Detailed information for compound 1113035

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 313.825 | Formula: C18H20ClN3
  • H donors: 1 H acceptors: 1 LogP: 3.92 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)Cn1c(nc2c1cccc2)[C@H](C(C)C)N
  • InChi: 1S/C18H20ClN3/c1-12(2)17(20)18-21-15-8-3-4-9-16(15)22(18)11-13-6-5-7-14(19)10-13/h3-10,12,17H,11,20H2,1-2H3/t17-/m0/s1
  • InChiKey: ZMEUFFRISVGDIO-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0092 0.031 0.1048
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0375 0.123
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0092 0.031 0.1048
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0066 0.0207 0.068
Entamoeba histolytica hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.0471 0.1801 0.6096
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0049 0.0139 0.047
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0049 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.002
Schistosoma mansoni RAR-like nuclear receptor 0.0092 0.031 0.1048
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0013 0.0013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0375 0.123
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.067 0.2583 0.2559
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0032 0.0105
Echinococcus multilocularis pyruvate kinase 0.0092 0.031 0.0439
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0107 0.0364
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0107 0.0364
Mycobacterium tuberculosis Conserved protein 0.0041 0.0107 0.0156
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0092 0.19
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.0069
Loa Loa (eye worm) hypothetical protein 0.003 0.0068 0.0068
Trypanosoma brucei transcription factor BTF3, putative 0.0075 0.0244 0.08
Onchocerca volvulus Bile acid receptor homolog 0.0092 0.031 0.031
Echinococcus multilocularis pyruvate kinase 0.0117 0.0407 0.0576
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Onchocerca volvulus Pyruvate kinase homolog 0.0117 0.0407 0.0407
Giardia lamblia Fructose-bisphosphate aldolase 0.1371 0.5343 0.5343
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.2555 1 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0117 0.0407 0.0407
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0107 0.0156
Schistosoma mansoni pyruvate kinase 0.0117 0.0407 0.1379
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0107 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0092 0.031 0.031
Echinococcus multilocularis dnaJ subfamily B 0.0471 0.1801 0.2547
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0032 0.0108
Schistosoma mansoni thyroid hormone receptor 0.0092 0.031 0.1048
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.0487 0.0456
Giardia lamblia Pyruvate kinase 0.006 0.0183 0.0183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.0487 0.0456
Loa Loa (eye worm) DR-78 0.0043 0.0118 0.0118
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.0244 0.08
Schistosoma mansoni ap endonuclease 0.0066 0.0207 0.0702
Toxoplasma gondii pyruvate kinase PyKII 0.006 0.0183 0.377
Brugia malayi hypothetical protein 0.0043 0.0118 0.0118
Plasmodium falciparum pyruvate kinase 0.0117 0.0407 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0092 0.031 0.031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0137 0.0487 0.0705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0092 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0041 0.0107 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Giardia lamblia DINP protein human, muc B family 0.0021 0.0032 0.0032
Brugia malayi ecdysteroid receptor 0.0092 0.031 0.031
Schistosoma mansoni pyruvate kinase 0.006 0.0183 0.0621
Loa Loa (eye worm) intermediate filament protein 0.0031 0.007 0.007
Trypanosoma cruzi transcription factor btf3, putative 0.0075 0.0244 0.08
Brugia malayi nuclear receptor NHR-88 0.0092 0.031 0.031
Echinococcus multilocularis pyruvate kinase 0.006 0.0183 0.026
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0107 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0092 0.031 0.031
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0032 0.0032
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0375 0.1269
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0092 0.031 0.1048
Echinococcus multilocularis expressed protein 0.0038 0.0096 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0066 0.0207 0.0702
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0032 0.0032
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0032 0.0046
Echinococcus granulosus tumor protein p63 0.0376 0.1426 0.483
Entamoeba histolytica protein tyrosine phosphatase, putative 0.2555 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0066 0.0207 0.068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Trypanosoma brucei pyruvate kinase 1, putative 0.0117 0.0407 0.1337
Brugia malayi pyruvate kinase, muscle isozyme 0.0025 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0059 0.0178 0.0178
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.018 0.0254
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0787 0.3046 1
Schistosoma mansoni retinoic acid receptor RXR 0.0092 0.031 0.1048
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0043 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0006 0.0019
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.0069
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0032 0.0105
