Detailed information for compound 1154465

Basic information

Technical information
  • TDR Targets ID: 1154465
  • Name: 1-(but-3-ynoxymethyl)-2,3-dimethylimidazol-3- ium
  • MW: 179.239 | Formula: C10H15N2O+
  • H donors: 0 H acceptors: 0 LogP: 1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1n(C)cc[n+]1COCCC#C
  • InChi: 1S/C10H15N2O/c1-4-5-8-13-9-12-7-6-11(3)10(12)2/h1,6-7H,5,8-9H2,2-3H3/q+1
  • InChiKey: OFQCKNPKVTZTFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(but-3-ynoxymethyl)-2,3-dimethyl-imidazol-3-ium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyruvate kinase 0.0037 0.0394 0.2105
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0358 0.1864
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0377 0.2014
Toxoplasma gondii ABC1 family protein 0.0078 0.1258 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1258 0.3981
Loa Loa (eye worm) hypothetical protein 0.0025 0.0164 0.0857
Brugia malayi PHD-finger family protein 0.0025 0.015 0.0742
Onchocerca volvulus 0.0078 0.1258 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0245 0.1296
Leishmania major pyruvate kinase 0.0037 0.0394 0.3088
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0394 0.3088
Brugia malayi PHD-finger family protein 0.0032 0.0309 0.1575
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.1841 1
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1258 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0245 0.1243
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0164 0.0857
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0024 0.0135 0.0127
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.049 0.2554
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0573 0.308
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.049 0.1577
Leishmania major pyruvate kinase 0.0037 0.0394 0.3088
Loa Loa (eye worm) hypothetical protein 0.011 0.1918 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.1258 0.1251
Brugia malayi beta-lactamase family protein 0.0078 0.1258 0.6542
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.2362 0.2356
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.1258 0.1251
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1026 0.5348
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0475 0.3739
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0024 0.0135 0.0127
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0169 0.3147 0.3141
Brugia malayi intermediate filament protein 0.0029 0.0245 0.1243
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.2088 0.2082
Loa Loa (eye worm) hypothetical protein 0.0078 0.1258 0.6556
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.071 0.5622
Loa Loa (eye worm) hypothetical protein 0.0038 0.0427 0.2228
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.071 0.3704
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0889 0.2882
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0573 0.308
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0309 0.1641
Toxoplasma gondii thioredoxin reductase 0.0052 0.071 0.5622
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.2088 0.2082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0358 0.1908
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0394 0.202
Echinococcus multilocularis musashi 0.0029 0.0245 0.1296
Loa Loa (eye worm) hypothetical protein 0.0032 0.0309 0.161
Echinococcus granulosus GPCR family 2 0.0035 0.0358 0.1908
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0889 0.4805
Schistosoma mansoni lamin 0.0029 0.0245 0.0777
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.071 0.3833
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0309 0.2408
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1258 1
Echinococcus granulosus ornithine aminotransferase 0.0024 0.0135 0.0691
Schistosoma mansoni inositol monophosphatase 0.004 0.0475 0.1529
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0309 0.1641
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.1918 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0061 0.0319
Loa Loa (eye worm) hypothetical protein 0.004 0.0476 0.2483
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.171 0.9286
Echinococcus granulosus pyruvate kinase 0.0019 0.0025 0.0091
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.1841 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0889 0.0882
Brugia malayi beta-lactamase family protein 0.0078 0.1258 0.6542
Plasmodium vivax glutathione reductase, putative 0.0052 0.071 0.5622
Schistosoma mansoni hypothetical protein 0.0032 0.0309 0.0985
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0309 0.2408
Mycobacterium tuberculosis Probable reductase 0.0118 0.2088 0.2082
Echinococcus multilocularis zinc finger protein 0.0019 0.0039 0.0172
Loa Loa (eye worm) glutathione reductase 0.0052 0.071 0.3704
Chlamydia trachomatis pyruvate kinase 0.0037 0.0394 1
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0394 0.1466
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0169 0.3147 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1095 0.571
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0889 0.7048
Mycobacterium ulcerans beta-lactamase 0.0078 0.1258 0.3981
Mycobacterium tuberculosis Conserved protein 0.0078 0.1258 0.1251
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0101 0.0506
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.2362 0.2356
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.1258 0.1251
Brugia malayi Inositol-1 0.004 0.0475 0.2446
Schistosoma mansoni bromodomain containing protein 0.0063 0.0942 0.3055
Brugia malayi glutathione reductase 0.0052 0.071 0.3678
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0475 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.2088 0.2082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0358 0.1908
Plasmodium falciparum thioredoxin reductase 0.0052 0.071 1
Echinococcus granulosus pyruvate kinase 0.0037 0.0394 0.2105
