Detailed information for compound 1206914

Basic information

Technical information
  • TDR Targets ID: 1206914
  • Name: N-(3-acetamidophenyl)-5-methyl-1,2-oxazole-3- carboxamide
  • MW: 259.261 | Formula: C13H13N3O3
  • H donors: 2 H acceptors: 3 LogP: 1.11 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1cccc(c1)NC(=O)c1noc(c1)C
  • InChi: 1S/C13H13N3O3/c1-8-6-12(16-19-8)13(18)15-11-5-3-4-10(7-11)14-9(2)17/h3-7H,1-2H3,(H,14,17)(H,15,18)
  • InChiKey: HQXYQNGIPVOSPC-UHFFFAOYSA-N  


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Synonyms

  • N-(3-acetamidophenyl)-5-methyl-isoxazole-3-carboxamide
  • N-(3-acetamidophenyl)-5-methyl-3-isoxazolecarboxamide
  • IVK/4005248
  • ZINC01054481
  • MLS000065784
  • N-[3-(acetylamino)phenyl]-5-methyl-3-isoxazolecarboxamide
  • SMR000080468

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Onchocerca volvulus 0.03 0.2319 0.2367
Trypanosoma cruzi hypothetical protein, conserved 0.1001 0.8759 1
Onchocerca volvulus 0.1114 0.9799 1
Trypanosoma brucei trypanothione reductase 0.0048 0.0007 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Brugia malayi glutathione reductase 0.0048 0.0007 0.0007
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Onchocerca volvulus 0.03 0.2319 0.2367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0074 0.0074
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1084 0.1106
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1114 0.9799 0.9799
Onchocerca volvulus 0.03 0.2319 0.2367
Loa Loa (eye worm) PAN domain-containing protein 0.0076 0.0268 0.0273
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0571 0.3315
Loa Loa (eye worm) hypothetical protein 0.0054 0.0063 0.0064
Onchocerca volvulus 0.0641 0.5453 0.5565
Schistosoma mansoni alpha-glucosidase 0.0142 0.0873 0.0873
Toxoplasma gondii microneme protein MIC17A 0.0076 0.0268 0.0306
Loa Loa (eye worm) hypothetical protein 0.0076 0.0268 0.0273
Echinococcus granulosus enteropeptidase 0.03 0.2319 0.2648
Loa Loa (eye worm) hypothetical protein 0.0076 0.0268 0.0273
Loa Loa (eye worm) PAN domain-containing protein 0.0076 0.0268 0.0273
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Onchocerca volvulus 0.0641 0.5453 0.5565
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0074 0.0075
Loa Loa (eye worm) hypothetical protein 0.0128 0.0741 0.0756
Schistosoma mansoni alpha-glucosidase 0.0142 0.0873 0.0873
Brugia malayi Calcium binding EGF domain containing protein 0.0054 0.0063 0.0064
Brugia malayi Fibulin-1 precursor 0.0106 0.0539 0.055
Loa Loa (eye worm) hypothetical protein 0.0076 0.0268 0.0273
Echinococcus multilocularis tissue type plasminogen activator 0.1001 0.8759 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0306 0.2382 0.2382
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.03 0.2319 0.2319
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.03 0.2319 0.2648
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.03 0.2319 0.2648
Brugia malayi hypothetical protein 0.0124 0.0707 0.0722
Echinococcus multilocularis enteropeptidase 0.03 0.2319 0.2648
Loa Loa (eye worm) hypothetical protein 0.0076 0.0268 0.0273
Brugia malayi Calcium binding EGF domain containing protein 0.0106 0.0539 0.055
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.1709 1
Onchocerca volvulus 0.0076 0.0268 0.0273
Echinococcus multilocularis Tolloid protein 1 0.0113 0.0602 0.0688
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1084 0.1106
Toxoplasma gondii PAN domain-containing protein 0.0258 0.1937 0.2211
Onchocerca volvulus 0.0076 0.0268 0.0273
Loa Loa (eye worm) hypothetical protein 0.0076 0.0268 0.0273
Toxoplasma gondii hypothetical protein 0.0076 0.0268 0.0306
Leishmania major hypothetical protein, conserved 0.1001 0.8759 1
Toxoplasma gondii PAN domain-containing protein 0.0076 0.0268 0.0306
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0571 0.3315
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1084 0.1238
Mycobacterium tuberculosis Probable reductase 0.0109 0.0571 0.3315
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0074 0.0084
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.219 0.25
Brugia malayi hypothetical protein 0.0286 0.219 0.2235
Brugia malayi Protein kinase domain containing protein 0.1001 0.8759 0.8939
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Loa Loa (eye worm) hypothetical protein 0.0106 0.0539 0.055
Onchocerca volvulus 0.0688 0.5887 0.6008
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.219 0.25
