Detailed information for compound 1131696

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 289.374 | Formula: C19H19N3
  • H donors: 0 H acceptors: 1 LogP: 3.71 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc2c(c1)n(CCCCn1cncc1)c1c2cccc1
  • InChi: 1S/C19H19N3/c1-3-9-18-16(7-1)17-8-2-4-10-19(17)22(18)13-6-5-12-21-14-11-20-15-21/h1-4,7-11,14-15H,5-6,12-13H2
  • InChiKey: ZYAPNNYQULYQGL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0555 0.1601
Trichomonas vaginalis rotamase, putative 0.0033 0.0323 0.0938
Brugia malayi jmjC domain containing protein 0.0101 0.1154 0.3455
Mycobacterium ulcerans hypothetical protein 0.0161 0.1896 0.5452
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0333 0.0968
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0244 0.0667
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.172 0.1709
Loa Loa (eye worm) hypothetical protein 0.0072 0.08 0.1901
Schistosoma mansoni jumonji domain containing protein 0.0145 0.1692 0.1984
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0448 0.1315
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0448 0.1315
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0673 0.191
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0239 0.0684
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.089 0.2539
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0323 0.0847
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0323 0.0847
Echinococcus granulosus dna polymerase eta 0.002 0.0158 0.017
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0377 0.9215
Brugia malayi jmjC domain containing protein 0.0026 0.0242 0.0692
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0377 0.0995
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0158 0.0176
Onchocerca volvulus 0.0016 0.0118 0.033
Schistosoma mansoni cpg binding protein 0.0031 0.0295 0.0338
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0673 0.0783
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.0137
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0262 0.0294
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0158 0.0455
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0448 0.0512
Brugia malayi Probable ClpP-like protease 0.0079 0.089 0.2654
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0013 0.0038
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0244 0.0703
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0242 0.0276
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0158 0.0394
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0242 0.0276
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0242 0.0553
Echinococcus granulosus expressed protein 0.0034 0.0333 0.0377
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0234 0.2787 0.6705
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0357
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0253 0.0693
Onchocerca volvulus Alhambra homolog 0.0033 0.0318 0.0963
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0013 0.0072 0.1501
Entamoeba histolytica hypothetical protein 0.0026 0.0239 0.5788
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0377 0.1102
Loa Loa (eye worm) inositol-1 0.0037 0.0377 0.0879
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0013 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0318 0.0884
Echinococcus granulosus pyruvate kinase 0.0019 0.0153 0.0165
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0336 0.0323
Loa Loa (eye worm) acetyltransferase 0.0147 0.172 0.4125
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0377 0.9333
Loa Loa (eye worm) hypothetical protein 0.002 0.0158 0.0349
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0357
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0244 0.0697
Schistosoma mansoni hypothetical protein 0.0033 0.0318 0.0366
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.089 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.0038
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0013 0.0072 0.0177
Onchocerca volvulus 0.0015 0.0104 0.0285
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0403 1
Echinococcus multilocularis geminin 0.019 0.2248 0.2237
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.3673 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0099 0.1134 0.1122
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0135
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.0014 0.0003
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0377 0.0993
Echinococcus granulosus pyruvate kinase 0.0037 0.0376 0.0428
Loa Loa (eye worm) histone methyltransferase 0.001 0.0043 0.0072
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0475 0.0545
Toxoplasma gondii exonuclease III APE 0.0021 0.0176 0.1858
Echinococcus multilocularis dna polymerase kappa 0.002 0.0158 0.0144
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0244 0.0667
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0072 0.0075
Echinococcus granulosus importin subunit beta 1 0.0032 0.0314 0.0354
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0313 0.0353
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0377 0.0993
Schistosoma mansoni pyruvate kinase 0.0037 0.0376 0.0434
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0056 0.013
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0242 0.0553
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0244 0.5903
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0148 0.0427
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0044 0.0084
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0242 0.0229
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0377 0.4147
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0376 0.0992
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0244 0.0667
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0013 0.0038
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0013 0.0072 0.017
Leishmania major pyruvate kinase 0.0037 0.0376 0.0992
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0176 0.0493
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0242 0.0276
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0176 0.0472
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Schistosoma mansoni microtubule-associated protein tau 0.07 0.8498 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.0038
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0673 0.7521
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0673 0.0777
