Detailed information for compound 1171659

Basic information

Technical information
  • TDR Targets ID: 1171659
  • Name: [4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl ]piperazin-1-yl]-phenylmethanone
  • MW: 361.437 | Formula: C22H23N3O2
  • H donors: 0 H acceptors: 2 LogP: 3.2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)N1CCN(CC1)Cc1nc(oc1C)c1ccccc1
  • InChi: 1S/C22H23N3O2/c1-17-20(23-21(27-17)18-8-4-2-5-9-18)16-24-12-14-25(15-13-24)22(26)19-10-6-3-7-11-19/h2-11H,12-16H2,1H3
  • InChiKey: CJYYVSKSBLOKGZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[(5-methyl-2-phenyl-oxazol-4-yl)methyl]piperazin-1-yl]-phenyl-methanone
  • [4-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-1-piperazinyl]-phenylmethanone
  • [4-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]piperazin-1-yl]-phenyl-methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis zinc finger protein 0.0045 0.0153 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0672 0.0643
Schistosoma mansoni hypothetical protein 0.003 0.0069 0.0066
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0109 0.0079
Trichomonas vaginalis set domain proteins, putative 0.0732 0.389 1
Schistosoma mansoni transient receptor potential channel 0.0075 0.0313 0.031
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0147 0.0116
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0308 0.0838
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0308 0.0838
Loa Loa (eye worm) hypothetical protein 0.0154 0.0742 0.0714
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.1823 0.4628
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0126 0.0096
Loa Loa (eye worm) hypothetical protein 0.0074 0.0308 0.0278
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0109 0.0175
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0119 0.0089
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0305 0.0275
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0387 0.0358
Leishmania major GTP-binding protein, putative 0.0044 0.0147 0.0455
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0305 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0672 0.0669
Onchocerca volvulus 0.0074 0.0308 0.0581
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0088 0.0058
Onchocerca volvulus 0.0074 0.0308 0.0581
Brugia malayi SET domain containing protein 0.0018 0.0006 0.0006
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0147 0.0615
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0275 0.0245
Brugia malayi beta-lactamase family protein 0.0074 0.0308 0.0308
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0109 0.0079
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0052 0.0168
Loa Loa (eye worm) hypothetical protein 0.0042 0.0135 0.0104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0109 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0136 0.0246
Echinococcus multilocularis geminin 0.0659 0.3489 0.3469
Trichomonas vaginalis glucosylceramidase, putative 0.0371 0.1926 0.4897
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0233 0.1025
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0147 0.0673
Schistosoma mansoni hypothetical protein 0.0105 0.0478 0.0474
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.0732 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0109 0.0079
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1856 1 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0147 0.0116
Schistosoma mansoni hypothetical protein 0.0049 0.017 0.0167
Echinococcus multilocularis chromobox protein 1 0.0076 0.0318 0.0288
Echinococcus multilocularis transient receptor potential ion channel A 0.011 0.0502 0.0472
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0095 0.042 0.1771
Loa Loa (eye worm) hypothetical protein 0.04 0.208 0.2056
Echinococcus granulosus GPCR family 2 0.0049 0.017 0.014
Loa Loa (eye worm) beta-lactamase 0.0074 0.0308 0.0278
Schistosoma mansoni serine/threonine protein kinase 0.0409 0.213 0.2127
Echinococcus multilocularis snurportin 1 0.0643 0.3405 0.3385
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.029 0.0261
Echinococcus multilocularis importin subunit beta 1 0.006 0.0233 0.0203
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0122 0.0208
Schistosoma mansoni ets-related 0.0223 0.1118 0.1115
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.0732 0.3272
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0106 0.0103
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0308 0.069
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0088 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0122 0.0208
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0644 0.3408 0.3387
Loa Loa (eye worm) hypothetical protein 0.0105 0.0478 0.0448
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0308 0.2169
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0409 0.213 1
Onchocerca volvulus 0.0107 0.0487 0.1054
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0152 0.0732 0.3425
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0122 0.0208
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0109 0.0439
