TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 293.403 | Formula: C20H23NO
H donors: 1 H acceptors: 1 LogP: 4.42 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)CN1c2ccc(cc2C(=CC1(C)C)C)O
InChi: 1S/C20H23NO/c1-14-5-7-16(8-6-14)13-21-19-10-9-17(22)11-18(19)15(2)12-20(21,3)4/h5-12,22H,13H2,1-4H3
InChiKey: VWLCXBULZCVZHP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Inositol-1	0.0036	0.0171	0.0512
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0011	0.0016	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Loa Loa (eye worm)	cytochrome P450 family protein	0.0055	0.0289	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0128	0.0382
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.002	0.0072	0.2213
Toxoplasma gondii	FATC domain-containing protein	0.0028	0.012	0.0302
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0188	0.0561
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0171	0.6383
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.0258	1
Schistosoma mansoni	cytochrome P450	0.0012	0.0019	0.0019
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0012	0.0019	0.0122
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0258	1
Onchocerca volvulus		0.0232	0.1401	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0016	0.0016
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0019	0.0122
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0016	0.0016
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0128	0.0128
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0171	0.0466
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.002	0.0072	0.0167
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0016	0.0047
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.002	0.0072	0.0072
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0016	0.0047
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0049
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0016	0.0047
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0258	0.0258
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0258	0.077
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0019	0.0058
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0019	0.0122
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.002	0.0072	0.0072
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0231	0.1395	0.4171
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0016	0.0016
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0121	0.0121
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0016	0.0016
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0016	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0016	0.0049
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Schistosoma mansoni	coup transcription factor	0.0011	0.0016	0.0016
Trypanosoma brucei	transcription factor BTF3, putative	0.0039	0.0188	0.7066
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.0541	0.3346	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0128	0.0128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0016	0.0047
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0171	0.0171
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0171	0.0171
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0019	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0013	0.0025	0.0073
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0024	0.0095	0.3267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0016	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0541	0.3346	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0047
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0128	0.0128
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0016	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0016	0.0047
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0258	0.0258
Brugia malayi	MAP kinase sur-1	0.005	0.0258	0.077
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0019	0.0058
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0171	0.0171
Schistosoma mansoni	hypothetical protein	0.0012	0.0019	0.0019
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0259	0.1574	0.4705
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0128	0.0128
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0016	0.0047
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0016	0.0047
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0016	0.0047
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0016	0.0047
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Echinococcus granulosus	geminin	0.039	0.2396	0.2396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0016	0.0016
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.097	0.6035	0.6035
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0047
Echinococcus multilocularis	transcription factor btf3	0.0039	0.0188	0.0188
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.0258	0.0716
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0016	0.0016
Plasmodium falciparum	macrophage migration inhibitory factor	0.0541	0.3346	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.002	0.0072	0.0215
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0231	0.1395	0.4171
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.002	0.0072	0.0072
Brugia malayi	beta-NAC-like protein	0.0039	0.0188	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0016	0.0049
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.002	0.0072	0.2308
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0188	0.0561
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0016	0.0016
Plasmodium vivax	basic transcription factor 3b, putative	0.0039	0.0188	0.0186
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0258	0.0258
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0016	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0016	0.0049
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.002	0.0072	0.2308
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.002	0.0072	0.2213
Entamoeba histolytica	hypothetical protein	0.0039	0.0188	0.0515
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0016	0.0016
Echinococcus granulosus	transcription factor btf3	0.0039	0.0188	0.0188
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.002	0.0072	0.2318
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.0541	0.3346	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0016	0.0016
Echinococcus multilocularis	neuropeptide receptor A26	0.0555	0.3429	0.3429
Trichomonas vaginalis	set domain proteins, putative	0.0232	0.1401	0.4186
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.0258	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.002	0.0072	0.2308
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0016	0.0047
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0016	0.0016
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0171	0.6427
Toxoplasma gondii	target of rapamycin (TOR), putative	0.002	0.0072	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0025	0.0073
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.002	0.0072	0.0167
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.002	0.0072	0.0159
Echinococcus granulosus	neuropeptide s receptor	0.0555	0.3429	0.3429
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.002	0.0072	0.2213
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0016	0.0047
Loa Loa (eye worm)	inositol-1	0.0036	0.0171	0.0512
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0188	0.0561
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.0258	1
Leishmania major	phosphatidylinositol kinase related protein, putative	0.002	0.0072	0.0159
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0016	0.0016
Entamoeba histolytica	hypothetical protein	0.0028	0.012	0.031
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0016	0.0016
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0016	0.0047
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Leishmania major	basic transcription factor 3a, putative	0.0039	0.0188	0.0506
