Detailed information for compound 1204666

Basic information

Technical information
  • TDR Targets ID: 1204666
  • Name: ethyl 5-[2-[(5-chloro-2-methoxyphenyl)amino]- 2-oxoethyl]-4-oxo-[1,2]oxazolo[5,4-d]pyrimidi ne-3-carboxylate
  • MW: 406.777 | Formula: C17H15ClN4O6
  • H donors: 1 H acceptors: 4 LogP: 1.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1noc2c1c(=O)n(cn2)CC(=O)Nc1cc(Cl)ccc1OC
  • InChi: 1S/C17H15ClN4O6/c1-3-27-17(25)14-13-15(28-21-14)19-8-22(16(13)24)7-12(23)20-10-6-9(18)4-5-11(10)26-2/h4-6,8H,3,7H2,1-2H3,(H,20,23)
  • InChiKey: NCMMGZAQINVBBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 5-[2-[(5-chloro-2-methoxy-phenyl)amino]-2-oxo-ethyl]-4-oxo-isoxazolo[5,4-d]pyrimidine-3-carboxylate
  • 5-[2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl]-4-oxo-3-isoxazolo[5,4-d]pyrimidinecarboxylic acid ethyl ester
  • 5-[2-[(5-chloro-2-methoxy-phenyl)amino]-2-keto-ethyl]-4-keto-isoxazolo[5,4-d]pyrimidine-3-carboxylic acid ethyl ester
  • ethyl 5-[2-[(5-chloro-2-methoxy-phenyl)amino]-2-oxo-ethyl]-4-oxo-[1,2]oxazolo[5,4-d]pyrimidine-3-carboxylate
  • NCGC00132916-01
  • G662-0067

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0017 0.1203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Onchocerca volvulus 0.0016 0.0007 0.0102
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0057 0.0143 0.0407
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0057 0.0143 0.0431
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0198 0.0564
Onchocerca volvulus 0.0048 0.0114 0.1575
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0193 0.0193
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.111 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0074 0.0074
Mycobacterium tuberculosis Conserved protein 0.0074 0.0201 0.0607
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.005
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0207 0.5
Mycobacterium tuberculosis Conserved protein 0.0074 0.0201 0.0607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0074 0.0211
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0143 0.0407
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0201 0.0574
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0057 0.0143 0.0431
Echinococcus granulosus geminin 0.0165 0.0505 0.0505
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0198 0.0596
Schistosoma mansoni loxhd1 0.0019 0.0017 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.1004 0.3313 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0074 0.0666
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0198 0.1779
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0057 0.0143 0.0431
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0057 0.0143 0.0431
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0169 0.0518 0.1563
Trichomonas vaginalis antibiotic synthetase, putative 0.0057 0.0143 0.1286
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0725 0.6528
Onchocerca volvulus 0.0016 0.0007 0.0102
Brugia malayi beta-lactamase 0.0074 0.0201 0.0574
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0057 0.0143 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0198 0.0564
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0057 0.0143 0.4024
Loa Loa (eye worm) hypothetical protein 0.0074 0.0201 0.0574
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0007 0.0518
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0193 0.0582
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0122 0.0122
Echinococcus granulosus RUN 0.0019 0.0017 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0201 0.1811
Onchocerca volvulus 0.0029 0.0048 0.0663
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0074 0.0074
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0057 0.0143 0.0407
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.005 0.005
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0031 0.0055 0.0165
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0031 0.0055 0.0156
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0143 0.0407
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0143 0.0407
Echinococcus multilocularis RUN 0.0019 0.0017 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0143 0.0407
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.111 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0067
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0007 0.0102
Onchocerca volvulus 0.0016 0.0007 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0067
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0207 0.0626
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0143 0.0407
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0198 0.0564
Onchocerca volvulus 0.0057 0.0143 0.197
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0346 0.111 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0156
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0067
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0007 0.0021
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0117 0.0349
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0057 0.0143 0.0407
Onchocerca volvulus 0.0057 0.0143 0.197
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0067
Toxoplasma gondii ABC1 family protein 0.0074 0.0201 0.5667
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0201 0.1811
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0198 0.0596
Echinococcus multilocularis microtubule associated protein 2 0.3002 1 1
Echinococcus granulosus lamin dm0 0.0029 0.0048 0.0048
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0057 0.0143 0.0431
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0631 0.1801
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0162 0.0482
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0057 0.0143 0.1286
Brugia malayi Pre-SET motif family protein 0.0203 0.0631 0.1801
Onchocerca volvulus 0.0029 0.0048 0.0663
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0067
