Detailed information for compound 1132562

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 434.438 | Formula: C24H20F2N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)n1ncc2c1n(C)c(=O)c(c2)c1cc(ccc1C)C(=O)NC1CC1
  • InChi: 1S/C24H20F2N4O2/c1-13-3-4-14(22(31)28-17-6-7-17)9-18(13)19-10-15-12-27-30(23(15)29(2)24(19)32)21-8-5-16(25)11-20(21)26/h3-5,8-12,17H,6-7H2,1-2H3,(H,28,31)
  • InChiKey: XQRUWZMHPKNIDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References
Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma japonicum ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative Get druggable targets OG5_131483 All targets in OG5_131483
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus macrophage colony stimulating factor 1 receptor Get druggable targets OG5_132967 All targets in OG5_132967
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi map kinase activated protein kinase protein 2 Get druggable targets OG5_131483 All targets in OG5_131483
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase-activated protein kinase 2 370 aa 303 aa 26.4 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.143 0.1832
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0093 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0093 0.0093
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0118 0.0496
Trichomonas vaginalis glucosylceramidase, putative 0.1005 1 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0019 0.0084 0.0127
Brugia malayi map kinase activated protein kinase protein 2 0.0218 0.2088 0.2088
Echinococcus granulosus importin subunit beta 1 0.003 0.0197 0.0297
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0058 0.0088
Onchocerca volvulus 0.0047 0.0366 0.0425
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1031 0.7111
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0058 0.0088
Echinococcus granulosus chromatin regulatory protein sir2 0.0016 0.0058 0.0088
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0176 0.0176
Brugia malayi RNA, U transporter 1 0.0085 0.0752 0.0752
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0093 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.1005 1 1
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0089 0.0088
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0668 0.6615 0.9981
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0164 0.0164
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0051 0.0406 0.0986
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0084
Leishmania major hypothetical protein, conserved 0.0049 0.0391 0.2479
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.003 0.0202 0.0259
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0093 0.014
Loa Loa (eye worm) sirtuin 4 0.0016 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0047 0.0366 0.0553
Schistosoma mansoni hypothetical protein 0.0164 0.1545 0.2332
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0218 0.2088 0.2674
Schistosoma mansoni ran 0.0022 0.0118 0.0177
Schistosoma mansoni ap endonuclease 0.0019 0.0083 0.0125
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0503 0.0447
Trichomonas vaginalis glucosylceramidase, putative 0.0659 0.6526 0.6505
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0627 0.0804
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0118 0.0177
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2203 0.2822
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0049 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0659 0.6526 0.6505
Echinococcus granulosus FTZ F1 alpha 0.002 0.0093 0.014
Brugia malayi hypothetical protein 0.0073 0.0627 0.0627
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0058 0.0088
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0503 0.329
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0503 0.0447
Brugia malayi Fibronectin type III domain containing protein 0.0019 0.0084 0.0084
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0083 0.0106
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0153 0.143 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0093 0.0093
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0051 0.0406 0.2582
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0093
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0627 0.0947
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0058 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0085 0.0754 0.0754
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0058 0.0058
Echinococcus multilocularis cpg binding protein 0.0029 0.0192 0.0246
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0197 0.1072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0093 0.0119
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0019 0.0084 0.0108
Schistosoma mansoni importin beta-1 0.003 0.0197 0.0297
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0083 0.0069
Schistosoma mansoni coup transcription factor 0.002 0.0093 0.014
Brugia malayi CXXC zinc finger family protein 0.0028 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0229 0.2203 0.2203
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0083 0.0246
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0366 0.3579 0.3541
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0093 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0093 0.0093
Brugia malayi P38 map kinase family protein 2 0.0153 0.143 0.143
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0366 0.3579 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.1005 1 1
Echinococcus multilocularis GPCR, family 2 0.003 0.0202 0.0259
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0093
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0083 0.0083
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0503 0.0447
Loa Loa (eye worm) hypothetical protein 0.0085 0.0754 0.0754
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0486 0.0733
