Detailed information for compound 1122650

Basic information

Technical information
  • TDR Targets ID: 1122650
  • Name: 2-[3-methyl-4-(2-phenylethyl)piperazin-1-yl]e thyl N-(4-ethoxyphenyl)carbamate
  • MW: 411.537 | Formula: C24H33N3O3
  • H donors: 1 H acceptors: 1 LogP: 4.08 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC(=O)OCCN1CCN(C(C1)C)CCc1ccccc1
  • InChi: 1S/C24H33N3O3/c1-3-29-23-11-9-22(10-12-23)25-24(28)30-18-17-26-15-16-27(20(2)19-26)14-13-21-7-5-4-6-8-21/h4-12,20H,3,13-19H2,1-2H3,(H,25,28)
  • InChiKey: HQNZUJSOBUCFOS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-ethoxyphenyl)carbamic acid 2-[3-methyl-4-(2-phenylethyl)-1-piperazinyl]ethyl ester
  • N-(4-ethoxyphenyl)carbamic acid 2-[3-methyl-4-(2-phenylethyl)piperazin-1-yl]ethyl ester
  • NSC87942

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis geminin 0.0205 0.0918 0.1297
Loa Loa (eye worm) aminopeptidase N 0.0036 0.0043 0.0043
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0008 0.0008
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0321 0.152 0.215
Loa Loa (eye worm) hypothetical protein 0.047 0.2292 0.2292
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.196 1 1
Schistosoma mansoni hypothetical protein 0.0166 0.0718 0.1014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.09 0.09
Loa Loa (eye worm) hypothetical protein 0.0315 0.149 0.149
Schistosoma mansoni hypothetical protein 0.0064 0.0192 0.0268
Brugia malayi peptidase family M13 containing protein 0.0155 0.0661 0.0659
Brugia malayi hypothetical protein 0.0032 0.0025 0.0023
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0056 0.042
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0538 0.0538
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0116 0.0319
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0039 0.0091
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0008 0.0008
Treponema pallidum polypeptide deformylase (def) 0.0684 0.3398 0.5
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0321 0.152 0.215
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0155 0.0661 0.0933
Plasmodium vivax importin-beta 2, putative 0.0035 0.0039 0.0091
Schistosoma mansoni hypothetical protein 0.0166 0.0718 0.1014
Echinococcus granulosus survival motor neuron protein 1 0.0475 0.2315 0.3275
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0321 0.152 0.215
Echinococcus multilocularis GPCR, family 2 0.0064 0.0192 0.0268
Loa Loa (eye worm) hypothetical protein 0.0481 0.235 0.235
Schistosoma mansoni survival motor neuron protein 0.0097 0.036 0.0506
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0684 0.3398 0.5
Onchocerca volvulus 0.0315 0.149 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0043 0.0057
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1043 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0064 0.0192 0.0192
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0056 0.0075
Loa Loa (eye worm) RNA binding protein 0.0131 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0481 0.235 0.235
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0056 0.0141
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0155 0.0661 0.0933
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0043 0.0057
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0192 0.0268
Loa Loa (eye worm) hypothetical protein 0.0038 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0481 0.235 0.235
Mycobacterium ulcerans peptide deformylase 0.0684 0.3398 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0056 0.0487
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0043 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0008 0.0008
Echinococcus granulosus aminopeptidase N 0.0121 0.0484 0.0681
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0636 0.3152 0.446
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0043 0.0031
Loa Loa (eye worm) hypothetical protein 0.047 0.2292 0.2292
Loa Loa (eye worm) hypothetical protein 0.047 0.2292 0.2292
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0538 0.0758
Echinococcus multilocularis tumor protein p63 0.0326 0.1548 0.219
Echinococcus multilocularis survival motor neuron protein 1 0.0475 0.2315 0.3275
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0008 0.0008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0056 0.0075
Onchocerca volvulus 0.0048 0.0106 0.0698
Toxoplasma gondii hypothetical protein 0.0684 0.3398 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0043 0.0313
Plasmodium falciparum peptide deformylase 0.0684 0.3398 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0166 0.0718 0.1014
Loa Loa (eye worm) hypothetical protein 0.0475 0.2315 0.2315
