Detailed information for compound 1182053

Basic information

Technical information
  • TDR Targets ID: 1182053
  • Name: 3-(3-bromophenyl)-1-(3-methyl-1,1-dioxothiola n-3-yl)urea
  • MW: 347.228 | Formula: C12H15BrN2O3S
  • H donors: 2 H acceptors: 3 LogP: 1.38 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1(C)CCS(=O)(=O)C1)Nc1cccc(c1)Br
  • InChi: 1S/C12H15BrN2O3S/c1-12(5-6-19(17,18)8-12)15-11(16)14-10-4-2-3-9(13)7-10/h2-4,7H,5-6,8H2,1H3,(H2,14,15,16)
  • InChiKey: NBAUNJOGRKABSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-bromophenyl)-1-(3-methyl-1,1-dioxo-thiolan-3-yl)urea
  • 3-(3-bromophenyl)-1-(3-methyl-1,1-dioxo-3-thiolanyl)urea
  • 3-(3-bromophenyl)-1-(1,1-diketo-3-methyl-thiolan-3-yl)urea
  • STOCK5S-20076

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide s receptor 0.0492 0.5665 0.9573
Brugia malayi Carboxylesterase family protein 0.0087 0.0874 0.1443
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0038 0.0295 0.0459
Schistosoma mansoni importin beta-1 0.0031 0.0213 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0617 0.1007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0437 0.0414
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.027 0.1247
Schistosoma mansoni hypothetical protein 0.0044 0.0364 0.0576
Entamoeba histolytica glycogen phosphorylase, putative 0.0454 0.5215 1
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0216 0.7096
Brugia malayi Carboxylesterase family protein 0.0513 0.5916 1
Entamoeba histolytica hypothetical protein 0.0075 0.0736 0.1371
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0024 0.0112
Echinococcus granulosus acetylcholinesterase 0.0513 0.5916 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0117 0.0158
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0112
Loa Loa (eye worm) carboxylesterase 0.0087 0.0874 0.1443
Brugia malayi AMP-binding enzyme family protein 0.005 0.0446 0.0715
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0216 0.037
Echinococcus granulosus glycogen phosphorylase 0.0454 0.5215 0.881
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3082 0.589
Schistosoma mansoni acetylcholinesterase 0.0087 0.0874 0.1443
Entamoeba histolytica hypothetical protein 0.0031 0.0216 0.037
Echinococcus multilocularis snurportin 1 0.0329 0.3737 0.3722
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0117 0.4845
Brugia malayi carbohydrate phosphorylase 0.0454 0.5215 0.881
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0087 0.0874 0.0852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0103 0.0134
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0273 0.3082 0.519
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0103 0.0152
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0031 0.0216 0.037
Onchocerca volvulus 0.0087 0.0874 0.1638
Echinococcus multilocularis GPCR, family 2 0.005 0.0437 0.0414
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2085 0.3969
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0437 0.0414
Onchocerca volvulus 0.0051 0.0453 0.0826
Echinococcus multilocularis expressed conserved protein 0.0099 0.1017 0.0995
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0117 0.4604
Brugia malayi Carboxylesterase family protein 0.0087 0.0874 0.1443
Leishmania major GTP-binding protein, putative 0.0023 0.0117 0.2208
Echinococcus multilocularis neuroligin 0.0087 0.0874 0.0852
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0213 0.9855
Echinococcus granulosus expressed conserved protein 0.0099 0.1017 0.1685
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0216 0.0326
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0446 0.1963
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0446 0.1963
Brugia malayi Latrophilin receptor protein 2 0.005 0.0437 0.0701
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0117 0.0158
Echinococcus granulosus snurportin 1 0.0329 0.3737 0.6302
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0103 0.0152
Loa Loa (eye worm) hypothetical protein 0.0031 0.0216 0.0326
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0117 0.4845
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0383 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0103 0.0134
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0087 0.0874 0.4031
Schistosoma mansoni glycogen phosphorylase 0.0454 0.5215 0.881
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0032 0.0225 0.0341
Echinococcus multilocularis glycogen phosphorylase 0.0454 0.5215 0.5204
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0103 0.0152
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0058 0.0268
Loa Loa (eye worm) hypothetical protein 0.0032 0.0226 0.0343
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0058 0.0268
Treponema pallidum DNA ligase (lig) 0.0031 0.0216 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0103 0.0134
Brugia malayi hypothetical protein 0.0075 0.0736 0.1208
Loa Loa (eye worm) hypothetical protein 0.0045 0.0383 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0087 0.0874 0.1443
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0446 0.1963
Leishmania major importin beta-1 subunit, putative 0.0025 0.0145 0.2855
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0134
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0103 0.0134
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.2809 0.2792