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0024 0.0135 0.0403
Mycobacterium ulcerans lipase LipD 0.0078 0.1258 0.3981
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0024 0.0135 0.0127
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0394 0.1229
Brugia malayi Bromodomain containing protein 0.0075 0.1184 0.6154
Loa Loa (eye worm) hypothetical protein 0.0078 0.1258 0.6556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.171 0.557
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.2088 0.6484
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.1258 1
Brugia malayi jmjC domain containing protein 0.0106 0.1841 0.9596
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0024 0.0135 0.3282
Schistosoma mansoni lamin 0.0029 0.0245 0.0777
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0024 0.0135 0.1013
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0169 0.3147 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.171 0.557
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0309 0.161
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0394 0.3088
Schistosoma mansoni pyruvate kinase 0.0037 0.0394 0.1263
Echinococcus multilocularis peregrin 0.0035 0.0358 0.1908
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0245 0.1279
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.1258 0.1251
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0889 0.2882
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.171 0.8916
Schistosoma mansoni pyruvate kinase 0.0019 0.0025 0.0055
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.1258 0.3981
Loa Loa (eye worm) hypothetical protein 0.0078 0.1258 0.6556
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.1918 1
Onchocerca volvulus Alhambra homolog 0.0032 0.0309 0.0626
Plasmodium falciparum glutathione reductase 0.0052 0.071 1
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0394 0.1466
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0024 0.0135 0.0414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.171 0.9286
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.2362 0.7393
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.2362 0.2356
Echinococcus granulosus pyruvate kinase 0.0019 0.0025 0.0091
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0135 0.0691
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0309 0.2408
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0475 0.3739
Echinococcus multilocularis GPCR, family 2 0.0035 0.0358 0.1908
Loa Loa (eye worm) hypothetical protein 0.0078 0.1258 0.6556
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.071 0.5622
Schistosoma mansoni hypothetical protein 0.0035 0.0358 0.1144
Mycobacterium leprae conserved hypothetical protein 0.0078 0.1258 0.3728
Mycobacterium tuberculosis Conserved protein 0.0078 0.1258 0.1251
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0394 0.2053
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1258 0.3981
Plasmodium falciparum phd finger protein, putative 0.0032 0.0309 0.4283
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0101 0.0304
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0025 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.171 0.557
Trypanosoma brucei trypanothione reductase 0.0052 0.071 0.5622
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1258 0.4089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.171 0.9286
Schistosoma mansoni hypothetical protein 0.0035 0.0358 0.1144
Schistosoma mansoni hypothetical protein 0.0075 0.1196 0.3887
Echinococcus multilocularis Aminotransferase class III 0.0024 0.0135 0.0691
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.171 0.8911
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0358 0.1908
Brugia malayi beta-lactamase 0.0078 0.1258 0.6542
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.1918 1
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0475 0.1489
Brugia malayi jmjC domain containing protein 0.0041 0.049 0.2523
Leishmania major trypanothione reductase 0.0052 0.071 0.5622
Plasmodium vivax hypothetical protein, conserved 0.0078 0.1258 1
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0394 0.2053
Mycobacterium ulcerans L-lysine aminotransferase 0.0024 0.0135 0.0403
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.1258 0.6817
Loa Loa (eye worm) hypothetical protein 0.0029 0.0245 0.1279
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0309 0.0985
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0475 0.1489
Loa Loa (eye worm) hypothetical protein 0.0037 0.0394 0.2053
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.1258 0.6556
Echinococcus granulosus pyruvate kinase 0.0037 0.0394 0.2105
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0475 0.2549
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0394 0.3088
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0394 0.3088
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.1258 0.6542
Plasmodium falciparum ornithine aminotransferase 0.0024 0.0135 0.1803
Schistosoma mansoni zinc finger protein 0.0019 0.0039 0.0103
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0358 0.1908
Mycobacterium ulcerans hypothetical protein 0.0078 0.1258 0.3981
Brugia malayi Bromodomain containing protein 0.0035 0.0358 0.1831
Echinococcus multilocularis pyruvate kinase 0.0029 0.0234 0.1234
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.071 0.0703
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0358 0.1831
Treponema pallidum NADH oxidase 0.0018 0.0008 0.5
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0101 0.0506
Loa Loa (eye worm) inositol-1 0.004 0.0475 0.2477
Brugia malayi Bromodomain containing protein 0.0038 0.0426 0.2188
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0024 0.0135 0.0403
Echinococcus multilocularis pyruvate kinase 0.0019 0.0025 0.0091
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0024 0.0135 0.2711
Mycobacterium ulcerans acetylornithine aminotransferase 0.0024 0.0135 0.0403