Onchocerca volvulus 0.0092 0.031 0.031
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0007 0.0022
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0032 0.0045
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0118 0.0401
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0224 0.0757
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.018 0.3695
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0092 0.031 0.031
Echinococcus multilocularis pyruvate kinase 0.006 0.0183 0.026
Echinococcus multilocularis nuclear receptor nhr 48 0.0043 0.0118 0.0167
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.002 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0092 0.031 0.031
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0139 0.0139
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0375 0.0375
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0375 0.0375
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0164 0.0555
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.018 0.059
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0375 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0006 0.0019
Leishmania major DNA polymerase eta, putative 0.0021 0.0032 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.018 0.018
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0092 0.031 0.0438
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0107 0.0076
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0194 0.3988
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0092 0.031 0.1048
Echinococcus multilocularis thyroid hormone receptor alpha 0.0092 0.031 0.0438
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Loa Loa (eye worm) hypothetical protein 0.0041 0.0107 0.0107
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.018 0.018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0066 0.0207 0.509
Plasmodium vivax basic transcription factor 3b, putative 0.0075 0.0244 0.5984
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Mycobacterium tuberculosis Conserved protein 0.0041 0.0107 0.0156
Entamoeba histolytica hypothetical protein 0.02 0.0736 0.0736
Trichomonas vaginalis ap endonuclease, putative 0.0066 0.0207 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0092 0.031 0.031
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.2555 1 1
Echinococcus granulosus dna polymerase eta 0.0021 0.0032 0.0108
Echinococcus granulosus pyruvate kinase 0.0117 0.0407 0.1379
Brugia malayi Steroid receptor seven-up type 2 0.0092 0.031 0.031
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0092 0.031 0.1048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0092 0.031 0.031
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0107 0.264
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0096 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0092 0.031 0.0438
Schistosoma mansoni hypothetical protein 0.02 0.0736 0.2492
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0107 0.0156
Loa Loa (eye worm) hypothetical protein 0.004 0.0105 0.0105
Entamoeba histolytica transcription factor BTF3, putative 0.0075 0.0244 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0244 0.0244
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0117 0.0407 0.059
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0107 0.0107
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0032 0.0032
Trichomonas vaginalis esterase, putative 0.0041 0.0107 0.0107
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0107 0.0107
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0032 0.0032
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0137 0.0487 0.1597
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0041 0.0107 0.0107
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0032 0.0032
Trichomonas vaginalis rotamase, putative 0.0038 0.0096 0.0096
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0032 0.0105
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0092 0.031 0.1048
Schistosoma mansoni steroid hormone receptor ad4bp 0.0092 0.031 0.1048
Trypanosoma cruzi pyruvate kinase 2, putative 0.0117 0.0407 0.1337
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.002 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0375 0.1269
Leishmania major pyruvate kinase 0.0117 0.0407 0.1337
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0787 0.3046 1
Schistosoma mansoni cpg binding protein 0.0035 0.0085 0.0288
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.2555 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0043 0.0118 0.0118
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.0969 0.1404
Schistosoma mansoni cpg binding protein 0.0033 0.0078 0.0263
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0043 0.0118 0.0167
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0066 0.0207 0.0293
Toxoplasma gondii aldehyde dehydrogenase 0.0137 0.0487 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0032 0.0045
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0032 0.0108
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0066 0.0207 0.03
Onchocerca volvulus 0.0041 0.0107 0.0107
Brugia malayi nuclear receptor RXR 0.0043 0.0118 0.0118
Trypanosoma brucei protein kinase, putative 0.0059 0.018 0.059
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.02 0.0736 0.2492
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.016 0.016
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.067 0.2583 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0107 0.0156
