Detailed information for compound 1136643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 476.473 | Formula: C25H15F3N4OS
  • H donors: 1 H acceptors: 4 LogP: 5.53 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)C(F)(F)F)Nc1cccc(c1)c1ncnc2c1cc(s2)c1ccncc1
  • InChi: 1S/C25H15F3N4OS/c26-25(27,28)18-5-1-4-17(11-18)23(33)32-19-6-2-3-16(12-19)22-20-13-21(15-7-9-29-10-8-15)34-24(20)31-14-30-22/h1-14H,(H,32,33)
  • InChiKey: CXIYVOOQCNGGIB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta Starlite/ChEMBL References
Homo sapiens protein kinase C, theta Starlite/ChEMBL References
Homo sapiens pyruvate dehydrogenase kinase, isozyme 1 Starlite/ChEMBL References
Homo sapiens LYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens IL2-inducible T-cell kinase Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 4 Starlite/ChEMBL References
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References
Homo sapiens Bruton agammaglobulinemia tyrosine kinase Starlite/ChEMBL References
Homo sapiens B-Raf proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Onchocerca volvulus Get druggable targets OG5_132502 All targets in OG5_132502
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi kinase, mitochondrial precursor Get druggable targets OG5_127409 All targets in OG5_127409
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi developmentally regulated phosphoprotein, putative Get druggable targets OG5_127409 All targets in OG5_127409
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase Get druggable targets OG5_127409 All targets in OG5_127409
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei developmentally regulated phosphoprotein Get druggable targets OG5_127409 All targets in OG5_127409
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127409 All targets in OG5_127409
Schistosoma mansoni pyruvate dehydrogenase Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Tyrosine-protein kinase BTK, putative Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania braziliensis developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma congolense developmentally regulated phosphoprotein, putative Get druggable targets OG5_127409 All targets in OG5_127409
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial precursor, putative Get druggable targets OG5_127409 All targets in OG5_127409
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania mexicana developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K00898 pyruvate dehydrogenase kinase [EC2.7.11.2], putative Get druggable targets OG5_127409 All targets in OG5_127409
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense developmentally regulated phosphoprotein Get druggable targets OG5_127409 All targets in OG5_127409
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni pyruvate dehydrogenase Get druggable targets OG5_127409 All targets in OG5_127409
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans similar to S. pombe SPAC644.11c predicted pyruvate dehydrogenase kinase Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni pyruvate dehydrogenase Get druggable targets OG5_127409 All targets in OG5_127409
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129320 All targets in OG5_129320
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Btk29A Get druggable targets OG5_129320 All targets in OG5_129320
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma japonicum ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative Get druggable targets OG5_129320 All targets in OG5_129320
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase Get druggable targets OG5_127409 All targets in OG5_127409
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Leishmania major developmentally regulated phosphoprotein-like protein Get druggable targets OG5_127409 All targets in OG5_127409
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132502 All targets in OG5_132502
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative pyruvate dehydrogenase kinase, isozyme 1 456 aa 397 aa 22.7 %
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0144 0.3475 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0047 0.063 0.0872
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0027 0.0044 0.0015
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0939 0.3318
Schistosoma mansoni growth factor receptor-bound protein 0.0039 0.0401 0.0402
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0081 0.1633 0.1609
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0733 0.2056
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0027 0.0044 0.0052
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0027 0.0044 0.0052
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0061 0.1036 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0038 0.0372 0.0511
Trypanosoma cruzi Protein kinase B 0.0032 0.0199 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0358 0.049
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0366 1 1
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0733 0.2043
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0056 0.0901 0.311
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0058 0.0954 0.099
