Detailed information for compound 1206429

Basic information

Technical information
  • TDR Targets ID: 1206429
  • Name: 2-(4-chlorophenyl)-N-(3-methoxyphenyl)-5-meth yl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
  • MW: 365.816 | Formula: C19H16ClN5O
  • H donors: 1 H acceptors: 3 LogP: 4.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)Nc1cc(C)nc2n1nc(n2)c1ccc(cc1)Cl
  • InChi: 1S/C19H16ClN5O/c1-12-10-17(22-15-4-3-5-16(11-15)26-2)25-19(21-12)23-18(24-25)13-6-8-14(20)9-7-13/h3-11,22H,1-2H3
  • InChiKey: CTAHXQAHTPEKJW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-(4-chlorophenyl)-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-yl]-(3-methoxyphenyl)amine
  • NCGC00117547-01
  • D245-0174

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0085 0.0586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0086 0.0133 0.0312
Brugia malayi Pyruvate kinase, muscle isozyme 0.0103 0.0166 0.0381
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0042 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.0133 0.0304
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0064
Trypanosoma brucei polo-like protein kinase 0.0096 0.0153 0.119
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.006 0.013
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0074 0.0506
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0068 0.0529
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0397 0.1333
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0153 0.0276
Schistosoma mansoni nuclear receptor 0.004 0.0051 0.0043
Loa Loa (eye worm) ICD-1 protein 0.0076 0.0116 0.0272
Brugia malayi beta-lactamase family protein 0.0036 0.0044 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.006 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0046 0.0359
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.0068 0.0073
Schistosoma mansoni pyruvate kinase 0.0103 0.0166 0.0158
Brugia malayi pyruvate kinase 0.0022 0.0018 0.0029
Chlamydia trachomatis pyruvate kinase 0.0103 0.0166 0.5
Schistosoma mansoni hypothetical protein 0.0423 0.0746 0.0739
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0068 0.0529
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0085 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0068 0.0529
Toxoplasma gondii pyruvate kinase PyK1 0.0103 0.0166 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1526 0.2746 0.6473
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0312
Trypanosoma cruzi hypothetical protein, conserved 0.0721 0.1286 1
Echinococcus multilocularis pyruvate kinase 0.0103 0.0166 0.0526
Echinococcus multilocularis pyruvate kinase 0.0103 0.0166 0.0526
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0068 0.0456
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0092 0.064
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0153 0.0276
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Echinococcus granulosus pyruvate kinase 0.0103 0.0166 0.1349
Trypanosoma brucei pyruvate kinase 1, putative 0.0103 0.0166 0.129
Toxoplasma gondii pyruvate kinase PyKII 0.0053 0.0075 0.4409
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0024 0.0113
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.0051 0.0118
Onchocerca volvulus 0.234 0.4222 1
Mycobacterium ulcerans hypothetical protein 0.0192 0.0327 0.0677
Leishmania major hypothetical protein, conserved 0.0721 0.1286 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0312
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0074 0.0088
Brugia malayi beta-lactamase 0.0036 0.0044 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0153 0.0276
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0074 0.0506
Onchocerca volvulus 0.0086 0.0133 0.0249
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0085 0.0258
Brugia malayi hypothetical protein 0.0045 0.006 0.013
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0044 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0116 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0086 0.0133 0.0304
Echinococcus multilocularis lamin 0.0028 0.0029 0.0084
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0038 0.0066
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0051 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0085 0.0586
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.0133 0.0304
Schistosoma mansoni pyruvate kinase 0.0103 0.0166 0.0158
Onchocerca volvulus 0.0036 0.0044 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0044 0.0036
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0024 0.005
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.006 0.0185
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0153 0.1122
Brugia malayi MAP kinase sur-1 0.0053 0.0074 0.0164
Schistosoma mansoni nuclear hormone receptor 0.0086 0.0133 0.0125
Mycobacterium tuberculosis Conserved protein 0.0036 0.0044 0.0117
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0065 0.0066
Schistosoma mansoni nuclear hormone receptor 0.004 0.0051 0.0043
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0085 0.0197
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0085 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0068 0.0529
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0005 0.0009