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.016 0.016
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.018 0.0609
Brugia malayi hypothetical protein 0.0142 0.0506 0.0506
Loa Loa (eye worm) beta-lactamase 0.0041 0.0107 0.0107
Schistosoma mansoni kinase 0.0055 0.0166 0.0561
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0107 0.0107
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0043 0.0118 0.0401
Echinococcus granulosus microtubule associated protein 2 0.0764 0.2954 1
Schistosoma mansoni transcription factor btf3 0.0075 0.0244 0.0825
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.2555 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0032 0.0108
Echinococcus multilocularis GPCR, family 2 0.0019 0.002 0.0029
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0032 0.0105
Onchocerca volvulus Pyruvate kinase homolog 0.0117 0.0407 0.0407
Echinococcus multilocularis musashi 0.0031 0.007 0.0099
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0038 0.0096 0.0096
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0066 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0049 0.0139 0.0139
Plasmodium vivax pyruvate kinase, putative 0.0117 0.0407 1
Echinococcus granulosus nuclear receptor nhr 48 0.0043 0.0118 0.0401
Treponema pallidum exodeoxyribonuclease (exoA) 0.0066 0.0207 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi ecdysone receptor 0.0043 0.0118 0.0118
Echinococcus granulosus lamin dm0 0.0031 0.007 0.0236
Loa Loa (eye worm) pyruvate kinase 0.0117 0.0407 0.0407
Echinococcus multilocularis FTZ F1 alpha 0.0092 0.031 0.0438
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0375 0.0375
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.0069
Brugia malayi hypothetical protein 0.0043 0.0118 0.0118
Mycobacterium ulcerans lipase LipD 0.0041 0.0107 0.0076
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0092 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0049 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0142 0.0506 0.0506
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.018 0.059
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0107 0.0353
Brugia malayi Nuclear hormone receptor-like 1 0.0092 0.031 0.031
Echinococcus granulosus dna polymerase kappa 0.0021 0.0032 0.0108
Entamoeba histolytica hypothetical protein 0.02 0.0736 0.0736
Entamoeba histolytica hypothetical protein 0.02 0.0736 0.0736
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0375 0.0375
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0375 0.123
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Mycobacterium ulcerans pyruvate kinase 0.0117 0.0407 0.0376
Schistosoma mansoni hypothetical protein 0.02 0.0736 0.2493
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.018 0.059
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0032 0.0105
Echinococcus granulosus GPCR family 2 0.0019 0.002 0.0069
Treponema pallidum fructose-bisphosphate aldolase 0.1371 0.5343 1
Onchocerca volvulus 0.0043 0.0118 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0092 0.031 0.1048
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0092 0.0303
Toxoplasma gondii exonuclease III APE 0.0066 0.0207 0.4259
Trypanosoma cruzi pyruvate kinase 2, putative 0.0117 0.0407 0.1337
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0092 0.0303
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.2555 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0118 0.0401
Brugia malayi nuclear receptor NHR-88 0.0043 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0092 0.031 0.031
Brugia malayi nuclear receptor RXR 0.0049 0.0139 0.0139
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0066 0.0207 0.509
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0092 0.031 0.1048
Schistosoma mansoni nuclear receptor 0.0043 0.0118 0.0401
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1767 0.6901 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0066 0.0207 0.0207
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0035 0.0087 0.0087
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0049 0.0139 0.047
Schistosoma mansoni aldehyde dehydrogenase 0.0137 0.0487 0.1647
Loa Loa (eye worm) hypothetical protein 0.0055 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0049 0.0139 0.0139
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.018 0.059
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.0069
Mycobacterium ulcerans hypothetical protein 0.0041 0.0107 0.0076
Echinococcus granulosus geminin 0.02 0.0736 0.2493
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.2555 1 1
Trypanosoma brucei pyruvate kinase 1 0.0117 0.0407 0.1337
Plasmodium falciparum basic transcription factor 3b, putative 0.0075 0.0244 0.5984
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0032
Echinococcus multilocularis cpg binding protein 0.0035 0.0085 0.012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0092 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0081 0.0268 0.0268
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0244 0.0244
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0107 0.0107
Brugia malayi conserved hypotetical protein 0.0043 0.0118 0.0118
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0137 0.0487 0.1647
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.0178 0.0178
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0092 0.031 0.1048
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.018 0.018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0066 0.0207 0.068