Echinococcus granulosus microtubule associated protein 2 0.07 0.8498 1
Plasmodium falciparum importin beta, putative 0.0032 0.0314 0.0871
Loa Loa (eye worm) hypothetical protein 0.0034 0.0336 0.078
Brugia malayi Protein kinase domain containing protein 0.0016 0.0118 0.0316
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0013 0.0072 0.016
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0376 0.1099
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0262 0.0249
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0176 0.0493
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0318 0.0738
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0044 0.0084
Onchocerca volvulus 0.0266 0.3182 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0209 0.0536
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0314 0.0822
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0158 0.0394
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.089 0.0878
Onchocerca volvulus 0.0016 0.0118 0.033
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0673 0.1802
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.029 0.3466 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0336 0.0323
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0376 0.1145
Chlamydia trachomatis pyruvate kinase 0.0037 0.0376 0.2952
Echinococcus granulosus CTD small phosphatase protein like 0.0013 0.0072 0.0069
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0013 0.0038
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0376 0.1099
Schistosoma mansoni pyruvate kinase 0.0019 0.0153 0.0171
Leishmania major hypothetical protein, conserved 0.0026 0.0242 0.0625
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.069 0.0803
Onchocerca volvulus 0.0015 0.0104 0.0285
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0318 0.3481
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0158 0.0418
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0013 0.0038
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0242 0.0229
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0376 0.1145
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0158 0.0437
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0377 0.1102
Trichomonas vaginalis dullard protein, putative 0.0013 0.0072 0.0177
Onchocerca volvulus 0.0029 0.0275 0.0825
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0242 0.2609
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0209 0.4148
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0377 0.0995
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0161 0.0428
Echinococcus multilocularis peregrin 0.0036 0.0363 0.035
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0314 0.0301
Schistosoma mansoni cpg binding protein 0.0031 0.0295 0.0338
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.089 0.2539
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0237 0.5747
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0013 0.0072 0.0069
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0323 0.0847
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0673 0.191
Brugia malayi glutaminase DH11.1 0.0277 0.3316 1
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.3673 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0555 0.1601
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0376 0.1099
Echinococcus granulosus lysine specific demethylase 5A 0.0101 0.1154 0.1345
Loa Loa (eye worm) hypothetical protein 0.0027 0.0244 0.0557
Brugia malayi Bromodomain containing protein 0.0036 0.0363 0.1057
Schistosoma mansoni hypothetical protein 0.0012 0.007 0.0073
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0446 0.1181
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0021 0.001
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0323 0.3534
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1669 0.1952
Onchocerca volvulus 0.0015 0.0104 0.0285
Echinococcus multilocularis pyruvate kinase 0.0037 0.0376 0.0363
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0475 0.0463
Echinococcus multilocularis pyruvate kinase 0.003 0.028 0.0267
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.089 0.2539
Loa Loa (eye worm) hypothetical protein 0.0027 0.0244 0.0557
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0176 0.4175
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0673 0.066
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0244 0.0667
Echinococcus granulosus pyruvate kinase 0.0019 0.0153 0.0165
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0218
Echinococcus granulosus snurportin 1 0.0345 0.415 0.4876
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0167 0.1962 0.2297
Loa Loa (eye worm) hypothetical protein 0.0026 0.0242 0.0553
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0167 0.1962 0.1951
Loa Loa (eye worm) hypothetical protein 0.0033 0.0318 0.0738
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0044 0.0349
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.089 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0376 0.0992
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0158 0.0394
Leishmania major pyruvate kinase 0.0037 0.0376 0.0992
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.0038
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.029 0.3466 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0244 0.0667
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0377 0.1053
Brugia malayi jmjC domain containing protein 0.0026 0.0242 0.0692
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0377 0.0429
Schistosoma mansoni hypothetical protein 0.0011 0.0049 0.0048
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0253 0.0232
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0176 0.0445
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0377 0.1101
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0333 0.0773
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0158 0.0437
Loa Loa (eye worm) hypothetical protein 0.0032 0.0314 0.0727
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0013 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0336 0.0386
Echinococcus multilocularis snurportin 1 0.0345 0.415 0.4142
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0275 0.0632
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.089 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0176 0.3146
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0176 0.1564
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0239 0.0617