Trypanosoma cruzi Peptide deformylase 2, putative 0.0261 0.121 1
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0636 0.3152 0.315
Trypanosoma cruzi aminopeptidase, putative 0.0036 0.0043 0.0313
Schistosoma mansoni endothelin-converting enzyme-related 0.0155 0.0661 0.0933
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0036 0.0043 0.0057
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.0043 0.0363
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0116 0.0319
Schistosoma mansoni hypothetical protein 0.0166 0.0718 0.1014
Echinococcus granulosus snurportin 1 0.0372 0.1783 0.2522
Loa Loa (eye worm) hypothetical protein 0.047 0.2292 0.2292
Schistosoma mansoni hypothetical protein 0.0166 0.0718 0.1014
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0155 0.0661 0.0933
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0538 0.0758
Echinococcus multilocularis microtubule associated protein 2 0.1392 0.7063 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.0911 0.0909
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0043 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0538 0.0758
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0056 0.042
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0036 0.0043 0.0057
Brugia malayi RNA, U transporter 1 0.0099 0.0372 0.0369
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0039 0.0052
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0056 0.0075
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0043 0.0057
Brugia malayi Peptidase family M1 containing protein 0.0121 0.0484 0.0481
Onchocerca volvulus 0.0036 0.0043 0.0272
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.036 0.0358
Schistosoma mansoni importin beta-1 0.0035 0.0039 0.0052
Echinococcus granulosus endothelin converting enzyme 1 0.0636 0.3152 0.446
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0192 0.0192
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0056 0.042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.0911 0.0909
Loa Loa (eye worm) hypothetical protein 0.0139 0.0579 0.0579
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0106 0.0147
Trypanosoma brucei Polypeptide deformylase 1 0.0261 0.121 1
Onchocerca volvulus 0.0121 0.0484 0.3233
Echinococcus granulosus microtubule associated protein 2 0.1392 0.7063 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0043 0.0057
Schistosoma mansoni hypothetical protein 0.0205 0.0918 0.1297
Schistosoma mansoni microtubule-associated protein tau 0.1392 0.7063 1
Plasmodium vivax peptide deformylase, putative 0.0684 0.3398 1
Leishmania major polypeptide deformylase-like protein, putative 0.0261 0.121 1
Leishmania major hypothetical protein, conserved 0.005 0.0116 0.0923
Schistosoma mansoni neprilysin-2 (M13 family) 0.0321 0.152 0.215
Loa Loa (eye worm) hypothetical protein 0.0636 0.3152 0.3152
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0116 0.0229
Loa Loa (eye worm) hypothetical protein 0.0048 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0205 0.0918 0.1297
Loa Loa (eye worm) hypothetical protein 0.0636 0.3152 0.3152
Loa Loa (eye worm) peptidase family M13 containing protein 0.047 0.2292 0.2292
Loa Loa (eye worm) hypothetical protein 0.0028 0.0003 0.0003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1783 0.1783
Schistosoma mansoni neprilysin 0.0166 0.0718 0.1014
Toxoplasma gondii peptidase family M13 protein 0.0636 0.3152 0.9272
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0003 0.0003
Brugia malayi Pre-SET motif family protein 0.0029 0.0008 0.0006
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0043 0.0313
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0008 0.0008
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0155 0.0661 0.0933
Loa Loa (eye worm) hypothetical protein 0.0108 0.0419 0.0419
Brugia malayi TAR-binding protein 0.0131 0.0538 0.0535
Echinococcus granulosus tar DNA binding protein 0.0131 0.0538 0.0758
Brugia malayi Pre-SET motif family protein 0.0201 0.09 0.0897
Mycobacterium ulcerans zinc metalloprotease 0.0636 0.3152 0.9264
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0579 0.0576
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0192 0.0268
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0056 0.0487
Loa Loa (eye worm) hypothetical protein 0.0481 0.235 0.235
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0538 0.0758
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0056 0.0075
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0043 0.0057
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0116 0.0923
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0043 0.004