Loa Loa (eye worm) hypothetical protein 0.0092 0.031 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0092 0.0092
Chlamydia trachomatis pyruvate kinase 0.0117 0.0407 0.5
Echinococcus multilocularis transcription factor btf3 0.0075 0.0244 0.0345
Loa Loa (eye worm) hypothetical protein 0.0092 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0041 0.0107 0.0107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.007 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.018 0.018
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0118 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Schistosoma mansoni transcription factor LCR-F1 0.02 0.0736 0.2492
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0787 0.3046 0.3046
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0092 0.031 0.1048
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.018 0.059
Brugia malayi photoreceptor-specific nuclear receptor 0.0092 0.031 0.031
Brugia malayi hypothetical protein 0.02 0.0736 0.0736
Brugia malayi beta-lactamase 0.0041 0.0107 0.0107
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.02 0.0736 0.1041
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0032 0.0105
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0107 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Echinococcus multilocularis lamin 0.0031 0.007 0.0099
Mycobacterium ulcerans aldehyde dehydrogenase 0.0137 0.0487 0.0456
Echinococcus granulosus pyruvate kinase 0.006 0.0183 0.0621
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.018 0.0254
Leishmania major hypothetical protein, conserved 0.0787 0.3046 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0139 0.0139
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0139 0.047
Schistosoma mansoni DNA polymerase eta 0.0021 0.0032 0.0108
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0137 0.0487 0.0688
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0092 0.031 0.0438
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0092 0.031 0.1048
Loa Loa (eye worm) pyruvate kinase 0.0025 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.004 0.0105 0.0356
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.002 0.0069
Loa Loa (eye worm) pyruvate kinase 0.0117 0.0407 0.0407
Brugia malayi Latrophilin receptor protein 2 0.0019 0.002 0.002
Toxoplasma gondii NAC domain-containing protein 0.0075 0.0244 0.5007
Trypanosoma brucei unspecified product 0.0015 0.0006 0.0019
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.018 0.018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.002 0.0069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Loa Loa (eye worm) steroid hormone receptor 0.0092 0.031 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0092 0.031 0.031
Onchocerca volvulus Protein ultraspiracle homolog 0.0092 0.031 0.031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0107 0.0364
Brugia malayi MAP kinase sur-1 0.0059 0.018 0.018
Brugia malayi tailless protein 0.0043 0.0118 0.0118
Schistosoma mansoni nuclear receptor 0.0043 0.0118 0.0401
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0118 0.0118
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0107 0.0156
Schistosoma mansoni zinc finger protein 0.0043 0.0118 0.0401
Echinococcus granulosus dnaJ subfamily B 0.0471 0.1801 0.6096
Schistosoma mansoni intermediate filament proteins 0.0031 0.007 0.0236
Brugia malayi orphan nuclear receptor NR2E1 0.0043 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0107 0.0156
Plasmodium vivax pyruvate kinase 2, putative 0.006 0.0183 0.4506
Loa Loa (eye worm) hypothetical protein 0.0142 0.0506 0.0506
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.002 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0107 0.0107
Onchocerca volvulus Pyruvate kinase homolog 0.0117 0.0407 0.0407
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0049 0.0139 0.0196
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Schistosoma mansoni aldehyde dehydrogenase 0.0137 0.0487 0.1647
Loa Loa (eye worm) hypothetical protein 0.0049 0.0139 0.0139
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0375 0.0375
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0375 0.0375
Brugia malayi beta-NAC-like protein 0.0075 0.0244 0.0244
Trypanosoma brucei unspecified product 0.0021 0.0032 0.0105
Loa Loa (eye worm) ICD-1 protein 0.0075 0.0244 0.0244
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0092 0.031 0.1048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0092 0.031 0.031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Schistosoma mansoni microtubule-associated protein tau 0.0764 0.2954 1
Echinococcus multilocularis lamin dm0 0.0031 0.007 0.0099
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.002 0.002
Trichomonas vaginalis rotamase, putative 0.0037 0.0092 0.0092
Onchocerca volvulus Huntingtin homolog 0.0142 0.0506 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Giardia lamblia Kinase, PLK 0.0109 0.0375 0.0375
Brugia malayi nuclear hormone receptor family member odr-7 0.0043 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0041 0.0107 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0092 0.031 0.031
Onchocerca volvulus 0.0055 0.0164 0.0164
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0078 0.0078
Schistosoma mansoni rotamase 0.0038 0.0096 0.0325
Brugia malayi intermediate filament protein 0.0031 0.007 0.007
Echinococcus granulosus FTZ F1 alpha 0.0092 0.031 0.1048
