TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.225 | Formula: C16H17BrF3N3
H donors: 0 H acceptors: 0 LogP: 5.14 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(cc1C(F)(F)F)/N=N/C1=C2CCCCN2CCC1
InChi: 1S/C16H17BrF3N3/c17-13-7-6-11(10-12(13)16(18,19)20)21-22-14-4-3-9-23-8-2-1-5-15(14)23/h6-7,10H,1-5,8-9H2/b22-21+
InChiKey: WCMUEKDJFWJLTB-QURGRASLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	beta-lactamase	0.0177	0.1486	0.1546
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0177	0.1486	0.1546
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1058	0.9323	1
Echinococcus multilocularis	expressed protein	0.0035	0.0214	0.0173
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1058	0.9323	1
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1605	0.1674
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0177	0.1486	0.1546
Plasmodium vivax	hypothetical protein, conserved	0.0177	0.1486	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0177	0.1486	0.1546
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.001	0	0.5
Trichomonas vaginalis	Sialidase-1 precursor, putative	0.0512	0.4467	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0145	0.0099
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1058	0.9323	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1058	0.9323	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1486	0.1546
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0145	0.0099
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0191	0.1605	0.1674
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0145	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0155	0.0109
Trichomonas vaginalis	conserved hypothetical protein	0.0512	0.4467	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0027	0.0145	0.0099
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Trypanosoma brucei	trans-sialidase, putative	0.0028	0.0159	0.1069
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0027	0.0145	0.0099
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0027	0.0145	0.0099
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Schistosoma mansoni	lamin	0.0058	0.0421	0.0396
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0027	0.0145	0.0099
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0035	0.0214	0.0173
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0027	0.0145	0.0099
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0027	0.0145	0.0099
Mycobacterium ulcerans	lipase LipD	0.0177	0.1486	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Trichomonas vaginalis	D-aminoacylase, putative	0.0177	0.1486	0.3103
Brugia malayi	RNA binding protein	0.0191	0.1605	0.1674
Brugia malayi	hypothetical protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0869	0.088
Brugia malayi	beta-lactamase family protein	0.0177	0.1486	0.1546
Onchocerca volvulus		0.0108	0.0869	0.5396
Leishmania major	tyrosine specific protein phosphatase, putative	0.0027	0.0145	0.0977
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	TAR-binding protein	0.0191	0.1605	0.1674
Mycobacterium leprae	Probable lipase LipE	0.0177	0.1486	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0177	0.1486	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Echinococcus granulosus	tumor protein p63	0.0739	0.6482	0.6934
Onchocerca volvulus		0.0177	0.1486	1
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1486	0.1546
Leishmania major	hypothetical protein, conserved	0.0177	0.1486	1
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0159	0.1069
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Brugia malayi	hypothetical protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1486	0.1546
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0145	0.0099
Trypanosoma brucei	trans-sialidase, putative	0.0028	0.0159	0.1069
Mycobacterium ulcerans	esterase/lipase LipP	0.0177	0.1486	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0034	0.0207	0.1391
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0027	0.0145	0.0099
Mycobacterium ulcerans	beta-lactamase	0.0177	0.1486	0.5
Schistosoma mansoni	rotamase	0.0035	0.0214	0.0173
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Onchocerca volvulus		0.0058	0.0421	0.2053
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Echinococcus granulosus	tar DNA binding protein	0.0191	0.1605	0.1674
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	hypothetical protein	0.0027	0.0145	0.0099
Trichomonas vaginalis	D-aminoacylase, putative	0.0177	0.1486	0.3103
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1605	0.1674
Brugia malayi	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Echinococcus multilocularis	tumor protein p63	0.0739	0.6482	0.6934
Loa Loa (eye worm)	intermediate filament protein	0.0058	0.0421	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1486	0.1546
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0177	0.1486	0.5
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0177	0.1486	0.1546
Echinococcus multilocularis	lamin dm0	0.0058	0.0421	0.0396
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Trichomonas vaginalis	rotamase, putative	0.0034	0.0207	0.0142
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0027	0.0145	0.0099
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0145	0.0099
Trichomonas vaginalis	esterase, putative	0.0177	0.1486	0.3103
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0214	0.0159
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0027	0.0145	0.0977
Brugia malayi	intermediate filament protein	0.0058	0.0421	0.0396
Echinococcus granulosus	beta LACTamase domain containing family member	0.0177	0.1486	0.1546
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0411	0.0386
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0034	0.0207	0.1391
Giardia lamblia	Protein tyrosine phosphatase	0.0027	0.0145	0.5
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0159	0.1069
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Echinococcus granulosus	intermediate filament protein	0.0058	0.0421	0.0396
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0035	0.0214	0.0173
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0027	0.0145	0.0099
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0034	0.0207	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	hypothetical protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Schistosoma mansoni	intermediate filament proteins	0.0058	0.0421	0.0396
Brugia malayi	Protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.0155	0.0109
Loa Loa (eye worm)	beta-lactamase	0.0177	0.1486	0.1546