Echinococcus multilocularis protein kinase c iota type 0.0045 0.0579 0.0552
Echinococcus granulosus protein kinase c epsilon type 0.0045 0.0579 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0628 0.2219
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0036 0.0317 0.0836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0628 0.2219
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0043 0.0523 0.1845
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0358 0.1263
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0055 0.087 0.0844
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0579 0.0591
Echinococcus multilocularis rac serine:threonine kinase 0.0032 0.0199 0.017
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0115 0.2626 0.9267
Brugia malayi protein-tyrosine kinase 0.0062 0.107 0.1558
Loa Loa (eye worm) hypothetical protein 0.0185 0.4685 0.6534
Brugia malayi beta-lactamase family protein 0.0037 0.0358 0.0514
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0358 0.1263
Loa Loa (eye worm) TK protein kinase 0.0062 0.107 0.1485
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0523 0.1761
Echinococcus granulosus tyrosine protein kinase Lyn 0.0082 0.1677 0.1653
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0122 0.2832 1
Schistosoma mansoni serine/threonine kinase 0.0027 0.0044 0.0023
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0058 0.0954 0.2697
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0122 0.2832 0.8133
Entamoeba histolytica protein kinase, putative 0.0042 0.0492 0.1652
Entamoeba histolytica hypothetical protein 0.0098 0.2123 0.7471
Echinococcus multilocularis tyrosine protein kinase HCK 0.0042 0.0492 0.0464
Loa Loa (eye worm) SRC-1 0.0081 0.1633 0.2272
Echinococcus granulosus NCK adaptor protein 0.0039 0.0401 0.0373
Onchocerca volvulus 0.0037 0.0358 0.078
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0026 0.0029 0.5
Mycobacterium ulcerans lipase LipD 0.0037 0.0358 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0401 0.055
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0226 0.5888 0.5876
Brugia malayi beta-lactamase 0.0037 0.0358 0.0514
Schistosoma mansoni serine/threonine-protein kinase 0.0032 0.0199 0.0187
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0226 0.5888 0.6231
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0358 0.049
Schistosoma mansoni tyrosine kinase 0.0347 0.9436 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0081 0.1633 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0628 0.2219
Echinococcus multilocularis c src tyrosine kinase 0.0046 0.06 0.0573
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.1633 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0304 0.1073
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0081 0.1633 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0721 0.2547
Loa Loa (eye worm) hypothetical protein 0.0144 0.3475 0.4845
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0027 0.0044 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0395 0.1397
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0044 0.0154
Brugia malayi hypothetical protein 0.0027 0.0037 0.0044
Echinococcus multilocularis serine:threonine protein kinase 38 0.0027 0.0044 0.0015
Onchocerca volvulus 0.0037 0.0358 0.078
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0044 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0044 0.0154
Echinococcus granulosus protein kinase C gamma type 0.0027 0.0044 0.0015
Echinococcus multilocularis tyrosine protein kinase Blk 0.0062 0.107 0.1044
Echinococcus granulosus NDR protein kinase 0.0027 0.0044 0.0015
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0043 0.0523 0.1761
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0027 0.0037 0.0008
Loa Loa (eye worm) TK/ABL protein kinase 0.0027 0.0037 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0939 0.3318
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0098 0.2123 0.7471
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0043 0.0523 0.0531
Echinococcus multilocularis NCK adaptor protein 0.0039 0.0401 0.0373
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0081 0.1633 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0546 0.1928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0222 0.0782
Brugia malayi SH2 domain containing protein 0.0027 0.0037 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.043 0.1518
Loa Loa (eye worm) hypothetical protein 0.0042 0.0482 0.0663
Loa Loa (eye worm) hypothetical protein 0.0167 0.4149 0.5787
Schistosoma mansoni tyrosine kinase 0.0081 0.1633 0.1711
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.0954 0.1389
Toxoplasma gondii AGC kinase 0.0051 0.077 0.6758
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.2315 0.3384
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0939 0.3318
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0031 0.0173 0.1433
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0358 0.0514
Echinococcus multilocularis protein kinase c epsilon type 0.0045 0.0579 0.0552
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0039 0.0401 0.0402
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0358 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0081 0.1633 0.1609