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0088 0.0784 0.1005
Brugia malayi steroid hormone receptor 0.002 0.0093 0.0093
Echinococcus multilocularis snurportin 1 0.032 0.311 0.3983
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0093 0.0119
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0016 0.0058 0.0075
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0366 0.3579 0.3541
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0016 0.0058 0.0088
Echinococcus multilocularis microtubule associated protein 2 0.067 0.6628 0.849
Schistosoma mansoni hypothetical protein 0.003 0.0202 0.0305
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0153 0.143 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.003 0.0202 0.0305
Entamoeba histolytica hypothetical protein 0.0073 0.0627 0.1616
Schistosoma mansoni vesicular amine transporter 0.0019 0.0084 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0089 0.0031
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0089 0.0028
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0083 0.0953
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0093 0.014
Toxoplasma gondii histone deacetylase SIR2-like 0.0016 0.0058 0.0251
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.143 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0427 0.9948
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0197 0.1072
Trichomonas vaginalis glucosylceramidase, putative 0.1005 1 1
Brugia malayi hypothetical protein 0.0229 0.2203 0.2203
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0089 0.1136
Onchocerca volvulus 0.0049 0.0387 0.0457
Schistosoma mansoni survival motor neuron protein 0.0047 0.0366 0.0553
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0065 0.0083
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0503 0.0447
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0058 0.0058
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0113 0.1031 0.0978
Brugia malayi NAD-dependent deacetylase SIRT1 0.0016 0.0058 0.0058
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0019 0.0084 0.0127
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2203 0.3324
Brugia malayi Importin beta-1 subunit 0.003 0.0197 0.0197
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0503 0.0645
Brugia malayi ecdysteroid receptor 0.002 0.0093 0.0093
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0118 0.0496
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0118 0.0496
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.3886 0.4978
Schistosoma mansoni hypothetical protein 0.0066 0.0558 0.0842
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus granulosus roundabout 2 0.0019 0.0084 0.0127
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0118 0.0178
Onchocerca volvulus 0.0028 0.0176 0.0129
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0164 0.0106
Echinococcus granulosus neuroglian 0.0019 0.0084 0.0127
Brugia malayi jmjC domain containing protein 0.0059 0.0486 0.0486
Loa Loa (eye worm) latrophilin receptor protein 2 0.003 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0093
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0503 0.329
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.003 0.0202 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0084
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.031 0.1889
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.014 0.0082
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0093 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0093 0.0093
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.031 0.0253
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0558 0.0558
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0093 0.0119
Echinococcus multilocularis roundabout 2 0.0019 0.0084 0.0108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.003 0.0202 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0088 0.0784 0.1184
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0787 0.7807 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.032 0.311 0.311
Brugia malayi nuclear receptor NHR-88 0.002 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0093 0.0093
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0049 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0093 0.0093
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0366 0.3579 0.3541
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus granulosus twitchin 0.002 0.0095 0.0144
Entamoeba histolytica hypothetical protein 0.0024 0.014 0.0232
Mycobacterium ulcerans NAD-dependent deacetylase 0.0051 0.0406 0.0986
Loa Loa (eye worm) hypothetical protein 0.0049 0.0391 0.0391
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0083 0.0125
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0391 0.2479
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0164 0.0106
Leishmania major silent information regulator 2, putative 0.0016 0.0058 0.0069
Schistosoma mansoni hypothetical protein 0.032 0.311 0.4692
Echinococcus granulosus mitogen activated protein kinase 14 0.0153 0.143 0.2158
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0503 0.0447
Leishmania major importin beta-1 subunit, putative 0.0024 0.014 0.066
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0113 0.1031 0.7111
Schistosoma mansoni eyes absent homolog 0.0085 0.0754 0.1137
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0093 0.014
Schistosoma mansoni jumonji domain containing protein 0.0057 0.047 0.0709
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0118 0.0168
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0093 0.0119
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0164 0.0248
Schistosoma mansoni hypothetical protein 0.003 0.0202 0.0305
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0049 0.0049
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0118 0.1922
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0391 0.2479
