Detailed information for compound 1145913

Basic information

Technical information
  • TDR Targets ID: 1145913
  • Name: 2-(phenylamino)-9-[4-(2-phenylpiperidin-1-yl) butyl]-3H-purin-6-one
  • MW: 442.556 | Formula: C26H30N6O
  • H donors: 2 H acceptors: 4 LogP: 4.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc(Nc2ccccc2)nc2c1ncn2CCCCN1CCCCC1c1ccccc1
  • InChi: 1S/C26H30N6O/c33-25-23-24(29-26(30-25)28-21-13-5-2-6-14-21)32(19-27-23)18-10-9-17-31-16-8-7-15-22(31)20-11-3-1-4-12-20/h1-6,11-14,19,22H,7-10,15-18H2,(H2,28,29,30,33)
  • InChiKey: HNBKFHFBSZEYKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(phenylamino)-9-[4-(2-phenyl-1-piperidyl)butyl]-3H-purin-6-one
  • 2-(phenylamino)-9-[4-(2-phenyl-1-piperidinyl)butyl]-3H-purin-6-one
  • AIDS-280051
  • AIDS280051
  • 6H-Purin-6-one, 1,9-dihydro-2-(phenylamino)-9-[4-(2-phenyl-1-piperidinyl)butyl]-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0223 0.09
Schistosoma mansoni elf1 0.001 0.0004 0.0012
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0154 0.3664
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0223 0.0592
Onchocerca volvulus 0.0036 0.0223 0.0223
Schistosoma mansoni ferritin 0.0017 0.0061 0.0164
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0122 0.0174
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0053 0.0061
Onchocerca volvulus 0.0028 0.0153 0.0153
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0122 0.032
Echinococcus multilocularis geminin 0.0336 0.2759 0.4052
Echinococcus multilocularis zinc finger protein 0.0021 0.0097 0.0137
Loa Loa (eye worm) histone methyltransferase 0.0014 0.0038 0.0038
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0213 0.0307
Echinococcus granulosus expressed protein 0.0017 0.0061 0.0152
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0223 0.0603
Schistosoma mansoni hypothetical protein 0.0297 0.2431 0.6578
Brugia malayi hypothetical protein 0.0158 0.1253 0.1427
Brugia malayi Ets-domain containing protein 0.001 0.0004 0.0005
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0089 0.0155
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0107 0.0277
Brugia malayi phosphoinositide-dependent protein kinase I 0.0447 0.3695 0.421
Schistosoma mansoni cpg binding protein 0.0031 0.0183 0.0494
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0762 0.0864
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0109 0.0049
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0109 0.2127
Schistosoma mansoni ap endonuclease 0.002 0.0089 0.024
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.051 0.0743
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0089 1
Schistosoma mansoni ferritin light chain 0.0017 0.0061 0.0164
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0092 0.0105
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0151 0.1194 0.323
Schistosoma mansoni hypothetical protein 0.0022 0.0107 0.0288
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0063 0.017
Schistosoma mansoni ets-related 0.001 0.0004 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0223 0.0163
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0151 0.1194 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0223 0.6037
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0004 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0223 0.09
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.051 0.0576
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0223 0.09
Entamoeba histolytica hypothetical protein 0.0035 0.0213 0.0346
Schistosoma mansoni gabp alpha 0.007 0.051 0.1379
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0063 0.0086
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0092 0.003
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0012
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0495 0.0564
Schistosoma mansoni cpg binding protein 0.0031 0.0183 0.0494
Brugia malayi beta-lactamase family protein 0.0036 0.0223 0.0254
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0089 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0223 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0213 0.0566
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0186 0.0491
Loa Loa (eye worm) hypothetical protein 0.0028 0.0154 0.0171
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.2431 0.2766
Echinococcus multilocularis cpg binding protein 0.0031 0.0183 0.0262
Loa Loa (eye worm) hypothetical protein 0.0036 0.0223 0.0249
Schistosoma mansoni hypothetical protein 0.0032 0.0186 0.0502
Trichomonas vaginalis set domain proteins, putative 0.1193 1 1
Schistosoma mansoni hypothetical protein 0.0068 0.0495 0.134
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0089 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0223 0.6037
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0815 0.6803 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0145 0.1142 0.3082
Loa Loa (eye worm) hypothetical protein 0.0071 0.0516 0.0583
Schistosoma mansoni ran 0.0021 0.0092 0.0249
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0093 0.0101
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0447 0.3695 1
Brugia malayi Pre-SET motif family protein 0.1049 0.8777 1
Schistosoma mansoni cpg binding protein 0.0028 0.0153 0.0414
Schistosoma mansoni hypothetical protein 0.0032 0.0186 0.0502
Brugia malayi Ets-domain containing protein 0.007 0.051 0.0581
Loa Loa (eye worm) hypothetical protein 0.0036 0.0223 0.0249
Echinococcus granulosus importin subunit beta 1 0.0028 0.0154 0.0405
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0063 0.017
Loa Loa (eye worm) hypothetical protein 0.01 0.0762 0.0864