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0027 0.0037 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0939 0.3318
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0939 0.3318
Schistosoma mansoni adapter molecule crk 0.0039 0.0401 0.0402
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0358 0.0954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.022 0.0778
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0122 0.2832 1
Schistosoma mansoni growth factor receptor-bound protein 0.0039 0.0401 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0628 0.2219
Mycobacterium leprae Probable lipase LipE 0.0037 0.0358 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0037 0.0358 0.049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0122 0.2832 0.414
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0401 0.055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0358 0.049
Loa Loa (eye worm) hypothetical protein 0.0193 0.4934 0.6882
Brugia malayi Protein kinase domain containing protein 0.0057 0.0939 0.1367
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0027 0.0037 0.0008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.1633 0.1609
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0401 0.0577
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0954 0.1323
Mycobacterium ulcerans beta-lactamase 0.0037 0.0358 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0523 0.0756
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0038 0.0372 0.0345
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0027 0.0037 0.0028
Schistosoma mansoni serine/threonine protein kinase 0.0276 0.7365 0.78
Brugia malayi kinase, mitochondrial precursor 0.0144 0.3475 0.5084
Brugia malayi Sex muscle abnormal protein 5 0.0039 0.0401 0.0577
Echinococcus multilocularis N chimaerin 0.0038 0.0372 0.0345
Loa Loa (eye worm) hypothetical protein 0.0167 0.4149 0.5787
Echinococcus granulosus tyrosine protein kinase HCK 0.0042 0.0492 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0222 0.0782
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Entamoeba histolytica protein kinase, putative 0.0051 0.077 0.2643
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0546 0.1928
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0085 0.1745 0.6162
Brugia malayi RhoGAP domain containing protein 0.0038 0.0372 0.0536
Schistosoma mansoni tyrosine kinase 0.0046 0.06 0.0614
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0029 0.0115 0.0266
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0043 0.0523 0.1432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0546 0.1928
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Trypanosoma brucei developmentally regulated phosphoprotein 0.0144 0.3475 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0202 0.5179 0.7226
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0044 0.0023
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0058 0.0968 1
Echinococcus granulosus tyrosine kinase 0.0027 0.0037 0.0008
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0038 0.0372 0.0372
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0358 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0038 0.0372 0.0372
Echinococcus granulosus tyrosine protein kinase Srms 0.0027 0.0037 0.0008
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0043 0.0523 0.1845
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.6277 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0058 0.0954 0.2684
Schistosoma mansoni nck2/grb4 0.0039 0.0401 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0546 0.1928
Schistosoma mansoni serine/threonine-protein kinase 0.0032 0.0199 0.0187
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0358 0.049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0358 0.0356
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0058 0.0954 0.2697
Echinococcus granulosus growth factor receptor bound protein 2 0.0039 0.0401 0.0373
Loa Loa (eye worm) AGC/AKT protein kinase 0.0057 0.0939 0.1303
Onchocerca volvulus 0.0037 0.0358 0.078
Echinococcus granulosus raf serine:threonine protein kinase 0.0276 0.7365 0.7358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0546 0.1928
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.005 0.0733 0.6155
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0122 0.2832 1
Brugia malayi Protein kinase domain containing protein 0.0027 0.0044 0.0054
Echinococcus granulosus N chimaerin 0.0038 0.0372 0.0345
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0358 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.0027 0.0037 0.0008
Brugia malayi Protein kinase domain containing protein 0.0027 0.0037 0.0044
Brugia malayi Protein kinase domain containing protein 0.0027 0.0037 0.0044
Loa Loa (eye worm) hypothetical protein 0.0037 0.0358 0.049
Echinococcus multilocularis tyrosine kinase 0.0027 0.0037 0.0008
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0154 0.3774 0.5262
Schistosoma mansoni vav2 0.0044 0.0542 0.0552
Schistosoma mansoni tyrosine kinase 0.0046 0.06 0.0614
Echinococcus granulosus serine:threonine protein kinase N2 0.0027 0.0044 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0954 0.3369
