Detailed information for compound 1169412

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.42 | Formula: C19H25N3O4
  • H donors: 0 H acceptors: 2 LogP: 0.71 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1cnc2c1C(COCC1CCOCC1)CN(C2)C(=O)c1ccco1
  • InChi: 1S/C19H25N3O4/c1-21-13-20-16-10-22(19(23)17-3-2-6-26-17)9-15(18(16)21)12-25-11-14-4-7-24-8-5-14/h2-3,6,13-15H,4-5,7-12H2,1H3
  • InChiKey: OZXSNLNUFDAUSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0025 0.0012 0.01
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0012 0.0047
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0001 0.0007
Trypanosoma brucei pyruvate kinase 1, putative 0.0223 0.032 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0007 0.0058
Brugia malayi MH2 domain containing protein 0.0017 0.0001 0.0007
Brugia malayi MH1 domain containing protein 0.0017 0.0001 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0027 0.0231
Brugia malayi CHE-14 protein 0.0042 0.004 0.0521
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0048 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.0438 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0048 0.0041
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0059 0.165
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0027 0.0356
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0027 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.0438 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0025 0.0327
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0126 0.1658
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0126 0.1093
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0295 0.6677
Plasmodium falciparum pyruvate kinase 2 0.0115 0.0152 0.4618
Echinococcus granulosus lamin dm0 0.0031 0.0022 0.0191
Schistosoma mansoni hypothetical protein 0.0363 0.0537 0.4675
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0223 0.032 0.0313
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0027 0.0231
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0048 0.1968
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0027 0.0356
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0126 0.1093
Mycobacterium leprae Probable pyruvate kinase PykA 0.0223 0.032 0.0558
Brugia malayi Pre-SET motif family protein 0.0229 0.0328 0.4321
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.1148 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0356
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.1148 0.4651
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0026 0.0019
Echinococcus granulosus lamin 0.0031 0.0022 0.0191
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0002 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0001 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0082 0.0075
Echinococcus granulosus neuropeptide s receptor 0.0508 0.0761 0.6625
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.0082 0.0707
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0048 0.0634
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0027 0.0129
Loa Loa (eye worm) hypothetical protein 0.0138 0.0188 0.2473
Loa Loa (eye worm) hypothetical protein 0.0055 0.0059 0.0773
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0026 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0059 0.1646
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0027 0.0231
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0356
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.0295 0.6677
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0002 0.0027
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0388
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0027 0.0356
Trypanosoma cruzi pyruvate kinase 2, putative 0.0223 0.032 1
Onchocerca volvulus Pyruvate kinase homolog 0.0223 0.032 0.8393
Loa Loa (eye worm) hypothetical protein 0.0052 0.0054 0.0715
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0356
Onchocerca volvulus 0.026 0.0377 1
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0059 0.165
Schistosoma mansoni ap endonuclease 0.0021 0.0007 0.0058
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0027 0.0231
Schistosoma mansoni pyruvate kinase 0.0223 0.032 0.2785
Leishmania major hypothetical protein, conserved 0.0055 0.0059 0.165
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0057 0.0751
Loa Loa (eye worm) pyruvate kinase 0.0223 0.032 0.4215
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0025 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.0438 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0025 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.0438 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0027 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0027 0.0356
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0278 0.6297
Echinococcus multilocularis muscleblind protein 0.0507 0.0759 0.3075
Loa Loa (eye worm) hypothetical protein 0.0048 0.0048 0.0634
Brugia malayi nuclear receptor NHR-88 0.0034 0.0027 0.0356
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0027 0.0231
Loa Loa (eye worm) hypothetical protein 0.0156 0.0215 0.2837
Brugia malayi hypothetical protein 0.0151 0.0208 0.2744
Onchocerca volvulus 0.0048 0.0048 0.0725
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0027 0.0356
Brugia malayi MH1 domain containing protein 0.0017 0.0001 0.0007
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.032