Echinococcus granulosus	expressed protein	0.0035	0.0214	0.0173
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0027	0.0145	0.0099
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0177	0.1486	0.1546
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0027	0.0145	0.0099
Trichomonas vaginalis	rotamase, putative	0.0035	0.0214	0.0159
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0145	0.0099
Trypanosoma brucei	trans-sialidase, putative	0.0028	0.0159	0.1069
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0034	0.0207	0.1391
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0027	0.0145	0.0977
Trypanosoma cruzi	hypothetical protein, conserved	0.0177	0.1486	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0027	0.0145	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0027	0.0145	0.0099
Loa Loa (eye worm)	TAR-binding protein	0.0191	0.1605	0.1674
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0027	0.0145	0.0099
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0027	0.0145	0.0977
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0027	0.0145	0.0099
Trichomonas vaginalis	penicillin-binding protein, putative	0.0177	0.1486	0.3103
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	RNA binding protein	0.0191	0.1605	0.1674
Brugia malayi	RNA recognition motif domain containing protein	0.0191	0.1605	0.1674
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0145	0.0099
Trichomonas vaginalis	conserved hypothetical protein	0.0319	0.2743	0.601
Schistosoma mansoni	lamin	0.0058	0.0421	0.0396
Onchocerca volvulus		0.0177	0.1486	1
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1605	0.1674
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0027	0.0145	0.0099
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0027	0.0145	0.0099
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1605	0.1674
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0027	0.0145	0.0099
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1058	0.9323	1
Echinococcus multilocularis		0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0145	0.0099
Trypanosoma brucei	trans-sialidase, putative	0.0028	0.0159	0.1069
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0027	0.0145	0.0977
Schistosoma mansoni	cellular tumor antigen P53	0.0108	0.0869	0.088
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0027	0.0145	0.0977
Schistosoma mansoni	protein tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Echinococcus multilocularis	musashi	0.0058	0.0421	0.0396
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0145	0.0099
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0058	0.0421	0.0396
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0027	0.0145	0.0099
Trypanosoma brucei	trans-sialidase	0.0028	0.0159	0.1069
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0159	0.1069
Echinococcus granulosus	lamin dm0	0.0058	0.0421	0.0396
Trypanosoma brucei	trans-sialidase, putative	0.0028	0.0159	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Echinococcus granulosus	lamin	0.0058	0.0421	0.0396
Brugia malayi	Protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Toxoplasma gondii	ABC1 family protein	0.0177	0.1486	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0145	0.0099
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Echinococcus multilocularis	lamin	0.0058	0.0421	0.0396
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0145	0.0099
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0027	0.0145	0.0099
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0027	0.0145	0.0099
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0421	0.0396
Trypanosoma cruzi	hypothetical protein, conserved	0.0177	0.1486	1
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Brugia malayi	beta-lactamase family protein	0.0177	0.1486	0.1546
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Trichomonas vaginalis	D-aminoacylase, putative	0.0177	0.1486	0.3103
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0182	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0182	0.0139
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0027	0.0145	0.0099
Onchocerca volvulus		0.0177	0.1486	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0027	0.0145	0.0099
Onchocerca volvulus		0.0058	0.0421	0.2053
Brugia malayi	Protein-tyrosine phosphatase 1	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Brugia malayi	Intermediate filament tail domain containing protein	0.0058	0.0421	0.0396
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	MH2 domain-containing protein	0.0242	0.2059	0.2164
Echinococcus multilocularis	hypothetical protein	0.0027	0.0145	0.0099
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0027	0.0145	0.0099
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0159	0.1069
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0159	0.1069
Mycobacterium ulcerans	hypothetical protein	0.0177	0.1486	0.5
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0159	0.1069
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.0155	0.0109
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Mycobacterium leprae	conserved hypothetical protein	0.0177	0.1486	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	transcription factor SMAD2	0.0242	0.2059	0.2164
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0034	0.0207	0.1391
Echinococcus multilocularis	tar DNA binding protein	0.0191	0.1605	0.1674
Schistosoma mansoni	tar DNA-binding protein	0.0191	0.1605	0.1674
Toxoplasma gondii	peptidylprolyl isomerase	0.0034	0.0207	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1486	0.1546
Trypanosoma cruzi	trans-sialidase, putative	0.0028	0.0159	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1486	0.1546
Schistosoma mansoni	pcd6 interacting protein-related	0.0027	0.0145	0.0099
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0145	0.0099
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0145	0.0099
Brugia malayi	MH2 domain containing protein	0.0242	0.2059	0.2164
Trypanosoma cruzi	trans-sialidase, Group I, putative	0.0028	0.0159	0.1069
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0027	0.0145	0.0099
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0027	0.0145	0.0099
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0027	0.0145	0.0099
Trichomonas vaginalis	penicillin-binding protein, putative	0.0177	0.1486	0.3103
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0145	0.0099

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1213743

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1128046