Detailed information for compound 1103373

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 239.206 | Formula: C8H18NO5P
  • H donors: 3 H acceptors: 5 LogP: -0.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: ON(C(=O)C(C)(C)C)CCCP(=O)(O)O
  • InChi: 1S/C8H18NO5P/c1-8(2,3)7(10)9(11)5-4-6-15(12,13)14/h11H,4-6H2,1-3H3,(H2,12,13,14)
  • InChiKey: NEZISRPYGWZJCI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli 1-deoxy-D-xylulose 5-phosphate reductoisomerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis 1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium knowlesi 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Theileria parva 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium berghei 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Neospora caninum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium yoelii 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS Get druggable targets OG5_130462 All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.0514 0.304 0.3982
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0171 0.0271
Schistosoma mansoni ferritin 0.0026 0.0073 0.0087
Echinococcus multilocularis dnaJ subfamily B 0.0884 0.5289 0.5285
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0046 0.0123
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0167 0.0208
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0977 0.128
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.062 0.3686 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.013 0.0157
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.013 0.0122
Brugia malayi Inositol-1 0.0038 0.0145 0.0449
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0162 0.0505
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.1052 0.3442
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0027 0.0062
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0148 0.0815 0.266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1269 0.7634 1
Leishmania major hypothetical protein, conserved 0.0035 0.013 0.04
Brugia malayi serine/threonine-protein kinase 6 0.0514 0.304 1
Trypanosoma brucei unspecified product 0.0029 0.0091 0.0273
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0046 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1451 0.1901
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0167 0.0219
Giardia lamblia DINP protein human, muc B family 0.0042 0.0171 0.0189
Echinococcus granulosus dnaJ subfamily B 0.0884 0.5289 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Mycobacterium tuberculosis Conserved protein 0.0035 0.013 0.0329
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0357 0.1149
Echinococcus multilocularis dna polymerase eta 0.0042 0.0171 0.0163
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0162 0.0505
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0027 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0091 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0091 0.0273
Trichomonas vaginalis esterase, putative 0.0035 0.013 0.017
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0027 0.0062
Loa Loa (eye worm) AUR protein kinase 0.0514 0.304 1
Trichomonas vaginalis AGC family protein kinase 0.0514 0.304 0.3982
Loa Loa (eye worm) hypothetical protein 0.0029 0.0092 0.0276
Giardia lamblia Ribonuclease H 0.0022 0.0046 0.0025
Brugia malayi Dihydrofolate reductase 0.0043 0.0175 0.055
Brugia malayi RNase H family protein 0.0022 0.0046 0.0123
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0148 0.0815 0.2628
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0201 0.1136 0.1517
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0923 0.1209
Leishmania major carbonic anhydrase-like protein 0.0201 0.1136 0.372
Schistosoma mansoni hypothetical protein 0.0031 0.0102 0.0126
Schistosoma mansoni hypothetical protein 0.0346 0.2021 0.2706
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.013 0.023
Echinococcus multilocularis GPCR, family 2 0.0031 0.0102 0.0094
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0162 0.0505
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0171 0.0218
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0027 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Onchocerca volvulus 0.0062 0.0292 0.3099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0027 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0027 0.0036
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0121 0.0132
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0167 0.0523
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0167 0.0208
Mycobacterium tuberculosis Conserved protein 0.0035 0.013 0.0329
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.013 0.04
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0102 0.0308
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0000069902
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.013 0.0163
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0171 0.0163
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0162 0.0177
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0338 0.0735
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0046 0.0123
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0626 0.2037
Schistosoma mansoni ferritin 0.0026 0.0073 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0009 0.0011
Brugia malayi dihydrofolate reductase family protein 0.0043 0.0175 0.055
Schistosoma mansoni inositol monophosphatase 0.0038 0.0145 0.0184
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0514 0.304 0.9883
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0031 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1269 0.7634 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0027 0.0062
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0167 0.0159
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.04
Plasmodium falciparum serine/threonine protein kinase, putative 0.0514 0.304 0.9883
