Detailed information for compound 1207332

Basic information

Technical information
  • TDR Targets ID: 1207332
  • Name: N-[4-methyl-2-(4-methylpiperazin-1-yl)quinoli n-6-yl]azepane-1-carbothioamide
  • MW: 397.58 | Formula: C22H31N5S
  • H donors: 1 H acceptors: 1 LogP: 3.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)c1cc(C)c2c(n1)ccc(c2)NC(=S)N1CCCCCC1
  • InChi: 1S/C22H31N5S/c1-17-15-21(26-13-11-25(2)12-14-26)24-20-8-7-18(16-19(17)20)23-22(28)27-9-5-3-4-6-10-27/h7-8,15-16H,3-6,9-14H2,1-2H3,(H,23,28)
  • InChiKey: JOGWHDSFGXCBJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-methyl-2-(4-methylpiperazin-1-yl)-6-quinolyl]azepane-1-carbothioamide
  • N-[4-methyl-2-(4-methyl-1-piperazinyl)-6-quinolyl]-1-azepanecarbothioamide
  • MLS000730513
  • SMR000308789

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis pyruvate kinase 0.0017 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0067
Loa Loa (eye worm) hypothetical protein 0.0026 0.0218 0.0342
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.043 0.1111
Schistosoma mansoni ap endonuclease 0.0039 0.0385 0.0908
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0297 0.1989
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0085 0.0185
Echinococcus multilocularis pyruvate kinase 0.0017 0.0102 0.01
Echinococcus granulosus intermediate filament protein 0.0027 0.0224 0.0352
Mycobacterium ulcerans 6-phosphofructokinase 0.012 0.1403 0.2925
Echinococcus granulosus pyruvate kinase 0.0017 0.0102 0.0158
Brugia malayi intermediate filament protein 0.0027 0.0224 0.0354
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1082 0.2633
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0224 0.0352
Brugia malayi hypothetical protein 0.0302 0.3702 0.5838
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0061 0.0059
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0297 0.0514
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0085 0.0185
Echinococcus granulosus 6 phosphofructokinase 0.012 0.1403 0.2212
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0304 0.0477
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0385 0.0605
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.044 0.0873
Schistosoma mansoni alpha-glucosidase 0.0169 0.2029 0.4974
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.119 0.1876
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2376 0.2375
Brugia malayi CXXC zinc finger family protein 0.0029 0.0255 0.0402
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0815 0.1284
Echinococcus granulosus expressed conserved protein 0.0091 0.1041 0.164
Plasmodium falciparum pyruvate kinase 0.0033 0.0304 0.7306
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1713 0.4552
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.043 0.1111
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0273 0.6269
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1403 0.3301
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0815 0.136
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0152 0.0973
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0085 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0506 0.104
Schistosoma mansoni glutaminase 0.033 0.4062 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0152 0.0148
Schistosoma mansoni pyruvate kinase 0.0017 0.0102 0.0207
Schistosoma mansoni alpha glucosidase 0.0044 0.044 0.1044
Echinococcus multilocularis survival motor neuron protein 1 0.051 0.634 0.634
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0299 0.0759
Schistosoma mansoni lamin 0.0027 0.0224 0.0511
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0085 0.0132
Echinococcus granulosus pyruvate kinase 0.0017 0.0102 0.0158
Brugia malayi tumor suppressor. 0.0336 0.4141 0.6531
Brugia malayi Latrophilin receptor protein 2 0.0033 0.03 0.0473
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0297 0.1891
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.044 0.0873
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0304 0.0772
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0309 0.0487
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.03 0.0471
Loa Loa (eye worm) RecQ helicase 0.0021 0.0152 0.0238
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0085 0.0185
Loa Loa (eye worm) hypothetical protein 0.0103 0.119 0.1875
Echinococcus granulosus cpg binding protein 0.0031 0.0276 0.0432
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0304 0.3604
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0415 0.0652
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0085 0.0134
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.044 0.0873
Giardia lamblia Kinase, PLK 0.0099 0.1137 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.044 0.0873
Schistosoma mansoni cpg binding protein 0.0031 0.0276 0.0638
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1403 0.3301
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0085 0.0864
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1403 0.3721
Loa Loa (eye worm) hypothetical protein 0.0023 0.0178 0.0279
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1403 0.3426
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0297 0.7621
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.044 0.0439
Echinococcus granulosus geminin 0.0167 0.2001 0.3154
Schistosoma mansoni alpha-glucosidase 0.0169 0.2029 0.4974
Brugia malayi Temporarily assigned gene name protein 44 0.0028 0.0248 0.0391
Schistosoma mansoni cpg binding protein 0.0029 0.0255 0.0586
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.1149 0.8165
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0273 0.0689
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.03 0.0471
Schistosoma mansoni hypothetical protein 0.0167 0.2001 0.4904
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.044 0.3048
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.044 0.1137
Onchocerca volvulus 0.0104 0.1204 0.3078
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1137 0.2768
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.043 0.1111
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.3744 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0297 0.7621
Echinococcus multilocularis GPCR, family 2 0.0033 0.03 0.0298
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0152 0.0366
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0815 0.1972
