Detailed information for compound 1092511

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 515.29 | Formula: C17H28BrN2O9P
  • H donors: 5 H acceptors: 8 LogP: -0.53 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(Br)c(=O)n(c1=O)CCCCCCCCP(=O)(O)O
  • InChi: 1S/C17H28BrN2O9P/c18-11-9-20(16-14(23)13(22)12(10-21)29-16)17(25)19(15(11)24)7-5-3-1-2-4-6-8-30(26,27)28/h9,12-14,16,21-23H,1-8,10H2,(H2,26,27,28)/t12-,13-,14-,16-/m1/s1
  • InChiKey: PRAAYWBIBCEBSK-IXYNUQLISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0395 0.4353
Trichomonas vaginalis helicase, putative 0.0007 0.0009 0.0028
Echinococcus granulosus smad 0.0009 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0395 0.1239
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0845 0.0794
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0159 0.0497
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0293 0.3471
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0295 0.0335
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0198 0.0516
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0159 0.1877
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0295 0.0342
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0037 0.0042
Mycobacterium leprae Probable lipase LipE 0.0079 0.0845 0.2387
Schistosoma mansoni wnt related 0.0015 0.0103 0.0119
Brugia malayi Muscleblind-like protein 0.0162 0.1806 0.4712
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0295 0.077
Schistosoma mansoni smad1 5 8 and 0.0009 0.0037 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0295 0.077
Loa Loa (eye worm) hypothetical protein 0.0079 0.0845 0.2205
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0395 0.4674
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0159 0.5407
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0295 0.077
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.125 0.142
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0124 0.0322
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0845 0.265
Echinococcus multilocularis expressed protein 0.0033 0.0314 0.0314
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.3188 1
Echinococcus multilocularis muscleblind protein 1 0.0162 0.1806 0.1806
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0159 0.5
Loa Loa (eye worm) hypothetical protein 0.0162 0.1806 0.4712
Echinococcus granulosus Protein Wnt-04 0.0015 0.0103 0.0117
Brugia malayi ecdysone receptor 0.0015 0.0103 0.0269
Brugia malayi hypothetical protein 0.0017 0.0124 0.0322
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0225 0.0705
Loa Loa (eye worm) hypothetical protein 0.0054 0.056 0.1462
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0198 0.188
Loa Loa (eye worm) hypothetical protein 0.0017 0.013 0.0341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0124 0.0143
Schistosoma mansoni hypothetical protein 0.0354 0.4039 0.4678
Brugia malayi steroid hormone receptor 0.0031 0.0295 0.077
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.3188 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0238 0.282
Brugia malayi nuclear hormone receptor 0.0015 0.0103 0.0269
Loa Loa (eye worm) hypothetical protein 0.0079 0.0845 0.2205
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2068 0.6488
Schistosoma mansoni cpg binding protein 0.0031 0.0292 0.0338
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0295 0.0335
Loa Loa (eye worm) hypothetical protein 0.0031 0.0295 0.077
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0295 0.0295
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0159 0.1877
Loa Loa (eye worm) hypothetical protein 0.0079 0.0845 0.2205
Onchocerca volvulus 0.0079 0.0845 0.3775
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0048 0.0568
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0322
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Trichomonas vaginalis esterase, putative 0.0079 0.0845 0.265
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0577 0.6833
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0395 0.4353
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0845 0.2205
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0295 0.0342
Entamoeba histolytica hypothetical protein 0.0114 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0268
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0103 0.0103
Schistosoma mansoni rotamase 0.0033 0.0314 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0295 0.077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0268
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0845 0.0979
Schistosoma mansoni wnt related 0.0015 0.0103 0.0119
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.1478 0.3858
Schistosoma mansoni nuclear receptor 0.0015 0.0103 0.0119
Echinococcus multilocularis geminin 0.0354 0.4039 0.4039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.125 0.125
Mycobacterium tuberculosis Conserved protein 0.0079 0.0845 0.0794
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.056 0.1462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0295 0.077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0103 0.0117
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0198 0.0225
Echinococcus granulosus snurportin 1 0.0333 0.3793 0.4309
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0395 0.0449
Schistosoma mansoni wnt related 0.0015 0.0103 0.0119
Brugia malayi hypothetical protein 0.0015 0.0103 0.0269
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0159 0.018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0103 0.0117
Loa Loa (eye worm) hypothetical protein 0.0031 0.0295 0.077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.056 0.1462
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0124 0.0322
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0305 0.2443