Brugia malayi nuclear receptor NHR-88 0.0086 0.0133 0.0304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0086 0.0133 0.0312
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0068 0.0529
Brugia malayi ecdysteroid receptor 0.0086 0.0133 0.0304
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0086 0.0133 0.108
Echinococcus multilocularis dna polymerase kappa 0.005 0.0068 0.0211
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.234 0.4222 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0045 0.006 0.0138
Trichomonas vaginalis esterase, putative 0.0036 0.0044 0.0015
Leishmania major basic transcription factor 3a, putative 0.0076 0.0116 0.0835
Schistosoma mansoni ap endonuclease 0.0059 0.0085 0.0077
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0029 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.0086 0.0133 0.0304
Plasmodium vivax pyruvate kinase, putative 0.0103 0.0166 1
Echinococcus multilocularis expressed protein 0.0034 0.0039 0.0117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0051 0.0157
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.234 0.4222 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0074 0.0231
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0074 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0153 0.0276
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0044 0.034
Loa Loa (eye worm) DR-78 0.004 0.0051 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.0133 0.0304
Schistosoma mansoni zinc finger protein 0.004 0.0051 0.0043
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0745 0.133 1
Onchocerca volvulus 0.0036 0.0044 0.0036
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0039 0.0088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0044 0.0132
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0085 0.111
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0062
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0086 0.0133 0.0304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.0133 0.0421
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0051 0.0109
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0086 0.0133 0.0125
Echinococcus granulosus expressed protein 0.0034 0.0039 0.0301
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0068 0.0456
Brugia malayi steroid hormone receptor 0.0086 0.0133 0.0304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0086 0.0133 0.0421
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0051 0.0403
Mycobacterium tuberculosis Conserved protein 0.0036 0.0044 0.0117
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0745 0.133 0.4547
Brugia malayi nuclear receptor RXR 0.0045 0.006 0.013
Brugia malayi beta-NAC-like protein 0.0076 0.0116 0.0264
Loa Loa (eye worm) pyruvate kinase 0.0103 0.0166 0.0389
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0086 0.0133 0.0125
Onchocerca volvulus 0.0036 0.0044 0.0036
Brugia malayi Nuclear hormone receptor E75 0.004 0.0051 0.0109
Loa Loa (eye worm) beta-lactamase 0.0036 0.0044 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.0133 0.108
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0312
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0291 0.2264
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0044 0.0117
Loa Loa (eye worm) hypothetical protein 0.0126 0.0207 0.0486
Brugia malayi Pyruvate kinase, M2 isozyme 0.0103 0.0166 0.0381
Mycobacterium tuberculosis Conserved protein 0.0036 0.0044 0.0117
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0038 0.0217
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0086 0.0133 0.0421
Brugia malayi polk-prov protein 0.0038 0.0046 0.0097
Brugia malayi hypothetical protein 0.0045 0.006 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0046 0.0359
Brugia malayi nuclear receptor NHR-88 0.004 0.0051 0.0109
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0031 0.0035 0.007
Onchocerca volvulus Huntingtin homolog 0.0126 0.0207 0.0424
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0054 0.0417
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0153 0.0296
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0051 0.0109
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0312
Echinococcus granulosus pyruvate kinase 0.0053 0.0075 0.0594
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0044 0.0265
Schistosoma mansoni hypothetical protein 0.0035 0.0042 0.0035
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0721 0.1286 0.2984
Echinococcus multilocularis GPCR, family 2 0.0016 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.01
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.234 0.4222 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0068 0.0529
Brugia malayi nuclear receptor RXR 0.004 0.0051 0.0109
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0051 0.0157
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.009 0.0276
Entamoeba histolytica protein tyrosine phosphatase, putative 0.234 0.4222 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.009 0.0282
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0044 0.0117
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0038 0.2148
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0112
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0044 0.0117
Trichomonas vaginalis rotamase, putative 0.0034 0.0039 0.0003