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0297 0.7087
Toxoplasma gondii hypothetical protein 0.0049 0.051 0.6181
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0178 0.0279
Schistosoma mansoni hypothetical protein 0.0033 0.03 0.0698
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0102 0.2284
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1137 0.263
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0385 0.0605
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1082 0.1707
Schistosoma mansoni pyruvate kinase 0.0033 0.0304 0.0708
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0297 0.2019
Echinococcus multilocularis protein patched 0.0042 0.0415 0.0413
Trichomonas vaginalis rotamase, putative 0.0033 0.0299 0.0518
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0152 0.024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0385 0.0989
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0385 0.1634
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0415 0.0413
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0224 0.0354
Toxoplasma gondii exonuclease III APE 0.0039 0.0385 0.4614
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0224 0.0352
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0085 0.0167
Schistosoma mansoni pyruvate kinase 0.0033 0.0304 0.0708
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.03 0.0471
Onchocerca volvulus 0.0027 0.0224 0.0362
Trypanosoma brucei polo-like protein kinase 0.0099 0.1137 0.3007
Echinococcus multilocularis 6 phosphofructokinase 0.012 0.1403 0.1402
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1137 0.3007
Schistosoma mansoni hypothetical protein 0.0028 0.0248 0.0569
Schistosoma mansoni lamin 0.0027 0.0224 0.0511
Leishmania major pyruvate kinase 0.0033 0.0304 0.0772
Loa Loa (eye worm) hypothetical protein 0.007 0.0778 0.1225
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0085 0.0132
Giardia lamblia Pyruvate kinase 0.0033 0.0304 0.1955
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0152 0.0151
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0023 0.014
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0815 1
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0297 0.0514
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0152 0.024
Echinococcus multilocularis musashi 0.0027 0.0224 0.0223
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1403 0.3301
Leishmania major pyruvate kinase 0.0033 0.0304 0.0772
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.1135 0.2762
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.044 0.0873
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0385 0.0215
Loa Loa (eye worm) hypothetical protein 0.003 0.0273 0.0428
Trichomonas vaginalis glutaminase, putative 0.033 0.4062 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0102 0.01
Trichomonas vaginalis phosphofructokinase, putative 0.012 0.1403 0.3301
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1713 0.4552
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0583 0.7092
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0018 0.0021
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0273 0.0689
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0102 0.107
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1137 0.263
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1137 0.1792
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1643 0.1641
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1082 0.2633
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1137 0.263
Onchocerca volvulus 0.0027 0.0224 0.0362
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0299 0.0759
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0815 0.2144
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1137 0.263
Schistosoma mansoni kinase 0.005 0.0523 0.1249
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2376 0.3747
Loa Loa (eye worm) hypothetical protein 0.0051 0.0533 0.0839
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0152 0.0238
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0415 0.0652
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0152 0.2251
Chlamydia trachomatis pyruvate kinase 0.0033 0.0304 1
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1116 0.1758
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0085 0.0185
Echinococcus multilocularis geminin 0.0167 0.2001 0.2
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.043 0.1111
Echinococcus multilocularis protein quaking 0.0028 0.0248 0.0246
Loa Loa (eye worm) hypothetical protein 0.0013 0.005 0.0077
Schistosoma mansoni hypothetical protein 0.004 0.0396 0.0935
Schistosoma mansoni hypothetical protein 0.004 0.0396 0.0935
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0023 0.0013
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0152 0.0366
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0023 0.0085
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0094 0.0208
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0034
Schistosoma mansoni hypothetical protein 0.004 0.0396 0.0935
Onchocerca volvulus 0.0114 0.1327 0.3418
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1082 0.1705
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.012 0.1403 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.044 0.5306
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0304 0.0583
Echinococcus granulosus bloom syndrome protein 0.0021 0.0152 0.0238
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0304 0.053
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.044 0.0873
Echinococcus multilocularis lamin 0.0027 0.0224 0.0223
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.3744 1
Schistosoma mansoni hypothetical protein 0.0033 0.03 0.0698
Brugia malayi CHE-14 protein 0.0042 0.0415 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0415 0.081
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0085 0.1835
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1919 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1137 0.2892
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0152 0.0492
Loa Loa (eye worm) tumor suppressor 0.0336 0.4141 0.653
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0297 0.3521
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0815 0.136