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2068 0.6488
Echinococcus granulosus Protein Wnt-11b 0.0015 0.0103 0.0117
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0103 0.0119
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0103 0.0117
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0295 0.0342
Brugia malayi RNA, U transporter 1 0.0089 0.096 0.2506
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0037 0.0096
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0238 0.282
Schistosoma mansoni coup transcription factor 0.0031 0.0295 0.0342
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0295 0.0295
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2068 0.6488
Schistosoma mansoni ran 0.0023 0.0198 0.0229
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0295 0.0335
Brugia malayi tailless protein 0.0015 0.0103 0.0269
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0314 0.0821
Schistosoma mansoni inositol monophosphatase 0.004 0.0395 0.0457
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.013 0.0341
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0103 0.0269
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0395 0.0395
Trichomonas vaginalis ran, putative 0.0023 0.0198 0.062
Schistosoma mansoni cpg binding protein 0.0029 0.0272 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0295 0.077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0845 0.2205
Loa Loa (eye worm) hypothetical protein 0.0031 0.0295 0.077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0295 0.077
Brugia malayi MH1 domain containing protein 0.0009 0.0037 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0103 0.0103
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0845 1
Echinococcus multilocularis neuropeptide s receptor 0.0501 0.5733 0.5733
Schistosoma mansoni ran 0.0023 0.0198 0.0229
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0198 0.0516
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0295 0.0295
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0395 0.3159
Mycobacterium ulcerans hypothetical protein 0.0079 0.0845 0.0794
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0346 0.0217
Trichomonas vaginalis rotamase, putative 0.0033 0.0314 0.0986
Brugia malayi Wnt-2 protein precursor 0.0015 0.0103 0.0268
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0845 0.265
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.013 0.013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0159 0.0414
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0295 0.0342
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0305 0.323
Brugia malayi nuclear receptor NHR-88 0.0031 0.0295 0.077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0103 0.0269
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0293 0.3471
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0124 0.0124
Schistosoma mansoni ap endonuclease 0.002 0.0159 0.0184
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0048 0.0568
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0295 0.077
Schistosoma mansoni smad1 5 8 and 0.0009 0.0037 0.0043
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0037 0.0097
Brugia malayi CXXC zinc finger family protein 0.0029 0.0272 0.0711
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.3188 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.013 0.013
Mycobacterium ulcerans thymidine phosphorylase 0.0765 0.8803 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1042 0.2721
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0268
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0225 0.0705
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0079 0.0845 0.2205
Mycobacterium tuberculosis Conserved protein 0.0079 0.0845 0.0794
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0314 0.0986
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0151
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0295 0.077
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2068 0.6488
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0295 0.077
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0103 0.0269
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0198 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Schistosoma mansoni zinc finger protein 0.0015 0.0103 0.0119
Onchocerca volvulus 0.0079 0.0845 0.3775
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0037
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0103 0.0117
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0159 0.0159
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0238 0.8123
Brugia malayi MH2 domain containing protein 0.0009 0.0037 0.0096
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0295 0.0335
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0395 0.0273
Echinococcus multilocularis Smad4 0.0009 0.0037 0.0037
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0216 0.2436 0.2634
Onchocerca volvulus Glucosylceramidase homolog 0.0184 0.2068 1
Loa Loa (eye worm) CWN-2 protein 0.0015 0.0103 0.0268
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0295 0.077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1042 0.1207
Leishmania major hypothetical protein, conserved 0.0079 0.0845 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0295 0.0977
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0103 0.0103
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Loa Loa (eye worm) hypothetical protein 0.0031 0.0295 0.077
Loa Loa (eye worm) hypothetical protein 0.0037 0.0361 0.0943
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0159 0.1268
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0293 0.3471
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0028