Chlamydia trachomatis glycogen phosphorylase 0.0454 0.5215 1
Schistosoma mansoni hypothetical protein 0.005 0.0437 0.0701
Brugia malayi Carboxylesterase family protein 0.0087 0.0874 0.1443
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0117 0.4845
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0295 0.0157
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0446 0.1963
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0134
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0103 0.0134
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0213 0.019
Schistosoma mansoni hypothetical protein 0.005 0.0437 0.0701
Schistosoma mansoni hypothetical protein 0.005 0.0437 0.0701
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0103 0.0134
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0216 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0087 0.0874 0.1443
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0103 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.197 0.3749
Echinococcus multilocularis Glycosyl transferase, family 35 0.0454 0.5215 0.5204
Schistosoma mansoni glycogen phosphorylase 0.0196 0.2169 0.3641
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0226 0.0202
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0446 0.0811
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0216 0.037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0103 0.0134
Schistosoma mansoni ferritin 0.0018 0.0058 0.0057
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0117 0.3438
Echinococcus multilocularis glycogen phosphorylase 0.0454 0.5215 0.5204
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0216 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0103 0.0134
Echinococcus multilocularis acetylcholinesterase 0.0513 0.5916 0.5906
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0103 0.0079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0103 0.0134
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0024 0.0112
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0103 0.0134
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0453 0.0728
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0024 0.0112
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0058 0.0804
Echinococcus granulosus para nitrobenzyl esterase 0.0087 0.0874 0.1443
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0103 0.0134
Loa Loa (eye worm) carboxylesterase 0.0087 0.0874 0.1443
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0216 0.037
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0103 0.0134
Schistosoma mansoni patched 1 0.0045 0.0383 0.0609
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0087 0.0874 0.1443
Schistosoma mansoni ferritin 0.0018 0.0058 0.0057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.1707 0.2857
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3082 0.589
Entamoeba histolytica hypothetical protein 0.0075 0.0736 0.1371
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0117 0.0158
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0216 0.0326
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0058 0.0158
Onchocerca volvulus 0.0253 0.2841 0.5426
Schistosoma mansoni topbp1 0.0031 0.0216 0.0326
Schistosoma mansoni DNA ligase IV 0.0031 0.0216 0.0326
Echinococcus multilocularis nibrin 0.0031 0.0216 0.0192
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0383 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0216 0.037
Schistosoma mansoni hypothetical protein 0.005 0.0437 0.0701
Loa Loa (eye worm) hypothetical protein 0.0031 0.0216 0.0326
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0145 0.0232
Loa Loa (eye worm) hypothetical protein 0.0031 0.0216 0.0326
Brugia malayi CHE-14 protein 0.0045 0.0383 0.0609
Schistosoma mansoni ferritin light chain 0.0018 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0134
Brugia malayi topoisomerase 0.0031 0.0216 0.0326
Trichomonas vaginalis ran, putative 0.0023 0.0117 0.0179
Echinococcus multilocularis protein dispatched 1 0.0052 0.0458 0.0435
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0437 0.0701
Brugia malayi hypothetical protein 0.0031 0.0216 0.0326
Trichomonas vaginalis spcc417.12 protein, putative 0.0087 0.0874 0.1638
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0446 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0437 0.0701
Schistosoma mansoni ferritin 0.0018 0.0058 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0103 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0216 1
Onchocerca volvulus 0.005 0.0446 0.0811
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0383 0.0691
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0103 0.0134
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0024 0.0112
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0117 0.3438
Brugia malayi AMP-binding enzyme family protein 0.005 0.0446 0.0715
Loa Loa (eye worm) carboxylesterase 0.0513 0.5916 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0103 0.0079
Loa Loa (eye worm) RNA binding protein 0.0065 0.0617 0.1007
Schistosoma mansoni hypothetical protein 0.0075 0.0736 0.1208
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.027 0.1247
Loa Loa (eye worm) hypothetical protein 0.0107 0.112 0.1859
Echinococcus granulosus BC026374 protein S09 family 0.0087 0.0874 0.1443