Echinococcus multilocularis short transient receptor potential channel 6 0.0075 0.0313 0.0284
Brugia malayi cell division control protein 2 homolog 0.0409 0.213 0.213
Trichomonas vaginalis helicase, putative 0.0027 0.0054 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.0409 0.213 0.2127
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.0732 0.3272
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0109 0.0498
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.017 0.014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.017 0.014
Echinococcus granulosus snurportin 1 0.0643 0.3405 0.3385
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.029 0.0261
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0308 0.0838
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0033 0.0087 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0308 0.123
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.2475 1
Echinococcus granulosus geminin 0.0659 0.3489 0.3469
Schistosoma mansoni ran 0.0044 0.0147 0.0143
Leishmania major importin beta-1 subunit, putative 0.0049 0.0171 0.0573
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0308 0.069
Entamoeba histolytica hypothetical protein 0.0037 0.0106 0.0483
Loa Loa (eye worm) hypothetical protein 0.0128 0.0603 0.0574
Loa Loa (eye worm) hypothetical protein 0.0076 0.0317 0.0287
Brugia malayi CXXC zinc finger family protein 0.0121 0.0563 0.0563
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0041 0.0127 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0033
Onchocerca volvulus 0.0732 0.389 1
Entamoeba histolytica hypothetical protein 0.0037 0.0106 0.0483
Brugia malayi Ets-domain containing protein 0.0073 0.0305 0.0305
Trypanosoma cruzi ISWI complex protein 0.003 0.0069 0.0083
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0122 0.0208
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0147 0.0455
Schistosoma mansoni hypothetical protein 0.0037 0.0106 0.0103
Schistosoma mansoni bromodomain containing protein 0.0132 0.0621 0.0618
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0052 0.0229
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0152 0.0732 1
Brugia malayi Protein kinase domain containing protein 0.0409 0.213 0.213
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0033
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0031 0.0027
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0318 0.0716
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.0732 1
Mycobacterium ulcerans beta-lactamase 0.0074 0.0308 0.3184
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0409 0.213 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0275 0.1073
Echinococcus multilocularis cpg binding protein 0.0132 0.0621 0.0592
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0672 0.0643
Echinococcus granulosus transient receptor potential ion channel A 0.011 0.0502 0.0472
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0275 0.0245
Trichomonas vaginalis CMGC family protein kinase 0.0409 0.213 0.5426
Mycobacterium leprae Probable lipase LipE 0.0074 0.0308 0.2169
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0109 0.0276
Brugia malayi Pre-SET motif family protein 0.0644 0.3408 0.3408
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.0203
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0308 0.3184
Entamoeba histolytica cell division protein kinase 2, putative 0.0409 0.213 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0136 0.0131
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0152 0.0732 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0409 0.213 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0672 0.0643
Toxoplasma gondii hypothetical protein 0.0052 0.019 0.0664
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0672 0.0672
Schistosoma mansoni transient receptor potential channel 4 0.0113 0.0522 0.0519
Loa Loa (eye worm) hypothetical protein 0.0063 0.0247 0.0217
Loa Loa (eye worm) hypothetical protein 0.0074 0.0308 0.0278
Schistosoma mansoni hypothetical protein 0.0049 0.017 0.0167
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0308 0.0838
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0152 0.0732 0.0703
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0033
Trichomonas vaginalis ran, putative 0.0044 0.0147 0.0272
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0308 0.0308
Schistosoma mansoni ran 0.0044 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0074 0.0308 0.0278
Echinococcus granulosus cyclin dependent kinase 1 0.0409 0.213 0.2105
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.0742 0.0742
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0109 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0053 0.0028
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1856 1 1
Loa Loa (eye worm) fli-1 protein 0.0223 0.1118 0.1091
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0275 0.1278
Brugia malayi Bromodomain containing protein 0.0155 0.0747 0.0747
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0184 0.0181
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0409 0.213 0.2105
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0275 0.0245