Schistosoma mansoni bromodomain containing protein 0.0065 0.0466 0.1262
Schistosoma mansoni ets-related 0.0212 0.1713 0.4636
Echinococcus granulosus geminin 0.0336 0.2759 0.7465
Entamoeba histolytica Ran family GTPase 0.0021 0.0092 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0223 0.0163
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0223 0.0163
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0429 0.3085
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0186 0.0211
Mycobacterium ulcerans beta-lactamase 0.0036 0.0223 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0223 0.0249
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0089 0.1404
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0168 0.1338 0.1961
Schistosoma mansoni ferritin 0.0017 0.0061 0.0164
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0092 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0186 0.0266
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0089 0.0096
Plasmodium vivax SET domain protein, putative 0.0151 0.1194 1
Brugia malayi hypothetical protein 0.0032 0.0189 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.1194 0.323
Entamoeba histolytica hypothetical protein 0.0023 0.0109 0.0058
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1049 0.8777 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0186 0.0266
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0089 0.0028
Schistosoma mansoni hypothetical protein 0.0035 0.0213 0.0577
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0092 0.0134
Schistosoma mansoni zinc finger protein 0.0021 0.0097 0.0263
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0762 0.0868
Echinococcus granulosus cpg binding protein 0.0031 0.0183 0.0483
Loa Loa (eye worm) hypothetical protein 0.0032 0.0186 0.0207
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0154 0.0592
Schistosoma mansoni hypothetical protein 0.0032 0.0186 0.0502
Schistosoma mansoni serine/threonine protein kinase 0.0447 0.3695 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0337 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0089 0.1719
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0024 0.0028
Leishmania major hypothetical protein, conserved 0.005 0.0337 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0089 0.0124
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0107 0.015
Loa Loa (eye worm) hypothetical protein 0.0044 0.0292 0.0328
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0463 0.1252
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0024 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0089 0.0028
Brugia malayi Protein kinase domain containing protein 0.0447 0.3695 0.421
Loa Loa (eye worm) hypothetical protein 0.005 0.0337 0.038
Schistosoma mansoni hypothetical protein 0.0015 0.0048 0.013
Toxoplasma gondii ABC1 family protein 0.0036 0.0223 0.1214
Brugia malayi transcription factor E74 isoform 0.001 0.0004 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0168 0.1338 0.362
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0337 0.2253
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0223 1
Onchocerca volvulus 0.0158 0.1253 0.1253
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0024 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0038 0.0049
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0337 1
Echinococcus granulosus ferritin 0.0017 0.0061 0.0152
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0092 0.0237
Trichomonas vaginalis AGC family protein kinase 0.0447 0.3695 0.3657
Brugia malayi Pre-SET motif family protein 0.0151 0.1194 0.136
Entamoeba histolytica hypothetical protein 0.0035 0.0213 0.0346
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0089 0.1404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0089 0.1404
Loa Loa (eye worm) hypothetical protein 0.0158 0.1253 0.1423
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0122 0.0331
Echinococcus granulosus GA binding protein alpha chain 0.007 0.051 0.1369
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0154 0.022
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0213 0.0577
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0223 0.09
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0154 0.3664
Brugia malayi hypothetical protein 0.005 0.0337 0.0385
Leishmania major hypothetical protein, conserved 0.0036 0.0223 0.6037
Schistosoma mansoni importin beta-1 0.0028 0.0154 0.0417
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0223 0.0254
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0186 0.0266
Schistosoma mansoni ets 0.001 0.0004 0.0012
Plasmodium falciparum importin beta, putative 0.0028 0.0154 0.2629
Brugia malayi Bromodomain containing protein 0.0038 0.0242 0.0276
Onchocerca volvulus 0.0036 0.0223 0.0223
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0447 0.3695 0.5428
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0109 0.0049
Brugia malayi CXXC zinc finger family protein 0.0028 0.0153 0.0174
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0337 0.2253
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0222 0.059
Mycobacterium tuberculosis Conserved protein 0.0036 0.0223 0.09
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0223 0.6037
Brugia malayi hypothetical protein 0.0035 0.0213 0.0243
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0038 0.0091
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0337 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0223 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1861 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0068 0.0072