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0376 0.0992
Loa Loa (eye worm) hypothetical protein 0.0026 0.0242 0.0553
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0446 0.1181
Echinococcus multilocularis pyruvate kinase 0.0019 0.0153 0.014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0377 0.1101
Schistosoma mansoni hypothetical protein 0.0345 0.415 0.4879
Brugia malayi jmjC domain containing protein 0.0026 0.0242 0.0692
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0345 0.415 1
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0314 0.3431
Schistosoma mansoni inositol monophosphatase 0.0037 0.0377 0.0434
Giardia lamblia Pyruvate kinase 0.0037 0.0376 0.9182
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0376 0.1099
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.089 0.2539
Schistosoma mansoni glutaminase 0.0277 0.3316 0.3897
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.089 0.1039
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0158 0.0394
Onchocerca volvulus 0.0027 0.0244 0.0727
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0376 0.1051
Schistosoma mansoni ap endonuclease 0.0021 0.0176 0.0198
Brugia malayi jmjC domain containing protein 0.0026 0.0242 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0377 0.1102
Echinococcus multilocularis cpg binding protein 0.0031 0.0295 0.0282
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0209 0.0594
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0083 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0083 0.0191
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0673 0.0783
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0161 0.0465
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0448 0.4954
Loa Loa (eye worm) hypothetical protein 0.0013 0.0072 0.0142
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0357
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.5003 0.4997
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0242 0.027
Brugia malayi RNA, U transporter 1 0.0092 0.1045 0.3123
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0209 0.2237
Schistosoma mansoni hypothetical protein 0.0015 0.0104 0.0113
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0176 0.0493
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0446 0.1181
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0176 0.0472
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0323 0.0847
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0148 0.0427
Brugia malayi Pre-SET motif family protein 0.0234 0.2787 0.8397
Loa Loa (eye worm) hypothetical protein 0.0037 0.0376 0.0877
Loa Loa (eye worm) jmjC domain-containing protein 0.0101 0.1154 0.2758
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0158 0.0437
Brugia malayi Inositol-1 0.0037 0.0377 0.1101
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0013 0.0072 0.0059
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0745 0.1769
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0244 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0673 0.1941
Loa Loa (eye worm) hypothetical protein 0.0016 0.0118 0.0252
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0336 0.0386
Plasmodium vivax importin-beta 2, putative 0.0032 0.0314 0.0871
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0318 0.3481
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.029 0.3466 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0242 0.0625
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.089 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0013 0.0038
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0376 0.1086
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0244 0.0667
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0158 0.0394
Schistosoma mansoni cpg binding protein 0.0029 0.0275 0.0314
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0176 0.0445
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0242 0.0625
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0083 0.0191
Schistosoma mansoni hypothetical protein 0.0016 0.0118 0.0129
Plasmodium vivax hypothetical protein, conserved 0.0012 0.007 0.0165
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0021 0.0008
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0158 0.3698
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0448 0.1258
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0377 0.3936
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0376 0.4141
Trichomonas vaginalis dullard protein, putative 0.0013 0.0072 0.0177
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0318 0.036
Schistosoma mansoni DNA polymerase eta 0.002 0.0158 0.0176
Brugia malayi CXXC zinc finger family protein 0.0029 0.0275 0.0791
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0242 0.0229
Giardia lamblia Pyruvate kinase 0.0019 0.0153 0.2448
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0158 0.0394
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0244 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Echinococcus granulosus geminin 0.019 0.2248 0.2633
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0176 0.0445
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0377 0.0995
Trichomonas vaginalis set domain proteins, putative 0.0266 0.3182 0.9594
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0049 0.0403
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0043 0.003
Giardia lamblia PHD finger protein 15 0.0033 0.0318 0.7438
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0242 0.0276
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0158 0.017
Leishmania major hypothetical protein, conserved 0.0013 0.0072 0.016
Echinococcus granulosus dna polymerase kappa 0.002 0.0158 0.017
Echinococcus granulosus pyruvate kinase 0.0019 0.0153 0.0165
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0072 0.0177
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.089 0.2539
Echinococcus granulosus cpg binding protein 0.0031 0.0295 0.0332
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0242 0.0276
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0376 0.0877
Loa Loa (eye worm) hypothetical protein 0.0079 0.089 0.2119
Schistosoma mansoni hypothetical protein 0.019 0.2248 0.2638
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.007 0.0165
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0555 0.0638
Loa Loa (eye worm) hypothetical protein 0.0016 0.0118 0.0252
