor protein 2	0.0022	0.0009	0.0019
Echinococcus granulosus	geminin	0.0352	0.0518	0.0597
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0854	0.1293	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0009	0.01
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0022	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0022	0.0009	0.0009
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0009	0.01
Trypanosoma cruzi	DNA repair protein RAD51, putative	0.0093	0.0117	0.0863
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0019	0.0019
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0854	0.1293	1
Echinococcus granulosus	alkaline phosphatase	0.0196	0.0277	0.032
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0003	0.0003
Schistosoma mansoni	retinoic acid receptor RXR	0.0072	0.0084	0.0084
Giardia lamblia	DNA helicase	0.0063	0.0071	1
Loa Loa (eye worm)	hypothetical protein	0.0854	0.1293	1
Plasmodium vivax	hypothetical protein, conserved	0.0854	0.1293	1
Schistosoma mansoni	hypothetical protein	0.0303	0.0442	0.0442
Plasmodium vivax	DNA repair protein RAD51, putative	0.003	0.002	0.0107
Echinococcus multilocularis	muscleblind protein	0.0147	0.0201	0.0201
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.0334	1
Schistosoma mansoni	amine oxidase	0.0854	0.1293	0.1293
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0048	0.0344
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0022	0.0009	0.001
Brugia malayi	Muscleblind-like protein	0.0147	0.0201	0.1516
Echinococcus granulosus	muscleblind protein	0.0147	0.0201	0.0232
Leishmania major	RAD51 protein, putative	0.003	0.002	0.0107
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0006	0.0017
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0018	0.009
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0018	0.0018
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0072	0.0084	0.0097
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.0056	0.0388

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10 uM	Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assay	ChEMBL.	19821572
IC50 (binding)	> 100 um	PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (binding)	> 100 uM	PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL569638

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1070745