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0048 0.0041
Schistosoma mansoni coup transcription factor 0.0034 0.0027 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0027 0.0356
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0007 0.0005
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0029 0.0711
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0127 0.1669
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0082 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0126 0.0508
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0027 0.0231
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0027 0.0356
Onchocerca volvulus 0.0034 0.0027 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.004 0.0753
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0022 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0048 0.0041
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.004 0.034
Mycobacterium ulcerans pyruvate kinase 0.0223 0.032 0.0313
Schistosoma mansoni lamin 0.0031 0.0022 0.0191
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0007 0.0095
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0027 0.0231
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0082 0.0102 0.0883
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0048 0.1314
Brugia malayi hypothetical protein 0.0055 0.0059 0.0773
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0192 0.1671
Brugia malayi steroid hormone receptor 0.0034 0.0027 0.0356
Schistosoma mansoni lamin 0.0031 0.0022 0.0191
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0027 0.0231
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0022 0.0296
Loa Loa (eye worm) hypothetical protein 0.0151 0.0208 0.2744
Plasmodium vivax pyruvate kinase, putative 0.0223 0.032 1
Echinococcus multilocularis musashi 0.0031 0.0022 0.0089
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0192 0.0777
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0007 0.0093
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0388
Entamoeba histolytica hypothetical protein 0.0082 0.0102 0.4545
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0027 0.0107
Echinococcus granulosus expressed conserved protein 0.0093 0.0117 0.1019
Echinococcus multilocularis lamin dm0 0.0031 0.0022 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0278 0.6297
Plasmodium vivax pyruvate kinase 2, putative 0.0115 0.0152 0.4618
Trypanosoma brucei pyruvate kinase 1 0.0223 0.032 1
Brugia malayi hypothetical protein 0.0082 0.0102 0.1341
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.0438 1
Onchocerca volvulus 0.0151 0.0208 0.5243
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0027 0.0356
Entamoeba histolytica hypothetical protein 0.0082 0.0102 0.4545
Echinococcus multilocularis pyruvate kinase 0.0223 0.032 0.1295
Echinococcus multilocularis muscleblind protein 1 0.0507 0.0759 0.3075
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.0328 0.4321
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0027 0.0356
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0278 0.6297
Echinococcus multilocularis pyruvate kinase 0.0176 0.0247 0.1
Loa Loa (eye worm) Smad1 0.0017 0.0001 0.0007
Trichomonas vaginalis set domain proteins, putative 0.026 0.0377 0.8594
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0048 0.0041
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0048 0.1968
Onchocerca volvulus 0.0033 0.0025 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0048 0.0634
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0048 0.0041
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0002 0.0027
Schistosoma mansoni transcription factor LCR-F1 0.0082 0.0102 0.0883
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0388
Giardia lamblia Pyruvate kinase 0.0115 0.0152 0.4618
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0007 0.0005
Loa Loa (eye worm) pyruvate kinase 0.0223 0.032 0.4215
Echinococcus granulosus pyruvate kinase 0.0115 0.0152 0.1317
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0059 0.165
Leishmania major pyruvate kinase 0.0223 0.032 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0007 0.0093
Mycobacterium ulcerans hypothetical protein 0.0048 0.0048 0.0041
Echinococcus granulosus muscleblind protein 0.0507 0.0759 0.6612
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0022 0.0296
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0059 0.1646
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0027 0.0356
Brugia malayi nuclear hormone receptor 0.0034 0.0027 0.0356
Brugia malayi hypothetical protein 0.0018 0.0002 0.0027
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0002 0.0006
Loa Loa (eye worm) pyruvate kinase 0.0047 0.0047 0.0619
Echinococcus multilocularis expressed conserved protein 0.0093 0.0117 0.0474
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0027 0.0231
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0027 0.0231
Echinococcus granulosus microtubule associated protein 2 0.0758 0.1148 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0027
Entamoeba histolytica pyruvate kinase, putative 0.0156 0.0215 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0029 0.0022
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0048 0.0041
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0048 0.1968
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0027 0.0356