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0312
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.234 0.4222 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0312
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.1213 0.1206
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0051 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0039 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0068 0.0058
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0068 0.0456
Schistosoma mansoni retinoic acid receptor RXR 0.0086 0.0133 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0086 0.0133 0.0304
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0074 0.0506
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0051 0.0054
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Brugia malayi tailless protein 0.004 0.0051 0.0109
Schistosoma mansoni kinase 0.0049 0.0067 0.006
Echinococcus granulosus cpg binding protein 0.0031 0.0035 0.0269
Entamoeba histolytica hypothetical protein 0.0114 0.0184 0.0414
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0153 0.035
Giardia lamblia Fructose-bisphosphate aldolase 0.1526 0.2746 0.6484
Giardia lamblia Kinase, PLK 0.0096 0.0153 0.0307
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0072 0.0159
Trypanosoma brucei transcription factor BTF3, putative 0.0076 0.0116 0.0905
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0029 0.0064
Trypanosoma cruzi transcription factor btf3, putative 0.0076 0.0116 0.0835
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0086 0.0133 0.0304
Treponema pallidum fructose-bisphosphate aldolase 0.1526 0.2746 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0074 0.0088
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0051 0.0403
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0008 0.0044
Onchocerca volvulus Huntingtin homolog 0.0126 0.0207 0.0424
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1526 0.2746 0.6473
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0068 0.0529
Mycobacterium ulcerans pyruvate kinase 0.0103 0.0166 0.0292
Schistosoma mansoni cpg binding protein 0.0031 0.0035 0.0027
Entamoeba histolytica hypothetical protein 0.0114 0.0184 0.0414
Loa Loa (eye worm) hypothetical protein 0.0086 0.0133 0.0312
Schistosoma mansoni thyroid hormone receptor 0.0086 0.0133 0.0125
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0038 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0044 0.0265
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0008 0.0044
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0184 0.15
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0074 0.4402
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0085 0.0188
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1526 0.2746 0.6496
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1526 0.2746 0.6496
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0071 0.0553
Loa Loa (eye worm) hypothetical protein 0.0052 0.0072 0.0167
Echinococcus granulosus GPCR family 2 0.0016 0.0008 0.0044
Toxoplasma gondii NAC domain-containing protein 0.0076 0.0116 0.6973
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0074 0.0088
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0086 0.0133 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1526 0.2746 0.6473
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0008 0.0006
Onchocerca volvulus Pyruvate kinase homolog 0.0103 0.0166 0.0327
Echinococcus granulosus ecdysone induced protein 78C 0.0086 0.0133 0.108
Schistosoma mansoni lamin 0.0028 0.0029 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0044 0.0015
Onchocerca volvulus Pyruvate kinase homolog 0.0103 0.0166 0.0327
Schistosoma mansoni transcription factor btf3 0.0076 0.0116 0.0109
Brugia malayi conserved hypotetical protein 0.004 0.0051 0.0109
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0086 0.0133 0.108
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0039 0.008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0093 0.0085
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.001 0.0011
Entamoeba histolytica hypothetical protein 0.0076 0.0116 0.0253
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Schistosoma mansoni nuclear hormone receptor 0.004 0.0051 0.0043
Entamoeba histolytica hypothetical protein 0.0114 0.0184 0.0414
Echinococcus multilocularis pyruvate kinase 0.0053 0.0075 0.0232
Echinococcus granulosus FTZ F1 alpha 0.0086 0.0133 0.108
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0074 0.0231
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.009 0.0628
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0032 0.0072
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0044 0.0117
Brugia malayi intermediate filament protein 0.0028 0.0029 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0042 0.0097
Giardia lamblia Pyruvate kinase 0.0053 0.0075 0.012
Schistosoma mansoni cpg binding protein 0.003 0.0032 0.0024
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.006 0.0475
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.064 0.4934
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0745 0.133 0.3079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0086 0.0133 0.108
Schistosoma mansoni pyruvate kinase 0.0053 0.0075 0.0067