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0058 0.0954 0.3301
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.008 0.1609 0.2349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0954 0.3369
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0358 0.0954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0222 0.0782
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0401 0.0577
Loa Loa (eye worm) TK protein kinase 0.0042 0.0492 0.0678
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0579 0.0591
Brugia malayi Tyrosine-protein kinase abl-1 0.0046 0.06 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0546 0.1928
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0358 0.0969
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0358 0.1263
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0939 0.3318
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0058 0.0954 0.0928
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0358 0.033
Leishmania major developmentally regulated phosphoprotein-like protein 0.0144 0.3475 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0122 0.2832 1
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0044 0.0023
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0144 0.3475 0.3456
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0358 0.1263
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0039 0.0401 0.055
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0032 0.0199 0.0492
Echinococcus granulosus tyrosine protein kinase Fyn 0.0081 0.1633 0.1609
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0058 0.0954 0.2684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0313 0.1106
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0081 0.1633 0.1609
Trichomonas vaginalis esterase, putative 0.0037 0.0358 0.1263
Echinococcus granulosus tyrosine protein kinase shark 0.0027 0.0037 0.0008
Schistosoma mansoni tyrosine kinase 0.0081 0.1633 0.1711
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Echinococcus multilocularis serine:threonine protein kinase N2 0.0027 0.0044 0.0015
Onchocerca volvulus 0.0167 0.4149 1
Loa Loa (eye worm) raf kinase 0.0269 0.7166 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0042
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0199 0.0605
Brugia malayi Protein kinase domain containing protein 0.0027 0.0037 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0628 0.2219
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0027 0.0044 0.0015
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.008 0.1609 0.1585
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0038 0.0372 0.0345
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.3241 0.3419
Echinococcus granulosus tyrosine protein kinase Src42A 0.0055 0.087 0.0844
Loa Loa (eye worm) hypothetical protein 0.0167 0.4149 0.5787
Echinococcus multilocularis raf serine:threonine protein kinase 0.0276 0.7365 0.7358
Loa Loa (eye worm) hypothetical protein 0.008 0.1609 0.2239
Brugia malayi SRC-1 0.0081 0.1633 0.2384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0304 0.1073
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0081 0.1633 0.1609
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0358 0.1263
Brugia malayi beta-lactamase family protein 0.0037 0.0358 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.022 0.0778
Brugia malayi protein kinase C II. 0.0045 0.0579 0.0839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0313 0.1106
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0027 0.0044 0.0052
Echinococcus granulosus tyrosine protein kinase Fyn 0.0081 0.1633 0.1609
Schistosoma mansoni pyruvate dehydrogenase 0.0144 0.3475 0.3668
Echinococcus granulosus c src tyrosine kinase 0.0046 0.06 0.0573
Toxoplasma gondii target of rapamycin (TOR), putative 0.0044 0.0546 0.309
Brugia malayi SH2 domain containing protein 0.0027 0.0037 0.0044
Echinococcus granulosus tyrosine protein kinase Blk 0.0062 0.107 0.1044
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.3475 0.3456
Echinococcus granulosus serine/threonine protein kinase 0.0032 0.0199 0.017
Trypanosoma brucei rac serine-threonine kinase, putative 0.0057 0.0939 0.2654
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0358 0.033
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0144 0.3475 0.3456
Trypanosoma cruzi target of rapamycin kinase 3 0.0047 0.063 0.1743
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0222 0.0782
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Echinococcus multilocularis tyrosine protein kinase Abl 0.0046 0.06 0.0573
Brugia malayi Protein kinase domain containing protein 0.0027 0.0037 0.0044
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0081 0.1633 0.1609
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.005 0.0733 0.1204
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0045 0.0579 0.0552
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0122 0.2832 0.8133
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0358 0.5
Echinococcus multilocularis serine threonine protein kinase 0.0027 0.0044 0.0015
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.008 0.1609 0.1585
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0081 0.1633 0.1609