Brugia malayi MH2 domain containing protein 0.0251 0.0362 0.4771
Schistosoma mansoni ap endonuclease 0.0021 0.0007 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0299 0.0438 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.0082 0.0075
Echinococcus multilocularis lamin 0.0031 0.0022 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0027 0.0356
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0027 0.0356
Onchocerca volvulus Huntingtin homolog 0.0138 0.0188 0.4662
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0027 0.0107
Echinococcus granulosus neuropeptide receptor A26 0.0508 0.0761 0.6625
Echinococcus granulosus pyruvate kinase 0.0223 0.032 0.2785
Loa Loa (eye worm) hypothetical protein 0.0099 0.0127 0.1669
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0025 0.0212
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0388
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0007 0.0095
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0027 0.0231
Loa Loa (eye worm) hypothetical protein 0.0036 0.0029 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0027 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0027 0.0356
Brugia malayi MH2 domain containing protein 0.0017 0.0001 0.0007
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0082 0.0707
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0007 0.0027
Brugia malayi hypothetical protein 0.0035 0.0029 0.0378
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0027 0.0107
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0027 0.0231
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.0082 0.2379
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0059 0.1646
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0027 0.0231
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0299 0.0438 0.5762
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0027 0.0231
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.0082 0.2383
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0127 0.5741
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0027 0.0231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0126 0.1658
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0025 0.0565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0027 0.0356
Giardia lamblia Pyruvate kinase 0.0223 0.032 1
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.0082 0.0707
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0082 0.0102 0.0411
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.032
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.004 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0278 0.6297
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.6473 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0027 0.0107
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0048 0.0041
Trichomonas vaginalis pyruvate kinase, putative 0.0223 0.032 0.7271
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0002 0.0027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.0082 0.0329
Chlamydia trachomatis pyruvate kinase 0.0223 0.032 1
Echinococcus granulosus geminin 0.0363 0.0537 0.4675
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0127 0.11
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0007 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0025 0.0212
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.004 0.0521
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0356
Trichomonas vaginalis pyruvate kinase, putative 0.0223 0.032 0.7271
Schistosoma mansoni intermediate filament proteins 0.0031 0.0022 0.0191
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0027 0.0231
Echinococcus multilocularis protein patched 0.0042 0.004 0.0158
Entamoeba histolytica hypothetical protein 0.0082 0.0102 0.4545
Loa Loa (eye worm) hypothetical protein 0.0042 0.004 0.0521
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0048 0.1314
Loa Loa (eye worm) pyruvate kinase-PB 0.0156 0.0215 0.2837
Brugia malayi hypothetical protein 0.0138 0.0188 0.2473
Echinococcus multilocularis neuropeptide receptor A26 0.0508 0.0761 0.3081
Schistosoma mansoni hypothetical protein 0.0363 0.0537 0.4675
Echinococcus multilocularis pyruvate kinase 0.0115 0.0152 0.0613
Echinococcus multilocularis pyruvate kinase 0.0115 0.0152 0.0613
Brugia malayi pyruvate kinase, muscle isozyme 0.0047 0.0047 0.0619
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0029 0.0022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0027 0.0107
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0027 0.0356
Echinococcus granulosus Protein patched homolog 1 0.0042 0.004 0.034
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0048 0.1314
Loa Loa (eye worm) hypothetical protein 0.0223 0.032 0.4215
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0299 0.0438 0.5762
Loa Loa (eye worm) hypothetical protein 0.0048 0.0048 0.0634
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0296
Echinococcus granulosus pyruvate kinase 0.0115 0.0152 0.1317
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0027 0.0356
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0027 0.0231
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0027 0.0129
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0002 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0278 0.6297
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0027 0.0356