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0027 0.0062
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0000069902
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1269 0.7634 1
Schistosoma mansoni hypothetical protein 0.0031 0.0102 0.0126
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0338 0.0444
Echinococcus multilocularis flap endonuclease 1 0.003 0.0098 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1451 0.1901
Brugia malayi RNase H family protein 0.0022 0.0046 0.0123
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0129 0.0162
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0171 0.0535
Entamoeba histolytica hypothetical protein 0.0035 0.0129 0.0158
Schistosoma mansoni hypothetical protein 0.0109 0.0576 0.0764
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0145 0.0449
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0167 0.0219
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0923 0.1209
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0171 0.0224
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0129
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3076 1
Brugia malayi follicle stimulating hormone receptor 0.0249 0.1429 0.4685
Schistosoma mansoni hypothetical protein 0.0081 0.0407 0.0537
Schistosoma mansoni ferritin light chain 0.0026 0.0073 0.0087
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.062 0.3686 1
Treponema pallidum fructose-bisphosphate aldolase 0.1269 0.7634 1
Echinococcus granulosus carbonic anhydrase II 0.0201 0.1136 0.2136
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0201 0.1136 0.372
Schistosoma mansoni carbonic anhydrase 0.0109 0.0576 0.0764
Entamoeba histolytica hypothetical protein 0.0035 0.0129 0.0158
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.1052 0.1976
Toxoplasma gondii aurora kinase 0.0514 0.304 0.9883
Mycobacterium leprae conserved hypothetical protein 0.0035 0.013 0.0157
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0009 0.0011
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0148 0.0815 0.2628
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0357 0.1149
Schistosoma mansoni phosphoglucomutase 0.0022 0.0046 0.0051
Schistosoma mansoni ap endonuclease 0.0041 0.0162 0.0206
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.0175 0.0453
Trypanosoma cruzi aurora B kinase, putative 0.0514 0.304 1
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0167 0.0523
Echinococcus granulosus dna polymerase kappa 0.0042 0.0171 0.0308
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0357 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0923 0.1209
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0171 0.0535
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0507 0.1643
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0069 0.0201
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.013 0.04
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0145 0.0449
Echinococcus granulosus carbonic anhydrase 0.0109 0.0576 0.1075
Trypanosoma brucei unspecified product 0.0042 0.0171 0.0535
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.0175 0.055
Echinococcus multilocularis geminin 0.0346 0.2021 0.2014
Trichomonas vaginalis AGC family protein kinase 0.0514 0.304 0.3982
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.1451 0.476
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Trypanosoma brucei DNA polymerase eta, putative 0.0042 0.0171 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0167 0.0523
Brugia malayi RNA binding protein 0.0073 0.0357 0.1149
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0027 0.0062
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0338 0.1076
Mycobacterium ulcerans thymidylate synthase 0.0105 0.0554 0.1332
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.1052 0.1045
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0171 0.0163
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0225 0.1283 0.1715
Brugia malayi RNA, U transporter 1 0.008 0.0401 0.1293
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.0629 0.2024
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0145 0.0449
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0923 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0145 0.0326
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0027 0.0062
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0201 0.1136 0.372
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3076 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0162 0.0499
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.1451 0.476
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1451 0.1901
Onchocerca volvulus 0.0035 0.013 0.1325
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0129 0.012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1269 0.7634 1
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0162 0.0212
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0085 0.0254
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0357 0.0349
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0109 0.0576 0.1872
Echinococcus multilocularis carbonic anhydrase II 0.0201 0.1136 0.1129
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0167 0.03
Schistosoma mansoni alpha-glucosidase 0.0161 0.0894 0.1191
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0171 0.0224
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.013 0.0157
Schistosoma mansoni hypothetical protein 0.0067 0.0319 0.0418
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0145 0.0449
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0148 0.0815 0.2628
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0201 0.1136 0.372
Loa Loa (eye worm) AUR protein kinase 0.0514 0.304 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0109 0.0576 0.1872
Entamoeba histolytica protein kinase , putative 0.0514 0.304 0.3975