Loa Loa (eye worm) hypothetical protein 0.1114 0.9799 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0707 0.0722
Loa Loa (eye worm) hypothetical protein 0.03 0.2319 0.2367
Brugia malayi Trypsin family protein 0.03 0.2319 0.2367
Echinococcus granulosus Mastin 0.03 0.2319 0.2648
Schistosoma mansoni hypothetical protein 0.0058 0.0101 0.0101
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0571 0.3315
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0074 0.0074
Onchocerca volvulus 0.03 0.2319 0.2367
Echinococcus multilocularis glycoprotein Antigen 5 0.03 0.2319 0.2648
Loa Loa (eye worm) hypothetical protein 0.03 0.2319 0.2367
Toxoplasma gondii calcium binding egf domain-containing protein 0.0106 0.0539 0.0616
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Loa Loa (eye worm) hypothetical protein 0.1001 0.8759 0.8939
Onchocerca volvulus 0.03 0.2319 0.2367
Loa Loa (eye worm) PAN domain-containing protein 0.0076 0.0268 0.0273
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0074 0.0075
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.0683 0.3974
Schistosoma mansoni survival motor neuron protein 0.0058 0.0101 0.0101
Loa Loa (eye worm) PAN domain-containing protein 0.0076 0.0268 0.0273
Loa Loa (eye worm) hypothetical protein 0.0286 0.219 0.2235
Loa Loa (eye worm) hypothetical protein 0.0076 0.0268 0.0273
Loa Loa (eye worm) trypsin family protein 0.03 0.2319 0.2367
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0113 0.0602 0.0602
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.0683 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0106 0.0539 0.0616
Onchocerca volvulus 0.0096 0.0444 0.0453
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0571 0.3315
Loa Loa (eye worm) hypothetical protein 0.03 0.2319 0.2367
Loa Loa (eye worm) hypothetical protein 0.0124 0.0707 0.0722
Schistosoma mansoni hypothetical protein 0.1001 0.8759 0.8759
Toxoplasma gondii PAN domain-containing protein 0.0076 0.0268 0.0306
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.03 0.2319 0.2319
Brugia malayi Trypsin family protein 0.03 0.2319 0.2367
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0101 0.0103
Onchocerca volvulus 0.0076 0.0268 0.0273
Loa Loa (eye worm) hypothetical protein 0.0113 0.0602 0.0615
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0132 0.0151
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0132 0.0143
Echinococcus granulosus tissue type plasminogen activator 0.1001 0.8759 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0678 0.0692
Echinococcus multilocularis Mastin 0.03 0.2319 0.2648
Brugia malayi Thioredoxin reductase 0.0048 0.0007 0.0007
Onchocerca volvulus 0.0076 0.0268 0.0273
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1084 0.1238
Toxoplasma gondii PAN/Apple domain-containing protein 0.0076 0.0268 0.0306
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Onchocerca volvulus 0.0076 0.0268 0.0273
Echinococcus granulosus glycoprotein Antigen 5 0.03 0.2319 0.2648
Loa Loa (eye worm) hypothetical protein 0.0688 0.5887 0.6008
Toxoplasma gondii thioredoxin reductase 0.0048 0.0007 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0132 0.0132
Brugia malayi Trypsin-like protease protein 5 0.03 0.2319 0.2367
Onchocerca volvulus 0.0641 0.5453 0.5565
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.03 0.2319 0.2648
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Loa Loa (eye worm) hypothetical protein 0.0641 0.5453 0.5565
Loa Loa (eye worm) hypothetical protein 0.03 0.2319 0.2367
Loa Loa (eye worm) glutathione reductase 0.0048 0.0007 0.0007
Echinococcus granulosus Tolloid protein 1 0.0113 0.0602 0.0688
Toxoplasma gondii subtilisin SUB12 0.0076 0.0268 0.0306
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Onchocerca volvulus 0.1001 0.8759 0.8939
Loa Loa (eye worm) hypothetical protein 0.0076 0.0268 0.0273
Mycobacterium ulcerans hypothetical protein 0.03 0.2319 1
Toxoplasma gondii microneme protein MIC17C 0.0076 0.0268 0.0306
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.03 0.2319 0.2648
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0121 0.0678 0.0692
Onchocerca volvulus 0.0814 0.7046 0.7191
Onchocerca volvulus 0.0076 0.0268 0.0273
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.1768 0.1804
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Toxoplasma gondii PAN domain-containing protein 0.0076 0.0268 0.0306
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0106 0.0539 0.055