Trypanosoma brucei cdc2-related kinase 3 0.0409 0.213 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0122 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.017 0.017
Trypanosoma cruzi ISWI complex protein 0.003 0.0069 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.1823 0.4628
Schistosoma mansoni hypothetical protein 0.0049 0.017 0.0167
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0233 0.0872
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0052 0.019 0.0664
Brugia malayi Bromodomain containing protein 0.0075 0.0316 0.0316
Schistosoma mansoni cpg binding protein 0.0121 0.0563 0.056
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0308 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0069 0.007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0086 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0107 0.0487 0.0484
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0147 0.0147
Toxoplasma gondii histone lysine methyltransferase SET1 0.0237 0.1196 0.5506
Entamoeba histolytica Ran family GTPase 0.0044 0.0147 0.0673
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0147 0.0455
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0109 0.0498
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0033
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0147 0.0184
Mycobacterium ulcerans hypothetical protein 0.0074 0.0308 0.3184
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0128 0.0603 0.0574
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0672 0.0643
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.1823 0.4628
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0052 0.019 0.1296
Brugia malayi Probable ClpP-like protease 0.0152 0.0732 0.0732
Toxoplasma gondii exonuclease III APE 0.0038 0.0109 0.0276
Schistosoma mansoni gabp alpha 0.0073 0.0305 0.0301
Schistosoma mansoni zinc finger protein 0.0045 0.0153 0.0149
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0147 0.0455
Brugia malayi hypothetical protein 0.0027 0.0052 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.1823 0.4628
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0409 0.213 1
Entamoeba histolytica hypothetical protein 0.0037 0.0106 0.0483
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0308 0.0278
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0537 0.2828 0.2828
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0033
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0152 0.0732 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0342 0.0312
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0106 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.2828 0.724
Giardia lamblia Kinase, CMGC CDK 0.0409 0.213 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0672 0.0643
Schistosoma mansoni hypothetical protein 0.0041 0.0126 0.0123
Schistosoma mansoni mixed-lineage leukemia protein mll 0.026 0.132 0.1317
Schistosoma mansoni cpg binding protein 0.0132 0.0621 0.0618
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0119 0.0089
Echinococcus multilocularis short transient receptor potential channel 6 0.0075 0.0313 0.0284
Echinococcus multilocularis chromobox protein 1 0.0076 0.0318 0.0288
Schistosoma mansoni hypothetical protein 0.0643 0.3405 0.3403
Schistosoma mansoni chromobox protein 0.0076 0.0318 0.0314
Plasmodium vivax SET domain protein, putative 0.0095 0.042 0.1771
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0275 0.0275
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0308 0.0838
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.0087 0.0084
Echinococcus granulosus dnaJ subfamily B 0.0856 0.4561 0.4544
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.01 0.0447 0.1427
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0478 0.0478
Trypanosoma cruzi cdc2-related kinase 3 0.0409 0.213 1
Leishmania major hypothetical protein, conserved 0.0074 0.0308 0.123
Mycobacterium tuberculosis Conserved protein 0.0074 0.0308 0.0838
Giardia lamblia Kinase, CMGC CDK 0.0409 0.213 1
Echinococcus granulosus TRP transient receptor potential channel 0.0042 0.0135 0.0104
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.2828 0.724
Brugia malayi Ets-domain containing protein 0.0073 0.0305 0.0305
Loa Loa (eye worm) histone methyltransferase 0.0041 0.0127 0.0097
Trichomonas vaginalis esterase, putative 0.0074 0.0308 0.069
Plasmodium falciparum protein kinase 5 0.0409 0.213 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0122 0.0208
Echinococcus granulosus cyclin dependent kinase 5 0.0409 0.213 0.2105
Schistosoma mansoni peptidase Clp (S14 family) 0.0152 0.0732 0.0729
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0122 0.0208
Schistosoma mansoni ap endonuclease 0.0038 0.0109 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0672 0.0669
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0109 0.0276
Echinococcus multilocularis peptidase Clp (S14 family) 0.01 0.0447 0.0418
Echinococcus multilocularis cyclin dependent kinase 5 0.0409 0.213 0.2105
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0152 0.0732 0.0703
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0305 0.0275