Echinococcus multilocularis importin subunit beta 1 0.003 0.0197 0.0252
Onchocerca volvulus Glucosylceramidase homolog 0.0659 0.6526 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0019 0.0084 0.0084
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0153 0.143 0.143
Giardia lamblia Transcriptional regulator, Sir2 family 0.0051 0.0406 0.0986
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0049 0.0063
Echinococcus granulosus GPCR family 2 0.003 0.0202 0.0305
Entamoeba histolytica hypothetical protein 0.0073 0.0627 0.1616
Loa Loa (eye worm) hypothetical protein 0.0049 0.0387 0.0387
Echinococcus granulosus phd:f box containing protein 0.0015 0.0049 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.6882 0.6864
Trichomonas vaginalis glucosylceramidase, putative 0.0659 0.6526 0.6505
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0088 0.0784 0.1005
Brugia malayi hypothetical protein 0.0085 0.0754 0.0754
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0083 0.0069
Brugia malayi Calcitonin receptor-like protein seb-1 0.0096 0.0864 0.0864
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0051 0.0406 0.2582
Loa Loa (eye worm) hypothetical protein 0.0019 0.0089 0.0089
Brugia malayi hypothetical protein 0.0049 0.0391 0.0391
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0391 0.2479
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0093
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0391 0.9019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0093 0.0093
Echinococcus multilocularis tumor protein p63 0.0334 0.3249 0.4162
Schistosoma mansoni hypothetical protein 0.003 0.0202 0.0305
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0093 0.014
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0164 0.0106
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0083 0.0953
Schistosoma mansoni cell adhesion molecule 0.0019 0.0084 0.0127
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0083 0.0025
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0503 0.0759
Trichomonas vaginalis glucosylceramidase, putative 0.0659 0.6526 0.6505
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0366 0.3579 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0093 0.014
Loa Loa (eye worm) hypothetical protein 0.0016 0.0058 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1031 0.7111
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0096 0.0864 0.0864
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.2088 0.315
Echinococcus granulosus microtubule associated protein 2 0.067 0.6628 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0366 0.3579 0.3541
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0084
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0093 0.0093
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0065 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0093 0.0093
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0088 0.0784 0.0784
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus granulosus dnaJ subfamily B 0.0397 0.3886 0.5863
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0093 0.0119
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0503 0.329
Schistosoma mansoni cpg binding protein 0.0028 0.0176 0.0266
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0366 0.3579 1
Leishmania major hypothetical protein, conserved 0.0113 0.1031 0.7111
Schistosoma mansoni hypothetical protein 0.0073 0.0627 0.0947
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0035 0.0243 1
Echinococcus granulosus defective proboscis extension response 0.0019 0.0084 0.0127
Echinococcus granulosus Immunoglobulin 0.0019 0.0084 0.0127
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0093
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.0058 0.0069
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0093 0.0093
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0164 0.0164
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0093 0.0093
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.0784 0.1184
Schistosoma mansoni thyroid hormone receptor 0.002 0.0093 0.014
Echinococcus granulosus snurportin 1 0.032 0.311 0.4692
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0088 0.0784 0.0784
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0051 0.0406 0.2582
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0049 0.0049
Trichomonas vaginalis ran, putative 0.0022 0.0118 0.0059
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0486 0.0486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.0784 0.1184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0093 0.014
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0218 0.2088 0.315
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0503 0.0447
Leishmania major GTP-binding protein, putative 0.0022 0.0118 0.0496
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0093 0.0093
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0093 0.014
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0391 0.9601
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0387 0.0583
Toxoplasma gondii hypothetical protein 0.0053 0.0429 1
Schistosoma mansoni nephrin 0.0019 0.0084 0.0127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0164 0.0164
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0164 0.021
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0093 0.014
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0016 0.0058 0.0088
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0093 0.014
Loa Loa (eye worm) TK/KIN16 protein kinase 0.002 0.0101 0.0101
Entamoeba histolytica Ran family GTPase 0.0022 0.0118 0.0168
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0066 0.0558 0.0558
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0051 0.0406 1
Echinococcus multilocularis chromatin regulatory protein sir2 0.0016 0.0058 0.0075
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.014 0.066
