Detailed information for compound 1107429

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 321.188 | Formula: C11H13BrO4S
  • H donors: 3 H acceptors: 3 LogP: 1.06 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)SC[C@H]1OC([C@@H]([C@@H]1O)O)O
  • InChi: 1S/C11H13BrO4S/c12-6-1-3-7(4-2-6)17-5-8-9(13)10(14)11(15)16-8/h1-4,8-11,13-15H,5H2/t8-,9-,10-,11?/m1/s1
  • InChiKey: UOJULTDGRSNLRM-QHPFDFDXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0409
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0431 0.0989
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.076 0.4715
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0431 0.0873
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0409
Trypanosoma brucei unspecified product 0.0045 0.0458 0.2793
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0212 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0191 0.0409
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0041 0.0398 0.0398
Onchocerca volvulus 0.0113 0.1466 0.4366
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0019 0.0019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4112 0.8822
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0431 0.0925
Loa Loa (eye worm) hypothetical protein 0.0057 0.0637 0.1367
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0065 0.076 0.076
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0089 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0191 0.0409
Brugia malayi nuclear receptor NHR-88 0.0027 0.0191 0.0409
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0065 0.0139
Brugia malayi steroid hormone receptor 0.0027 0.0191 0.0409
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0076 0.092 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0409
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0184 0.2534 0.5414
Loa Loa (eye worm) hypothetical protein 0.0083 0.1017 0.2184
Echinococcus multilocularis SAM and MBT domain containing protein 0.0057 0.0637 0.0637
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0431 0.0873
Leishmania major DNA polymerase eta, putative 0.0076 0.092 0.573
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0908 0.0908
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4112 0.8822
Trichomonas vaginalis glutaminase, putative 0.0327 0.4658 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.076 0.4715
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0431 0.0873
Giardia lamblia DINP protein human, muc B family 0.0065 0.076 0.1717
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0259 0.0259
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0065 0.0294
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0686 0.0686
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0184 0.2534 0.5414
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.076 0.4715
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4112 0.8822
Toxoplasma gondii exonuclease III APE 0.0019 0.0065 0.0513
Schistosoma mansoni alpha glucosidase 0.0043 0.0431 0.0431
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0133 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0184 0.2534 0.5414
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0191 0.0409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0191 0.0409
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0133 0.0167
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0431 0.0925
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.076 0.4715
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0431 0.4574
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0191 0.0409
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0027 0.005
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0184 0.2534 0.544
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0065 0.076 0.1632
Echinococcus granulosus cpg binding protein 0.0036 0.0328 0.0328
Loa Loa (eye worm) MBCTL1 0.0065 0.0754 0.1619
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0431 0.2621
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0915 0.1965
Schistosoma mansoni microtubule-associated protein tau 0.0686 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0191 0.0409
Echinococcus granulosus polycomb protein SCMH1 0.0057 0.0637 0.0637
Onchocerca volvulus 0.0184 0.2534 0.7606
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0089 0.2911
Loa Loa (eye worm) hypothetical protein 0.0032 0.0259 0.0556
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0191 0.0409
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0191 0.0191
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0657 0.0657
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0637 0.0637
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0191 0.0409
Brugia malayi jmjC domain containing protein 0.006 0.0686 0.1473
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0191 0.0191
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.4112 1
Echinococcus multilocularis dna polymerase kappa 0.0065 0.076 0.076
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0191 0.0191
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0191 0.0191
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0065 0.0754 0.0754
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.076 0.4715
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0133 0.0369
Schistosoma mansoni cpg binding protein 0.0036 0.0328 0.0328
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0089 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0191 0.0409
Onchocerca volvulus 0.0034 0.0298 0.0825
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0191 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0191 0.0409
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0019 0.0019
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.076 0.3788
Giardia lamblia DNA damage repair protein 0.002 0.0089 0.0059
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0229 0.3192 0.3192
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0686 0.0686
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0089 0.0445
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0191 0.0191
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0191 0.0191
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.0792 0.8583
Schistosoma mansoni SET domain protein 0.0017 0.0032 0.0032
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0191 0.0191
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0184 0.2534 0.6137
Loa Loa (eye worm) glutaminase 2 0.0327 0.4658 1
Brugia malayi polk-prov protein 0.002 0.0089 0.0191
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0259 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0191 0.0409
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0019 0.0019
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0133 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.076 0.1584
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0191 0.0409
Echinococcus granulosus histone acetyltransferase MYST2 0.0065 0.0754 0.0754
Onchocerca volvulus 0.0032 0.0259 0.0706
Schistosoma mansoni hypothetical protein 0.0489 0.7075 0.7075
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0027 0.005
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.269 0.269
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0191 0.0191
Brugia malayi jmjC domain containing protein 0.0016 0.0019 0.004
Echinococcus granulosus dna polymerase eta 0.0121 0.1591 0.1591
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0191 0.0191
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0191 0.0191
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0184 0.2534 0.61
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0191 0.0191