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0125 0.0583 0.0554
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0021
Brugia malayi Importin beta-1 subunit 0.006 0.0233 0.0233
Loa Loa (eye worm) CXXC zinc finger family protein 0.0121 0.0563 0.0534
Brugia malayi RNA, U transporter 1 0.0171 0.0838 0.0838
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0109 0.0109
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0154 0.0291
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0275 0.1073
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0145 0.0145
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0052 0.019 0.0878
Schistosoma mansoni transient receptor potential channel 0.0075 0.0313 0.031
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0184 0.0154
Echinococcus granulosus chromobox protein 1 0.0076 0.0318 0.0288
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0042 0.0135 0.0104
Leishmania major hypothetical protein, conserved 0.003 0.0069 0.0083
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.0732 0.5
Onchocerca volvulus Glucosylceramidase homolog 0.0353 0.1823 0.4565
Schistosoma mansoni ap endonuclease 0.0038 0.0109 0.0106
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0275 0.1223
Schistosoma mansoni zinc finger protein 0.003 0.0069 0.0066
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0018 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0603 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0033
Schistosoma mansoni hypothetical protein 0.0659 0.3489 0.3487
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.1823 0.4628
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0275 0.1073
Schistosoma mansoni cpg binding protein 0.0132 0.0621 0.0618
Plasmodium vivax importin-beta 2, putative 0.006 0.0233 0.0872
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0308 0.3184
Mycobacterium tuberculosis Conserved protein 0.0074 0.0308 0.0838
Brugia malayi Latrophilin receptor protein 2 0.0049 0.017 0.017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0672 0.0669
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.004 0.0122 0.0208
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0184 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.2828 0.724
Brugia malayi Heterochromatin protein 1 0.0076 0.0318 0.0318
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0308 0.0838
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0147 0.0455
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0318 0.0288
Entamoeba histolytica hypothetical protein 0.0037 0.0106 0.0483
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0095 0.042 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0033
Brugia malayi beta-lactamase 0.0074 0.0308 0.0308
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0409 0.213 0.2105
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0409 0.213 0.2105
Loa Loa (eye worm) hypothetical protein 0.0074 0.0308 0.0278
Echinococcus multilocularis GPCR, family 2 0.0049 0.017 0.014
Trichomonas vaginalis CMGC family protein kinase 0.0409 0.213 0.5426
Echinococcus multilocularis cyclin dependent kinase 0.0409 0.213 0.2105
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0308 0.123
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.0087 0.0057
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0308 0.123
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.0732 0.5
Brugia malayi CHD4 protein 0.0023 0.0031 0.0031
Onchocerca volvulus 0.0074 0.0308 0.0581
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0053 0.0028
Schistosoma mansoni hypothetical protein 0.0659 0.3489 0.3487
Trypanosoma brucei ISWI complex protein 0.003 0.0069 0.025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0106 0.0076
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0275 0.0272
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.0087 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0308 0.069
Loa Loa (eye worm) hypothetical protein 0.0139 0.0663 0.0635
Loa Loa (eye worm) hypothetical protein 0.0074 0.0308 0.0278
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.1823 0.4628
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.1823 0.4628
Echinococcus granulosus zinc finger protein 0.0045 0.0153 0.0122
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0041 0.0127 0.0097
Loa Loa (eye worm) hypothetical protein 0.0152 0.0732 0.0703
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0308 0.0278
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0088 0.0085
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.2828 0.724
Loa Loa (eye worm) hypothetical protein 0.0038 0.0114 0.0084
Brugia malayi Pre-SET motif family protein 0.0095 0.042 0.042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.017 0.014
Brugia malayi chromobox protein homolog 3 0.0042 0.0136 0.0136
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0154 0.0291
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0308 0.0838
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0308 0.0304
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.01 0.0447 0.4744
Loa Loa (eye worm) hypothetical protein 0.0071 0.0293 0.0263