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.2555 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0043 0.0118 0.0401
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0043 0.0118 0.0167
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0092 0.031 0.0438
Brugia malayi exodeoxyribonuclease III family protein 0.0066 0.0207 0.0207
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.2555 1 1
Mycobacterium ulcerans beta-lactamase 0.0041 0.0107 0.0076
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0118 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0118 0.0401
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0066 0.0207 0.0176
Entamoeba histolytica protein tyrosine phosphatase, putative 0.2555 1 1
Brugia malayi pyruvate kinase 0.0025 0.0044 0.0044
Onchocerca volvulus 0.0031 0.007 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0006 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Brugia malayi nuclear hormone receptor family member nhr-6 0.0043 0.0118 0.0118
Entamoeba histolytica pyruvate kinase, putative 0.0081 0.0268 0.0268
Leishmania major pyruvate kinase 0.0117 0.0407 0.1337
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0007 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0092 0.031 0.1048
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0092 0.0303
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Brugia malayi CXXC zinc finger family protein 0.0033 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0092 0.031 0.031
Brugia malayi hypothetical protein 0.0049 0.0139 0.0139
Brugia malayi beta-lactamase family protein 0.0041 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0092 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0004 0.0004
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0092 0.031 0.031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0092 0.031 0.031
Leishmania major hypothetical protein, conserved 0.0041 0.0107 0.0353
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0787 0.3046 0.3046
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0038 0.0096 0.0096
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0107 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0092 0.031 0.031
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0107 0.0156
Onchocerca volvulus 0.0043 0.0118 0.0118
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0107 0.0353
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0107 0.0107
Schistosoma mansoni coup transcription factor 0.0092 0.031 0.1048
Schistosoma mansoni hypothetical protein 0.02 0.0736 0.2493
Onchocerca volvulus 0.0033 0.0078 0.0078
Echinococcus multilocularis pyruvate kinase 0.0117 0.0407 0.0576
Onchocerca volvulus Huntingtin homolog 0.0142 0.0506 0.0506
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0043 0.0118 0.0118
Schistosoma mansoni cpg binding protein 0.0035 0.0085 0.0288
Leishmania major basic transcription factor 3a, putative 0.0075 0.0244 0.08
Plasmodium falciparum pyruvate kinase 2 0.006 0.0183 0.4506
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0092 0.031 0.0438
Loa Loa (eye worm) nuclear receptor NHR-67 0.0043 0.0118 0.0118
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.181 0.7068 1
Trypanosoma brucei unspecified product 0.0015 0.0006 0.0019
Brugia malayi beta-lactamase family protein 0.0041 0.0107 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0787 0.3046 1
Schistosoma mansoni lamin 0.0031 0.007 0.0236
Echinococcus granulosus cpg binding protein 0.0035 0.0085 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0066 0.0207 0.068
Onchocerca volvulus 0.0041 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0092 0.031 0.031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0092 0.031 0.031
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0092 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Schistosoma mansoni lamin 0.0031 0.007 0.0236
Trichomonas vaginalis pyruvate kinase, putative 0.0117 0.0407 0.0407
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.2555 1 1
Echinococcus granulosus expressed protein 0.0038 0.0096 0.0325
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0375 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.018 0.0609
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0178 0.0178
Echinococcus granulosus ecdysone induced protein 78C 0.0092 0.031 0.1048
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0118 0.0401
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.018 0.018
Schistosoma mansoni nuclear hormone receptor 0.0092 0.031 0.1048
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0118 0.0118
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0092 0.0303
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0375 0.053
Echinococcus granulosus lamin 0.0031 0.007 0.0236
Echinococcus granulosus transcription factor btf3 0.0075 0.0244 0.0825
Echinococcus multilocularis pyruvate kinase 0.006 0.0183 0.026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0092 0.031 0.031
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.018 0.059
Loa Loa (eye worm) hypothetical protein 0.0092 0.031 0.031
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0032 0.0046
Echinococcus granulosus pyruvate kinase 0.006 0.0183 0.0621
Loa Loa (eye worm) hypothetical protein 0.0031 0.007 0.007
Echinococcus granulosus thyroid hormone receptor alpha 0.0043 0.0118 0.0401
Loa Loa (eye worm) hypothetical protein 0.0092 0.031 0.031
Onchocerca volvulus 0.0031 0.007 0.007
Brugia malayi Pyruvate kinase, muscle isozyme 0.0117 0.0407 0.0407