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0538 0.0535
Onchocerca volvulus 0.0097 0.036 0.2403
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0684 0.3398 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0008 0.0008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0192 0.0268
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0538 0.0538
Echinococcus multilocularis aminopeptidase N 0.0121 0.0484 0.0681
Loa Loa (eye worm) peptidase family M1 containing protein 0.0098 0.0364 0.0364
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0056 0.0075
Schistosoma mansoni hypothetical protein 0.0097 0.036 0.0506
Schistosoma mansoni hypothetical protein 0.0064 0.0192 0.0268
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0321 0.152 0.215
Onchocerca volvulus 0.0029 0.0008 0.0039
Brugia malayi RNA binding protein 0.0131 0.0538 0.0535
Echinococcus granulosus importin subunit beta 1 0.0035 0.0039 0.0052
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0116 0.0229
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0538 0.0758
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0036 0.0043 0.0057
Trypanosoma brucei Peptide deformylase 2 0.0261 0.121 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0056 0.5
Loa Loa (eye worm) zinc metallopeptidase 4 0.0155 0.0661 0.0661
Brugia malayi hypothetical protein 0.0475 0.2315 0.2313
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0166 0.0718 0.1014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.0911 0.0911
Echinococcus multilocularis snurportin 1 0.0372 0.1783 0.2522
Echinococcus multilocularis endothelin converting enzyme 1 0.0636 0.3152 0.446
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.0043 0.0363
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0192 0.019
Brugia malayi hypothetical protein 0.0036 0.0043 0.004
Schistosoma mansoni hypothetical protein 0.0372 0.1783 0.2522
Trypanosoma cruzi Aminopeptidase M1, putative 0.0036 0.0043 0.0313
Echinococcus granulosus GPCR family 2 0.0064 0.0192 0.0268
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0056 0.0075
Schistosoma mansoni hypothetical protein 0.0064 0.0192 0.0268
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0056 0.0075
Loa Loa (eye worm) hypothetical protein 0.0636 0.3152 0.3152
Trypanosoma cruzi Peptide deformylase 2, putative 0.0261 0.121 1
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0116 0.0659
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0684 0.3398 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0043 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0538 0.0758
Schistosoma mansoni hypothetical protein 0.0166 0.0718 0.1014
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0043 0.0057
Schistosoma mansoni hypothetical protein 0.0139 0.0579 0.0816
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0116 0.0923
Chlamydia trachomatis peptide deformylase 0.0684 0.3398 0.5
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0036 0.0043 0.0313
Onchocerca volvulus 0.0229 0.1043 0.6996
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0085 0.03 0.03
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0261 0.121 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0036 0.0043 0.0031
Loa Loa (eye worm) hypothetical protein 0.0203 0.0911 0.0911
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0192 0.0268
Schistosoma mansoni hypothetical protein 0.0064 0.0192 0.0268
Brugia malayi Peptidase family M13 containing protein 0.0636 0.3152 0.315
Echinococcus granulosus geminin 0.0205 0.0918 0.1297
Brugia malayi Importin beta-1 subunit 0.0035 0.0039 0.0037
Loa Loa (eye worm) peptidase family M13 containing protein 0.047 0.2292 0.2292
Entamoeba histolytica aminopeptidase, putative 0.0036 0.0043 0.7457
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0261 0.121 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0481 0.235 0.235
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0056 0.0075
Brugia malayi hypothetical protein 0.005 0.0116 0.0114
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0043 0.0031
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0192 0.019
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0056 0.0487
Echinococcus granulosus tumor protein p63 0.0326 0.1548 0.219
Loa Loa (eye worm) hypothetical protein 0.0481 0.235 0.235
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0155 0.0661 0.0933
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0008 0.0008
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0003 0.0003

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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