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0295 0.0342
Brugia malayi Inositol-1 0.004 0.0395 0.1031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1042 0.1207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Echinococcus multilocularis muscleblind protein 0.0162 0.1806 0.1806
Brugia malayi Importin beta-1 subunit 0.0031 0.0293 0.0766
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0845 0.0794
Echinococcus multilocularis thymidine phosphorylase 0.0765 0.8803 0.8803
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0305 0.3615
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0103 0.0119
Echinococcus granulosus Protein Wnt-5 0.0015 0.0103 0.0117
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0765 0.8803 1
Brugia malayi nuclear receptor RXR 0.0015 0.0103 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0028
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0103 0.0117
Brugia malayi hypothetical protein 0.0026 0.0238 0.0622
Schistosoma mansoni wnt related 0.0015 0.0103 0.0119
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0037 0.0037
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0305 0.3615
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.2436 0.2634
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0026 0.0238 0.0622
Leishmania major hypothetical protein, conserved 0.0026 0.0238 0.282
Brugia malayi beta-lactamase 0.0079 0.0845 0.2205
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0238 0.2387
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2068 0.6488
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0395 0.4674
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0295 0.0335
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0159 0.3187
Brugia malayi MH1 domain containing protein 0.0009 0.0037 0.0096
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0198 0.2341
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0295 0.0335
Echinococcus multilocularis protein Wnt 2 0.0015 0.0103 0.0103
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0036 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0295 0.077
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0028
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0295 0.0977
Echinococcus granulosus cpg binding protein 0.0031 0.0292 0.0332
Echinococcus multilocularis WNT 0.0015 0.0103 0.0103
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0295 0.0342
Brugia malayi hypothetical protein 0.0015 0.0103 0.0269
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0079 0.0845 0.2205
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0268
Echinococcus granulosus neuropeptide s receptor 0.0501 0.5733 0.6512
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0295 0.0295
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0845 0.265
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0845 0.0794
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0845 0.0794
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0159 0.1877
Schistosoma mansoni smad1 5 8 and 0.0009 0.0037 0.0043
Mycobacterium ulcerans beta-lactamase 0.0079 0.0845 0.0794
Schistosoma mansoni inositol monophosphatase 0.004 0.0395 0.0457
Brugia malayi MH2 domain containing protein 0.0009 0.0037 0.0096
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0103 0.0269
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0845 0.265
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0295 0.077
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0322
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0845 0.2387
Echinococcus granulosus Protein Wnt-111 0.0015 0.0103 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0295 0.077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0295 0.077
Toxoplasma gondii exonuclease III APE 0.002 0.0159 0.1877
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0151
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0069 0.0069
Echinococcus granulosus protein Wnt 2 0.0015 0.0103 0.0117
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0395 0.1239
Brugia malayi Latrophilin receptor protein 2 0.0017 0.013 0.0341
Schistosoma mansoni hypothetical protein 0.0354 0.4039 0.4678
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0238 0.2387
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0124 0.0143
Brugia malayi ecdysteroid receptor 0.0031 0.0295 0.077
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0295 0.077
Loa Loa (eye worm) inositol-1 0.004 0.0395 0.1031
Entamoeba histolytica hypothetical protein 0.0114 0.125 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0037 0.0043
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0103 0.0269
Brugia malayi Smad1 0.0009 0.0037 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0295 0.077
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0103 0.0269
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Echinococcus granulosus geminin 0.0354 0.4039 0.4588
Plasmodium falciparum importin beta, putative 0.0031 0.0293 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0159 0.0414
Schistosoma mansoni hypothetical protein 0.0012 0.0069 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0295 0.0335
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0009 0.0028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0016 0.0019
Mycobacterium ulcerans lipase LipD 0.0079 0.0845 0.0794
Brugia malayi beta-lactamase family protein 0.0079 0.0845 0.2205
Brugia malayi Wnt-4 protein precursor 0.0015 0.0103 0.0268
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0268
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1042 0.1184
Brugia malayi Zinc finger, C2H2 type family protein 0.0336 0.3831 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0225 0.222
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.013 0.0148