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0058 0.0954 0.3301
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0046 0.06 0.0614
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0027 0.0044 0.0015
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0372 0.0536
Loa Loa (eye worm) AGC/PKN protein kinase 0.0027 0.0044 0.0052
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0058 0.0954 0.1913
Schistosoma mansoni atypical protein kinase C 0.0045 0.0579 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.022 0.0778
Trichomonas vaginalis AGC family protein kinase 0.0057 0.0939 0.3318
Echinococcus granulosus tyrosine protein kinase Fyn 0.0081 0.1633 0.1609
Schistosoma mansoni tyrosine kinase 0.0027 0.0037 0.0015
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0058 0.0954 0.1913
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0062 0.107 0.1044
Trichomonas vaginalis AGC family protein kinase 0.0027 0.0044 0.0154
Echinococcus multilocularis growth factor receptor bound protein 2 0.0039 0.0401 0.0373
Echinococcus granulosus tyrosine protein kinase Src42A 0.0081 0.1633 0.1609
Entamoeba histolytica protein kinase, putative 0.0057 0.0939 0.3249
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0047 0.063 0.1757
Schistosoma mansoni pyruvate dehydrogenase 0.0136 0.3241 0.3419
Entamoeba histolytica protein kinase, putative 0.0027 0.0044 0.0052
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0045 0.0579 0.0799
Loa Loa (eye worm) beta-lactamase 0.0037 0.0358 0.049
Brugia malayi p70 ribosomal S6 kinase beta 0.0051 0.077 0.1119
Mycobacterium ulcerans hypothetical protein 0.0037 0.0358 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0358 0.049
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0062 0.107 0.1044
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0085 0.1745 0.6162
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0051 0.077 0.1066
Giardia lamblia GTOR 0.0058 0.0954 0.9183
Brugia malayi Protein kinase domain containing protein 0.0027 0.0044 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0954 0.3369
Brugia malayi Protein kinase domain containing protein 0.0027 0.0037 0.0044
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0058 0.0954 0.0928
Entamoeba histolytica protein kinase, putative 0.0057 0.0939 0.3249
Echinococcus granulosus tyrosine protein kinase Src64B 0.0081 0.1633 0.1609
Echinococcus multilocularis tyrosine protein kinase shark 0.0027 0.0037 0.0008
Echinococcus granulosus tyrosine kinase 0.0062 0.107 0.1044
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0043 0.0523 0.1447
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0226 0.5888 0.5876
Brugia malayi Raf kinase 0.0258 0.683 1
Echinococcus granulosus protein kinase c iota type 0.0045 0.0579 0.0552
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0579 0.0591
Brugia malayi Hr1 repeat family protein 0.0027 0.0044 0.0054
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0199 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0546 0.1928
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0044 0.0023
Echinococcus multilocularis tyrosine protein kinase Srms 0.0062 0.107 0.1044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0313 0.1106
Trichomonas vaginalis AGC family protein kinase 0.0033 0.0213 0.0753
Loa Loa (eye worm) AGC/NDR protein kinase 0.0027 0.0044 0.0052
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0037 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0358 0.0356
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0027 0.0044 0.0015
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0027 0.0044 0.0015
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.0317 0.0434
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0043 0.0523 0.1845
Echinococcus multilocularis serine:threonine protein kinase N2 0.0027 0.0044 0.0015
Echinococcus granulosus Protein kinase C brain isozyme 0.0045 0.0579 0.0552

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.08 uM Inhibition of B-Raf ChEMBL. 20307980
IC50 (functional) = 0.15 uM Growth inhibition of human HT-29 cells ChEMBL. 20307980
IC50 (functional) = 0.23 uM Growth inhibition of human A375 cells ChEMBL. 20307980
IC50 (functional) = 0.3 uM Growth inhibition of human LoVo cells ChEMBL. 20307980
IC50 (functional) = 1.1 uM Growth inhibition of human Caco-2 cells ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of IKK2 ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of AKT ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of mTOR ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of ITK ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of PKCtheta ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of BTK ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of SRC ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of LYN ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of PDK1 ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of LCK ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of PI3Kalpha ChEMBL. 20307980
IC50 (binding) > 10 uM Inhibition of CDK4 ChEMBL. 20307980

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20307980

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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