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0297 0.3521
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0385 1
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0152 0.0148
Trichomonas vaginalis rotamase, putative 0.0033 0.0309 0.0543
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0297 0.3521
Schistosoma mansoni cpg binding protein 0.0031 0.0276 0.0638
Brugia malayi 6-phosphofructokinase 0.012 0.1403 0.2213
Mycobacterium ulcerans glutaminase 0.033 0.4062 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0152 0.0148
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.03 0.0298
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1137 0.1794
Loa Loa (eye worm) hypothetical protein 0.0027 0.0224 0.0352
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.044 0.0692
Schistosoma mansoni hypothetical protein 0.0167 0.2001 0.4904
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0152 0.0366
Echinococcus granulosus pyruvate kinase 0.0017 0.0102 0.0158
Schistosoma mansoni hypothetical protein 0.0033 0.03 0.0698
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0506 0.104
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.03 0.0298
Onchocerca volvulus 0.0029 0.0255 0.0446
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1082 0.1081
Brugia malayi hypothetical protein 0.003 0.0273 0.043
Loa Loa (eye worm) hypothetical protein 0.0033 0.0304 0.0477
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0304 0.0477
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0152 0.024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1082 0.1081
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2376 0.3746
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0297 0.0514
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.044 0.0692
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0815 0.1972
Leishmania major hypothetical protein, conserved 0.003 0.0273 0.0689
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0297 0.0514
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0299 0.0759
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0178 0.1158
Echinococcus granulosus pyruvate kinase 0.0033 0.0304 0.0477
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0068 0.0105
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.044 0.0873
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.044 0.3048
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0094 0.0148
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0297 0.0514
Echinococcus multilocularis pyruvate kinase 0.0033 0.0304 0.0303
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1137 0.3007
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0304 0.053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0666 0.1603
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0014 0.0022
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0385 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0489 0.0488
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1403 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0023 0.0018
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0415 0.0652
Schistosoma mansoni hypothetical protein 0.0033 0.03 0.0698
Echinococcus granulosus survival motor neuron protein 1 0.051 0.634 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0304 0.78
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0085 0.0084
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.012 0.1403 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.012 0.1403 0.7188
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0299 0.0759
Loa Loa (eye worm) hypothetical protein 0.0033 0.03 0.0471
Echinococcus multilocularis lamin dm0 0.0027 0.0224 0.0223
Echinococcus granulosus hypothetical protein 0.0028 0.0248 0.0389
Schistosoma mansoni ap endonuclease 0.0039 0.0385 0.0908
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0152 0.0151
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0385 1
Schistosoma mansoni hypothetical protein 0.007 0.0778 0.188
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0385 0.0607
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0152 0.0238
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2376 0.3746
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1082 0.1705
Brugia malayi phosphofructokinase 0.012 0.1403 0.2213
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.044 0.0873
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0068 0.0107
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0085 0.0084
Loa Loa (eye worm) hypothetical protein 0.0016 0.0094 0.0145
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1137 0.1136
Loa Loa (eye worm) glutaminase 0.033 0.4062 0.6406
Loa Loa (eye worm) hypothetical protein 0.0302 0.3702 0.5837
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1137 0.263
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0304 0.0772
Loa Loa (eye worm) hypothetical protein 0.0097 0.1116 0.1758
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0385 0.2649
Loa Loa (eye worm) hypothetical protein 0.0011 0.0023 0.0034
Schistosoma mansoni hypothetical protein 0.004 0.0396 0.0935
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0023 0.0037
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1137 0.1792
Schistosoma mansoni rotamase 0.0033 0.0309 0.072
Loa Loa (eye worm) hypothetical protein 0.01 0.1149 0.181
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.044 0.1137
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.119 0.1875
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.012 0.1403 0.3721
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0094 0.0208
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0385 0.0989
Schistosoma mansoni survival motor neuron protein 0.0104 0.1204 0.2933
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2376 0.2375
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0385 0.0383
Echinococcus granulosus expressed protein 0.0033 0.0309 0.0485
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0299 0.3542
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0304 0.1194
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0304 0.0772
Schistosoma mansoni DNA helicase recq1 0.0021 0.0152 0.0333
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0304 0.0477
Schistosoma mansoni intermediate filament proteins 0.0027 0.0224 0.0511