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0216 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0087 0.0874 0.1443
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0213 0.9855
Echinococcus granulosus glycogen phosphorylase 0.0454 0.5215 0.881
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0103 0.0134
Loa Loa (eye worm) acetylcholinesterase 1 0.0513 0.5916 1
Brugia malayi RNA, U transporter 1 0.0088 0.0885 0.1461
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0058 0.0158
Echinococcus granulosus survival motor neuron protein 1 0.025 0.2809 0.4727
Loa Loa (eye worm) hypothetical protein 0.0087 0.0874 0.1443
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3082 0.589
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0103 0.0134
Trichomonas vaginalis replication factor C large subunit, putative 0.0031 0.0216 0.037
Echinococcus granulosus expressed protein 0.0018 0.0058 0.0057
Entamoeba histolytica glycogen phosphorylase, putative 0.0454 0.5215 1
Schistosoma mansoni ran 0.0023 0.0117 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0103 0.0134
Brugia malayi steroid hormone receptor 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0038 0.0295 0.0459
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0216 0.0192
Schistosoma mansoni coup transcription factor 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0055 0.0503 0.0812
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0103 0.0134
Echinococcus granulosus tar DNA binding protein 0.0065 0.0617 0.1007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0617 0.1007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0103 0.0134
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0103 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0103 0.0134
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0103 0.0134
Echinococcus granulosus ferritin 0.0018 0.0058 0.0057
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.1093 0.2058
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.197 0.3749
Schistosoma mansoni hypothetical protein 0.0044 0.0364 0.0576
Trichomonas vaginalis ferritin, putative 0.0018 0.0058 0.0065
Brugia malayi Pre-SET motif family protein 0.0032 0.0226 0.0343
Echinococcus granulosus GPCR family 2 0.005 0.0437 0.0701
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0024 0.0112
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0437 0.0701
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.1626 0.1606
Loa Loa (eye worm) hypothetical protein 0.0105 0.1093 0.1813
Loa Loa (eye worm) hypothetical protein 0.0513 0.5916 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0295 0.0459
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0031 0.0216 0.4557
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0103 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0103 0.0134
Brugia malayi Carboxylesterase family protein 0.0513 0.5916 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0103 0.0134
Brugia malayi hypothetical protein 0.0031 0.0216 0.0326
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0617 0.0595
Schistosoma mansoni ferritin 0.0018 0.0058 0.0057
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0216 0.0326
Echinococcus multilocularis ferritin 0.0018 0.0058 0.0034
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0617 0.1007
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0736 0.1208
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0446 0.1963
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0617 0.1007
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0031 0.0216 0.0326
Schistosoma mansoni topbp1 0.0031 0.0216 0.0326
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0112
Loa Loa (eye worm) hypothetical protein 0.0087 0.0874 0.1443
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0446 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0617 0.1007
Brugia malayi RNA binding protein 0.0065 0.0617 0.1007
Trichomonas vaginalis glycogen phosphorylase, putative 0.0454 0.5215 1
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0196 0.2169 1
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.1093 0.1813
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0282 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0103 0.0134
Entamoeba histolytica Ran family GTPase 0.0023 0.0117 0.0179
Schistosoma mansoni glycogen phosphorylase 0.0454 0.5215 0.881
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0103 0.0079
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0383 0.0609
Giardia lamblia Replication factor C, subunit 1 0.0031 0.0216 0.0194
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0145 0.0232
Brugia malayi AMP-binding enzyme family protein 0.005 0.0446 0.0715
Onchocerca volvulus Glycogen phosphorylase homolog 0.0454 0.5215 1
Onchocerca volvulus 0.0021 0.0103 0.0152
Loa Loa (eye worm) hypothetical protein 0.0038 0.0295 0.0459
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0031 0.0216 0.0895
Onchocerca volvulus 0.0031 0.0216 0.037
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.197 0.3749
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0216 0.037
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0103 0.0079
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0226 0.0343
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.1112 0.1846