Schistosoma mansoni coup transcription factor 0.0086 0.0133 0.0125
Schistosoma mansoni hypothetical protein 0.0358 0.0628 0.062
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.0051 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0291 0.2204
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0071 0.048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0086 0.0133 0.0304
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.009 0.0722
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0051 0.0157
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0086 0.0133 0.0421
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1726 0.3109 1
Schistosoma mansoni ap endonuclease 0.0059 0.0085 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0044 0.0015
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.0068 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0044 0.0015
Leishmania major pyruvate kinase 0.0103 0.0166 0.1222
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0085 0.0264
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0044 0.0015
Entamoeba histolytica protein tyrosine phosphatase, putative 0.234 0.4222 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.006 0.0138
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0051 0.0403
Schistosoma mansoni hypothetical protein 0.0358 0.0628 0.062
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.234 0.4222 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0103 0.0166 0.095
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0112
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0044 0.0117
Plasmodium falciparum basic transcription factor 3b, putative 0.0076 0.0116 0.4586
Onchocerca volvulus Bile acid receptor homolog 0.0086 0.0133 0.0249
Brugia malayi hypothetical protein 0.0114 0.0184 0.0424
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0074 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0068 0.0529
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0074 0.0088
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0008 0.0015
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.004 0.0051 0.0157
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.001 0.0019
Schistosoma mansoni nuclear receptor 0.004 0.0051 0.0043
Loa Loa (eye worm) hypothetical protein 0.0045 0.006 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0086 0.0133 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0068 0.0529
Loa Loa (eye worm) hypothetical protein 0.0126 0.0207 0.0486
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.01
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0153 0.0359
Schistosoma mansoni RAR-like nuclear receptor 0.0086 0.0133 0.0125
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0153 0.1243
Trypanosoma cruzi pyruvate kinase 2, putative 0.0103 0.0166 0.1222
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.064 0.4934
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0074 0.0506
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.001 0.0023
Echinococcus multilocularis cpg binding protein 0.0031 0.0035 0.0105
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1618 0.2914 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0068 0.0456
Loa Loa (eye worm) steroid hormone receptor 0.0086 0.0133 0.0312
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0074 0.0593
Brugia malayi hypothetical protein 0.004 0.0051 0.0109
Echinococcus multilocularis FTZ F1 alpha 0.0086 0.0133 0.0421
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0014 0.0112
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0327 0.1091
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0291 0.2204
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0153 0.1122
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0153 0.1122
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1526 0.2746 0.6473
Plasmodium vivax pyruvate kinase 2, putative 0.0053 0.0075 0.252
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0072 0.0167
Brugia malayi hypothetical protein 0.0126 0.0207 0.0477
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0051 0.0109
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Echinococcus granulosus pyruvate kinase 0.0053 0.0075 0.0594
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0721 0.1286 1
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0116 0.0188
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.234 0.4222 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0085 0.335
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0051 0.0118
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0068 0.0058
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0074 0.0578
Echinococcus granulosus geminin 0.0358 0.0628 0.5161
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0721 0.1286 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0051 0.0109
Echinococcus granulosus pyruvate kinase 0.0053 0.0075 0.0594
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.009 0.0111
Loa Loa (eye worm) hypothetical protein 0.0103 0.0166 0.0389
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0071 0.048
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0051 0.0118
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.009 0.0111
Plasmodium vivax basic transcription factor 3b, putative 0.0076 0.0116 0.595
