TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 552.753 | Formula: C31H26N3OS3+
H donors: 0 H acceptors: 1 LogP: 8.34 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: CCn1/c(=C/c2sc3c([n+]2CC)ccc2c3cccc2)/s/c(=c\2/sc3c(n2C)c2ccccc2cc3)/c1=O
InChi: 1S/C31H26N3OS3/c1-4-33-23-16-14-20-11-7-9-13-22(20)28(23)37-25(33)18-26-34(5-2)30(35)29(38-26)31-32(3)27-21-12-8-6-10-19(21)15-17-24(27)36-31/h6-18H,4-5H2,1-3H3/q+1/b31-29+
InChiKey: DFEUBRUFFWKQBD-OWWNRXNESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0142	0.185	0.2951
Plasmodium vivax	vivapain-2	0.0142	0.185	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Echinococcus multilocularis	cathepsin b	0.0436	0.6271	0.6271
Loa Loa (eye worm)	fibroinase	0.0142	0.185	0.1867
Leishmania major	cytochrome p450-like protein	0.0064	0.069	0.1415
Toxoplasma gondii	cathepsin CPC1	0.005	0.0473	0.097
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1292	0.1304
Echinococcus granulosus	cathepsin l1	0.0104	0.1292	0.1292
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0074	0.0074
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.005	0.0473	0.1233
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0074	0.0074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Brugia malayi	Cathepsin L-like precursor	0.0142	0.185	0.1867
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0074	0.0074
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0473	0.0473
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.005	0.0473	0.1233
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0019	0	0.5
Onchocerca volvulus	Cathepsin F homolog	0.0142	0.185	1
Brugia malayi	Papain family cysteine protease containing protein	0.0087	0.1032	0.1041
Plasmodium vivax	vivapain-1	0.0087	0.1032	0.4787
Onchocerca volvulus		0.0142	0.185	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.185	0.3127
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.005	0.0473	0.1233
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0074	0.0075
Entamoeba histolytica	cysteine proteinase, putative	0.0142	0.185	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.005	0.0473	0.1233
Entamoeba histolytica	cysteine proteinase, putative	0.0142	0.185	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0142	0.185	0.185
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0074	0.0075
Loa Loa (eye worm)	cysteine protease	0.0142	0.185	0.1867
Loa Loa (eye worm)	hypothetical protein	0.005	0.0473	0.0477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0074	0.0075
Trypanosoma cruzi	cysteine peptidase, putative	0.0037	0.028	0.0446
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Brugia malayi	ecdysteroid receptor	0.0023	0.0074	0.0075
Brugia malayi	cathepsin Z-like cysteine proteinase	0.005	0.0473	0.0477
Brugia malayi	Cathepsin L-like precursor	0.0142	0.185	0.1867
Brugia malayi	Cytochrome P450 family protein	0.0064	0.069	0.0696
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0074	0.0075
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0074	0.0075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0104	0.1292	0.186
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0104	0.1292	0.1304
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0074	0.0074
Toxoplasma gondii	cathepsin CPC2	0.005	0.0473	0.097
Brugia malayi	Cathepsin L-like precursor	0.0037	0.028	0.0282
Onchocerca volvulus		0.0142	0.185	1
Schistosoma mansoni	cathepsin S (C01 family)	0.005	0.0473	0.0473
Leishmania major	cathepsin L-like protease	0.0142	0.185	0.3794
Brugia malayi	fibroinase precursor	0.005	0.0473	0.0477
Leishmania major	cathepsin L-like protease	0.0142	0.185	0.3794
Schistosoma mansoni	cathepsin F (C01 family)	0.0142	0.185	0.185
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.005	0.0473	0.0473
Brugia malayi	Cathepsin L-like precursor	0.0142	0.185	0.1867
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0074	0.0075
Brugia malayi	Cathepsin L-like precursor	0.0104	0.1292	0.1304
Loa Loa (eye worm)	cathepsin B	0.0343	0.4877	0.492
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Loa Loa (eye worm)	hypothetical protein	0.005	0.0473	0.0477
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0074	0.0075
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0019	0	0.5
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0037	0.028	0.0282
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0074	0.0074
Entamoeba histolytica	cysteine proteinase 2	0.0087	0.1032	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0087	0.1032	0.1645
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0104	0.1292	0.206
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0074	0.0074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0087	0.1032	0.2115
Loa Loa (eye worm)	cytochrome P450 family protein	0.0064	0.069	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0037	0.028	0.0282
Echinococcus multilocularis	microtubule associated protein 2	0.0684	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0019	0	0.5
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0074	0.0074
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.005	0.0473	0.1233