Brugia malayi nuclear hormone receptor 0.0021 0.0103 0.0134
Onchocerca volvulus 0.0032 0.0226 0.0389
Schistosoma mansoni gliotactin 0.0087 0.0874 0.1443
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0103 0.0134
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0295 1
Echinococcus granulosus nibrin 0.0031 0.0216 0.0326
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0134
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0087 0.0874 0.1443
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0087 0.0874 0.4031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0024 0.0112
Echinococcus granulosus neuroligin 0.0087 0.0874 0.1443
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.1626 0.2719
Brugia malayi DKFZp564C0469 protein 0.0031 0.0216 0.0326
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.197 0.3749
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0322 0.0505
Onchocerca volvulus 0.0087 0.0874 0.1638
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0273 0.3082 0.519
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.1707 0.2857
Brugia malayi Pre-SET motif family protein 0.0222 0.2478 0.4164
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3082 0.589
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0031 0.0216 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0446 0.2054
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3082 0.589
Onchocerca volvulus 0.0087 0.0874 0.1638
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0383 0.0609
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0282 0.0438
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0282 0.0438
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0216 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.005 0.0437 0.0701
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0446 0.1963
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0087 0.0874 0.1443
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0103 0.0079
Echinococcus granulosus Glycosyl transferase family 35 0.0454 0.5215 0.881
Echinococcus multilocularis neuropeptide receptor A26 0.0492 0.5665 0.5654
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.2478 0.4164
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.197 0.3749
Echinococcus multilocularis para nitrobenzyl esterase 0.0087 0.0874 0.0852
Mycobacterium tuberculosis Carboxylesterase LipT 0.0087 0.0874 0.4031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0103 0.0134
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3082 0.589
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0103 0.0134
Echinococcus multilocularis protein patched 0.0045 0.0383 0.0359
Loa Loa (eye worm) hypothetical protein 0.0031 0.0216 0.0326
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0216 0.7096
Entamoeba histolytica hypothetical protein 0.0075 0.0736 0.1371
Brugia malayi hypothetical protein 0.0087 0.0874 0.1443
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0295 1
Schistosoma mansoni apoferritin-2 0.0018 0.0058 0.0057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0446 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0103 0.0134
Onchocerca volvulus 0.0087 0.0874 0.1638
Echinococcus granulosus importin subunit beta 1 0.0031 0.0213 0.0321
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0254 0.0442
Giardia lamblia Glycogen phosphorylase 0.0454 0.5215 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0103 0.0134
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.197 0.3749
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0216 0.037
Brugia malayi TAR-binding protein 0.0065 0.0617 0.1007
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0617 0.1007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0736 0.1208
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0196 0.2169 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0254 0.0442
Echinococcus granulosus carboxylesterase 5A 0.0513 0.5916 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0446 0.0811
Echinococcus multilocularis expressed protein 0.0018 0.0058 0.0034
Onchocerca volvulus 0.0087 0.0874 0.1638
Echinococcus multilocularis acetylcholinesterase 0.0513 0.5916 0.5906
Entamoeba histolytica hypothetical protein 0.0075 0.0736 0.1371
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0145 0.0232
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0145 0.6266
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0103 0.0079
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0446 0.1963
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0216 0.037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0226 0.0343
Entamoeba histolytica glycogenphosphorylase, putative 0.0196 0.2169 0.4132
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0103 0.0134
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0226 0.0202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0446 0.2054
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0446 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0021 0.0103 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.027 0.1247
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0513 0.5916 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0446 0.0715
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.197 0.3749
Entamoeba histolytica hypothetical protein 0.0025 0.0145 0.0232