Schistosoma mansoni alpha-glucosidase 0.0168 0.2286 0.2286
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0191 0.0191
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0089 0.0445
Brugia malayi nuclear hormone receptor 0.0027 0.0191 0.0409
Onchocerca volvulus 0.0083 0.1017 0.3005
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0191 0.0409
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0065 0.0065
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0184 0.2534 0.544
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0065 0.1922
Schistosoma mansoni glutaminase 0.0327 0.4658 0.4658
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0195 0.269 0.5775
Schistosoma mansoni myelin transcription factor 1 myt1 0.0065 0.0754 0.0754
Leishmania major DNA polymerase kappa, putative 0.0065 0.076 0.4715
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0065 0.0754 0.0754
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0633 0.131
Trypanosoma brucei unspecified product 0.0065 0.076 0.4715
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0065 0.0294
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.1017 0.1017
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.076 0.1584
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0259 0.0259
Schistosoma mansoni SET domain protein 0.0041 0.0398 0.0398
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0259 0.2669
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0915 0.1965
Echinococcus multilocularis microtubule associated protein 2 0.0686 1 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0019 0.0019
Schistosoma mansoni alpha-glucosidase 0.0168 0.2286 0.2286
Entamoeba histolytica hypothetical protein 0.0023 0.0133 0.026
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0191 0.0191
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0191 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0915 0.0915
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0133 0.1265
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0191 0.0409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4112 0.8822
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0191 0.0409
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0027 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0431 0.0873
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0133 0.0147
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0431 0.0873
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0065 0.0139
Loa Loa (eye worm) glutaminase 0.0327 0.4658 1
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0191 0.0409
Schistosoma mansoni terminal deoxycytidyl transferase 0.0065 0.076 0.076
Brugia malayi jmjC domain containing protein 0.0058 0.0657 0.1411
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0445
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.4112 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0184 0.2534 0.5414
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0191 0.0497
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.076 0.3788
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4112 0.8822
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.076 0.1513
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0128 0.1687 0.8841
Trypanosoma brucei DNA polymerase eta, putative 0.0121 0.1591 1
Echinococcus multilocularis cpg binding protein 0.0036 0.0328 0.0328
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0015 0.0003 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0191 0.0191
Echinococcus multilocularis dna polymerase eta 0.0121 0.1591 0.1591
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0133 0.474
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0458 0.2793
Schistosoma mansoni ap endonuclease 0.0019 0.0065 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0019 0.004
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0019 0.0019
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.076 0.4715
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0686 0.0686
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.076 0.4715
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4112 0.8822
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0633 0.391
Onchocerca volvulus 0.0027 0.0191 0.0497
Plasmodium vivax SET domain protein, putative 0.0032 0.0259 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0915 0.0915
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0657 0.0657
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0057 0.0637 0.0637
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.1017 0.2184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0191 0.0191
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0133 0.0147
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3323 0.7118
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0229 0.3192 0.3192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0191 0.0409
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0191 0.0191
Brugia malayi TAR-binding protein 0.0076 0.0915 0.1965
Brugia malayi ImpB/MucB/SamB family protein 0.0121 0.1591 0.3416
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0015 0.0003 0.0003
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.19 1
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0633 0.391
Schistosoma mansoni coup transcription factor 0.0027 0.0191 0.0191
Schistosoma mansoni sex comb on midleg homolog 0.0057 0.0637 0.0637
Brugia malayi Pre-SET motif family protein 0.0209 0.2898 0.6221
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0089 0.0445
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0184 0.2534 0.5414
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0191 0.0497
Leishmania major hypothetical protein, conserved 0.0057 0.0633 0.391
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0259 0.0259
Echinococcus granulosus dna polymerase kappa 0.0065 0.076 0.076
Echinococcus multilocularis polycomb protein SCMH1 0.0057 0.0637 0.0637
Brugia malayi mbt repeat family protein 0.0057 0.0637 0.1367
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0191 0.0409
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0191 0.0191
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0191 0.0191
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.1017 0.1017
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0065 0.0083
Brugia malayi jmjC domain containing protein 0.0016 0.0019 0.004
Brugia malayi CXXC zinc finger family protein 0.0034 0.0298 0.0641
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0191 0.0409
Echinococcus multilocularis dnaJ subfamily B 0.0489 0.7075 0.7075
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0191 0.0191
Mycobacterium ulcerans hypothetical protein 0.002 0.0089 0.0052
Schistosoma mansoni hypothetical protein 0.0351 0.501 0.501
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0409
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0019 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0019 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0686 0.1473
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0048 0.0048
Brugia malayi glutaminase DH11.1 0.0327 0.4658 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Onchocerca volvulus 0.0057 0.0637 0.1851
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0191 0.0191
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0019 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0065 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Leishmania major DNA polymerase eta, putative 0.0121 0.1591 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0195 0.269 0.269
Onchocerca volvulus 0.0238 0.3323 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0431 0.0873