Schistosoma mansoni	microtubule-associated protein tau	0.0684	1	1
Leishmania major	cathepsin L-like protease	0.0142	0.185	0.3794
Leishmania major	cathepsin L-like protease	0.0142	0.185	0.3794
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0436	0.6271	0.6271
Brugia malayi	nuclear hormone receptor	0.0023	0.0074	0.0075
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0142	0.185	0.1867
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0142	0.185	0.1867
Schistosoma mansoni	cathepsin C	0.005	0.0473	0.0473
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Leishmania major	cathepsin L-like protease	0.0142	0.185	0.3794
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0473	0.0473
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.185	0.3127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.1032	0.1268
Onchocerca volvulus		0.0142	0.185	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0074	0.0074
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.185	0.3127
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0074	0.0074
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0074	0.0075
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0087	0.1032	0.1032
Brugia malayi	Cathepsin L-like precursor	0.0142	0.185	0.1867
Plasmodium vivax	serine-repeat antigen (SERA)	0.005	0.0473	0.1233
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0343	0.4877	0.7777
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0104	0.1292	0.186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0142	0.185	0.3127
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0074	0.0075
Trypanosoma cruzi	cruzipain precursor, putative	0.0037	0.028	0.0446
Toxoplasma gondii	cathepsin CPL	0.0142	0.185	0.3794
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0473	0.0473
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.005	0.0473	0.0473
Trypanosoma cruzi	cytochrome P450, putative	0.0064	0.069	0.1101
Trypanosoma cruzi	cysteine peptidase, putative	0.0142	0.185	0.2951
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0019	0	0.5
Brugia malayi	cathepsin Z-like cysteine proteinase	0.005	0.0473	0.0477
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0074	0.0074
Brugia malayi	Cathepsin L-like precursor	0.0142	0.185	0.1867
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0074	0.0074
Entamoeba histolytica	cysteine proteinase, putative	0.0087	0.1032	0.4054
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0064	0.069	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0074	0.0074
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0343	0.4877	0.4877
Leishmania major	cathepsin L-like protease	0.0142	0.185	0.3794
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.005	0.0473	0.0477
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0074	0.0074
Trypanosoma cruzi	cysteine proteinase, putative	0.0087	0.1032	0.1645
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0142	0.185	1
Echinococcus multilocularis	cathepsin b	0.0436	0.6271	0.6271
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.0473	0.0477
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0019	0	0.5
Onchocerca volvulus		0.0142	0.185	1
Entamoeba histolytica	cysteine proteinase, putative	0.0087	0.1032	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.185	0.1867
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0436	0.6271	0.6271
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0074	0.0074
Echinococcus multilocularis	cathepsin L cysteine protease	0.0142	0.185	0.185
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0142	0.185	0.185
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0019	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0019	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Giardia lamblia	Cathepsin B precursor	0.0343	0.4877	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.005	0.0473	0.1233
Toxoplasma gondii	preprocathepsin c precursor, putative	0.005	0.0473	0.097
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.005	0.0473	0.0477
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0074	0.0074
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.005	0.0473	0.0473
Echinococcus granulosus	cathepsin L cysteine protease	0.0087	0.1032	0.1032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0074	0.0075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Trypanosoma cruzi	cysteine proteinase, putative	0.0087	0.1032	0.1645
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.185	0.3127
Leishmania major	cathepsin L-like protease	0.0142	0.185	0.3794
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0037	0.028	0.0282
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0074	0.0074
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0087	0.1032	0.4054
Brugia malayi	steroid hormone receptor	0.0023	0.0074	0.0075
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0019	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0074	0.0075
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0436	0.6271	1
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Onchocerca volvulus		0.0142	0.185	1