Loa Loa (eye worm) hypothetical protein 0.0031 0.0216 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0103 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0617 0.1007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0226 0.0343
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0024 0.0112
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0446 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.027 0.1247
Schistosoma mansoni hypothetical protein 0.0044 0.0364 0.0576
Echinococcus granulosus neuropeptide receptor A26 0.0492 0.5665 0.9573
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.1707 0.2857
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0226 1
Schistosoma mansoni hypothetical protein 0.0107 0.112 0.1859
Onchocerca volvulus 0.0019 0.0073 0.0093
Loa Loa (eye worm) hypothetical protein 0.025 0.2809 0.4727
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0103 0.0134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0437 0.0701
Schistosoma mansoni ferritin light chain 0.0018 0.0058 0.0057
Loa Loa (eye worm) glycogen phosphorylase 0.0454 0.5215 0.881
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0617 0.1007
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0103 0.0134
Schistosoma mansoni BC026374 protein (S09 family) 0.0087 0.0874 0.1443
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0103 0.0134
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0295 0.1359
Entamoeba histolytica glycogen phosphorylase, putative 0.0196 0.2169 0.4132
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0103 0.0134
Schistosoma mansoni ran 0.0023 0.0117 0.0158
Echinococcus multilocularis BC026374 protein (S09 family) 0.0087 0.0874 0.0852
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.112 0.1859
Brugia malayi ecdysteroid receptor 0.0021 0.0103 0.0134
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0513 0.5916 1
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0216 0.0326
Loa Loa (eye worm) hypothetical protein 0.0031 0.0213 0.0321
Brugia malayi hypothetical protein 0.025 0.2809 0.4727
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0446 0.0811
Echinococcus granulosus acetylcholinesterase 0.0513 0.5916 1
Mycobacterium ulcerans carboxylesterase, LipT 0.0087 0.0874 0.3963
Mycobacterium ulcerans hypothetical protein 0.005 0.0446 0.1963
Plasmodium vivax importin-beta 2, putative 0.0031 0.0213 0.6994
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0295 0.1261
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.1093 0.1071
Trichomonas vaginalis glycogen phosphorylase, putative 0.0454 0.5215 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0117 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0087 0.0874 0.1443
Loa Loa (eye worm) hypothetical protein 0.005 0.0446 0.0715
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0282 0.0438
Plasmodium vivax SET domain protein, putative 0.0032 0.0226 0.7469
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.197 0.3749
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0226 0.0343
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0216 0.037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0736 0.0713
Plasmodium falciparum importin beta, putative 0.0031 0.0213 0.6994
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0087 0.0874 0.1443
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0213 0.9364
Loa Loa (eye worm) hypothetical protein 0.0157 0.1707 0.2857
Loa Loa (eye worm) hypothetical protein 0.0038 0.0295 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0103 0.0134
Loa Loa (eye worm) hypothetical protein 0.0087 0.0874 0.1443
Schistosoma mansoni hypothetical protein 0.0051 0.0453 0.0728
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0216 0.037
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0216 0.9502
Brugia malayi Carboxylesterase family protein 0.0087 0.0874 0.1443
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2085 0.3969
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0103 0.0134
Schistosoma mansoni survival motor neuron protein 0.0051 0.0453 0.0728
Echinococcus multilocularis neuropeptide s receptor 0.0492 0.5665 0.5654
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0322 0.0505
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.3737 0.6302
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0216 0.9501
Schistosoma mansoni hypothetical protein 0.0329 0.3737 0.6302
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0212 0.0319
Schistosoma mansoni apoferritin-2 0.0018 0.0058 0.0057
Echinococcus multilocularis carboxylesterase 5A 0.0513 0.5916 0.5906
Trichomonas vaginalis set domain proteins, putative 0.0253 0.2841 0.5426
Loa Loa (eye worm) hypothetical protein 0.005 0.0446 0.0715
Entamoeba histolytica glycogen phosphorylase, putative 0.0196 0.2169 0.4132
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0087 0.0874 0.1443
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0103 0.0079
Brugia malayi Importin beta-1 subunit 0.0031 0.0213 0.0321
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0226 0.0343
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.1093 0.1813
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0087 0.0874 0.1638
Schistosoma mansoni hypothetical protein 0.0044 0.0364 0.0576

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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