Schistosoma mansoni hypothetical protein 0.0346 0.2021 0.2706
Brugia malayi isocitrate dehydrogenase 0.0015 0.0009 0.0000069902
Echinococcus granulosus expressed protein 0.0026 0.0073 0.0122
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0507 0.1643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0121 0.0305
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trypanosoma brucei RNA helicase, putative 0.0081 0.0407 0.1316
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0027 0.0062
Echinococcus granulosus flap endonuclease 1 0.003 0.0098 0.017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.013 0.04
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0145 0.019
Loa Loa (eye worm) thymidylate synthase 0.0105 0.0554 0.1799
Trypanosoma brucei unspecified product 0.0023 0.0057 0.016
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0027 0.0026
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0171 0.0271
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1289 0.3482
Echinococcus granulosus importin subunit beta 1 0.0028 0.0085 0.0146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1269 0.7634 1
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0073 0.0035
Entamoeba histolytica hypothetical protein 0.0035 0.0129 0.0158
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0098 0.0293
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0171 0.0535
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1238 0.7444 1
Echinococcus multilocularis carbonic anhydrase 0.0109 0.0576 0.0568
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0027 0.0062
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0027 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0923 0.1209
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0162 0.0246
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3076 0.3993
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0073 0.0089
Schistosoma mansoni hypothetical protein 0.03 0.1739 0.2328
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0357 0.1149
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.3076 1
Echinococcus granulosus neuropeptide s receptor 0.0454 0.2677 0.5054
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.04
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Schistosoma mansoni hypothetical protein 0.0035 0.0129 0.0162
Schistosoma mansoni alpha glucosidase 0.0041 0.0167 0.0213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1078 0.1439
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0145 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Plasmodium vivax importin-beta 2, putative 0.0028 0.0085 0.0251
Mycobacterium ulcerans hypothetical protein 0.0035 0.013 0.0157
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.013 0.0329
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1269 0.7634 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0009 0.0011
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0046 0.0122
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0171 0.0441
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1269 0.7634 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0073 0.0175
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0626 0.2037
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.013 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0923 0.1209
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.04
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.2677 0.2671
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0084 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Plasmodium falciparum importin beta, putative 0.0028 0.0085 0.0251
Entamoeba histolytica protein kinase domain containing protein 0.0514 0.304 0.3975
Leishmania major hypothetical protein, conserved 0.0029 0.0092 0.0276
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0009 0.0011
Brugia malayi Cytochrome P450 family protein 0.0028 0.0084 0.0249
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0057 0.016
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0514 0.304 0.3975
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0009 0.0001
Leishmania major DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0129 0.0228
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0514 0.304 0.5741
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0201 0.1136 0.372
Brugia malayi hypothetical protein 0.0029 0.0092 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0069 0.0091
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.0175 0.0284
Echinococcus multilocularis thymidylate synthase 0.0105 0.0554 0.0546
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.013 0.0157
Leishmania major ribonuclease H1, putative 0.0022 0.0046 0.0123
Echinococcus granulosus cpg binding protein 0.0066 0.0313 0.0578
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.013 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Loa Loa (eye worm) hypothetical protein 0.0109 0.0576 0.1872
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0027 0.0062
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0027 0.0062
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0219 0.0693
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0027 0.0061
Schistosoma mansoni hypothetical protein 0.0884 0.5289 0.7102
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0098 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0109 0.0576 0.1872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.3076 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1451 0.1901
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0167 0.0219
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0167 0.0523
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1078 0.1071
Loa Loa (eye worm) hypothetical protein 0.0109 0.0576 0.1872
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0048 0.0129
Loa Loa (eye worm) inositol-1 0.0038 0.0145 0.0449