Echinococcus granulosus cpg binding protein 0.0132 0.0621 0.0592
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0171 0.0336
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0308 0.1377
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0152 0.0732 0.3272
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0308 0.069
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.2828 0.724
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.0742 0.0742
Brugia malayi beta-lactamase family protein 0.0074 0.0308 0.0308
Trypanosoma cruzi cdc2-related kinase 1 0.0409 0.213 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0154 0.0177
Echinococcus granulosus importin subunit beta 1 0.006 0.0233 0.0203
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0125 0.0583 0.0554
Echinococcus multilocularis cyclin dependent kinase 1 0.0409 0.213 0.2105
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.042 0.0417
Schistosoma mansoni hypothetical protein 0.0049 0.017 0.0167
Trichomonas vaginalis glucosylceramidase, putative 0.0371 0.1926 0.4897
Trichomonas vaginalis glucosylceramidase, putative 0.0537 0.2828 0.724
Schistosoma mansoni chromobox protein 0.0076 0.0318 0.0314
Echinococcus multilocularis transient receptor potential gamma protein 0.0113 0.0522 0.0493
Echinococcus granulosus transient receptor potential gamma protein 0.0113 0.0522 0.0493
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0643 0.3405 0.3385
Echinococcus granulosus mixed lineage leukemia protein mll 0.0033 0.0087 0.0057
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0308 0.0304
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0095 0.0064
Echinococcus multilocularis cyclin dependent kinase 1 0.0409 0.213 0.2105
Trichomonas vaginalis CMGC family protein kinase 0.0409 0.213 0.5426
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0171 0.0573
Mycobacterium ulcerans lipase LipD 0.0074 0.0308 0.3184
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1856 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0136 0.0246
Schistosoma mansoni importin beta-1 0.006 0.0233 0.023
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0128 0.0603 0.06
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0052 0.0229
Brugia malayi Transient-receptor-potential like protein 0.0042 0.0135 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0054 0.0033
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0088 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.1856 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.017 0.014
Entamoeba histolytica hypothetical protein 0.0049 0.0171 0.0789
Schistosoma mansoni hypothetical protein 0.0856 0.4561 0.4559
Trypanosoma cruzi cdc2-related kinase 3 0.0409 0.213 1
Onchocerca volvulus 0.0121 0.0563 0.1254
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0233 0.1025
Echinococcus granulosus cyclin dependent kinase 0.0409 0.213 0.2105
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0109 0.0175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.017 0.014
Plasmodium vivax protein kinase Crk2 0.0409 0.213 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0136 0.0106
Plasmodium falciparum importin beta, putative 0.006 0.0233 0.1081
Toxoplasma gondii ABC1 family protein 0.0074 0.0308 0.123
Echinococcus granulosus short transient receptor potential channel 6 0.0075 0.0313 0.0284
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0318 0.0716
Loa Loa (eye worm) hypothetical protein 0.0091 0.04 0.037
Loa Loa (eye worm) hypothetical protein 0.0074 0.0308 0.0278
Trypanosoma cruzi cdc2-related kinase 1 0.0409 0.213 1
Schistosoma mansoni transient receptor potential channel 0.0113 0.0522 0.0519
Trypanosoma brucei cdc2-related kinase 1 0.0409 0.213 1
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0171 0.0336
Mycobacterium tuberculosis Conserved protein 0.0074 0.0308 0.0838
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0147 0.0116
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.0742 0.0714
Brugia malayi hypothetical protein 0.0037 0.0106 0.0106
Echinococcus multilocularis dnaJ subfamily B 0.0856 0.4561 0.4544
Echinococcus granulosus short transient receptor potential channel 6 0.0075 0.0313 0.0284
Loa Loa (eye worm) hypothetical protein 0.0113 0.0522 0.0493
Echinococcus granulosus peptidase Clp S14 family 0.01 0.0447 0.0418
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0308 0.069
Brugia malayi Fli-1 protein 0.0223 0.1118 0.1118
Echinococcus granulosus chromobox protein 1 0.0076 0.0318 0.0288
Brugia malayi PHD-finger family protein 0.0056 0.021 0.021
Echinococcus granulosus histone lysine methyltransferase setb 0.0128 0.0603 0.0574
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.017 0.014
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.01 0.0447 0.1427
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0409 0.213 0.2105
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0537 0.2828 0.2805
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0171 0.0336
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0069 0.007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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