Toxoplasma gondii ABC1 family protein 0.0041 0.0107 0.2209
Leishmania major DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0013 0.0013
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0092 0.031 0.0438
Loa Loa (eye worm) hypothetical protein 0.0092 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0092 0.031 0.031
Trichomonas vaginalis ap endonuclease, putative 0.0066 0.0207 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0107 0.0353
Schistosoma mansoni ap endonuclease 0.0066 0.0207 0.0702
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0118 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0375 0.0375
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0107 0.0076
Loa Loa (eye worm) pyruvate kinase-PB 0.0081 0.0268 0.0268
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0118
Onchocerca volvulus 0.0041 0.0107 0.0107
Schistosoma mansoni pyruvate kinase 0.0117 0.0407 0.1379
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0043 0.0118 0.0401
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Echinococcus multilocularis tumor protein p63 0.0376 0.1426 0.2018
Echinococcus granulosus pyruvate kinase 0.0117 0.0407 0.1379
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0139 0.0139
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0066 0.0207 0.0207
Brugia malayi hypothetical protein 0.0049 0.0139 0.0139
Echinococcus granulosus pyruvate kinase 0.006 0.0183 0.0621
Trichomonas vaginalis pyruvate kinase, putative 0.0117 0.0407 0.0407
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0092 0.031 0.1048
Echinococcus granulosus intermediate filament protein 0.0031 0.007 0.0236
Brugia malayi steroid hormone receptor 0.0092 0.031 0.031
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0032 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0375 0.0375
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0178 0.0178
Brugia malayi nuclear receptor NHR-67 0.0043 0.0118 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0118 0.0167
Echinococcus multilocularis geminin 0.02 0.0736 0.1042
Schistosoma mansoni nuclear receptor nhr-48 0.0043 0.0118 0.0401
Loa Loa (eye worm) hypothetical protein 0.0117 0.0407 0.0407
Toxoplasma gondii pyruvate kinase PyK1 0.0117 0.0407 0.8368
Echinococcus multilocularis dna polymerase eta 0.0021 0.0032 0.0045
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.018 0.059
Onchocerca volvulus 0.2555 1 1
Entamoeba histolytica hypothetical protein 0.02 0.0736 0.0736
Echinococcus multilocularis microtubule associated protein 2 0.0764 0.2954 0.4179
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0118 0.0401
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.018 0.0609
Echinococcus multilocularis ecdysone induced protein 78C 0.0092 0.031 0.0438
Loa Loa (eye worm) hypothetical protein 0.0041 0.0107 0.0107
Giardia lamblia Pyruvate kinase 0.0117 0.0407 0.0407
Brugia malayi nuclear hormone receptor 0.0092 0.031 0.031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1371 0.5343 0.5343
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.067 0.2583 0.3743
Loa Loa (eye worm) pyruvate kinase 0.0117 0.0407 0.0407
Mycobacterium leprae Probable pyruvate kinase PykA 0.0117 0.0407 0.121
Brugia malayi nuclear hormone receptor 0.0043 0.0118 0.0118
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0066 0.0207 0.5
Trypanosoma brucei polo-like protein kinase 0.0109 0.0375 0.123

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 97.5 uM Cytotoxicity against human HeLa cells assessed as cell viability after 5 days by fluorescein diacetate assay ChEMBL. 21711055
IC50 (functional) = 0.75 uM Antifungal activity against Candida albicans SC5314 infected in HeLa cells after 5 days by fluorescein diacetate assay ChEMBL. 21711055
MIC (functional) = 0.125 ug ml-1 Antifungal activity against Candida albicans CA20 by broth dilution method ChEMBL. 21711055
MIC (functional) = 0.125 ug ml-1 Antifungal activity against Candida albicans CA21 by broth dilution method ChEMBL. 21711055
MIC (functional) = 0.25 ug ml-1 Antifungal activity against Candida albicans AM2001/2007 by broth dilution method ChEMBL. 21711055
MIC (functional) = 0.25 ug ml-1 Antifungal activity against Candida albicans VB 1723 by broth dilution method ChEMBL. 21711055
MIC (functional) = 2 ug ml-1 Antifungal activity against Candida albicans DSMZ 11949 by broth dilution method ChEMBL. 21711055
MIC (functional) = 16 ug ml-1 Antifungal activity against Candida albicans MY 2902/2008 by broth dilution method ChEMBL. 21711055
MIC (functional) = 16 ug ml-1 Antifungal activity against Candida albicans Jg 32570 by broth dilution method ChEMBL. 21711055
MIC (functional) = 16 ug ml-1 Antifungal activity against Candida albicans AN 1994 by broth dilution method ChEMBL. 21711055
MIC (functional) = 16 ug ml-1 Antifungal activity against Candida albicans AN 562 by broth dilution method ChEMBL. 21711055
MIC (functional) = 16 ug ml-1 Antifungal activity against Candida albicans AN 3156 by broth dilution method ChEMBL. 21711055
MIC (functional) = 32 ug ml-1 Antifungal activity against Candida albicans AN 1699 by broth dilution method ChEMBL. 21711055
MIC (functional) = 64 ug ml-1 Antifungal activity against Candida albicans SCS 71865 L by broth dilution method ChEMBL. 21711055

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Candida albicans 21711055

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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