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0889 0.2806
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0475 0.3739
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.045 0.2414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.171 0.9286
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.1196 0.6219
Echinococcus multilocularis pyruvate kinase 0.0037 0.0394 0.2105
Echinococcus multilocularis ornithine aminotransferase 0.0024 0.0135 0.0691
Loa Loa (eye worm) hypothetical protein 0.0078 0.1258 0.6556
Echinococcus granulosus peregrin 0.0035 0.0358 0.1908
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0475 0.2549
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0868 0.469
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0358 0.1831
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1258 0.4089
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.049 0.2629
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0245 0.1279
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0024 0.0135 0.0127
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.1258 0.3981
Leishmania major hypothetical protein, conserved 0.0078 0.1258 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.2088 0.2082
Schistosoma mansoni jumonji domain containing protein 0.0084 0.1388 0.4515
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0024 0.0135 0.0403
Echinococcus granulosus zinc finger protein 0.0019 0.0039 0.0172
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0475 0.1489
Echinococcus multilocularis pyruvate kinase 0.0019 0.0025 0.0091
Loa Loa (eye worm) hypothetical protein 0.0078 0.1258 0.6556
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1258 0.3981
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0475 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0889 0.2806
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0889 0.4805
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0475 0.3739
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0889 0.7048
Loa Loa (eye worm) hypothetical protein 0.0075 0.1196 0.6234
Giardia lamblia Pyruvate kinase 0.0037 0.0394 1
Giardia lamblia PHD finger protein 15 0.0032 0.0309 0.7796
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0394 0.1466
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0394 0.0861
Schistosoma mansoni hypothetical protein 0.0035 0.0358 0.1144
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0387 0.0839
Loa Loa (eye worm) hypothetical protein 0.0056 0.079 0.4118
Schistosoma mansoni intermediate filament proteins 0.0029 0.0245 0.0777
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.1258 0.1251
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0377 0.2014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0475 0.3739
Mycobacterium leprae Probable lipase LipE 0.0078 0.1258 0.3728
Trichomonas vaginalis esterase, putative 0.0078 0.1258 0.3981
Giardia lamblia Pyruvate kinase 0.0019 0.0025 0.0434
Mycobacterium ulcerans hypothetical protein 0.0169 0.3147 1
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0169 0.3147 1
Schistosoma mansoni pyruvate kinase 0.0037 0.0394 0.1263
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1258 0.3981
Loa Loa (eye worm) hypothetical protein 0.0029 0.0234 0.1221
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.071 0.3833
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.1258 0.1251
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0394 0.1229
Echinococcus granulosus lamin dm0 0.0029 0.0245 0.1296
Onchocerca volvulus 0.0078 0.1258 1
Schistosoma mansoni hypothetical protein 0.0021 0.0061 0.0175
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0868 0.469
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0025 0.0238
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1258 0.3981
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0025 0.0134
Plasmodium falciparum pyruvate kinase 0.0037 0.0394 0.5493
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0394 0.1229
Echinococcus multilocularis lamin dm0 0.0029 0.0245 0.1296
Schistosoma mansoni hypothetical protein 0.0035 0.0358 0.1144
Schistosoma mansoni inositol monophosphatase 0.004 0.0475 0.1529
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0394 0.202
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0394 0.3088
Loa Loa (eye worm) hypothetical protein 0.0042 0.0516 0.2688
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0475 0.1489
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0394 0.0386
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.049 0.1577
Loa Loa (eye worm) hypothetical protein 0.0035 0.0358 0.1864
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.2088 0.2082
Brugia malayi Thioredoxin reductase 0.0052 0.071 0.3678
Echinococcus granulosus Aminotransferase class III 0.0024 0.0135 0.0691
Echinococcus granulosus lamin 0.0029 0.0245 0.1296
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0394 0.3088
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0024 0.0135 0.0663
Loa Loa (eye worm) beta-lactamase 0.0078 0.1258 0.6556
Echinococcus multilocularis lamin 0.0029 0.0245 0.1296
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0024 0.0135 0.0403
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0889 0.2806
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0394 0.2053
Echinococcus granulosus pyruvate kinase 0.0019 0.0025 0.0091
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.1258 0.1251
Mycobacterium tuberculosis Probable aminotransferase 0.0169 0.3147 0.3141
Mycobacterium tuberculosis Conserved protein 0.0078 0.1258 0.1251
Plasmodium vivax ornithine aminotransferase, putative 0.0024 0.0135 0.1013
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.1258 0.6817
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0387 0.038
Echinococcus multilocularis pyruvate kinase 0.0019 0.0025 0.0091
Onchocerca volvulus 0.0078 0.1258 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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