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0657 0.0657
Brugia malayi Pre-SET motif family protein 0.0032 0.0259 0.0556
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0259 0.0259
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0191 0.0191
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.4112 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0065 0.076 0.076
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.076 0.1513
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.1017 0.1017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4112 0.8822
Loa Loa (eye worm) hypothetical protein 0.0065 0.0754 0.1619
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0133 0.1265
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0027 0.0057
Schistosoma mansoni DNA polymerase eta 0.0121 0.1591 0.1591
Brugia malayi ecdysteroid receptor 0.0027 0.0191 0.0409
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0089 0.0445
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0089 0.0445
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0184 0.2534 0.6137
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0019 0.0019
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0089 0.0777
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0057
Brugia malayi jmjC domain containing protein 0.0016 0.0019 0.004
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0191 0.0191
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0027 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0431 0.2621
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0057 0.0637 0.1851
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0431 0.0431
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0019 0.004
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0191 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0191 0.0191
Echinococcus granulosus dnaJ subfamily B 0.0489 0.7075 0.7075
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0048 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0915 0.0915
Schistosoma mansoni cpg binding protein 0.0036 0.0328 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0458 0.2793
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0458 0.2793
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0409
Echinococcus multilocularis lysosomal alpha glucosidase 0.0195 0.269 0.269
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.4112 1
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0089 0.0445
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0657 0.0657
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0409
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0259 0.0259
Schistosoma mansoni ap endonuclease 0.0019 0.0065 0.0065
Trypanosoma cruzi DNA polymerase eta, putative 0.0121 0.1591 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0065 0.076 0.076
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0633 0.131
Loa Loa (eye worm) hypothetical protein 0.0121 0.1591 0.3416
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0089 0.0191
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0431 0.0431
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2898 0.6221
Brugia malayi jmjC domain containing protein 0.0016 0.0019 0.004
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0431 0.0873
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0431 0.0989
Brugia malayi mbt repeat family protein 0.0057 0.0637 0.1367
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0133 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0633 0.391
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0065 0.0294
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0065 0.0754 0.1619
Entamoeba histolytica deoxycytidyl transferase, putative 0.0065 0.076 0.1795
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0298 0.0641
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0409
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0089 0.6142
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Echinococcus granulosus tar DNA binding protein 0.0076 0.0915 0.0915
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0184 0.2534 0.5375
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.076 0.1632
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.4112 0.8822
Brugia malayi RNA binding protein 0.0076 0.0915 0.1965
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0191 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Mycobacterium ulcerans glutaminase 0.0327 0.4658 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.19 0.3995
Brugia malayi Glycosyl hydrolases family 31 protein 0.0195 0.269 0.5775
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.004
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0191 0.0191
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0915 0.0915
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0915 0.1965
Echinococcus granulosus phd:f box containing protein 0.0016 0.0019 0.0019
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.19 1
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0089 0.0445
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0191 0.0191
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0065 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0431 0.0873
Trypanosoma cruzi DNA polymerase eta, putative 0.0076 0.092 0.573
Echinococcus granulosus SAM and MBT domain containing protein 0.0057 0.0637 0.0637
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0191 0.0409
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0133 0.0725
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0133 0.0725
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0409
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0184 0.2534 0.5414
Loa Loa (eye worm) RNA binding protein 0.0076 0.0915 0.1965
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0915 0.0915
Leishmania major DNA polymerase kappa, putative 0.002 0.0089 0.0445
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0065 0.4056
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0019 0.0019
Schistosoma mansoni cpg binding protein 0.0034 0.0298 0.0298
Echinococcus multilocularis histone acetyltransferase MYST2 0.0065 0.0754 0.0754
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0089 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0191 0.0409
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0191 0.0409
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0431 0.2621
Leishmania major DNA damage repair protein, putative 0.002 0.0089 0.0445
Loa Loa (eye worm) mbt repeat family protein 0.0057 0.0637 0.1367
Trypanosoma brucei glucosidase, putative 0.0043 0.0431 0.2621
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0915 0.0915
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0431 0.0873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0191 0.0409
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0019 0.0019
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0041 0.0398 0.0398
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0191 0.0191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0259 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0191 0.0409
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0065 0.0094
Trypanosoma brucei unspecified product 0.0045 0.0458 0.2793
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0089 0.0777
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.076 0.4715
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.076 0.4715
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0191 0.0191

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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