Loa Loa (eye worm) hypothetical protein 0.0045 0.006 0.0138
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0015
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0029 0.0056
Leishmania major DNA polymerase kappa, putative 0.0025 0.0024 0.0113
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0103 0.0166 0.0537
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.01
Schistosoma mansoni intermediate filament proteins 0.0028 0.0029 0.0021
Entamoeba histolytica hypothetical protein 0.0114 0.0184 0.0414
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0044 0.01
Onchocerca volvulus 0.004 0.0051 0.0054
Echinococcus granulosus lamin dm0 0.0028 0.0029 0.0216
Echinococcus multilocularis musashi 0.0028 0.0029 0.0084
Leishmania major hypothetical protein, conserved 0.0036 0.0044 0.0265
Echinococcus granulosus transcription factor btf3 0.0076 0.0116 0.094
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0051 0.0043
Trypanosoma cruzi pyruvate kinase 2, putative 0.0103 0.0166 0.1222
Echinococcus granulosus intermediate filament protein 0.0028 0.0029 0.0216
Brugia malayi hypothetical protein 0.004 0.0051 0.0109
Brugia malayi nuclear receptor NHR-67 0.004 0.0051 0.0109
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0721 0.1286 0.2984
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.01
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.234 0.4222 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.006 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.064 0.4934
Loa Loa (eye worm) hypothetical protein 0.0036 0.0044 0.01
Trypanosoma brucei unspecified product 0.0042 0.0054 0.0417
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.009 0.0082
Schistosoma mansoni hypothetical protein 0.0114 0.0184 0.0176
Schistosoma mansoni DNA polymerase eta 0.0017 0.001 0.0002
Echinococcus granulosus dna polymerase eta 0.0017 0.001 0.006
Schistosoma mansoni thyroid hormone receptor 0.0086 0.0133 0.0125
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.001 0.0002
Trypanosoma brucei pyruvate kinase 1 0.0103 0.0166 0.129
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0086 0.0133 0.108
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0153 0.0276
Trichomonas vaginalis pyruvate kinase, putative 0.0103 0.0166 0.0307
Brugia malayi ecdysone receptor 0.004 0.0051 0.0109
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0085 0.0144
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0086 0.0133 0.108
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0086 0.0133 0.0312
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0051 0.0403
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.001 0.006
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0074 0.0506
Toxoplasma gondii exonuclease III APE 0.0059 0.0085 0.503
Entamoeba histolytica transcription factor BTF3, putative 0.0076 0.0116 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0065 0.0066
Trypanosoma brucei protein kinase, putative 0.0053 0.0074 0.0578
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0153 0.0484
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0074 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0153 0.0145
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.001 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1526 0.2746 0.6473
Schistosoma mansoni steroid hormone receptor ad4bp 0.0086 0.0133 0.0125
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0074 0.0506
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.064 0.4973
Brugia malayi Nuclear hormone receptor E75 0.004 0.0051 0.0109
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0044 0.0091
Entamoeba histolytica pyruvate kinase, putative 0.0072 0.0109 0.0236
Echinococcus multilocularis geminin 0.0358 0.0628 0.2012
Toxoplasma gondii ABC1 family protein 0.0036 0.0044 0.2525
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0086 0.0133 0.0125
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.009 0.0111
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.234 0.4222 1
Loa Loa (eye worm) pyruvate kinase 0.0103 0.0166 0.0389
Brugia malayi pyruvate kinase, muscle isozyme 0.0022 0.0018 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0086 0.0133 0.0304
Onchocerca volvulus Protein ultraspiracle homolog 0.0086 0.0133 0.0249
Brugia malayi beta-lactamase family protein 0.0036 0.0044 0.0091
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0086 0.0133 0.0421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0086 0.0133 0.0312
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0044 0.0117
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0086 0.0133 0.0125
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.1004 0.18 0.1794
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0068 0.0529
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.006 0.0052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0008 0.0017
Echinococcus granulosus dnaJ subfamily B 0.0423 0.0746 0.6141
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.234 0.4222 1
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.009 0.5359
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0051 0.0157
Leishmania major pyruvate kinase 0.0103 0.0166 0.1222
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0038 0.0292