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.003 0.0202 0.0202
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0118 0.0118
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0016 0.0058 0.0069
Schistosoma mansoni hypothetical protein 0.0022 0.0118 0.0178
Brugia malayi jmjC domain containing protein 0.0015 0.0049 0.0049
Echinococcus multilocularis neuroglian 0.0019 0.0084 0.0108
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0051 0.0406 0.2582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0088 0.0784 0.1184
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0058 0.0088
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0366 0.3579 0.3541
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0049 0.0063
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0058 0.0058
Toxoplasma gondii exonuclease III APE 0.0019 0.0083 0.0895
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0051 0.0406 0.1367
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0406 0.0349
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0016 0.0058 0.0268
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0164 0.0248
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.031 0.0253
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0093 0.0093
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0503 0.329
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.0058 0.0075
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0118 0.1922
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0083 0.0069
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0391 0.9601
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0096 0.0864 0.0864
Echinococcus multilocularis Immunoglobulin 0.0019 0.0084 0.0108
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0049
Trichomonas vaginalis glucosylceramidase, putative 0.1005 1 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.0058 0.0088
Plasmodium vivax importin-beta 2, putative 0.003 0.0197 0.415
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0093 0.0119
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.014 0.0082
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0093
Schistosoma mansoni microtubule-associated protein tau 0.067 0.6628 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Brugia malayi jmjC domain containing protein 0.0015 0.0049 0.0049
Toxoplasma gondii hypothetical protein 0.0019 0.0089 0.1067
Schistosoma mansoni chromatin regulatory protein sir2 0.0051 0.0406 0.0612
Schistosoma mansoni ap endonuclease 0.0019 0.0083 0.0125
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0083 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0093 0.014
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0083 0.0246
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0486 0.0733
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0164 0.1545 0.2332
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.143 0.1832
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0627 0.0947
Schistosoma mansoni thyroid hormone receptor 0.002 0.0093 0.014
Entamoeba histolytica hypothetical protein 0.0073 0.0627 0.1616
Brugia malayi hypothetical protein 0.0032 0.0216 0.0216
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0093 0.014
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0058 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0429 0.0372
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0503 0.0759
Leishmania major sir2-family protein-like protein 0.0016 0.0058 0.0069
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0101 0.0101
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.047 0.0602
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0083 0.0246
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0049 0.0074
Plasmodium vivax NAD-dependent deacetylase, putative 0.0051 0.0406 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0406 0.0349
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0366 0.3579 1
Trypanosoma brucei SIR2-like protein 4, putative 0.0016 0.0058 0.0069
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0083 0.5
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.0058 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0695 0.6882 0.6864
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0089 0.0088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0084
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0503 0.329
Loa Loa (eye worm) hypothetical protein 0.0015 0.0049 0.0049
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0093 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.1005 1 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0083 0.0083
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0089 0.0088
Schistosoma mansoni cpg binding protein 0.0029 0.0192 0.029
Echinococcus granulosus cpg binding protein 0.0029 0.0192 0.029
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1005 1 1
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0049 0.0074
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.0058 0.0088
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0366 0.3579 0.3579
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0049 0.0074
Loa Loa (eye worm) transcriptional regulator 0.0016 0.0058 0.0058
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0503 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0093 0.0093
Toxoplasma gondii hypothetical protein 0.0019 0.0089 0.1067
Brugia malayi jmjC domain containing protein 0.0015 0.0049 0.0049
Echinococcus granulosus geminin 0.0164 0.1545 0.2332
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0093 0.0093
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.047 0.0602
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0016 0.0058 0.0075
Echinococcus multilocularis mitogen activated protein kinase 14 0.0153 0.143 0.1832
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0083 0.0246