Brugia malayi	Cytochrome P450 family protein	0.0064	0.069	0.0696
Echinococcus granulosus	cathepsin b	0.0436	0.6271	0.6271
Echinococcus granulosus	cathepsin L	0.005	0.0473	0.0473
Mycobacterium leprae	putative cytochrome p450	0.0019	0	0.5
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.005	0.0473	0.1233
Loa Loa (eye worm)	hypothetical protein	0.0037	0.028	0.0282
Plasmodium vivax	vivapain-3	0.0087	0.1032	0.4787
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.0473	0.0477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Brugia malayi	cathepsin F-like cysteine proteinase	0.0037	0.028	0.0282
Entamoeba histolytica	cysteine proteinase, putative	0.0087	0.1032	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.185	0.3127
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0343	0.4877	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0473	0.0755
Schistosoma mansoni	coup transcription factor	0.0023	0.0074	0.0074
Echinococcus multilocularis	cysteine protease	0.0142	0.185	0.185
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0019	0	0.5
Schistosoma mansoni	cathepsin B (C01 family)	0.005	0.0473	0.0473
Loa Loa (eye worm)	CYP4Cod1	0.0064	0.069	0.0696
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0436	0.6271	0.6271
Plasmodium vivax	vivapain-2	0.0142	0.185	1
Plasmodium vivax	unspecified product	0.0087	0.1032	0.4787
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Echinococcus granulosus	cathepsin l1	0.0142	0.185	0.185
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0142	0.185	1
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0019	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0074	0.0075
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0142	0.185	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0087	0.1032	0.2115
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0074	0.0074
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0473	0.0755
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1292	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0074	0.0075
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.005	0.0473	0.1233
Giardia lamblia	Cathepsin B precursor	0.0343	0.4877	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0473	0.0477
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.005	0.0473	0.0477
Loa Loa (eye worm)	hypothetical protein	0.005	0.0473	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0074	0.0075
Echinococcus multilocularis	cathepsin L	0.0087	0.1032	0.1032
Brugia malayi	Papain family cysteine protease containing protein	0.0087	0.1032	0.1041
Onchocerca volvulus	Cathepsin L homolog	0.0142	0.185	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.005	0.0473	0.1233
Brugia malayi	Cathepsin L-like precursor	0.0104	0.1292	0.1304
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0074	0.0075
Schistosoma mansoni	cathepsin F (C01 family)	0.0142	0.185	0.185
Onchocerca volvulus		0.0104	0.1292	0.6857
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0473	0.0473
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0074	0.0074
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0411	0.0415
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0019	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.185	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0037	0.028	0.0282
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0074	0.0074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0074	0.0075
Trypanosoma cruzi	cysteine peptidase, putative	0.0142	0.185	0.2951
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0074	0.0074
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0142	0.185	0.1867
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0074	0.0075
Trypanosoma cruzi	cysteine peptidase, putative	0.0087	0.1032	0.1645
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0087	0.1032	0.1032
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Onchocerca volvulus		0.005	0.0473	0.2247
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.185	0.3127
Onchocerca volvulus	Cathepsin L homolog	0.005	0.0473	0.2247
Onchocerca volvulus		0.0142	0.185	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0074	0.0074
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0019	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0019	0	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0104	0.1292	0.1292
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0074	0.0075
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Entamoeba histolytica	cysteine proteinase, putative	0.0087	0.1032	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0074	0.0075
Echinococcus granulosus	cathepsin b	0.0436	0.6271	0.6271
Brugia malayi	follicle stimulating hormone receptor	0.0678	0.9912	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0087	0.1032	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0074	0.0075
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0142	0.185	0.185
Giardia lamblia	Cathepsin B precursor	0.0343	0.4877	1
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0019	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.0142	0.185	0.1867