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0159 0.1387
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0281 0.3188 0.8321
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0295 0.0335
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0295 0.0342
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0295 0.0977
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0103 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0295 0.077
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1042 0.2721
Loa Loa (eye worm) DR-78 0.0015 0.0103 0.0269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.013 0.0341
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0151
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0028
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0295 0.077
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.2436 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0295 0.077
Loa Loa (eye worm) hypothetical protein 0.0031 0.0295 0.077
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.125 0.1448
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0305 0.323
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0295 0.0342
Echinococcus multilocularis protein Wnt 1 0.0015 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0322
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0103 0.0269
Echinococcus multilocularis wnt family member wnt11 2 0.0015 0.0103 0.0103
Brugia malayi nuclear hormone receptor 0.0031 0.0295 0.077
Schistosoma mansoni importin beta-1 0.0031 0.0293 0.034
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0198 0.0198
Echinococcus multilocularis snurportin 1 0.0333 0.3793 0.3793
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0845 0.0794
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0016 0.0018
Brugia malayi conserved hypotetical protein 0.0015 0.0103 0.0269
Echinococcus multilocularis cpg binding protein 0.0031 0.0292 0.0292
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0103 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2183 0.6848
Schistosoma mansoni hypothetical protein 0.0114 0.125 0.1448
Echinococcus multilocularis zinc finger transcription factor gli2 0.0336 0.3831 0.3831
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0198 0.6744
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0655 0.0758
Onchocerca volvulus 0.0031 0.0295 0.0977
Brugia malayi wnt family protein 0.0015 0.0103 0.0268
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0845 0.0794
Brugia malayi beta-lactamase family protein 0.0079 0.0845 0.2205
Schistosoma mansoni hypothetical protein 0.0419 0.4786 0.5544
Brugia malayi MH2 domain containing protein 0.0133 0.1478 0.3858
Leishmania major GTP-binding protein, putative 0.0023 0.0198 0.2341
Echinococcus granulosus protein Wnt 1 0.0015 0.0103 0.0117
Echinococcus granulosus microtubule associated protein 2 0.0751 0.8634 0.9808
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0295 0.0342
Plasmodium vivax importin-beta 2, putative 0.0031 0.0293 0.3471
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1042 0.1042
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0845 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0198 0.188
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0395 1
Echinococcus granulosus neuropeptide receptor A26 0.0501 0.5733 0.6512
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Echinococcus multilocularis wingless type MMTV integration site family 0.0015 0.0103 0.0103
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0103 0.0103
Echinococcus granulosus muscleblind protein 0.0162 0.1806 0.2051
Entamoeba histolytica hypothetical protein 0.0114 0.125 1
Schistosoma mansoni hypothetical protein 0.0017 0.013 0.0151
Leishmania major importin beta-1 subunit, putative 0.0025 0.0225 0.2662
Loa Loa (eye worm) beta-lactamase 0.0079 0.0845 0.2205
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.3793 0.99
Loa Loa (eye worm) hypothetical protein 0.0031 0.0293 0.0766
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0845 0.0794
Schistosoma mansoni cpg binding protein 0.0031 0.0292 0.0338
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0198 0.2341
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0314 0.0821
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.3188 1
Echinococcus multilocularis smad 0.0009 0.0037 0.0037
Echinococcus multilocularis neuropeptide receptor A26 0.0501 0.5733 0.5733
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0028
Echinococcus multilocularis GPCR, family 2 0.0017 0.013 0.013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0295 0.077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0295 0.077
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0295 0.0295
Schistosoma mansoni Smad4 0.0009 0.0037 0.0043
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0845 0.265
Echinococcus granulosus zinc finger transcription factor gli2 0.0336 0.3831 0.4353
Loa Loa (eye worm) wnt-4 protein 0.0015 0.0103 0.0268
Brugia malayi hypothetical protein 0.0114 0.125 0.3263
Echinococcus granulosus expressed protein 0.0033 0.0314 0.0357
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0295 0.0295
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0124 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2068 0.6488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1042 0.1184
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0103 0.0119
Loa Loa (eye worm) hypothetical protein 0.0162 0.1806 0.4712
Loa Loa (eye worm) hypothetical protein 0.0079 0.0845 0.2205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0295 0.077
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0395 0.1239
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0295 0.0295
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0238 0.282