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1116 0.1114
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.044 0.0694
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0094 0.0208
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0385 0.0989
Schistosoma mansoni patched 1 0.0042 0.0415 0.0982
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0304 0.0583
Echinococcus granulosus pyruvate kinase 0.0033 0.0304 0.0477
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0815 0.136
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0385 0.2735
Trypanosoma brucei glucosidase, putative 0.0044 0.044 0.1137
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0778 0.1227
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1082 0.1705
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0152 0.2251
Loa Loa (eye worm) hypothetical protein 0.0042 0.0415 0.0652
Loa Loa (eye worm) hypothetical protein 0.0028 0.0248 0.0389
Loa Loa (eye worm) phosphofructokinase 0.012 0.1403 0.2212
Brugia malayi hypothetical protein 0.002 0.0136 0.0215
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0094 0.0548
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0815 0.3981
Echinococcus multilocularis expressed conserved protein 0.0091 0.1041 0.104
Onchocerca volvulus 0.0302 0.3702 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0297 0.0514
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0085 0.0864
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0385 0.0734
Schistosoma mansoni 6-phosphofructokinase 0.012 0.1403 0.3426
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1403 0.2212
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.3744 1
Echinococcus multilocularis pyruvate kinase 0.0026 0.0216 0.0215
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.044 0.1137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1082 0.2633
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0297 0.7087
Leishmania major ATP-dependent phosphofructokinase 0.012 0.1403 0.3721
Loa Loa (eye worm) glutaminase 2 0.033 0.4062 0.6406
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0102 0.055
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0152 0.0151
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0304 0.0479
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1137 0.8079
Echinococcus granulosus lamin 0.0027 0.0224 0.0352
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0385 0.2621
Brugia malayi hypothetical protein 0.0028 0.0248 0.0391
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0085 0.0185
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0385 0.0734
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0304 0.0772
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.3744 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0304 0.0479
Schistosoma mansoni hypothetical protein 0.0028 0.0248 0.0569
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0297 0.0514
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.119 0.1876
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0273 0.3214
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.1149 0.8165
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0304 0.0583
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0385 0.0989
Brugia malayi isocitrate dehydrogenase 0.0016 0.0085 0.0134
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1403 1
Loa Loa (eye worm) hypothetical protein 0.051 0.634 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.005 0.0077
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.005 0.0049
Echinococcus granulosus GPCR family 2 0.0033 0.03 0.0471
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0085 0.0084
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1116 0.176
Schistosoma mansoni hypothetical protein 0.0104 0.1204 0.2933
Schistosoma mansoni DNA helicase recq5 0.0021 0.0152 0.0333
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0023 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1137 0.263
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.044 0.0873
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0815 0.0814
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1137 0.263
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0549 0.1429
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0309 0.0485
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.1204 0.1899
Mycobacterium ulcerans hypothetical protein 0.0161 0.1919 0.4298
Brugia malayi glutaminase DH11.1 0.033 0.4062 0.6407
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0152 0.1708
Brugia malayi 6-phosphofructokinase 0.012 0.1403 0.2213
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0152 0.0238
Echinococcus multilocularis cpg binding protein 0.0031 0.0276 0.0274
Entamoeba histolytica phosphofructokinase, putative 0.012 0.1403 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0061 0.0093
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1643 0.2589
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0273 0.6953
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.03 0.0473
Loa Loa (eye worm) hypothetical protein 0.0012 0.0044 0.0067
Echinococcus granulosus lamin dm0 0.0027 0.0224 0.0352
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0094 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0273 0.6269
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.1713 0.4552
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0309 0.0543
Brugia malayi hypothetical protein 0.051 0.634 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0273 0.0689
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0255 0.04
Loa Loa (eye worm) 6-phosphofructokinase 0.012 0.1403 0.2212
Schistosoma mansoni hypothetical protein 0.0014 0.0061 0.0106
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1116 0.7924
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0085 0.0084
Echinococcus multilocularis pyruvate kinase 0.0033 0.0304 0.0303
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0299 0.2031
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0152 0.1708
Echinococcus multilocularis expressed protein 0.0033 0.0309 0.0308
Echinococcus granulosus protein quaking 0.0028 0.0248 0.0389
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1137 0.3007

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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