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0118 0.0151
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0083 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0093
Entamoeba histolytica hypothetical protein 0.0073 0.0627 0.1616
Trichomonas vaginalis glucosylceramidase, putative 0.0659 0.6526 0.6505
Trichomonas vaginalis glucosylceramidase, putative 0.0659 0.6526 0.6505
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0093 0.0119
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.003 0.0202 0.0202
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0049 0.0074
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0153 0.143 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0051 0.0406 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0503 0.0447
Schistosoma mansoni hypothetical protein 0.0397 0.3886 0.5863
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.003 0.0202 0.0259
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0019 0.0084 0.0127
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0118 0.1805
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0089 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0429 0.0372
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0391 0.9601
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0093 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0084
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0093 0.014
Echinococcus granulosus tumor protein p63 0.0334 0.3249 0.4902
Echinococcus multilocularis Immunoglobulin 0.0019 0.0084 0.0108
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0049 0.0074
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0093 0.014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0096 0.0864 0.0864
Plasmodium falciparum importin beta, putative 0.003 0.0197 0.415
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0118 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.0659 0.6526 0.6505
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0429 0.0372
Trichomonas vaginalis importin beta-1, putative 0.0024 0.014 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0093 0.0093
Onchocerca volvulus 0.0366 0.3579 0.5419
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0113 0.1031 0.0978
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0093 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0093
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0366 0.3579 0.3579
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0049 0.0074
Echinococcus granulosus mitogen activated protein kinase 11 0.0153 0.143 0.2158
Brugia malayi jmjC domain containing protein 0.0015 0.0049 0.0049
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.0058 0.0075
Brugia malayi jmjC domain containing protein 0.0057 0.047 0.047
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0366 0.3579 0.3541
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0503 0.0447
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0093 0.014
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0253 0.2443 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0049 0.0049
Schistosoma mansoni ran 0.0022 0.0118 0.0177
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0089 0.1136
Echinococcus multilocularis geminin 0.0164 0.1545 0.198
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.047 0.0709
Brugia malayi nuclear hormone receptor 0.002 0.0093 0.0093
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0218 0.2088 0.2088
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0016 0.0058 0.0069
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0049 0.0063
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0093 0.0093
Brugia malayi Latrophilin receptor protein 2 0.003 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.003 0.0197 0.0197
Echinococcus multilocularis mitogen activated protein kinase 11 0.0153 0.143 0.1832
Brugia malayi hypothetical protein 0.0019 0.0084 0.0084
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0093 0.014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0486 0.0733
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0118 0.0151
Schistosoma mansoni cpg binding protein 0.0029 0.0192 0.029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0088 0.0784 0.1184
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.049 0.074
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.0058 0.0088
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0049 0.0063
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0197 0.3898
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0089 0.1067
Toxoplasma gondii histone deacetylase SIR2 0.0051 0.0406 0.9394

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.5 nM Inhibition of LPS-induced TNFalpha production in human THP1 cells after 3 hrs ChEMBL. 20218619
IC50 (functional) = 3.9 nM Inhibition of IL-8 production in TNFalpha challenged human whole blood after 16 to 18 hrs ChEMBL. 20218619
IC50 (binding) = 5.7 nM Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysis ChEMBL. 20218619
Kd (binding) = 0.31 nM Binding affinity to p38alpha by scintillation proximity assay ChEMBL. 20218619
Kd (binding) = 13000 nM Binding affinity to c-Kit by scintillation proximity assay ChEMBL. 20218619
Kd (binding) = 40000 nM Binding affinity to Kdr by scintillation proximity assay ChEMBL. 20218619
Kd (binding) = 40000 nM Binding affinity to Lck by scintillation proximity assay ChEMBL. 20218619
Ki (binding) = 2.3 nM Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assay ChEMBL. 20218619
Papp (ADMET) = 20 10^-6 cm/s Apparent permeability from apical to basolateral side of human Caco-2 cells ChEMBL. 20218619
Papp (ADMET) = 29 10^-6 cm/s Apparent permeability from basolateral to apical side of human Caco-2 cells ChEMBL. 20218619

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20218619

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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