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0295 0.077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0295 0.0295
Echinococcus multilocularis microtubule associated protein 2 0.0751 0.8634 0.8634
Echinococcus granulosus Smad4 0.0009 0.0037 0.0042
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0295 0.0342
Brugia malayi nuclear receptor NHR-88 0.0015 0.0103 0.0269
Echinococcus multilocularis WNT 0.0015 0.0103 0.0103
Onchocerca volvulus 0.0079 0.0845 0.3775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0295 0.077
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0159 0.0497
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.2068 0.6488
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.3188 1
Brugia malayi nuclear receptor NHR-67 0.0015 0.0103 0.0269
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0845 0.0794
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0069 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0028
Loa Loa (eye worm) Smad1 0.0009 0.0037 0.0096
Schistosoma mansoni hypothetical protein 0.0333 0.3793 0.4393
Brugia malayi hypothetical protein 0.0017 0.0124 0.0322
Entamoeba histolytica hypothetical protein 0.0025 0.0225 0.1799
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0238 0.8123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1042 0.1042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1042 0.1207
Toxoplasma gondii ABC1 family protein 0.0079 0.0845 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0103 0.0117
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0845 0.0845
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0103 0.0269
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0048 0.0568
Echinococcus granulosus thymidine phosphorylase 0.0765 0.8803 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Entamoeba histolytica Ran family GTPase 0.0023 0.0198 0.1582
Echinococcus granulosus importin subunit beta 1 0.0031 0.0293 0.0333
Schistosoma mansoni hypothetical protein 0.0037 0.0361 0.0419
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0845 0.0794
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0225 0.0705
Brugia malayi hypothetical protein 0.0017 0.013 0.0338
Schistosoma mansoni nuclear receptor 0.0015 0.0103 0.0119
Onchocerca volvulus 0.0029 0.0272 0.0862
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0845 0.096
Trichomonas vaginalis rotamase, putative 0.0032 0.0305 0.0958
Mycobacterium tuberculosis Conserved protein 0.0079 0.0845 0.0794
Brugia malayi nuclear receptor RXR 0.0017 0.0124 0.0322
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0295 0.0295
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.056 0.1462
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0103 0.0269
Echinococcus granulosus dnaJ subfamily B 0.0419 0.4786 0.5437
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0845 1
Schistosoma mansoni smad 0.0009 0.0037 0.0043
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0395 0.4674
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0322
Brugia malayi wnt family protein 0.0015 0.0103 0.0268
Entamoeba histolytica hypothetical protein 0.0114 0.125 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0028
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0037 0.0037
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0504 0.5767 0.6488
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0272 0.0711
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0124 0.0322
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0295 0.0335
Schistosoma mansoni wnt-5 0.0015 0.0103 0.0119
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0103 0.0103
Loa Loa (eye worm) Wnt2 protein 0.0015 0.0103 0.0268
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0159 0.1387
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0009 0.0028
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0037 0.0042
Schistosoma mansoni ap endonuclease 0.002 0.0159 0.0184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0009 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.2183 0.6848
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.013 0.0148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0018
Echinococcus granulosus GPCR family 2 0.0017 0.013 0.0148
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.3188 1
Brugia malayi wnt family protein 0.0015 0.0103 0.0268
Loa Loa (eye worm) hypothetical protein 0.0031 0.0295 0.077
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0361 0.0943
Schistosoma mansoni microtubule-associated protein tau 0.0751 0.8634 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0009 0.0028
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0295 0.0342
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0295 0.077
Brugia malayi wnt family protein 0.0015 0.0103 0.0268
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0198 0.2341
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0016 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.4786 0.4786
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0845 0.0979
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0322
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0281 0.3188 0.8321
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.1478 0.3858
Loa Loa (eye worm) zinc finger protein 0.0336 0.3831 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0295 0.0342
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0845 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0305 0.3615
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0037 0.0042

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 236 nM Inhibition of human recombinant thymidine phosphorylase ChEMBL. 20053558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.