Schistosoma mansoni polycystin 1-related 0.0019 0.0017 0.0017
Loa Loa (eye worm) ctsf protein 0.0016 0.0007 0.0021
Leishmania major cathepsin L-like protease 0.0063 0.0162 0.0489
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0193 0.0551
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0207 0.1869
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0122 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0074 0.0666
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0201 0.1811
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0143 0.0407
Schistosoma mansoni inositol monophosphatase 0.0076 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0073 0.0198 0.0564
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0201 0.0607
Mycobacterium ulcerans lipase LipD 0.0074 0.0201 0.0574
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0122 0.0349
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0007 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.111 1
Leishmania major hypothetical protein, conserved 0.0074 0.0201 0.0607
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0143 0.0431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0031 0.0055 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0074 0.0666
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0201 0.0574
Treponema pallidum fructose-bisphosphate aldolase 0.0346 0.111 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0007 0.0518
Schistosoma mansoni acetyl-CoA synthetase 0.0057 0.0143 0.0143
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0057 0.0143 0.0407
Onchocerca volvulus 0.0016 0.0007 0.0102
Onchocerca volvulus 0.0074 0.0201 0.2774
Onchocerca volvulus 0.0019 0.0017 0.0237
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0165 0.0505 0.0505
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0074 0.022
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0057 0.0143 0.0431
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0048 0.0137
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0057 0.0143 0.0407
Plasmodium vivax SET domain protein, putative 0.0029 0.005 0.2472
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0021
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0007 0.0102
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0181 0.0545
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0201 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0143 0.0431
Loa Loa (eye worm) hypothetical protein 0.0074 0.0201 0.0574
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0007 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0057 0.0143 0.0425
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0134 0.0134
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0201 0.0607
Toxoplasma gondii MAPEG family protein 0.012 0.0355 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0049
Mycobacterium tuberculosis Conserved protein 0.0074 0.0201 0.0607
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0156
Plasmodium vivax vivapain-2 0.0016 0.0007 0.0368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0067
Onchocerca volvulus 0.0057 0.0143 0.197
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0156
Schistosoma mansoni FFA transport protein 0.1018 0.3361 0.3361
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0057 0.0143 0.6881
Loa Loa (eye worm) hypothetical protein 0.0073 0.0198 0.0564
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0201 0.1811
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0122 0.0122
Loa Loa (eye worm) oxidoreductase 0.0057 0.0143 0.0407
Loa Loa (eye worm) hypothetical protein 0.0029 0.0048 0.0137
Loa Loa (eye worm) hypothetical protein 0.0074 0.0201 0.0574
Schistosoma mansoni intermediate filament proteins 0.0029 0.0048 0.0048
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0201 0.0574
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0201 0.0574
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0207 0.0207
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0198 0.0596
Schistosoma mansoni lipoxygenase 0.0019 0.0017 0.0017
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0017 0.0854
Echinococcus granulosus long chain fatty acid transport protein 4 0.1018 0.3361 0.3361
Loa Loa (eye worm) hypothetical protein 0.0036 0.0074 0.0211
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0049
Schistosoma mansoni lipoxygenase 0.0054 0.0134 0.0134
Brugia malayi beta-lactamase family protein 0.0074 0.0201 0.0574
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0022
Onchocerca volvulus 0.0074 0.0201 0.2774
Brugia malayi hypothetical protein 0.0019 0.0017 0.0049
Brugia malayi beta-lactamase family protein 0.0074 0.0201 0.0574
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0122 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.111 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Schistosoma mansoni rab6-interacting 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0048 0.0114 0.0326
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0067
Brugia malayi Pre-SET motif family protein 0.0029 0.005 0.0142
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0017
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0074 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0201 0.0607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0057 0.0143 0.0143
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0043 0.0095 0.0287
Brugia malayi AMP-binding enzyme family protein 0.1061 0.3504 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0017 0.0017
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0346 0.111 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.005 0.1401
Echinococcus multilocularis musashi 0.0029 0.0048 0.0048
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0207 1
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0201 0.969
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0143 0.0407