Echinococcus granulosus pyruvate kinase 0.0223 0.032 0.2785
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0059 0.1646
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0278 0.6297
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0027 0.0107
Brugia malayi pyruvate kinase 0.0047 0.0047 0.0619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0126 0.1093
Echinococcus multilocularis protein dispatched 1 0.0048 0.0049 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0027 0.0231
Loa Loa (eye worm) hypothetical protein 0.0048 0.0048 0.0634
Plasmodium falciparum pyruvate kinase 0.0223 0.032 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0023 0.0196
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0048 0.0634
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0027
Entamoeba histolytica hypothetical protein 0.0082 0.0102 0.4545
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.0082 0.0074
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0127 0.0511
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0068 0.0079 0.1037
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0012 0.01
Loa Loa (eye worm) hypothetical protein 0.0507 0.0759 1
Toxoplasma gondii pyruvate kinase PyK1 0.0223 0.032 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0027 0.0231
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0129 0.112
Echinococcus multilocularis geminin 0.0363 0.0537 0.2174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0126 0.1093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0126 0.1093
Trypanosoma cruzi pyruvate kinase 2, putative 0.0223 0.032 1
Echinococcus multilocularis pyruvate kinase 0.0223 0.032 0.1295
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.032
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0027 0.0231
Brugia malayi intermediate filament protein 0.0031 0.0022 0.0296
Brugia malayi ecdysteroid receptor 0.0034 0.0027 0.0356
Brugia malayi Muscleblind-like protein 0.0507 0.0759 1
Schistosoma mansoni patched 1 0.0042 0.004 0.034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0026 0.0019
Brugia malayi Pre-SET motif family protein 0.0033 0.0025 0.0327
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0048 0.0041
Brugia malayi Cytochrome P450 family protein 0.0021 0.0007 0.0093
Echinococcus multilocularis neuropeptide s receptor 0.0508 0.0761 0.3081
Brugia malayi Smad1 0.0017 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0356
Echinococcus granulosus pyruvate kinase 0.0115 0.0152 0.1317
Schistosoma mansoni hypothetical protein 0.0041 0.0037 0.032
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0029 0.0711
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0278 0.6297
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.3193 0.4919 1
Leishmania major pyruvate kinase 0.0223 0.032 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0027 0.0231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0025 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0027 0.0356
Onchocerca volvulus Glucosylceramidase homolog 0.0196 0.0278 0.7211
Brugia malayi hypothetical protein 0.0018 0.0002 0.0027
Onchocerca volvulus Pyruvate kinase homolog 0.0223 0.032 0.8393
Toxoplasma gondii pyruvate kinase PyKII 0.0115 0.0152 0.4618
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0356
Loa Loa (eye worm) pyruvate kinase 0.0223 0.032 0.4215
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0027 0.0107
Schistosoma mansoni pyruvate kinase 0.0223 0.032 0.2785
Brugia malayi nuclear receptor RXR 0.0018 0.0002 0.0027
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0007 0.5
Loa Loa (eye worm) hypothetical protein 0.0507 0.0759 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.0362 0.4771
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0126 0.0508
Schistosoma mansoni pyruvate kinase 0.0115 0.0152 0.1317
Brugia malayi Cytochrome P450 family protein 0.0054 0.0057 0.0751
Loa Loa (eye worm) hypothetical protein 0.0138 0.0188 0.2473
Schistosoma mansoni hypothetical protein 0.0082 0.0102 0.0883
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.161 0.2468 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0027 0.0129
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.0362 0.4771
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0356
Onchocerca volvulus Pyruvate kinase homolog 0.0223 0.032 0.8393
Plasmodium vivax SET domain protein, putative 0.0033 0.0025 0.0565
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0027 0.0356
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0025 0.0212
Brugia malayi Pyruvate kinase, M2 isozyme 0.0223 0.032 0.4215
Brugia malayi Pyruvate kinase, muscle isozyme 0.0223 0.032 0.4215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0027 0.0356
Echinococcus granulosus intermediate filament protein 0.0031 0.0022 0.0191
Loa Loa (eye worm) hypothetical protein 0.0034 0.0027 0.0356
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0007 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0027 0.0356
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0027 0.0107
Onchocerca volvulus Huntingtin homolog 0.0138 0.0188 0.4662
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0025 0.0212
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0026 0.0019
Echinococcus multilocularis pyruvate kinase 0.0115 0.0152 0.0613

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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