Loa Loa (eye worm) hypothetical protein 0.0027 0.0244 0.0557
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0209 0.0568
Schistosoma mansoni rotamase 0.0034 0.0333 0.0383
Echinococcus multilocularis 0.0013 0.0072 0.0059
Brugia malayi AF-10 protein 0.0011 0.0049 0.0107
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0329 0.0914
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0161 0.0428
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0377 0.0993
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0021 0.0008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0176 0.0163
Leishmania major DNA polymerase kappa, putative 0.002 0.0158 0.0394
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0253 0.0693
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.1154 0.135
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.029 0.3466 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0336 0.0386
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0377 0.0429
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0209 0.0196
Brugia malayi Importin beta-1 subunit 0.0032 0.0314 0.0911
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0072 0.0177
Schistosoma mansoni ran 0.0024 0.0209 0.0237
Treponema pallidum hypothetical protein 0.029 0.3466 1
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0403 0.113
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0377 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0333 0.0968
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0242 0.027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0237 0.0542
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0448 0.4954
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1695 0.4595
Loa Loa (eye worm) glutaminase 0.0277 0.3316 0.7985
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1896 0.547
Echinococcus granulosus dnaJ subfamily B 0.0415 0.5003 0.5881
Loa Loa (eye worm) hypothetical protein 0.0016 0.0118 0.0252
Schistosoma mansoni ran 0.0024 0.0209 0.0237
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0376 0.1051
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0244 0.0667
Echinococcus multilocularis microtubule associated protein 2 0.07 0.8498 0.8496
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0148 0.0427
Loa Loa (eye worm) hypothetical protein 0.0015 0.0104 0.0218
Trypanosoma brucei unspecified product 0.0014 0.0083 0.0191
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0318 0.0306
Mycobacterium ulcerans glutaminase 0.0277 0.3316 0.9568
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0239 0.0684
Onchocerca volvulus 0.0034 0.0336 0.1018
Schistosoma mansoni pyruvate kinase 0.0037 0.0376 0.0434
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0314 0.0822
Trypanosoma brucei unspecified product 0.0014 0.0083 0.0191
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0158 0.0144
Plasmodium falciparum phd finger protein, putative 0.0033 0.0318 0.0884
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0377 0.0995
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.029 0.3466 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0376 0.0992
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0072 0.016
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0242 0.0625
Brugia malayi jmjC domain containing protein 0.0167 0.1962 0.5899
Giardia lamblia DINP protein human, muc B family 0.002 0.0158 0.2584
Mycobacterium ulcerans hypothetical protein 0.0027 0.0244 0.0667
Schistosoma mansoni inositol monophosphatase 0.0037 0.0377 0.0434
Loa Loa (eye worm) DOMON domain-containing protein 0.0015 0.0104 0.0218
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0377 0.9319
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0244 0.0667
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0013 0.0072 0.0668
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0021 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0561 0.1497
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0242 0.0662
Onchocerca volvulus 0.0015 0.0104 0.0285
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0377 0.1102
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0049 0.0096
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0209 0.0568
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0013 0.0038
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0209 0.0474
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0377 0.0365
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0377 0.0364
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0555 0.1569
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0049 0.0096
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0013 0.0072 0.0075
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.089 1
Brugia malayi Pre-SET motif family protein 0.0034 0.0336 0.0976
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0336 0.0386
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0013 0.0038
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.1695 0.4595
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0043 0.0035
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0209 0.0536
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0239 0.0684
Toxoplasma gondii hypothetical protein 0.0049 0.0523 0.5817
Trichomonas vaginalis dullard protein, putative 0.0013 0.0072 0.0177
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0377 0.0993
Schistosoma mansoni importin beta-1 0.0032 0.0314 0.0361
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0673 0.191
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0377 0.0365
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.3673 1
Schistosoma mansoni ap endonuclease 0.0021 0.0176 0.0198
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0376 0.0877
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0209 0.0536
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0013 0.0072 0.017
Echinococcus granulosus peregrin 0.0036 0.0363 0.0412
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0072 0.0177
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0044 0.0084
Echinococcus granulosus MAM 0.0016 0.0118 0.0123
Loa Loa (eye worm) TK/ALK protein kinase 0.0016 0.0118 0.0252
Toxoplasma gondii hypothetical protein 0.0027 0.0253 0.273
Echinococcus multilocularis expressed protein 0.0034 0.0333 0.032
Trichomonas vaginalis rotamase, putative 0.0034 0.0333 0.0968
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0049 0.0403
Schistosoma mansoni hypothetical protein 0.0016 0.0118 0.0129