Brugia malayi hypothetical protein 0.03 0.2319 0.2367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0074 0.0084
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0132 0.0735
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0132 0.0151
Giardia lamblia High cysteine protein 0.0047 0 0.5
Onchocerca volvulus 0.0076 0.0268 0.0273
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.03 0.2319 0.2367
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0132 0.0151
Brugia malayi Trypsin family protein 0.03 0.2319 0.2367
Loa Loa (eye worm) PAN domain-containing protein 0.0076 0.0268 0.0273
Onchocerca volvulus Huntingtin homolog 0.0124 0.0707 0.0722
Toxoplasma gondii microneme protein MIC4 0.0076 0.0268 0.0306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0074 0.0084
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.03 0.2319 0.2319
Brugia malayi SEA domain containing protein 0.0641 0.5453 0.5565
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Schistosoma mansoni hypothetical protein 0.03 0.2319 0.2319
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1084 0.1238
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Toxoplasma gondii PAN domain-containing protein 0.0258 0.1937 0.2211
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Plasmodium falciparum cysteine repeat modular protein 1 0.1001 0.8759 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.1001 0.8759 1
Onchocerca volvulus 0.0076 0.0268 0.0273
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0571 0.3315
Toxoplasma gondii microneme protein, putative 0.0076 0.0268 0.0306
Onchocerca volvulus 0.0076 0.0268 0.0273
Onchocerca volvulus Putative cubilin 0.0054 0.0063 0.0064
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.03 0.2319 0.2319
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0113 0.0602 0.0615
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.0683 0.3974
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0106 0.0539 0.055
Schistosoma mansoni hypothetical protein 0.0641 0.5453 0.5453
Echinococcus granulosus transmembrane protease serine 3 0.03 0.2319 0.2648
Brugia malayi Kringle domain containing protein 0.1001 0.8759 0.8939
Loa Loa (eye worm) hypothetical protein 0.1114 0.9799 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.03 0.2319 0.2319
Brugia malayi Trypsin family protein 0.1114 0.9799 1
Onchocerca volvulus 0.0076 0.0268 0.0273
Echinococcus multilocularis fibrillin 1 0.0106 0.0539 0.0616
Loa Loa (eye worm) hypothetical protein 0.03 0.2319 0.2367
Echinococcus granulosus laminin 0.0106 0.0539 0.0616
Toxoplasma gondii PAN domain-containing protein 0.0076 0.0268 0.0306
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0132 0.0132
Echinococcus multilocularis laminin 0.0106 0.0539 0.0616
Onchocerca volvulus 0.0058 0.0101 0.0103
Toxoplasma gondii kringle domain-containing protein 0.1001 0.8759 1
Onchocerca volvulus 0.0641 0.5453 0.5565
Brugia malayi PAN domain containing protein 0.0076 0.0268 0.0273
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Toxoplasma gondii microneme protein MIC17B 0.0076 0.0268 0.0306
Schistosoma mansoni hypothetical protein 0.03 0.2319 0.2319
Loa Loa (eye worm) TK/ROR protein kinase 0.1001 0.8759 0.8939
Onchocerca volvulus 0.0076 0.0268 0.0273
Brugia malayi follicle stimulating hormone receptor 0.024 0.1768 0.1804
Echinococcus multilocularis transmembrane protease serine 3 0.03 0.2319 0.2648
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0007 0.0008
Brugia malayi Muscle positioning protein 4 0.0688 0.5887 0.6008
Onchocerca volvulus Arrow homolog 0.0121 0.0678 0.0692
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0074 0.0074
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0121 0.0678 0.0692
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0007 0.0008
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.0683 0.3974
Loa Loa (eye worm) DOMON domain-containing protein 0.0641 0.5453 0.5565
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0074 0.0084
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0076 0.0268 0.0306
Toxoplasma gondii hypothetical protein 0.0076 0.0268 0.0306
Schistosoma mansoni egf-like domain protein 0.0106 0.0539 0.0539
Schistosoma mansoni cercarial elastase (S01 family) 0.03 0.2319 0.2319
Onchocerca volvulus Huntingtin homolog 0.0124 0.0707 0.0722
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0831 0.72 0.822

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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