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0338 0.1088
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0514 0.304 0.3034
Trypanosoma brucei aurora B kinase 0.0514 0.304 1
Toxoplasma gondii ABC1 family protein 0.0035 0.013 0.0395
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0923 0.1209
Echinococcus multilocularis ribonuclease H1 0.0022 0.0046 0.0038
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0009 0.0011
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.2677 0.5054
Loa Loa (eye worm) hypothetical protein 0.0097 0.0507 0.1643
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0027 0.0062
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0085 0.0251
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0109 0.0576 0.1872
Echinococcus multilocularis cpg binding protein 0.0066 0.0313 0.0305
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0338 0.0444
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1451 0.1901
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0162 0.0416
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0357 0.0469
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0162 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0091 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0201 0.1136 0.372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.003 0.007
Loa Loa (eye worm) beta-lactamase 0.0035 0.013 0.04
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.013 0.0329
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1269 0.7634 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.013 0.017
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0092 0.0276
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1269 0.7634 1
Echinococcus granulosus geminin 0.0346 0.2021 0.3811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Toxoplasma gondii hypothetical protein 0.0109 0.0576 0.185
Echinococcus granulosus ribonuclease H1 0.0022 0.0046 0.0071
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.013 0.0329
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0098 0.0296
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0069 0.0082
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0069 0.0201
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0069 0.0061
Brugia malayi CXXC zinc finger family protein 0.0062 0.0292 0.0935
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1078 0.1439
Schistosoma mansoni hypothetical protein 0.0031 0.0102 0.0126
Leishmania major importin beta-1 subunit, putative 0.0023 0.0053 0.0147
Trypanosoma brucei carbonic anhydrase-like protein 0.0201 0.1136 0.372
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0098 0.0296
Schistosoma mansoni inositol monophosphatase 0.0038 0.0145 0.0184
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.013 0.0329
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0171 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0057 0.016
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0027 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0053 0.0147
Brugia malayi hypothetical protein 0.0019 0.0029 0.0068
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.1078 0.3529
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0085 0.0254
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.2677 0.2671
Entamoeba histolytica protein kinase, putative 0.0514 0.304 0.3975
Giardia lamblia Fructose-bisphosphate aldolase 0.1269 0.7634 1
Schistosoma mansoni cpg binding protein 0.0062 0.0292 0.0381
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0167 0.0219
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0167 0.0516
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0171 0.0308
Giardia lamblia Aurora kinase 0.0514 0.304 0.396
Schistosoma mansoni serine/threonine protein kinase 0.0514 0.304 0.4077
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0162 0.0505
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0167 0.0219
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0319 0.1025
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0145 0.019
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.1052 0.3442
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0162 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Schistosoma mansoni phosphoglucomutase 0.0022 0.0046 0.0051
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.013 0.0329
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0109 0.0576 0.1872
Trypanosoma brucei glucosidase, putative 0.0041 0.0167 0.0523
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0031 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.013 0.017
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0031 0.0075
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0201 0.1136 0.1517
Schistosoma mansoni protein kinase 0.0514 0.304 0.4077
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0167 0.0219
Echinococcus granulosus ferritin 0.0026 0.0073 0.0122
Entamoeba histolytica Flap nuclease, putative 0.003 0.0098 0.0118
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0027 0.0062
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.0175 0.0284
Schistosoma mansoni dihydrofolate reductase 0.0043 0.0175 0.0225
Brugia malayi thymidylate synthase 0.0105 0.0554 0.1799
Brugia malayi serine/threonine protein kinase 6 0.0514 0.304 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0148 0.0815 0.266
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0338 0.0897
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0102 0.0177
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0027 0.0062
Brugia malayi MH2 domain containing protein 0.0117 0.0626 0.2037
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.0046 0.0409
Schistosoma mansoni carbonic anhydrase-related 0.0109 0.0576 0.0764
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0292 0.0935
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0027 0.0036