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0007 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0198 0.0564
Brugia malayi hypothetical protein 0.0019 0.0017 0.0049
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0198 0.0596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0122 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0143 0.0407
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0193 0.0193
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0007 0.0022
Echinococcus multilocularis long chain fatty acid transport protein 4 0.1018 0.3361 0.3361
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0207 0.0207
Loa Loa (eye worm) beta-lactamase 0.0074 0.0201 0.0574
Loa Loa (eye worm) hypothetical protein 0.0074 0.0201 0.0574
Echinococcus multilocularis lamin dm0 0.0029 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.1541 0.4651
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0207 0.1869
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0143 0.0431
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0169 0.0518 0.1478
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0162 0.0482
Onchocerca volvulus 0.0074 0.0201 0.2774
Onchocerca volvulus 0.0016 0.0007 0.0102
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.005 0.005
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0057 0.0143 0.0425
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0007
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0207 0.0617
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0143 0.0431
Loa Loa (eye worm) hypothetical protein 0.0074 0.0201 0.0574
Trichomonas vaginalis antibiotic synthetase, putative 0.0057 0.0143 0.1286
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0193 0.0551
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0143 0.0407
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0198 0.1779
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0162 0.0482
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0201 0.0598
Schistosoma mansoni hypothetical protein 0.0165 0.0505 0.0505
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.1061 0.3504 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0201 0.0201
Toxoplasma gondii propionate-CoA ligase 0.0057 0.0143 0.4024
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0017 0.0049
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0198 0.0596
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0057 0.0143 0.0407
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0004 0.001
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0074 0.0074
Brugia malayi Inositol-1 0.0076 0.0207 0.0592
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0074 0.022
Mycobacterium ulcerans hypothetical protein 0.0074 0.0201 0.0574
Loa Loa (eye worm) hypothetical protein 0.0074 0.0201 0.0574
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0074 0.0074
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0198 0.1779
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0201 0.0201
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Trichomonas vaginalis esterase, putative 0.0074 0.0201 0.1811
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0201 0.0201
Loa Loa (eye worm) AMP-binding enzyme family protein 0.1061 0.3504 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0201 0.0598
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0525 0.1708 0.1708
Toxoplasma gondii cathepsin CPL 0.0016 0.0007 0.0208
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0007 0.0021
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0046 0.0046
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0074 0.0666
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0201 0.0607
Onchocerca volvulus 0.0057 0.0143 0.197
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0048 0.0137
Mycobacterium leprae Probable lipase LipE 0.0074 0.0201 0.0607
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0022
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0181 0.0545
Onchocerca volvulus 0.0016 0.0007 0.0102
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0207 0.5848
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0004 0.001
Onchocerca volvulus 0.0231 0.0725 1
Mycobacterium ulcerans beta-lactamase 0.0074 0.0201 0.0574
Leishmania major acetyl-CoA synthetase, putative 0.0057 0.0143 0.0431
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0198 0.0564
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0198 0.0596
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0007 0.0518
Giardia lamblia Fructose-bisphosphate aldolase 0.0346 0.111 1
Leishmania major fatty acid transporter protein-like protein 0.1004 0.3313 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.111 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0074 0.0074
Echinococcus granulosus cathepsin l1 0.0016 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0201 0.1811
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.111 1
Brugia malayi Doublecortin family protein 0.0019 0.0017 0.0049
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0007 0.0007
Onchocerca volvulus 0.0019 0.0017 0.0237
Echinococcus multilocularis tumor protein p63 0.033 0.1058 0.1058
Echinococcus multilocularis cysteine protease 0.0016 0.0007 0.0007
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0057 0.0143 0.0407
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0201 0.0607
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0021
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0057 0.0143 0.0431
Plasmodium vivax vivapain-2 0.0016 0.0007 0.0368
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0074 0.3563
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0073 0.0198 0.0564
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0162 0.0482
Echinococcus multilocularis geminin 0.0165 0.0505 0.0505
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0198 0.0596
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0207 0.1869
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0198 0.0564