Loa Loa (eye worm)	ctsf protein	0.0142	0.185	0.1867
Onchocerca volvulus	Cathepsin L homolog	0.0142	0.185	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0074	0.0075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0074	0.0075
Entamoeba histolytica	cysteine protease, putative	0.0142	0.185	1
Trypanosoma brucei	cytochrome P450, putative	0.0064	0.069	0.1415
Brugia malayi	cathepsin L precursor	0.005	0.0473	0.0477
Entamoeba histolytica	cysteine proteinase, putative	0.0104	0.1292	0.5946
Brugia malayi	cathepsin B-like cysteine proteinase	0.0436	0.6271	0.6327
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0343	0.4877	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.005	0.0473	0.0473
Plasmodium vivax	unspecified product	0.005	0.0473	0.1233
Loa Loa (eye worm)	hypothetical protein	0.005	0.0473	0.0477
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0074	0.0074
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0087	0.1032	0.1032
Echinococcus granulosus	cathepsin L	0.0087	0.1032	0.1032
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.185	0.3127
Brugia malayi	cathepsin F-like cysteine proteinase	0.005	0.0473	0.0477
Leishmania major	cathepsin L-like protease	0.0142	0.185	0.3794
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0019	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0142	0.185	0.185
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.185	0.3127
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Loa Loa (eye worm)	hypothetical protein	0.0436	0.6271	0.6327
Schistosoma mansoni	cathepsin s	0.0037	0.028	0.028
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0343	0.4877	1
Brugia malayi	cathepsin L-like precursor	0.0104	0.1292	0.1304
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0074	0.0075
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0074	0.0075
Brugia malayi	Papain family cysteine protease containing protein	0.005	0.0473	0.0477
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0019	0	0.5
Toxoplasma gondii	cathepsin B	0.0343	0.4877	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0074	0.0075
Trypanosoma cruzi	cytochrome P450, putative	0.0064	0.069	0.1101
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0074	0.0075
Leishmania major	cysteine peptidase A (CPA)	0.0142	0.185	0.3794
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0142	0.185	0.185
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1292	0.1304
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.0473	0.0473
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0436	0.6271	0.6271
Trypanosoma cruzi	cysteine protease, putative	0.0087	0.1032	0.1645
Trypanosoma cruzi	cysteine peptidase, putative	0.0142	0.185	0.2951
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0074	0.0074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0087	0.1032	0.1268
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0019	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.0473	0.0477
Echinococcus multilocularis	cathepsin L	0.005	0.0473	0.0473
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0074	0.0074
Loa Loa (eye worm)	cytochrome P450 family protein	0.0064	0.069	0.0696
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0074	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0074	0.0075
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0074	0.0074
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.005	0.0473	0.0477
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0074	0.0075
Plasmodium vivax	serine-repeat antigen (SERA)	0.005	0.0473	0.1233
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0019	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0087	0.1032	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0142	0.185	0.3127
Trypanosoma cruzi	cruzipain precursor, putative	0.0142	0.185	0.2951
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.005	0.0473	0.1233
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0074	0.0075
Echinococcus multilocularis	cysteine protease	0.0142	0.185	0.185
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0074	0.0074
Brugia malayi	cathepsin L-like cysteine proteinase	0.005	0.0473	0.0477
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0074	0.0075
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0074	0.0075
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0074	0.0074
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.185	0.3127
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0074	0.0074
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0019	0	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0678	0.9912	1
Onchocerca volvulus		0.0142	0.185	1
Echinococcus granulosus	cysteine protease	0.0087	0.1032	0.1032
Mycobacterium leprae	Conserved hypothetical protein	0.0019	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0074	0.0075
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.185	0.3794
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0019	0	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1178522

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1144837