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0336 0.038
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0153 0.0405
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0044 0.0084
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0377 0.0435
Echinococcus granulosus pyruvate kinase 0.0037 0.0376 0.0428
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0209 0.0231
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0376 0.0877
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0377 0.1101
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0237 0.0542
Brugia malayi PHD-finger family protein 0.0033 0.0318 0.0924
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.089 0.217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0148 0.0427
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0176 0.0445
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0158 0.0394
Echinococcus multilocularis dna polymerase eta 0.002 0.0158 0.0144
Echinococcus multilocularis pyruvate kinase 0.0019 0.0153 0.014
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0653 0.7301
Echinococcus multilocularis pyruvate kinase 0.0037 0.0376 0.0363
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0357
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0158 0.0176
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0376 0.1145
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0158 0.0437
Brugia malayi Muscle positioning protein 4 0.0015 0.0104 0.0274
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0318 0.0366
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0244 0.0697
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0158 0.0455
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0377 0.0428
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0158 0.0394
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0242 0.2609
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0158 0.0394
Leishmania major GTP-binding protein, putative 0.0024 0.0209 0.0536
Trichomonas vaginalis glutaminase, putative 0.0277 0.3316 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0158 0.0394
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0176 0.0472
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0377 0.0365
Schistosoma mansoni jumonji/arid domain-containing protein 0.0101 0.1154 0.135
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.172 0.2016
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0244 0.0629
Loa Loa (eye worm) hypothetical protein 0.0038 0.0377 0.088
Loa Loa (eye worm) glutaminase 2 0.0277 0.3316 0.7985
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0253 0.0693
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0158 0.0418
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0555 0.0542
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.3673 1
Onchocerca volvulus 0.0015 0.0104 0.0285
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0152 0.017
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0446 0.1181
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0176 0.0508
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0173 0.0483
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0376 0.1051
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0158 0.0394
Brugia malayi hypothetical protein 0.0016 0.0118 0.0316
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0176 0.0394
Echinococcus multilocularis MAM 0.0016 0.0118 0.0105
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0176 0.0192
Leishmania major DNA polymerase eta, putative 0.002 0.0158 0.0394
Schistosoma mansoni hypothetical protein 0.0415 0.5003 0.5884
Trypanosoma brucei unspecified product 0.002 0.0158 0.0394
Schistosoma mansoni hypothetical protein 0.019 0.2248 0.2638
Brugia malayi SEA domain containing protein 0.0015 0.0104 0.0274
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0244 0.5903
Brugia malayi pyruvate kinase 0.0008 0.0014 0.0003
Trichomonas vaginalis ran, putative 0.0024 0.0209 0.0594
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0013 0.0072 0.0177
Loa Loa (eye worm) hypothetical protein 0.002 0.0161 0.0357
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0244 0.0629
Loa Loa (eye worm) pyruvate kinase 0.0008 0.0014 0.0002
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0323 0.7942
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0153 0.1594
Echinococcus granulosus phd:f box containing protein 0.0026 0.0242 0.027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0244 0.0667
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0244 0.0697
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0329 0.0948
Plasmodium vivax SET domain protein, putative 0.0034 0.0336 0.0934
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0013 0.0072 0.017
Brugia malayi PHD-finger family protein 0.0012 0.0069 0.0169
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0242 0.0229
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0158 0.0349
Plasmodium vivax JmjC domain containing protein 0.0026 0.0242 0.0662
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.1695 0.4595
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0242 0.027
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0242 0.0553
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0244 0.5903
Plasmodium falciparum pyruvate kinase 0.0037 0.0376 0.1051
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.172 0.5166
Entamoeba histolytica Ran family GTPase 0.0024 0.0209 0.5027
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0403 1
Leishmania major importin beta-1 subunit, putative 0.0026 0.0239 0.0617
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0161 0.0428
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0336 0.3679
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.089 0.1033
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0153 0.0405
Echinococcus multilocularis pyruvate kinase 0.0019 0.0153 0.014
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0377 0.0429

Activities

Activity type Activity value Assay description Source Reference
MIC50 (functional) = 8 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by two fold serial dilution method ChEMBL. 20176480
MIC50 (functional) = 16 ug ml-1 Antifungal activity against Candida albicans ATCC 76615 after 24 hrs by two fold serial dilution method ChEMBL. 20176480

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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