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0007 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0007 0.0022
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0074 0.0074
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0201 0.0607
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0201 0.0607
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0132
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0407
Onchocerca volvulus 0.0073 0.0198 0.2726
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0007 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0134 0.0134
Echinococcus multilocularis lamin 0.0029 0.0048 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0198 0.0564
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0057 0.0143 0.0431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0122 0.0122
Schistosoma mansoni lamin 0.0029 0.0048 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0007 0.0022
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0007 0.0102
Leishmania major cathepsin L-like protease 0.0016 0.0007 0.0022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.111 1
Schistosoma mansoni rab6-interacting 0.0019 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.005
Plasmodium vivax acetyl-CoA synthetase, putative 0.0057 0.0143 0.7101
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0074 0.0666
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0156
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0114 0.0114
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0057 0.0143 0.0431
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0057 0.0143 0.0407
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0007 0.0067
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0057 0.0143 0.0431
Mycobacterium ulcerans acetyl-CoA synthetase 0.0057 0.0143 0.0407
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0143 0.0431
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0057 0.0143 0.6881
Onchocerca volvulus 0.0029 0.005 0.0686
Echinococcus granulosus lamin 0.0029 0.0048 0.0048
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0021
Onchocerca volvulus 0.0016 0.0007 0.0102
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0057 0.0143 0.0425
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0207 0.0617
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0193 0.5437
Loa Loa (eye worm) fibroinase 0.0016 0.0007 0.0021
Loa Loa (eye worm) inositol-1 0.0076 0.0207 0.0592
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0169 0.0518 0.1563
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0193 0.0582
Schistosoma mansoni lamin 0.0029 0.0048 0.0048
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0207 0.1869
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0193 0.0193
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0207 0.0592
Entamoeba histolytica cysteine protease, putative 0.0016 0.0007 0.0067
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0057 0.0143 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0198 0.0564
Leishmania major cathepsin L-like protease 0.0063 0.0162 0.0489
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0143 0.0407
Leishmania major cathepsin L-like protease 0.0063 0.0162 0.0489
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0144 0.0428
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0198 0.0564
Echinococcus multilocularis microsomal glutathione S transferase 3 0.012 0.0355 0.0355
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0346 0.111 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0201 0.0607
Schistosoma mansoni microsomal glutathione s-transferase 0.012 0.0355 0.0355
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0048 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.005 0.005
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1018 0.3361 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0007 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0007 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0007 0.0067
Leishmania major acetyl-CoA synthetase, putative 0.0057 0.0143 0.0431
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0007 0.0021
Brugia malayi Cathepsin L-like precursor 0.0016 0.0007 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0193 0.0551
Schistosoma mansoni inositol monophosphatase 0.0076 0.0207 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0162 0.7812
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0143 0.0407
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0193 0.0193
Mycobacterium ulcerans hypothetical protein 0.0073 0.0198 0.0564
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0057 0.0143 0.0425
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0198 0.0564
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0074 0.0074
Plasmodium vivax acyl-CoA synthetase, putative 0.0031 0.0055 0.2725
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.1018 0.3361 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0057 0.0143 0.0407
Plasmodium falciparum acyl-CoA synthetase 0.0031 0.0055 0.3838
Echinococcus granulosus tumor protein p63 0.033 0.1058 0.1058
Schistosoma mansoni microtubule-associated protein tau 0.3002 1 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0057 0.0143 0.0407
Echinococcus granulosus intermediate filament protein 0.0029 0.0048 0.0048
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.1004 0.3313 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.0142
Brugia malayi intermediate filament protein 0.0029 0.0048 0.0137
Loa Loa (eye worm) cysteine protease 0.0016 0.0007 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0057 0.0143 0.0407
Echinococcus granulosus microsomal glutathione S transferase 3 0.012 0.0355 0.0355
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0057 0.0143 0.4024

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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