Brugia malayi RNA, U transporter 1 0.0079 0.0588 0.067
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0223 0.0249
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0153 0.0169
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0447 0.3695 0.4207
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0436 0.0635
Schistosoma mansoni ferritin 0.0017 0.0061 0.0164
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0109 0.0049
Brugia malayi beta-lactamase 0.0036 0.0223 0.0254
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0495 0.056
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0223 0.09
Trichomonas vaginalis AGC family protein kinase 0.0447 0.3695 0.3657
Loa Loa (eye worm) hypothetical protein 0.0036 0.0223 0.0249
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0223 0.0163
Echinococcus granulosus snurportin 1 0.0297 0.2431 0.6574
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0024 0.0052
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0186 0.0491
Schistosoma mansoni hypothetical protein 0.0336 0.2759 0.7468
Loa Loa (eye worm) hypothetical protein 0.0041 0.0263 0.0294
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0762 0.0868
Echinococcus granulosus zinc finger protein 0.0021 0.0097 0.0252
Onchocerca volvulus 0.0036 0.0223 0.0223
Loa Loa (eye worm) fli-1 protein 0.0212 0.1713 0.1948
Brugia malayi Fli-1 protein 0.0212 0.1713 0.1952
Schistosoma mansoni hypothetical protein 0.0032 0.0186 0.0502
Schistosoma mansoni ap endonuclease 0.002 0.0089 0.024
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0223 0.1214
Echinococcus multilocularis expressed protein 0.0017 0.0061 0.0083
Schistosoma mansoni ferritin 0.0017 0.0061 0.0164
Schistosoma mansoni apoferritin-2 0.0017 0.0061 0.0164
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0223 0.0321
Entamoeba histolytica hypothetical protein 0.0035 0.0213 0.0346
Echinococcus multilocularis ferritin 0.0017 0.0061 0.0083
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0223 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0436 0.117
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0092 0.1519
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0024 0.0028
Brugia malayi Importin beta-1 subunit 0.0028 0.0154 0.0175
Schistosoma mansoni hypothetical protein 0.001 0.0004 0.0012
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0004 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0223 1
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0447 0.3695 0.4207
Mycobacterium tuberculosis Conserved protein 0.0036 0.0223 0.09
Loa Loa (eye worm) hypothetical protein 0.0036 0.0223 0.0249
Schistosoma mansoni hypothetical protein 0.0336 0.2759 0.7468
Mycobacterium tuberculosis Conserved protein 0.0036 0.0223 0.09
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0186 0.0207
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0151 0.1194 0.1749
Brugia malayi PHD-finger family protein 0.0026 0.0142 0.0162
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0092 0.01
Brugia malayi beta-lactamase family protein 0.0036 0.0223 0.0254
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0092 0.003
Schistosoma mansoni hypothetical protein 0.0021 0.0093 0.0251
Leishmania major importin beta-1 subunit, putative 0.0023 0.0109 0.2127
Entamoeba histolytica hypothetical protein 0.0035 0.0213 0.0346
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0089 0.0101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0186 0.0211
Schistosoma mansoni zinc finger protein 0.0015 0.0048 0.013
Leishmania major GTP-binding protein, putative 0.0021 0.0092 0.1519
Echinococcus granulosus GPCR family 2 0.0032 0.0186 0.0491
Mycobacterium leprae Probable lipase LipE 0.0036 0.0223 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0089 0.1404
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0063 0.0158
Schistosoma mansoni apoferritin-2 0.0017 0.0061 0.0164
Echinococcus granulosus histone lysine methyltransferase setb 0.0168 0.1338 0.3612
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0223 0.0163
Loa Loa (eye worm) hypothetical protein 0.0168 0.1338 0.152
Loa Loa (eye worm) hypothetical protein 0.0036 0.0223 0.0249
Entamoeba histolytica protein kinase, putative 0.0447 0.3695 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0223 0.0603
Trichomonas vaginalis ran, putative 0.0021 0.0092 0.0031
Loa Loa (eye worm) hypothetical protein 0.006 0.0424 0.0478
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0223 0.09
Loa Loa (eye worm) hypothetical protein 0.0036 0.0223 0.0249
Brugia malayi Bromodomain containing protein 0.0077 0.0565 0.0644
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0222 0.032
Onchocerca volvulus 0.0151 0.1194 0.1194
Loa Loa (eye worm) hypothetical protein 0.0038 0.0243 0.0272
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0092 0.0129
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0092 0.1519
Trichomonas vaginalis esterase, putative 0.0036 0.0223 0.0163
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0092 0.1519
Brugia malayi Ets-domain containing protein 0.007 0.051 0.0581
Schistosoma mansoni ran 0.0021 0.0092 0.0249
Plasmodium vivax importin-beta 2, putative 0.0028 0.0154 0.0592
Trichomonas vaginalis AGC family protein kinase 0.0447 0.3695 0.3657
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0223 0.09
Schistosoma mansoni ferritin light chain 0.0017 0.0061 0.0164
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0337 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0168 0.1338 0.362
Echinococcus multilocularis snurportin 1 0.0297 0.2431 0.3569

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.