Echinococcus multilocularis carbonic anhydrase 0.0109 0.0576 0.0568
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0171 0.0535
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.1052 0.1045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0308
Echinococcus granulosus GPCR family 2 0.0031 0.0102 0.0177
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0027 0.0025
Schistosoma mansoni cpg binding protein 0.0066 0.0313 0.041
Schistosoma mansoni ferritin light chain 0.0026 0.0073 0.0087
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0027 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.1078 0.3529
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0357 0.0469
Plasmodium vivax hypothetical protein, conserved 0.0035 0.013 0.0395
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.013 0.0163
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0027 0.0025
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3076 0.8312
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0069 0.0116
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0092 0.0273
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0338 0.0625
Echinococcus granulosus tar DNA binding protein 0.0073 0.0357 0.066
Brugia malayi hypothetical protein 0.0035 0.0129 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Brugia malayi RNase H family protein 0.0022 0.0046 0.0123
Schistosoma mansoni phosphoglucomutase 0.0022 0.0046 0.0051
Entamoeba histolytica hypothetical protein 0.0023 0.0053 0.0058
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0098 0.0296
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0357 0.0469
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0027 0.0062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1078 0.2026
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Echinococcus granulosus dihydrofolate reductase 0.0043 0.0175 0.0316
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0171 0.0213
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.013 0.017
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0085 0.0077
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0338 0.033
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0023 0.0057 0.016
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.052 0.3076 0.8312
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.013 0.04
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0357 0.0469
Echinococcus granulosus snurportin 1 0.03 0.1739 0.3278
Schistosoma mansoni carbonic anhydrase-related 0.0109 0.0576 0.0764
Trypanosoma brucei ingi protein (ORF1) 0.0023 0.0057 0.016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0171 0.0535
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0009 0.0011
Mycobacterium ulcerans lipase LipD 0.0035 0.013 0.0157
Toxoplasma gondii exonuclease III APE 0.0041 0.0162 0.0499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0338 0.0735
Entamoeba histolytica hypothetical protein 0.0025 0.0069 0.008
Schistosoma mansoni DNA polymerase eta 0.0042 0.0171 0.0218
Schistosoma mansoni importin beta-1 0.0028 0.0085 0.0104
Onchocerca volvulus 0.0105 0.0554 0.5965
Schistosoma mansoni cpg binding protein 0.0066 0.0313 0.041
Brugia malayi beta-lactamase 0.0035 0.013 0.04
Plasmodium falciparum flap endonuclease 1 0.003 0.0098 0.0293
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0053 0.007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0171 0.0535
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0073 0.0175
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.013 0.0329
Brugia malayi Importin beta-1 subunit 0.0028 0.0085 0.0254
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0092 0.0273
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0171 0.0535
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0125 0.0675 0.1812
Echinococcus granulosus dna polymerase eta 0.0042 0.0171 0.0308
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0923 0.1209
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0009 0.0011
Leishmania major protein kinase, putative 0.0514 0.304 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.1078 0.1439
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1451 0.1901
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0514 0.304 0.3975
Brugia malayi serine/threonine kinase 12 0.0514 0.304 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0102 0.0177
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0148 0.0815 0.266
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0053 0.007
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0162 0.0152
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0009 0.0000069902
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0171 0.0218
Echinococcus granulosus aurora kinase A 0.0514 0.304 0.5741
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0069 0.0201
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0145 0.0137
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0102 0.0308
Brugia malayi Flap endonuclease-1 0.003 0.0098 0.0296
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0162 0.0505
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0162 0.0505
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0167 0.0523
Loa Loa (eye worm) carbonic anhydrase 3 0.0201 0.1136 0.372
Trypanosoma brucei ribonuclease H1 0.0022 0.0046 0.0123
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0092 0.0276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.1078 0.1071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0102 0.0094
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.04
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0145 0.0258
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0102 0.0094
Schistosoma mansoni hypothetical protein 0.0031 0.0102 0.0126
Schistosoma mansoni ferritin 0.0026 0.0073 0.0087
Onchocerca volvulus 0.0108 0.0572 0.6166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Schistosoma mansoni ap endonuclease 0.0041 0.0162 0.0206