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0019	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0047
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0171	0.0457
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.002	0.0072	0.0215
Giardia lamblia	Macrophage migration inhibitory factor	0.0541	0.3346	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0028	0.012	0.4215
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0013	0.0025	0.0016
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0258	0.077
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Loa Loa (eye worm)	ICD-1 protein	0.0039	0.0188	0.0561
Loa Loa (eye worm)	phosphatidylinositol 3	0.002	0.0072	0.0215
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Echinococcus multilocularis	neuropeptide s receptor	0.0555	0.3429	0.3429
Echinococcus granulosus	serine protein kinase ATM	0.0028	0.012	0.012
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.002	0.0072	0.0159
Brugia malayi	Bm-MIF-1, identical	0.0541	0.3346	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0016	0.0016
Trypanosoma cruzi	transcription factor btf3, putative	0.0039	0.0188	0.7102
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0025	0.0073
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0016	0.0016
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0258	0.077
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.002	0.0072	0.0215
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0258	0.077
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.0258	0.0567
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.002	0.0072	0.0159
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0128	0.0128
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0013	0.0025	0.0222
Leishmania major	macrophage migration inhibitory factor-like protein	0.0541	0.3346	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.002	0.0072	0.0072
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0171	0.6427
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0028	0.012	0.012
Loa Loa (eye worm)	cytochrome P450	0.0012	0.0019	0.0058
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0016	0.0016
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0016	0.0016
Echinococcus multilocularis	geminin	0.039	0.2396	0.2396
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.0541	0.3346	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0016	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.002	0.0072	0.2213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0047
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0012	0.0019	0.0122
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.0541	0.3346	1
Brugia malayi	Pre-SET motif family protein	0.0204	0.1224	0.3657
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0016	0.0047
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0012	0.0019	0.0122
Schistosoma mansoni	hypothetical protein	0.039	0.2396	0.2396
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0016	0.0047
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0148	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0011	0.0016	0.0016
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0016	0.0016
Echinococcus multilocularis		0.0012	0.0019	0.0019
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0016	0.0016
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0016	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0047
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0016	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0095	0.0284
Trypanosoma cruzi	target of rapamycin kinase 3	0.002	0.0072	0.2308
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0028	0.012	0.0358
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0258	0.0258
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0148	1
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.0541	0.3346	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0016	0.0049
Brugia malayi	Cytochrome P450 family protein	0.0055	0.0289	0.0863
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.0258	0.0716
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0016	0.0016
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0019	0.0058
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.002	0.0072	0.0159
Brugia malayi	ecdysteroid receptor	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0028	0.012	0.4285
Brugia malayi	steroid hormone receptor	0.0011	0.0016	0.0047
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.0258	0.077
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0128	0.0128
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.0258	1
Onchocerca volvulus		0.0029	0.0128	0.081
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.002	0.0072	0.2308
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.002	0.0072	0.0072
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0016	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0016	0.0016
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0016	0.0016
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0171	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0016	0.0047
Entamoeba histolytica	transcription factor BTF3, putative	0.0039	0.0188	0.0515
Trypanosoma brucei	protein kinase, putative	0.005	0.0258	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0016	0.0049
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0171	0.0512
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0016	0.0047
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0171	0.0457
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0016	0.0016
Echinococcus granulosus	neuropeptide receptor A26	0.0555	0.3429	0.3429
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0171	0.0171
Echinococcus granulosus	cytochrome P450 2K1	0.0012	0.0019	0.0019
Toxoplasma gondii	NAC domain-containing protein	0.0039	0.0188	0.0506
Brugia malayi	cytochrome P450	0.0012	0.0019	0.0058
Brugia malayi	Pre-SET motif family protein	0.0029	0.0128	0.0382
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0258	0.0258
Trypanosoma cruzi	transcription factor btf3, putative	0.0039	0.0188	0.7102
Brugia malayi	nuclear hormone receptor	0.0011	0.0016	0.0047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0128	0.0128
Echinococcus multilocularis	serine protein kinase ATM	0.0028	0.012	0.012
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0171	1
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0016	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0011	0.0016	0.0016
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0171	0.0512
Leishmania major	phosphatidylinositol 3-kinase, putative	0.002	0.0072	0.0159
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.002	0.0072	0.0072
Schistosoma mansoni	transcription factor btf3	0.0039	0.0188	0.0188
Leishmania major	macrophage migration inhibitory factor-like protein	0.0541	0.3346	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.002	0.0072	0.2213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0011	0.0016	0.0049
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0019	0.0058
Schistosoma mansoni	hypothetical protein	0.039	0.2396	0.2396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0171	0.5
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0204	0.1224	0.3657
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.0258	0.0716
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.012	0.0358
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0011	0.0016	0.0049
Brugia malayi	follicle stimulating hormone receptor	0.0259	0.1574	0.4705
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0072	0.0215
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0128	0.0326

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.058 microM	Antitrypanosomal activity against bloodstream Trypanosoma brucei rhodesiense STIB 900 after 70 hrs by alamar blue assay	ChEMBL.	20047276

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei gambiense		20047276

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL575019

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1073550