Echinococcus multilocularis pyruvate kinase 0.0053 0.0075 0.0232
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0074 0.0172
Echinococcus multilocularis pyruvate kinase 0.0053 0.0075 0.0232
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0085 0.0113
Trypanosoma cruzi transcription factor btf3, putative 0.0076 0.0116 0.0835
Loa Loa (eye worm) hypothetical protein 0.0045 0.006 0.0138
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0019
Echinococcus multilocularis pyruvate kinase 0.0082 0.0126 0.0398
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0153 0.034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0072 0.0159
Brugia malayi CXXC zinc finger family protein 0.003 0.0032 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0086 0.0133 0.0312
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.009 0.0082
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0085 0.0658
Toxoplasma gondii hypothetical protein 0.0059 0.0085 0.5042
Loa Loa (eye worm) hypothetical protein 0.0072 0.0109 0.0255
Giardia lamblia Pyruvate kinase 0.0103 0.0166 0.0337
Echinococcus granulosus dna polymerase kappa 0.005 0.0068 0.0541
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0086 0.0133 0.0312
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0184 0.0585
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1526 0.2746 0.6473
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0024 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0086 0.0133 0.0304
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0051 0.0403
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.008 0.4764
Schistosoma mansoni rotamase 0.0034 0.0039 0.0031
Echinococcus multilocularis ecdysone induced protein 78C 0.0086 0.0133 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0116 0.0188
Schistosoma mansoni lamin 0.0028 0.0029 0.0021
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.0746 0.2394
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0086 0.0133 0.108
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0184 0.0176
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0085 0.0678
Echinococcus granulosus pyruvate kinase 0.0103 0.0166 0.1349
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0153 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0086 0.0133 0.0304
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0044 0.034
Loa Loa (eye worm) pyruvate kinase 0.0022 0.0018 0.0038
Echinococcus multilocularis dna polymerase eta 0.0017 0.001 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0085 0.0113
Echinococcus multilocularis lamin dm0 0.0028 0.0029 0.0084
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0086 0.0133 0.0249
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0085 0.0586
Brugia malayi nuclear hormone receptor 0.004 0.0051 0.0109
Echinococcus granulosus lamin 0.0028 0.0029 0.0216
Echinococcus multilocularis thyroid hormone receptor alpha 0.0086 0.0133 0.0421
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0008 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0153 0.0276
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1526 0.2746 0.6473
Onchocerca volvulus 0.003 0.0032 0.0008
Echinococcus granulosus microtubule associated protein 2 0.0681 0.1213 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0086 0.0133 0.0125
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0118
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0051 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0051 0.0403
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0044 0.0015
Onchocerca volvulus 0.004 0.0051 0.0054
Brugia malayi photoreceptor-specific nuclear receptor 0.0086 0.0133 0.0304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0086 0.0133 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0086 0.0133 0.0304
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0068 0.0529
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.1213 0.3898
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0085 0.0098
Loa Loa (eye worm) pyruvate kinase-PB 0.0072 0.0109 0.0255
Brugia malayi nuclear hormone receptor 0.0086 0.0133 0.0304
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0071 0.048
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0045 0.006 0.0138
Loa Loa (eye worm) hypothetical protein 0.0038 0.0046 0.0106
Plasmodium falciparum pyruvate kinase 0.0103 0.0166 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0044 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0086 0.0133 0.0304
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0008 0.0006
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0038 0.0217
Echinococcus multilocularis transcription factor btf3 0.0076 0.0116 0.0366
Trichomonas vaginalis pyruvate kinase, putative 0.0103 0.0166 0.0307
Schistosoma mansoni cpg binding protein 0.0031 0.0035 0.0027
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0086 0.0133 0.0421
Onchocerca volvulus Pyruvate kinase homolog 0.0103 0.0166 0.0327
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.234 0.4222 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1526 0.2746 0.6473
Loa Loa (eye worm) pyruvate kinase 0.0103 0.0166 0.0389

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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