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0507 0.1643
Entamoeba histolytica protein kinase, putative 0.0514 0.304 0.3975
Loa Loa (eye worm) hypothetical protein 0.0067 0.0319 0.1025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.1078 0.2026
Brugia malayi beta-lactamase family protein 0.0035 0.013 0.04
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0092 0.0273
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.0715 0.095
Trypanosoma brucei unspecified product 0.0029 0.0091 0.0273
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0338 0.0735
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0098 0.0093
Schistosoma mansoni alpha-glucosidase 0.0161 0.0894 0.1191
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0167 0.0219
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0009 0.0000069902
Loa Loa (eye worm) RNA binding protein 0.0073 0.0357 0.1149
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.04
Brugia malayi beta-lactamase family protein 0.0035 0.013 0.04
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0514 0.304 0.3975
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0092 0.0276
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0105 0.0554 0.1483
Echinococcus granulosus thymidylate synthase 0.0105 0.0554 0.1033
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0053 0.007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0162 0.0499
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0092 0.0273
Brugia malayi hypothetical protein 0.005 0.0219 0.0693
Mycobacterium leprae Probable lipase LipE 0.0035 0.013 0.0157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0977 0.128
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0219 0.0572
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0027 0.0062
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0009 0.0000069902
Schistosoma mansoni carbonic anhydrase-related 0.0109 0.0576 0.0764
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0069 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0219 0.0287
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0171 0.0535
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.062 0.3686 1
Trichomonas vaginalis AGC family protein kinase 0.0514 0.304 0.3982
Mycobacterium tuberculosis Conserved protein 0.0035 0.013 0.0329
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0145 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Leishmania major DNA polymerase eta, putative 0.0042 0.0171 0.0535
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.013 0.0329
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0105 0.0554 0.1332
Brugia malayi TAR-binding protein 0.0073 0.0357 0.1149
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0102 0.0308
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0145 0.0444
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0162 0.0382
Entamoeba histolytica hypothetical protein 0.0035 0.0129 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Onchocerca volvulus 0.0035 0.013 0.1325
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0009 0.0000069902
Loa Loa (eye worm) hypothetical protein 0.0028 0.0085 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0027 0.0036
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0027 0.0026
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0098 0.0296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1269 0.7634 1
Onchocerca volvulus 0.0035 0.013 0.1325
Echinococcus multilocularis carbonic anhydrase 0.0109 0.0576 0.0568
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.013 0.04
Schistosoma mansoni flap endonuclease-1 0.0027 0.0081 0.0097
Schistosoma mansoni ferritin 0.0026 0.0073 0.0087
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0162 0.0201
Echinococcus granulosus carbonic anhydrase 0.0109 0.0576 0.1075
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0009 0.0011
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0098 0.0129
Echinococcus multilocularis expressed protein 0.0026 0.0073 0.0065
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0027 0.0062
Echinococcus granulosus carbonic anhydrase 0.0109 0.0576 0.1075
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0145 0.0199
Echinococcus multilocularis ferritin 0.0026 0.0073 0.0065
Loa Loa (eye worm) AUR protein kinase 0.0514 0.304 1
Echinococcus multilocularis aurora kinase A 0.0514 0.304 0.3034
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0167 0.0219
Loa Loa (eye worm) hypothetical protein 0.0109 0.0576 0.1872
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0109 0.0576 0.1872
Schistosoma mansoni apoferritin-2 0.0026 0.0073 0.0087
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0162 0.0212
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.0175 0.0167
Loa Loa (eye worm) hypothetical protein 0.0035 0.013 0.04
Echinococcus multilocularis snurportin 1 0.03 0.1739 0.1732
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0171 0.0535
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0027 0.0062
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0105 0.0554 0.0734
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.1429 0.4685
Trichomonas vaginalis ferritin, putative 0.0026 0.0073 0.0095
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.1739 0.5709
Schistosoma mansoni apoferritin-2 0.0026 0.0073 0.0087
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0009 0.0000069902
Plasmodium falciparum carbonic anhydrase 0.0109 0.0576 0.185
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0171 0.0535
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0167 0.0219
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.3076 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -4.96 Inhibitory concentration against DOXP reductoisomerase ChEMBL. 15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.